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Thymoquinone as a potential therapeutic for Alzheimer’s disease in transgenic Drosophila melanogaster model

BIOCELL 2021年第5期45卷 1251-1262页

作者： NARAYANAN NAMPOOTHIRI V.P. vignesh sundararajan PALLAVI DAN G.DEVANAND VENKATASUBBU SAHABUDEEN SHEIK MOHIDEEN Department of Biotechnology School of BioengineeringSRM Institute of Science and TechnologyKattankulathur603203India Department of Physics and Nanotechnology School of BioengineeringSRM Institute of Science and TechnologyKattankulathur603203India

Alzheimer’s disease(AD)is one of the most common forms of *** dysfunction and memory loss are the two main clinical symptoms of *** melanogaster models of AD,which are based on overexpression of human amyloidβ(Aβ)or human tau(hTau)protein,have been used to study the mechanism underlying AD and to screen potential therapeutic *** that are currently available for AD provide only symptomatic *** unmet medical needs exists to slow,stop,or reverse the progression of ***(TQ)is an active ingredient isolated from Nigella sativa(NS)and possesses various pharmacological activities,and it is also a potential neuropharmacological *** current study was performed to investigate the effect of dietary administration of TQ at concentrations of 12.5μM and 25μM for 15 and 30 days on biochemical and behavioral parameters,gene,and protein expression of hTau,using Drosophila models of *** Drosophila models exhibiting pan-neuronal and eye-specific expression of hTau were generated using the GAL4/UAS *** with TQ at both concentrations resulted in a significant increase in behavioral activity,a significant reduction in the amount of reactive oxygen species(ROS),and restoration of depleted superoxide dismutase(SOD)and acetylcholine esterase(AChE)activities.A significant decrease in gene and protein expression of hTau was also observed at the molecular level for both concentrations of ***,TQ has the potential to be investigated as a potential therapeutic phytochemical for the treatment of AD in future studies.

关键词： hTau GAL4/UAS system Nigella sativa

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