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Preclinical and clinical evidence of the association of colibactinproducing Escherichia coli with anxiety and depression in colon cancer

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World Journal of Gastroenterology 2024年第21期30卷 2817-2826页

作者： Fabien Rondepierre maëva Meynier Johan Gagniere Vincent Deneuvy Anissa Deneuvy Gwenaelle Roche Elodie Baudu Bruno Pereira Richard Bonnet nicolas Barnich Frédéric Antonio Carvalho Denis Pezet mathilde Bonnet Isabelle Jalenques Service de Psychiatrie de l’Adulte A et Psychologie Médicale CHU Clermont-FerrandClermont-Ferrand 63000France M2iSH UMR 1071INSERMUniversity of Clermont AuvergneINRAE USC 1382Clermont-Ferrand 63001France neuroDol UMR 1107INSERMUniversity of Clermont AuvergneClermont-Ferrand 63001France Department of Digestive Surgery CHU de Clermont-FerrandClermont-Ferrand 63001France Biostatistics Unit Department of Clinical Research and InnovationCHU Clermont-FerrandClermont-Ferrand 63000France Department of Bacteriology CHU de Clermont-FerrandClermont-Ferrand 63001France UniversitéClermont Auvergne INPCNRSClermont Auvergne Institut PascalClermont-Ferrand 63000France

BACKGROUnD The association between the intestinal microbiota and psychiatric disorders is becoming increasingly *** gut microbiota contributes to colorectal carcinogenesis(CRC),as demonstrated with colibactin-producing Escherichia coli(CoPEC).AIM To evaluate the association between CoPEC prevalence and anxiety-and depressive-like behaviors with both preclinical and clinical *** Patients followed after a CRC surgery and for whom the prevalence of CoPEC has been investigated underwent a psychiatric *** were compared according to the CoPEC *** parallel C57BL6/J wild type mice and mice with a CRC susceptibility were chronically infected with a CoPEC *** behavior was assessed using the Elevated Plus maze test,the Forced Swimming Test and the Behavior recognition system PhenoTyper®.RESULTS In a limited cohort,all patients with CoPEC colonization presented with psychiatric disorders several years before cancer diagnosis,whereas only one patient(17%)without CoPEC *** result was confirmed in C57BL6/J wildtype mice and in a CRC susceptibility mouse model(adenomatous polyposis colimultiple intestinal neoplasia/+).Mice exhibited a significant increase in anxiety-and depressive-like behaviors after chronic infection with a CoPEC *** This finding provides the first evidence that CoPEC infection can induce microbiota-gut-brain axis disturbances in addition to its procarcinogenic properties.

关键词： Colorectal cancer Colibactin Escherichia coli Colibactin-producing Escherichia coli Inflammation Anxiety Depression Behavior

Weighted multilinear p-adic Hardy operators and commutators on p-adic Herz-type spaces

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Applied mathematics(A Journal of Chinese Universities) 2024年第3期39卷 554-570页

作者： ma Teng ZHOU Jiang College of mathematics and System Sciences Xinjiang UniversityUrumqi 830046China

In this paper,we introduce the weighted multilinear p-adic Hardy operator and weighted multilinear p-adic Ces`aro operator,we also obtain the boundedness of these two operators on the product of p-adic Herz spaces and p-adic Morrey-Herz spaces,the corresponding operator norms are also established in each ***,the boundedness of commutators of these two operators with symbols in central bounded mean oscillation spaces and Lipschitz spaces on p-adic Morrey-Herz spaces are also given.

关键词： Morrey-Herz spaces weighted multilinear p-adic Hardy operator commutators operator norms

A novel dynamic step size LMS optimization scheme for interference reducing in FBMC-QAM

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High Technology Letters 2024年第3期30卷 290-296页

作者： DOnG Qiyang ma Tianming JIAnG Xiaoxiao ma Honglei School of Electrical and Electronic Engineering Shanghai University of Engineering ScienceShanghai 201620P.R.China

Filter bank multicarrier quadrature amplitude modulation(FBMC-QAM)will encounter inter-ference and noise during the process of channel *** order to suppress the interference in the communication system,channel equalization is carried out at the *** that the con-ventional least mean square(LMS)equilibrium algorithm usually suffer from drawbacks such as the inability to converge quickly in large step sizes and poor stability in small step sizes when searching for optimal weights,in this paper,a design scheme for adaptive equalization with dynamic step size LMS optimization is proposed,which can further improve the convergence and error stability of the algorithm by calling the Sigmoid function and introducing three new parameters to control the range of step size values,adjust the steepness of step size,and reduce steady-state errors in small step *** analysis and simulation results demonstrate that compared with the conventional LMS algorithm and the neural network-based residual deep neural network(Res-Dnn)algorithm,the adopted dynamic step size LMS optimization scheme can not only obtain faster convergence speed,but also get smaller error values in the signal recovery process,thereby achieving better bit error rate(BER)performance.

关键词： filter bank multicarrier quadrature amplitude modulation(FBMC-QAM) adap-tive equalization least mean square(LMS) dynamic step size

Catalytic recycling of polyesters via a binuclear catalyst

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Science China Chemistry 2024年第2期67卷 426-427页

作者： Bo Sun Ding ma Beijing national Laboratory for Molecular Science New Cornerstone Science LaboratoryCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China

Plastics play a crucial role in modern society life. While the increasing use of plastics and rapid accumulation of plastic waste in nature environment have caused severe environmental crisis and the waste of carbon resources. Catalytic upcycling is a promising approach to transform plastic waste into high value-added chemicals to achieve a sustainable circular economy.

关键词： Catalytic polyester catalyst

Partial regularity and nonlinear potential estimates for Stokes systems with super-quadratic growth

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Science China mathematics 2024年第7期67卷 1525-1554页

作者： Lingwei ma Zhenqiu Zhang School of mathematical Sciences Tianjin Normal UniversityTianjin300387China School of mathematical Sciences and LPMC Nankai UniversityTianjin300071China

This paper builds a bridge between partial regularity theory and nonlinear potential theory for the following generalized stationary Stokes system with super-quadratic growth and continuous coefficients:-div A(x,Du)+■π=f,div u=0,where Du is the symmetric part of the gradient■*** first establish anε-regularity criterion involving both the excess functional of the symmetric gradient Du and Wolff potentials of the nonhomogeneous term f to guarantee the local vanishing mean oscillation(VMO)-regularity of Du in an open subset Ω_(u) of Ω with full *** anε-regularity criterion leads to a pointwise Wolff potential estimate of Du,which immediately infers that Du is partially C^(0)-regular under appropriate ***,we give a local continuous modulus estimate of Du.

关键词： nonlinear Stokes system partial regularity Wolff potential estimates continuous modulus estimates

nuance of inward rectifying potassium(Kir)channel dysfunctions in neurodegenerative diseases

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neural Regeneration Research 2024年第6期19卷 1195-1196页

作者： Benjamin Garland Linlin ma Griffith Institute for Drug Discovery&School of Environment and Science Griffith UniversityNathanBrisbaneQLDAustralia

neurodegenerative disorders are highly prevalent and diverse in *** manifestation largely depends on the cell types involved,with aberrant inflammatory episodes progressively inducing a constellation of phenotypes that are classified into specific diseases based on their neuropathological *** two most prevalent neurodegenerative diseases worldwide,Alzheimer’s disease(AD)and Parkinson’s disease(PD),for example,share notable similarities,yet they differ in terms of the specific cell types lost within the central nervous system(CnS).The significant and progressive loss of cortical and certain subcortical neurons in various regions is a major defining trait of *** contrast,the specific loss of dopaminergic neurons(DA)within the substantial nigra pars compacta(Snpc)is sufficient to cause motor symptoms associated with *** devastating condition arising from neurodegeneration within the CnS,amyotrophic lateral sclerosis(ALS),results in the progressive death of upper and lower motor *** degeneration originates in oligodendrocytes,whose defective myelination abilities lead to the denervation of the anterior horn,aggravating motor neuron death.

关键词： diseases degenerative degeneration

DiffGR:Detecting Differentially Interacting Genomic Regions from Hi-C Contact maps

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 143-155页

作者： Huiling Liu Wenxiu ma Department of Statistics University of California RiversideRiversideCA 92521USA

Recent advances in high-throughput chromosome conformation capture(Hi-C)techniques have allowed us to map genome-wide chromatin interactions and uncover higher-order chromatin structures,thereby shedding light on the principles of genome architecture and ***,statistical methods for detecting changes in large-scale chromatin organization such as topologically associating domains(TADs)are still ***,we proposed a new statistical method,DiffGR,for detecting differentially interacting genomic regions at the TAD level between Hi-C contact *** utilized the stratum-adjusted correlation coefficient to measure similarity of local TAD *** then developed a nonparametric approach to identify statistically significant changes of genomic interacting *** simulation studies,we demonstrated that DiffGR can robustly and effectively discover differential genomic regions under various ***,we successfully revealed cell type-specific changes in genomic interacting regions in both human and mouse Hi-C datasets,and illustrated that DiffGR yielded consistent and advantageous results compared with state-of-the-art differential TAD detection *** DiffGR R package is published under the GnU General Public License(GPL)≥2 license and is publicly available at https://***/wmalab/DiffGR.

关键词： Hi-C Differential analysis Topologically associating domain Stratum-adjusted correlation coefficient nonparametric method

Time-inconsistent stochastic linear-quadratic control problem with indefinite control weight costs

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Science China mathematics 2024年第1期67卷 211-236页

作者： Qi Lü Bowen ma School of mathematics Sichuan UniversityChengdu 610064China

A time-inconsistent linear-quadratic optimal control problem for stochastic differential equations is *** introduce conditions where the control cost weighting matrix is possibly *** such conditions,we obtain a family of closed-loop equilibrium strategies via multi-person differential *** result extends Yong’s work(2017) in the case of stochastic differential equations,where a unique closed-loop equilibrium strategy can be derived under standard conditions(namely,the control cost weighting matrix is uniformly positive definite,and the other weighting coefficients are positive semidefinite).

关键词： linear-quadratic optimal control problem time-inconsistent cost functional generalized Riccati equation indefinite control weight cost closed-loop equilibrium strategy

Development of a novel signal restoration algorithm to eliminate the distorted components in space charge measurement excited by femtosecond laser irradiation

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High Voltage 2024年第3期9卷 659-673页

作者： Tianrun Qi Hanwen Ren Haoyu Gao Qingmin Li Yidan ma Yiqun ma Tao Xiao State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijingChina

For the space charge measurement method with optical excitation for electrical insulation,the distortion of the excitation laser on the measurement signal and the accumulation of space charge have not been discussed *** experiment and simulation results show that three types of distorted components introduced by optical excitation can lead to distortion of the upper interface ***,the factors causing distortion of the measured signal and the formation mechanism are analysed.A virtual electrode potential compensation method and a distorted component extraction method are ***,an attenuation restoration and charge conversion correction factor is intro-duced,leading to a novel signal processing algorithm adapted to space charge optical measurement *** with the traditional algorithm,the novel algorithm has an error of less than 1%in the calculation of charge and electric field strength,with an increase in accuracy of 47.7%and 9.81%,*** applying the novel restoration algorithm,the comparison shows that the space charge accumulation does not change significantly under laser irradiation,verifying the reliability of the optical *** given algorithm can provide a theoretical and technical foundation for the realisation of the optical measurement method for space charge.

关键词： charge algorithm excitation