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PHOTOTHERAPY OF GINGIVITIS:PILOT CLINICAL STUDY

Journal of Innovative Optical Health Sciences 2011年第4期4卷 437-446页

作者： ELINA A.GENINA vladimir a.titorenko VALERY V.TUCHIN GEORGY V.SIMONENKO ALEXEY N.BASHKATOV GENNADY M.SHUB ALEXANDER V.LEPILIN ILYA V.YAROSLAVSKY GREGORY B.ALTSHULER Saratov State University Saratov410012Russia Saratov State Medical University Saratov410012Russia Institute of Precise Mechanics and Control of RAS Saratov 410028Russia Palomar Medical Technology Inc.Burlington MA 01803USA

The goal of this work was to evaluate the safety and efficacy of the Red Light Emitted Toothbrush(R-LETB)emitting at wavelength of 663 nm with power density of 3.3mW/cm2 in combination with 0.1%-methylene blue(MB)solution for the reduction of plaque and treatment of gingivitis.A microbiological in vitro study and a pilot clinical study were *** microbiological study has shown total suppression of pathogenicflora after a 3-min exposure to the dye solution followed by a 20-sec treatment with the *** the clinical study,37 subjects of both sexes with gingivitis were enrolled and randomly assigned to one of two *** in thefirst(treatment)group were instructed to rinse their mouth with MB solution provided for 1 min and then brush the teeth with the R-LETB and standardized *** second(control)group used only the toothpaste and a regular *** in both groups followed their respective procedures 2 times a day(morning and evening)for 30 *** of plaque,gingival bleeding,and inflammation were evaluated at 14-day and 30-day *** the both groups,all indices improved in comparison with ***,the treatment group demonstrated more pronounced improvement of the studied indices that was attributed to additional anti-microbial action of red light and MB on gum ***,the use of R-LETB with MB appears to have a multifactor therapeutic action on oral pathological microflora:mechanical removal of the bacteria and suppressing action on microorganisms due to photodynamic reaction.

关键词： Tooth brushing methylene blue photodynamic therapy pathogenic bacteria

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