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International Journal of Geosciences 2021年第4期12卷 381-403页

作者： Enzo mantovani Giuliano Brancolini Daniele Babbucci Caterina Tamburelli Marcello Viti Dipartimento di Scienze Fisiche della Terra e dell’Ambiente Università di Siena Siena Italy Istituto Nazionale di Oceanografia e Geofisica Sperimentale—OGS Trieste Italy

The strongest documented seismic disaster ever occurred in the Po Plain area (January 3, 1117, M = 6.5) involved significant damage over a large zone. The genetic mechanism of such an event, most probably caused by more than one earthquake, is still an object of debate. Above all, the sources so far proposed cannot account for significant features of the observed macroseismic field. In this work, we suggest that the damage in the Verona zone was caused by the activation of a fault in the Lessini tectonic district, while damage in the central Po Plain may be related to a thrust fault located beneath the Giudicarie belt. The effects felt in northern Tuscany might derive from the seismic activation of the presumed SW-ward buried prolongation of the Giudicarie fault. The presence of such transpressional lithospheric discontinuity in the Adriatic domain since the upper Miocene and its reactivation (Pliocene-Pleistocene) as a thrust zone is mainly suggested by an accurate analysis of the observed deformation pattern in the central Mediterranean region. The proposed Giudicarie source may also help to explain the damage observed in the central Po Plain on December 25, 1222, which is not compatible with the seismic sources so far proposed.

关键词： Northern Adriatic Tectonics Po Plain Giudicarie Thrust Zone January 3 1117 Earthquake Sources

The Physical Universe and the Theoretical Value of Science:Reflections on the Thought of ***

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Journal of Philosophy Study 2023年第8期13卷 325-334页

作者： Roberto mantovani Alessandro Prato University of Urbino UrbinoItaly University of Siena SienaItaly

The essay has two main *** first consists of discussing some literary and philosophical thoughts on the epistemological value of science by one of the most famous and celebrated poets in Italian literature,Giacomo *** poet firmly believes in the cognitive power of science,capable of revealing false beliefs with the light of ***,in his mature reflections,what will radically change will not be the value of scientific activity itself,always admirably accepted,but rather its true salvific *** was not a scientist,but he used the scientific culture of his time to critically address the great existential themes of man concerning nature and the *** had amply demonstrated a scientific culture since his youthful'History of Astronomy',which would reappear in many of his other literary *** deep and meditative reflections on the nature of finite and infinite space and time are a clear and fruitful testimony to ***,Giacomo writes icastically,reason alone is not enough;it needs *** second concerns a first reconstruction of the influence that the philosophy of Enlightenment had on Leopardi’s thought especially in relation to these topics:atheism,rejection of providentialism and anthropocentrism,the conception of nature,the question of the relationship between human and animal intelligence,the rejection of metaphysics,the importance of scientific knowledge.

关键词： Giacomo Leopardi Leopardi's philosophical thoughts Leopardi's scientific thoughts epistemological value of science materialism philosophy of Enlightenment metaphysics

Seismotectonics of the Padanian Region and Surrounding Belts: Which Driving Mechanism?

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International Journal of Geosciences 2016年第12期7卷 1412-1451页

作者： Marcello Viti Enzo mantovani Daniele Babbucci Caterina Tamburelli Nicola Cenni Dipartimento di Scienze Fisiche Della Terra e dell’Ambiente Università degli Studi di Siena Siena Italy Dipartimento di Fisica ed Astronomia Università degli Studi di Bologna Bologna Italy

It is argued that the complex tectonic pattern observed in the study area can plausibly be explained as an effect of the kinematics of the Iberia and Adria blocks, induced by the NNE ward motion of Africa and the roughly westward motion of the Anatolian-Aegean system with respect to Eurasia. These boundary conditions cause the constrictional regime which is responsible for the observed shortening processes in the Padanian region and Western Alps. The proposed dynamic context can plausibly account for the peculiar distribution of major seismic sources, located in the northern Apennines, the Giudicarie fault system, the offshore of the western Ligurian coast and the Swiss Alps. The observed tectonic pattern in Western Europe and the study area can hardly be reconciled with the implications of the roughly NWward convergence between Africa and Eurasia proposed by global kinematic models, whereas it is compatible with the alternative Africa-Eurasia kinematics and plate mosaic proposed by [1].

关键词： Seismotectonics Geodynamics GPS Mediterranean Padanian

疏水基取代的分枝状聚乙酰亚胺衍生物:促进原发性血管细胞中的转染（英文）

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Science China Materials 2017年第6期60卷 529-542页

作者： Daniele Pezzoli Eleni K.Tsekoura Remant Bahadur K.C. Gabriele Candiani Diego mantovani Hasan Uludag Laboratory for Biomaterials and Bioengineering CRC- I Department of Mining Metallurgical and Materials Engineering and CHU de Quebec Re- search Centre Laval University Quebec City QC GIV 0A6 Canada Department of Chemical & Material Engineering Faculty of Engineering University of Alberta Edmonton AB T6G 1H9 Canada Department of Chemistry Materials and Chemical Engineering "Giulio Natta" Politecnico di Milano Milan 20131 Italy

针对血管细胞的基因治疗代表了一种有望用于预防和治疗内膜增生、血管支架狭窄和血管成形术后狭窄等病理状态的方法.聚合物非病毒载体的基因传递系统可以安全替代病毒载体,但是为了提高临床效果,它们的治疗效率及细胞相容性还需要进一... 详细信息

针对血管细胞的基因治疗代表了一种有望用于预防和治疗内膜增生、血管支架狭窄和血管成形术后狭窄等病理状态的方法.聚合物非病毒载体的基因传递系统可以安全替代病毒载体,但是为了提高临床效果,它们的治疗效率及细胞相容性还需要进一步改善.本文合成了一系列24种被疏水基团修饰的分枝状聚乙酰亚胺衍生物(bPEI),并进行了表征及在体外原发性血管细胞内的测试,旨在筛选出具有优异的转染效率和低细胞毒性的传递剂.低分子量的聚乙酰亚胺(0.6,1.2 and 2 kDa)以不同取代程度接枝上了不同饱和度的长(C18)和短(C3)的不饱和脂肪链.丙酰取代衍生物(PEI2-PrA1,C3:0)在血管平滑肌细胞和内皮细胞转染中是最有效的,与著名的黄金标准25 kDa bPEI相比,具有更优异、更持久的基因表达,且毒性更低.此外,亚油酰基取代衍生物(PEI1.2-LA6,C18:2)由于在血管平滑肌细胞转染过程中效率高,而在内皮细胞中相对无效,且其具有可容忍的细胞毒性,可作为特定靶向于血管平滑肌细胞的载体.

关键词：血管成形术细胞相容性胺衍生物转染效率原发性疏水基乙酰枝状

Myostatin gene promoter:structure,conservation and importance as a target for muscle modulation

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Journal of Animal Science and Biotechnology 2019年第2期10卷 255-273页

作者： Carla Vermeulen Carvalho Grade Carolina Stefano mantovani Lúcia Elvira Alvares Universidade Federal da Integracao Latino-Americana UNILAInstituto Latino-Americano de Ciências da Vida e da NaturezaAvenida Tarquínio Joslin dos Santos1000Foz do IguacuPR CEP 85870-901Brazil Departamento de Bioquímica e Biologia Tecidual Universidade Estadual de Campinas-UNICAMPRua Monteiro Lobato255CampinasSP CEP 13083-862Brazil.

Myostatin(MSTN) is one of the key factors regulating myogenesis. Because of its role as a negative regulator of muscle mass deposition, much interest has been given to its protein and, in recent years, several studies have analysed MSTN gene regulation. This review discusses the MSTN gene promoter, focusing on its structure in several animal species, both vertebrate and invertebrate. We report the important binding sites considering their degree of phylogenetic conservation and roles they play in the promoter activity. Finally, we discuss recent studies focusing on MSTN gene regulation via promoter manipulation and the potential applications they have both in medicine and agriculture.

关键词： CAAT box E-box Gene promoter Myogenesis Myostatin SNP Transcription factors TATA box

Present Velocity Field in the Italian Region by GPS Data: Geodynamic/Tectonic Implications

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International Journal of Geosciences 2015年第12期6卷 1285-1316页

作者： Enzo mantovani Marcello Viti Nicola Cenni Daniele Babbucci Caterina Tamburelli Dipartimento di Scienze Fisiche della Terra e dell’Ambiente Università degli Studi di Siena Siena Italy Dipartimento di Fisica ed Astronomia Università degli Studi di Bologna Bologna Italy

The analysis of geodetic observations carried out by 478 continuous GPS stations in the Italian region since 2001 has allowed a fairly good definition of the ongoing horizontal velocity field with respect to Eurasia. It is argued that such evidence can provide important insights into the geodynamic context in the central Mediterranean area. Numerous velocity vectors in the Apulia zone coherently indicate that the southern Adriatic domain is moving roughly NE ward. Since no significant decoupling zone between this domain and Nubia has so far been recognized, one could expect that the kinematics of these two plates is compatible. However, this condition is not fulfilled if the Nubia-Eurasia relative motion is taken from the global kinematic models, either deduced by long-term evidence?[1]?or short-term geodetic data?[2]?[3]. This problem is considerably reduced if the alternative Nubia-Eurasia rotation pole suggested by?[4]?is taken into account. This choice is also suggested by other major long-term evidence in the Mediterranean region. The numerous geodetic vectors available in two Adriatic sectors, the Apulia zone and the Venetian plain, would imply an Adria-Eurasia rotation pole incompatible with all Nubia-Eurasia Eulerian poles so far proposed. Since a significant relative motion between these plates is not compatible with the absence of a tectonic decoupling zone, we suppose that the short-term kinematics of Adria might be influenced by a transient non-rigid behaviour of that plate. This hypothesis is compatible with the expected effects (post seismic relaxation) of the major decoupling earthquakes that have occurred along Periadriatic zones in the past tens of years. The compatibility of the GPS kinematic pattern in the Apennine belt, Calabria Arc and Sicily with the implications of the geodynamic/tectonic interpretations so far proposed for the central Mediterranean area is then discussed.

关键词： Geodesy Geodynamics Italy Central Mediterranean

Possible Location of the Next Major Earthquakes in the Northern Apennines: Present Key Role of the Romagna-Marche-Umbria Wedge

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International Journal of Geosciences 2017年第11期8卷 1301-1314页

作者： Enzo mantovani Marcello Viti Daniele Babbucci Caterina Tamburelli Nicola Cenni Dipartimento di Scienze Fisiche della Terra e dell’Ambiente Università degli Studi di Siena Siena Italy Dipartimento di Fisica e Astronomia Università degli Studi di Bologna Bologna Italy Dipartimento di Ingegneria Civile Chimica Ambientale e Meccanica Università degli Studi di Bologna Bologna Italy Abstract

It is argued that in some zones of the Northern Apennines, in particular the Rimini-Ancona thrust system, the Romagna Apennines and the Alta Valtiberina trough, the probability of major earthquakes is now higher than in other Apennine zones. This hypothesis is suggested by the comparison of the present short-term kinematics of the Romagna-Marche-Umbria wedge in the Northern Apennines, deduced by the distribution of major shocks in the last tens of years, with the previous repeated behavior of the same wedge, evidenced by the distribution of major earthquakes in the last seven centuries. The seismotectonics of the Apennine region here considered is closely connected with the larger context that involves the progressive migration (from south to north) of seismicity along the peri-Adriatic zones. The information provided by this study can be used to better manage the resources for prevention in Italy.

关键词： Peri-Adriatic Seismicity Northern Apennines Romagna-Marche-Umbria Seismotectonics

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创建宽带数字家庭

今日电子 2001年第7期 28-29页

作者： Alberto mantovani

一、概述目前人们谈论的"宽带数字家庭"更强调的可能是因特网的宽带接入.实际上,这是一个简单化的概念.宽带家庭其实有更广泛的涵义,它不仅包括因特网接入,还包括通过宽带传送到家庭的一整套捆绑服务,如,本地电话、长话、蜂窝电话、寻... 详细信息

一、概述目前人们谈论的"宽带数字家庭"更强调的可能是因特网的宽带接入.实际上,这是一个简单化的概念.宽带家庭其实有更广泛的涵义,它不仅包括因特网接入,还包括通过宽带传送到家庭的一整套捆绑服务,如,本地电话、长话、蜂窝电话、寻呼和娱乐服务,以及在家庭内传送这些服务并确保家庭网免受非法接入的必要技术.面对这一更为丰富的连接环境,线缆和ADSL调制解调器不能再以简单的因特网接入速度判断优劣,而必须以新的标准进行评估.但随之而来的问题是,每种技术能支持多少现有服务?客户如何定购服务?他们如何得到所需的硬件并进行安装?在目前和将来,硬件能在何种程度上支持客户需要的各式各样的捆绑宽带服务?它们能与多功能宽带数字家庭进行天衣无缝的集成吗?

关键词：宽带网 ADSL 通信网

Present Tectonic Setting and Spatio-Temporal Distribution of Seismicity in the Apennine Belt

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International Journal of Geosciences 2015年第4期6卷 429-454页

作者： Enzo mantovani Marcello Viti Daniele Babbucci Caterina Tamburelli Nicola Cenni Massimo Baglione Vittorio D’Intinosante Dipartimento di Scienze Fisiche della Terra e dell’Ambiente Università degli Studi di Siena Siena Italy Dipartimento di Scienze Biologiche Geologiche e Ambientali Università degli Studi di Bologna Bologna Italy Settore Sismica Regione Toscana Firenze Italy

In previous papers, we have argued that a close connection may exist between the discontinuous northward displacement of the Adria plate and the spatio-temporal distribution of major earthquakes in the?periAdriatic?regions?[1]-[3]. In particular, five seismic sequences are tentatively recognized in the post 1400 A.D. seismic history, each characterized by a progressive migration of major shocks along the eastern (Hellenides, Dinarides), western (Apennines) and northern (Eastern Southern Alps) boundaries of Adria. In this work, we describe an attempt at gaining insights into the short-term evolution of the strain field that underlies the migration of seismicity in the Apennine belt. The results of this study suggest that seismicity in the study area is mainly conditioned by the fact that the outer (Adriatic) sector of the Apennine belt, driven by the Adria plate, is moving faster than the inner (Tyrrhenian) belt. This kinematics is consistent with the observed Pleistocene deformation pattern and the velocity field inferred by GPS data. The spatio-temporal distribution of major shocks during the last still ongoing seismic sequence (post 1930) suggests that at present the probability of next major shocks is highest in the Northern Apennines. Within this area, we suggest that seismic hazard is higher in the zones located around the outer sector of the Romagna-Marche-Umbria units (RMU), since that wedge is undergoing an accelerated relative motion with respect to the inner Apennine belt. This hypothesis may also account for the pattern of background seismicity in the Northern Apennines. This last activity might indicate that the Upper Tiber Valley fault system is the most resisted boundary sector of the RMU mobile wedge, implying an higher probability of major earthquakes.

关键词： Seismotectonics Seismic Hazard GPS Apennines Mediterranean

Generation of Back-Arc Basins as Side Effect of Shortening Processes: Examples from the Central Mediterranean

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International Journal of Geosciences 2014年第10期5卷 1062-1079页

The evolution of the Mediterranean area since the Oligocene-Lower Miocene has been driven by the convergence of the surrounding plates. This implies that the observed deformation pattern in that region must be the most convenient shortening pattern, i.e. the one controlled by the minimum action principle. To understand why the fulfilment of such condition has required a complex spatio-temporal distribution of major tectonic events, such as uplift, lateral displacement and bending of orogenic belts, consumption of large lithospheric domains and formation of back arc basins, it may be very useful to take into account a basic tectonic concept, which helps to identify the process that can minimize the resistance of tectonic forces. Such concept starts from the fact that the most convenient consumption process is the one that involves low buoyancy oceanic lithosphere (Tethyan domains). However, such process is highly favoured where the oceanic lithosphere is stressed by vertical forces, a situation that develops when orogenic wedges are forced to over thrust and load the oceanic domain to be consumed. This interpretation can provide plausible and coherent explanations for the complex pattern of the observed deformations. In this view, the generation of back arc basins is taken as a side effect of an extrusion process, as suggested by numerical and mechanical experiments.

关键词： Central Mediterranean Extrusion Tectonics Back-Arc Basins