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Monitoring stress and recovery states: Structural and external stages of the short version of the RESTQ sport in elite swimmers before championships

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Journal of Sport and Health Science 2019年第1期8卷 77-88页

作者： Michel Nicolas Philippe vacher guillaume Martinent laurent Mourot laboratory of Socio Psychology and Management of Sport (SPMS EA 4180) University of Burgundy laboratory of Vulnerabilities and Innovation in Sport (l-ViS EA 7428) Univ Lyon University of Claude Bernard Lyon 1 University of Franche Comt-Prognostic Markers and Regulatory Factors of Heart and Vascular Diseases and Exercise Performance Health Innovation Platform

Background: Psychological stress and recovery monitoring is a key issue for increasing athletes' health, well-being, and performance. This multistudy report examined changes and the doseàresponse relationships between recoveryàstress psychological states, training load(Tl), heart rate(HR), heart rate recovery(HRR), and heart rate variability(HRV) while providing evidence for the factorial validity of a short French version of the RecoveryàStress Questionnaire for Athletes(RESTQ-36-R-Sport).Methods: Four hundred and seventy-three university athletes(Study 1), 72 full expert swimmers(Study 2), and 11 national to international swimmers(Study 3) participated in the study. Data were analyzed through confirmatory factor analyses(Study 1), repeated ANOVAs and correlational analyses(Study 2), t tests and correlational analyses(Study 3).Results: Multiple-group confirmatory factor analyses showed that the RESTQ-36-R-Sport scores were partially invariant across gender, type of sport, and practice level(Study 1). A doseàresponse relationship was performed between Tl and RESTQ-36-R-Sport scores during an ecological training program(Study 2). Finally, relationships were found between physiological(HRR) and psychological(RESTQ-36-R-Sport) states during an ecological tapering period leading to a national championship(Study 3).Conclusion: As a whole, these findings provided evidence for the usefulness of the short version of the RESTQ-36-R-Sport for regular monitoring to prevent potential maladaptation due to intensive competitive sport practice.

关键词： Adaptation Confirmatory factor analysis Heart rate variability Monitoring Recovery Stress

Plasma Formed in Argon,Acid Nitric and Water Used in Industrial ICP Torches

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Plasma Science and Technology 2012年第8期14卷 683-692页

作者： F.BENDJEBBAR P.ANDRE M.BENBAKKAR D.ROCHETTE S.FlAZI D.vacher lgEO Oran UniversityBP1505El Mnaouer ORANAlgerie Blaise Pascal University LAEPTBP 10448F-63000 CLERMONT-FERRANDFrance Blaise Pascal University LMVBP 10448F-63000 CLERMONT-FERRANDFrance

Inductively coupled plasmas （ICPs） are used in spectrochemical analyses. The introduction of the sample by means of an aerosol are widely used. The introduction and the total evaporation of the aerosol is required in order to obtain a good repeatability and reproducibility of analyses. To check whether the vaporization of the aerosol droplets inside the plasma is completed, a solution could be used to compare the experimental results of the emission spectral lines with theoretical results. An accurate calculation code to obtain monatomic spectral lines intensities is therefore required, which is the purpose of the present paper. The mixtures of argon, water and nitric acid are widely used in spectrochemical analyses with ICPs. With these mixtures, we calculate the composition, thermodynamic functions and monatomic spectral lines intensities of the plasma at thermodynamic equilibrium and at atmospheric pressure. To obtain a self sufficient paper and also to allow other researchers to compare their results, all required data and a robust accurate algorithm, which is simple and easy to compute, are given.

关键词： inductively coupled plasmas argon plasma monatomic spectral lines ther-modynamic properties thermal plasma

Biomarkers of cetuximab resistance in patients with head and neck squamous cell carcinoma

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Cancer Biology & Medicine 2020年第1期17卷 208-217页

作者： Olivia leblanc Sophie vacher Charlotte lecerf Emmanuelle Jeannot Jerzy Klijanienko Frederique Berger Caroline Hoffmann Valentin Calugaru Nathalie Badois Anne Chilles Maria lesnik Samar Krhili IvanBieche Christophe le Tourneau Maud Kamal Department of genetics Curie InstitutePSL Research UniversityParis 75005France Department of Drug Development and Innovation(D3i) Curie InstitutePSL Research UniversityParis 75005France Department of Pathology Curie InstitutePSL Research UniversityParis 75005France Department of Biostatistics Curie InstitutePSL Research UniversityParis 75005France Department of Surgery Curie InstitutePSL Research UniversityParis 75005France INSERM U932 Research Unit Paris 75005France Department of Radiotherapy Curie InstitutePSL Research UniversityParis 75005France EA7331 Faculty of Pharmaceutical and Biological SciencesParis Descartes UniversityParis 75005France INSERM U900 Research Unit Curie InstituteParis 75005France

Objective:In patients with head and neck squamous cell carcinoma(HNSCC),cetuximab[a monoclonal antibody targeting epidermal growth factor receptor(EgFR)]has been shown to improve overall survival when combined with radiotherapy in the locally advanced setting or with chemotherapy in first-line recurrent and/or metastatic(R/M)setting,*** biomarkers of resistance to cetuximab have been identified in metastatic colorectal cancer,no biomarkers of efficacy have been identified in ***,we aimed to identify biomarkers of cetuximab sensitivity/resistance in ***:HNSCC patients treated with cetuximab at the Curie Institute,for whom complete clinicopathological data and formalin-fixed paraffin-embedded(FFPE)tumor tissue collected before cetuximab treatment were available,were *** analyses of PTEN and EgFR were performed to assess protein expression ***3 CA and H/N/KRAS mutations were analyzed using high-resolution melting(HRM)and Sanger *** evaluated the predictive value of these alterations in terms of progression-free survival(PFS).Results:Hot spot activating PIK3 CA and KRAS/HRAS mutations were associated with poor PFS among HNSCC patients treated with cetuximab in the first-line R/M setting,but not among HNSCC patients treated with cetuximab in combination with *** of PTEN protein expression had a negative predictive value among HNSCC patients treated with cetuximab and *** EgFR expression did not predict cetuximab sensitivity in our patient ***:Hot spot activating PIK3 CA and RAS mutations predicted cetuximab resistance among HNSCC patients in the firstline R/M setting,whereas loss of PTEN protein expression predicted resistance to cetuximab when combined to radiotherapy.

关键词： Head and neck squamous cell carcinoma cetuximab biomarker PIK3CA RAS

Strain Capacities limits of Wrought Magnesium Alloys: Tension vs. Expansion

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Materials Sciences and Applications 2013年第12期4卷 768-772页

作者： R. Boissiere P. vacher J. J. Blandin A. Khelil Institut Jean lamour Université de Lorraine Nancy France SIMAP Université de Grenoble CNRS Grenoble France SYMME Université de Savoie Annecy-le-Vieux France

lightening structure is one of the goals of many fields of research. As a result, magnesium alloys are studied due to their low density. However, one drawback of these alloys is their low formability at room temperature due to their hexagonal closed-packed structure. In the present work, the forming capacity of an AZ31 Mg alloys has been studied using a mini deep-drawing device, image correlation techniques and tests (tension and expansion) at temperatures contained between 20°C and 200°C. To investigate formability limits of Mg alloys in expansion, major and minor strains data were generated using hemispherical punch tests and analyzed with 3D digital images correlation techniques. Thanks to images correlation, strains on the surface of the samples were observed by means of a double digitization of the sample in three dimensions before and after deformation by using stereoscopic vision and triangulation. Image correlations have also been used in 2D to measure strains on the surface of the tensile test samples. These tests gave interesting information on the evolution of various parameters such as hardening coefficient, strain rate sensitivity parameter, and lankford coefficient, which may affect the behavior of the alloys. Finally, the forming limits in both configurations (tension and expansion) were compared and discussed.

关键词： Tension Expansion Image Correlation Magnesium Alloys Strain Measurements 3D Digitization Hemispheric Punch Deep-Drawing

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心源性闭经与情欲身体(法国)

世界核心医学期刊文摘（妇产科学分册） 2005年第11期1卷 19-20页

作者： vacher-Vitasse C. 李奎 159 rue de la Marne 33500 Libourne France

Psychogenic amenorrhoea turns a life event into a body event, for the simple reason that the sexed body cannot be reduced to an organism ruled by physiological laws. In addition to being a datum of life, the body, which is dedicated to “ jouir” , is also a construction both created by the imaginary and dissolved by the symbolic. This element accounts for the sensitivity of a bodily symptom to speech. As an illustration, the relation of a clinical case will show how, in the course of psychogenic amenorrhoea, the body undergoes a process of “ jouissance" that translates into a kind of “ organ paralysis", along with the dormant state of one physiological function and the whole body. Psychotherapy enabled one of the subjects to awaken her inhibited body after she had unrolled the significant elements of her desire. Addressing to the Other of language allowed her to create a social link and thus, undo the symptom.

关键词：躯体症状生活事件物质体心理治疗休眠状态

子宫颈癌筛查中传统子宫颈涂片、单层细胞学及人乳头状瘤病毒DNA检测的横断面研究

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英国医学杂志中文版 2003年第4期6卷 215-219页

作者： Jol Coste Batrix Cochand-Priollet Patricia de Cremoux Catherine le gals Isabelle Cartier Vincent Molini Sylvain labb Marie-Cecile vacher-lavenu Philippe Vielh 徐艳峰 Departement de Biostatistique Hopital Cochin Assistance Publique-Hopitaux de ParisFaculte de Medecine Cochin-Port Royal Universite Paris V ParisFrance professor of medical statistics Service d Anatomie et Cytologie Pathologiques Hopital Lariboisiere Assistance Publique-Hopitaux de Paris.Paris France assistant professor of pathology laboratoire de Physiopathol ogi e Departement de Biologie des TumeursInstitut CurieParisFrance assistant professor of pharmacology Centre for Health Economics and Administration Research (CREgAS) INSERM U537-CNRS UPRESA 8052 Le Kremlin-Bicetre Francesenior economist laboratoire Cartier ParisFrance pathologist

目的比较子宫颈癌筛查中传统子宫颈涂片、单层细胞学,以及人乳头状瘤病毒检测的敏感性、特异性和观察者间的可信性。设计对同时进行了此3项检查并有参考标准(阴道镜和组织学)者进行横断面研究。研究单位法国的公立大学和私人诊所,... 详细信息

目的比较子宫颈癌筛查中传统子宫颈涂片、单层细胞学,以及人乳头状瘤病毒检测的敏感性、特异性和观察者间的可信性。设计对同时进行了此3项检查并有参考标准(阴道镜和组织学)者进行横断面研究。研究单位法国的公立大学和私人诊所,本研究完全独立于病例提供者。研究对象因先前检出的细胞学异常而进行阴道镜检查的828名妇女和参加常规涂片检查的1757名妇女。主要结果判定指标临床读片和最优化解释(为取得一致所进行的双盲读片)。根据诊断异常的不同阈值计算出敏感性、特异性和加权κ值。结果根据Bethesda系统,传统子宫颈涂片检查得到的结果更为满意(91％比87％),比单层细胞学更可靠(加权κ值0.70比0.57),其敏感性和特异性更高。这些结果适用于临床读片和最优化解释,区分高级别和低级别病变,以及有低和高异常发生率的人群。人乳头状瘤病毒检测与单层细胞学检查同时进行,不论是系统性的还是只对于意义不明的非典型细胞,并不比传统涂片检查优越。结论在子宫颈癌筛选中,单层细胞学检查不如传统子宫颈涂片检查可靠,且更容易出现假阳性和假阴性结果。

关键词：子宫颈癌子宫颈涂片单层细胞学人乳头状瘤病毒 DNA检测 HPV

The Expansion and Diversification of Pentatricopeptide Repeat RNA-Editing Factors in Plants

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Molecular Plant 2020年第2期13卷 215-230页

作者： Bernard gutmann Santana Royan Mareike Schallenberg-Rudinger Henning lenz Ian R.Castleden Rose McDowell Michael Avacher Julian Tonti-Filippini Charles SBond Volker Knoop Ian D.Small Australian Research Council Centre of Excellence in Plant Energy Biology The University of Western AustraliaCrawleyPerth 6009WAAustralia School of Molecular Sciences The University of Western AustraliaCrawleyPerth 6009WAAustralia IZMB-Institut fur Zellulare und Molekulare Botanik Abteilung Molekulare EvolutionUniversitat BonnKirschallee 153115 BonnGermany Present address:EditForce Inc. West zone#429Kyushu University744 MotookaNishi-KuFukuokaJapan Present address:IBg-2:Plant Sciences Forschungszentrum Jiilich GmbH52425 JulichGermany Present address:Australian eHealth Research Centre Commonwealth Scientific and Industrial Research OrganisationFloreatPerth 6014WAAustralia

The RNA-binding pentatricopeptide repeat(PPR)family comprises hundreds to thousands of genes in most plants,but only a few dozen in algae,indicating massive gene expansions during land plant *** nature and timing of these expansions has not been well defined due to the sparse sequence data available from early-diverging land plant *** this study,we exploit the comprehensive OneKP datasets of over 1000 transcriptomes from diverse plants and algae toward establishing a clear picture of the evolution of this massive gene family,focusing on the proteins typically associated with RNA editing,which show the most spectacular variation in numbers and domain composition across the plant *** characterize over 2250000 PPR motifs in over 400000 *** lycophytes,polypod ferns,and hornworts,nearly 10%of expressed protein-coding genes encode putative PPR editing factors,whereas they are absent from algae and complex-thalloid *** show that rather than a single expansion,most land plant lineages with high numbers of editing factors have continued to generate novel sequence *** identify sequence variations that imply functional differences between PPR proteins in seed plants versus non-seed plants and variations we propose to be linked to seed-plant-specific editing ***,using the sequence variations across the datasets,we develop a structural model of the catalytic DYW domain associated with C-to-U editing and identify a clade of unique DYW variants that are strong candidates as U-to-C RNA-editing factors,given their phylogenetic distribution and sequence characteristics.

关键词： RNA editing RNA-binding protein organelles

老年人鼻的外科解剖学:经口入路保守鼻成形术的价值

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中国临床解剖学杂志 2003年第4期21卷 416-416页

作者： C. vacher J. Acciolt J. P. lezy 李鉴轶傅群武

儿童前庭性偏头痛和儿童复发性眩晕:Bárány协会前庭疾病分类委员会和国际头痛协会诊断标准共识文件

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神经损伤与功能重建 2021年第8期16卷 435-439页

作者：凌霞(译) 张赛(译) 申博(译) 隋汝波(审校) 杨旭(审校) Raymond van de Berg Josine Widdershoven Alexandre Bisdorff Stefan Evers Sylvette Wiener-vacher Sharon lCushing Kenneth JMack Ji Soo Kim Klaus Jahn Michael Strupp Thomas lempert 航天中心医院(北京大学航天临床医学院)神经内科河北医科大学第一医院神经内科郑州大学第二附属医院神经内科锦州医科大学附属第一医院神经内科荷兰马斯特里赫特大学医疗中心耳鼻喉-头颈外科卢森堡埃施EmileMayrisch医疗中心眩晕门诊德国科彭布吕格lindenbrunn医院神经内科德国明斯特大学医学中心法国巴黎罗伯特德布雷儿童医院耳鼻喉科加拿大多伦多大学儿童医院耳鼻喉-头颈外科美国明尼苏达州罗彻斯特市梅奥诊所儿童和青少年神经内科分部韩国首尔大学医学院、首尔大学盆唐医院神经内科、头晕中心、临床神经科学中心德国巴特艾布灵施恩诊所神经内科德国慕尼黑大学眩晕与平衡疾病中心德国慕尼黑大学神经内科德国柏林大学Schlosspark-Klinik医院神经内科

本文介绍了Bárány协会国际前庭疾病分类(International Classification of Vestibular Disorders,ICVD)委员会和国际头痛协会偏头痛分类小组所提出的"儿童前庭性偏头痛"(vestibular migraine of childhood,VMC)、"很可能的儿童前庭性偏头痛"(probable VMC,pVMC)和"儿童复发性眩晕"(recurrent vertigo of childhood,RVC)的诊断标准。偏头痛在儿童期不同复发性眩晕亚型中起着重要作用。在此分类文件中,VMC、p VMC和RVC这3种与偏头痛相关的一组谱系疾病分类,上述诊断标准中的偏头痛成分为确定、很可能及可能不存在。VMC的诊断标准:(A)至少5次中度或重度前庭症状发作,持续时间5分钟~72小时;(B)当前或既往有伴或不伴先兆的偏头痛病史;(C)至少50%的发作与至少1种偏头痛样症状相关。pVMC的诊断标准:至少3次中度或重度前庭症状发作,持续时间5分钟~72小时,符合VMC诊断标准B或C中的1项。RVC的诊断标准:至少3次中度或重度前庭症状发作,持续时间为1分钟~72小时,VMC诊断标准中的B和C均不符合。对于以上3种疾病,患者的年龄必须<18岁。建议将来的研究应特别关注RVC,以研究和确定其可能的亚型及其与偏头痛的关系。

关键词：儿童前庭性偏头痛很可能的儿童前庭性偏头痛儿童复发性眩晕诊断标准 Bárány协会