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Asian Pacific Journal of Tropical Medicine 2011年第8期4卷 658-660页

作者： vr santhosh kumar Md Naseeruddin Inamdar Nayeemunnisa GL Viswanatha Department of Pharmacology Al-Ameen College of PharmacyHosur RoadBangaloreIndia Department of Pharmacology PES College of PharmacyHanumanthanagarBangaloreIndia

Objective:To evaluate the anti-hyperlipidemic activity of lemongrass oil against in dexamethasone induced hyperlipidemia in ***:Administration of dexamethasone was given at 10 mg/kg,*** the adult rats for 8 d induces hyperlipidemia characterized by marked increase in serum cholesterol and triglyceride levels along with increase in atherogenic ***:Lemongrass oil(100 and 200 mg/kg,po.) treatment has showed significant inhibition against dexamethasone hyperlipidemia by maintaining the serum levels of cholesterol, triglycerides and atherogenic index near to the normal levels and the antihyperlipidemic effect of the lemongross oil was comparable with atorvastatin 10 mg/kg,*** possible mechanism may be associated with decrease in lecithin cholesterol acetyl transferase(LCAT) ***:These results suggested that Lemon gross oil possess significant antihyperlipidemic activity.

关键词： Lemongrass oil Hvperlipidemia Dexametliasone Lipid-lowering activity

Automatic Rule Discovery for Data Transformation Using Fusion of Diversified Feature Formats

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Computers, Materials & Continua 2024年第7期80卷 695-713页

作者： G.Sunil santhosh kumar M.Rudra kumar Department of CSE Jawaharlal Nehru Technological UniversityAnantapur515002India Department of CSE Marri Laxman Reddy Institute of Technology and ManagementHyderabad500043India Department of Information Technology Mahatma Gandhi Institute of TechnologyHyderabad500075India

This article presents an innovative approach to automatic rule discovery for data transformation tasks leveraging XGBoost,a machine learning algorithm renowned for its efficiency and *** framework proposed herein utilizes the fusion of diversified feature formats,specifically,metadata,textual,and pattern *** goal is to enhance the system’s ability to discern and generalize transformation rules fromsource to destination formats in varied ***,the article delves into the methodology for extracting these distinct features from raw data and the pre-processing steps undertaken to prepare the data for the *** sections expound on the mechanism of feature optimization using Recursive Feature Elimination(RFE)with linear regression,aiming to retain the most contributive features and eliminate redundant or less significant *** core of the research revolves around the deployment of the XGBoostmodel for training,using the prepared and optimized feature *** article presents a detailed overview of the mathematical model and algorithmic steps behind this ***,the process of rule discovery(prediction phase)by the trained XGBoost model is explained,underscoring its role in real-time,automated data *** employingmachine learning and particularly,the XGBoost model in the context of Business Rule Engine(BRE)data transformation,the article underscores a paradigm shift towardsmore scalable,efficient,and less human-dependent data transformation *** research opens doors for further exploration into automated rule discovery systems and their applications in various sectors.

关键词： XGBoost business rule engine machine learning categorical query language humanitarian computing environment

Laparoscopic management of remnant gall bladder with stones: Lessons from a tertiary care centre's experience

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第1期7卷 27-33页

作者： Gilbert Samuel Jebakumar Jeevanandham Muthiah Loganathan Jayapal R.santhosh kumar Siddhesh Tasgaonkar K.S.santhosh Anand J.K.A.Jameel Sudeepta kumar Swain K.J.Raghunath Prasanna kumar Reddy Tirupporur Govindaswamy Balachandar Department of Surgical Gastroenterology Apollo HospitalsChennai 600006India Department of General Surgery Apollo HospitalsChennai 600006India Department of Minimal Access Surgery Apollo HospitalsChennai 600006India

Objective:Laparoscopic cholecystectomy is currently the gold standard for treating symptomatic gallstone *** its success,approximately 10%of patients may experience persistent biliary symptoms,leading to the post-cholecystectomy syndrome.A remnant gallbladder with cystic duct or bile duct stones is one of the causes of this *** objective of this study was to shed light on the clinical manifestations,evaluation,therapeutic strategies,and outcomes associated with laparoscopic management of symptomatic remnant ***:This was a retrospective study,conducted over a five-year period(January 2017 to December 2022)at Apollo Hospitals in South *** patients who underwent laparoscopic completion cholecystectomy for a remnant gall bladder were *** following data were collected:patient demographics,symptoms,preoperative investigations,intraoperative details and post operative ***:In total,36 patients were included and *** majority of patients were male(25,69.4%),with a mean age of 50.7±12.1 *** most common presentation was pain in the upper abdomen or right upper quadrant region(24,66.7%).The laparoscopic approach was attempted in all patients,with a success rate of 94.4%.Two patients required conversion to open *** fistula to the colon was observed in one *** was observed in 7 patients(19.4%),and stone clearance was successfully achieved using endoscopic retrograde cholangiopancreatography in all patients ***:Incomplete gall bladder removal either intentionally or unintentionally leaves a remnant gall bladder that is at risk for stone formation and *** who have this clinical entity with symptoms require a redo or complete cholecystectomy,a complex procedure associated with certain *** study highlights the feasibility and safety of laparoscopic completion cholecystectomy for the management of remnant gallbladder

关键词： Remnant gall bladder Stump cholecystitis Subtotal cholecystectomy Laparoscopic completion cholecystectomy

Laparoscopic plication for diaphragmatic eventration in adults:Unveiling the mystery of eventration

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第2期7卷 92-96页

作者： Balika Mahesan Prasanna kumar Reddy K.S.santhosh Anand Muvva Sri Harsha M Vijay N Sudarsan Srikanth Department of Minimal Access Surgery Apollo HospitalsChennaiIndia Department of Surgical Gastroenterology Apollo HospitalsChennaiIndia

Diaphragm eventration is the permanent elevation of a hemidiaphragm and can be due to congenital or acquired *** is a rather uncommon condition in adults and causes a spectrum of symptoms,ranging from asymptomatic incidental findings on imaging to life-threatening respiratory *** patients do not require any treatment,but plication is the conventional,well-known method for treating symptomatic *** varies depending on the *** this article,we discuss two rare cases of diaphragmatic eventration that were treated with minimal access surgery.

关键词： Diaphragmatic eventration Minimal access surgeryLaparoscopy

Tasks Scheduling in Cloud Environment Using PSO-BATS with MLRHE

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Intelligent Automation & Soft Computing 2023年第3期35卷 2963-2978页

作者： Anwar R Shaheen Sundar santhosh kumar Department of Computer Science Alagappa UniversityKaraikudiIndia

Cloud computing plays a signiﬁcant role in Information Technology(IT)industry to deliver scalable resources as a *** of the most important factor to increase the performance of the cloud server is maximizing the resource utilization in task *** main advantage of this scheduling is to max-imize the performance and minimize the time *** researchers examined numerous scheduling methods to achieve Quality of Service(QoS)and to reduce execution ***,it had disadvantages in terms of low throughput and high response ***,this study aimed to schedule the task efﬁciently and to eliminate the faults in scheduling the tasks to the Virtual Machines(VMs).For this purpose,the research proposed novel Particle Swarm Optimization-Bandwidth Aware divisible Task(PSO-BATS)scheduling with Multi-Layered Regression Host Employment(MLRHE)to sort out the issues of task scheduling and ease the scheduling operation by load *** proposed efﬁcient sche-duling provides beneﬁts to both cloud users and *** performance evalua-tion is undertaken with respect to cost,Performance Improvement Rate(PIR)and makespan which revealed the efﬁciency of the proposed ***,comparative analysis is undertaken which conﬁrmed the performance of the intro-duced system than conventional system for scheduling tasks with highﬂexibility.

关键词： Task scheduling virtual machines(VM) particle swarm optimization(PSO) bandwidth aware divisible task scheduling(BATS) multi-layered regression

Integrated Privacy Preserving Healthcare System Using Posture-Based Classifier in Cloud

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Intelligent Automation & Soft Computing 2023年第3期35卷 2893-2907页

作者： C.santhosh kumar K.Vishnu kumar Department of Computer Science and Engineering Priyadarshini Engineering College635751TamilnaduIndia Department of Computer Science and Engineering KPR Institute of Engineering&TechnologyCoimbatore641407India

Privacy-preserving online disease prediction and diagnosis are critical issues in the emerging edge-cloud-based healthcare *** patient data pro-cessing from remote places may lead to severe privacy ***,the existing cloud-based healthcare system takes more latency and energy consumption during diagnosis due to ofﬂoading of live patient data to remote cloud *** the privacy *** proposed research introduces the edge-cloud enabled privacy-preserving healthcare system by exploiting additive homomorphic encryption *** can help maintain the privacy preservation and conﬁdentiality of patients’medical data during diagnosis of Parkinson’s *** addition,the energy and delay aware computational ofﬂoading scheme is proposed to minimize the uncertainty and energy consumption of end-user *** proposed research maintains the better privacy and robustness of live video data processing during prediction and diagnosis compared to existing health-care systems.

关键词： Peer-to-peer computing energy and delay aware ofﬂoading edge-cloud enabled healthcare system parkinson’s disease prediction

A MULTIGRID-ACCELERATED THREE-DIMENSIONAL TRANSIENT-FLOW CODE AND ITS APPLICATION TO A NEW TEST PROBLEM

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Journal of Hydrodynamics 2010年第6期22卷 838-846页

作者： kumar D.santhosh DASS Anoop K. DEWAN Anupam School of Mechanical and Building Science Vellore Institute of TechnologyVellore-632014India Department of Mechanical Engineering Indian Institute of Technology GuwahatiGuwahati-781039India Department of Applied Mechanics Indian Institute of Technology Delhi Hauz KhasNew Delhi-110016India

A multigrid-assisted solver tbr the three-dimensional time-dependent incompressible Navier-Stokes equations on graded Cartesian meshes is developed. The spatial accuracy is third-order for the convective terms and fourth-order for the viscous terms, and a fractional-step strategy ensures second-order time accuracy. To achieve good time-wise efficiency a multigrid technique is used to solve the highly time-consuming pressure-Poisson equation that requires to be solved at every time step. The speed-up achieved by multigrid is shown in tabular form. The performance and accuracy of the code are first ascertained by computing the flow in a single-sided lid-driven cubic cavity with good grid-economy and comparing the results available in the literature. The code, thus validated, is then applied to a new test problem we propose and various transient and asymptotically obtained steady-state results are presented. Given the care taken to establish the credibility of the code and the good spatio-temporal accuracy of the discretization, these results are accurate and may be used for ascertaining the performance of any computational algorithm applied to this test problem.

关键词： incompressible flows three-dimensional cavity flow fractional-step method multigrid method Taylor-Gorier-Like (TGL) vortices grid transformation

Preparation and Characterization of Hydroxyapatite-Coated Selenium Nanoparticles and their Interaction with Osteosarcoma(SaOS-2) Cells

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Acta Metallurgica Sinica(English Letters) 2014年第6期27卷 1152-1158页

作者： Thiagarajan Hemalatha Gunasekaran Krithiga Baskar santhosh kumar Thotapalli P. Sastry Bioproducts laboratory Central Leather Research Institute

Nanotechnology has taken a firm step to revolutionize the field of orthopedic implants. Current research on bone implants focuses to develop implants with multifaceted functions viz., osteoinduction, chemoprevention, antimicrobial action etc., especially for cancerous bone resection. The objective of the present study was to synthesize a novel composite for bone implants, possessing the above properties. Selenium was selected owing to its chemopreventive and chemotherapeutic properties. Hydroxyapatite was selected owing to its bioactivity and similarity in composition to bone mineral properties. Selenium nanoparticles were prepared by chemical reduction method and coated with ***-coated selenium nanoparticle（HASnp） was characterized physico-chemically using fourier transform infrared spectroscopy, X-ray diffractometry, scanning electron microscope, and energy-dispersive X-ray *** was analysed in vitro using SaOS-2 cell line. Enhanced cell proliferation and alkaline phosphatase activity were observed in HASnp-treated cells. The results indicate that HASnp is highly suitable for the use in orthopedic applications.

关键词： Osteogenesis Biocompatibility Bone tissue engineering Biomaterials Biomedical applications

Neem(Azadirachta indica): Prehistory to contemporary medicinal uses to humankind

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Asian Pacific Journal of Tropical Biomedicine 2013年第7期3卷 505-514页

作者： Venugopalan santhosh kumar Visweswaran Navaratnam Centre for Drug Research Universiti Sains Malaysia11800 Penang Malaysia Drugs for Neglected Diseases Initiative (DNDi) 1 Place St GervaisCH-1201 Geneva Switzerland

The divine tree neem(Azadirachta indica)is mainly cultivated in the Indian *** been used extensively by humankind to treat various ailments before the availability ofwritten records which recorded the beginning of *** world health organization estimatesthat 80%of the population living in the developing countries relies exclusively on traditionalmedicine for their primary health *** than half of the world’s population still relies entirely on plants for medicines,and plants supply the active ingredients of most traditionalmedical *** review shows the neem has been used by humankind to treat variousailments from prehistory to contemporary.

关键词： Azadirachta indica Palm leaf manuscripts Prehistory

New Preamble Sequence for WiMAX System with Improved Synchronization Accuracy

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Intelligent Automation & Soft Computing 2023年第3期35卷 3187-3197页

作者： Suma Sekhar Sakuntala S.Pillai S.santhosh kumar Department of Electronics and Communication Engineering LBS Institute of Technology for WomenThiruvananthapuramKeralaIndia Mar Baselios College of Engineering and Technology ThiruvananthapuramKeralaIndia Department of Electronics and Communication Govt.Engineering CollegeIdukkiKeralaIndia

Worldwide Interoperability for Microwave Access(WiMAX)trusts Multiple Input Multiple Output-Orthogonal Frequency Division Multiplexing(MIMO-OFDM)combination for the deployment of physical layer functions and for connecting the medium access control to the wireless *** though Orthogonal Frequency Division Multiplexing(OFDM)facilitates reliable digital broadband transmission in the fading wireless channels,the presence of synchro-nization errors in the form of Carrier Frequency Offset(CFO)and Time Offset(TO)adversely affect the performance of OFDM based physical *** objective of this work is to improve the accuracy of the frequency and the time offset estimation in the WiMAX physical layer.A method to enhance the synchro-nization accuracy byﬁne-tuning the merit factor of the preamble sequence is sug-gested in this ***,a new preamble with improved synchronization accuracy is proposed for the WiMAX *** performance of the proposed preamble is evaluated in a Rayleigh fading channel and the results of simulations show that the Mean Square Error(MSE)in offset estimation is signiﬁcantly reduced and it outperforms the standard WiMAX preamble.

关键词： WiMAX MIMO OFDM time offset carrier frequency offset preamble sequence integrated sidelobe level merit factor