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Modeling limit force capacities of high force to volume lead extrusion dampers

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Frontiers of Structural and Civil Engineering 2021年第3期15卷 609-622页

作者： V.vishnupriya Geoffrey.W.RODGERS J.Geoffrey CHASE Department of Mechanical Engineering University of CanterburyChristchurch8140New Zealand QuakeCoRE NZ Centre for Earthquake Resilience Christchurch8041New Zealand

Lead extrusion dampers are supplemental energy-dissipation devices that are used to mitigate seismic structural *** volumetric sizes and high force capacities define high-force-to-volume(HF2V)devices,which can absorb significant response energy without sacrificial ***,the design of such devices for specific force capacities has proven difficult based on the complexities of their internal reaction mechanisms,leading to the adoption of empirical *** study developed upper-and lower-bound force capacity estimates from analytical mechanics based on direct and indirect metal extrusion for guiding *** derived equations are strictly functions of HF2V device geometric parameters,lead material properties,and extrusion *** upper-bound estimates from direct and indirect extrusion are denoted as(F_(UB,1),F_(UB,2))and(F_(UB,3),F_(UB,4)),respectively,and the lower-bound estimates are denoted as(F_(LB),F_(LB,1))based on the combination of extrusion and friction *** proposed models were validated by comparing the predicted bounds to experimental force capacity data from 15 experimental HF2V device *** experimental device forces all lie above the lower-bound estimates(F_(LB),F_(LB,1))and below the upper-bound estimates(F_(UB,1),F_(UB,2),F_(UB,4)).Overall,the(F_(LB),F_(UB,2))pair provides wider bounds and the(F_(LB,1),F_(UB,4)/F_(UB,1))pair provides narrower ***(F_(LB,1),F_(UB,1))pair has a mean lower-bound gap of 36%,meaning the lower bound was 74%of the actual device force on *** mean upper-bound gap was 33%.The bulge area and cylinder diameter of HF2V devices are key parameters affecting device *** relatively tight bounds provide useful mechanics-based predictive design guides for ensuring that device forces are within the targeted design range after manufacturing.

关键词： extrusion lead dampers upper and lower bound analytical modelling limit force

Security Vulnerability Analyses of Large Language Models (LLMs) through Extension of the Common Vulnerability Scoring System (CVSS) Framework

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Journal of Software Engineering and Applications 2024年第5期17卷 340-358页

作者： Alicia Biju vishnupriya Ramesh Vijay K. Madisetti School of Cybersecurity and Privacy College of Computing Georgia Institute of Technology Atlanta GA USA

Large Language Models (LLMs) have revolutionized Generative Artificial Intelligence (GenAI) tasks, becoming an integral part of various applications in society, including text generation, translation, summarization, and more. However, their widespread usage emphasizes the critical need to enhance their security posture to ensure the integrity and reliability of their outputs and minimize harmful effects. Prompt injections and training data poisoning attacks are two of the most prominent vulnerabilities in LLMs, which could potentially lead to unpredictable and undesirable behaviors, such as biased outputs, misinformation propagation, and even malicious content generation. The Common Vulnerability Scoring System (CVSS) framework provides a standardized approach to capturing the principal characteristics of vulnerabilities, facilitating a deeper understanding of their severity within the security and AI communities. By extending the current CVSS framework, we generate scores for these vulnerabilities such that organizations can prioritize mitigation efforts, allocate resources effectively, and implement targeted security measures to defend against potential risks.

关键词： Common Vulnerability Scoring System (CVSS) Large Language Models (LLMs) DALL-E Prompt Injections Training Data Poisoning CVSS Metrics

Role of essential oils in food safety: Antimicrobial and antioxidant applications

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Grain & Oil Science and Technology 2019年第2期2卷 49-55页

作者： Sundaresan Bhavaniramya Selvaraju vishnupriya Mohammad Saleh Al-Aboody Rajendran Vijayakumar Dharmar Baskaran College of Food and Dairy Technology Tamil Nadu Veterinary and Animal Sciences UniversityChennai 600052India Department of Biology College of Science in ZulfiMajmaah UniversityMajmaah 11952Saudi Arabia

Essential oils(EOs)are more complex and comprise a number of volatile and natural bioactive compounds,which often used in food industries as the best *** review focuses on the impact of EOs and the roles of their major components in food manufacturing as natural preservatives with the related mechanisms of *** addition,the major bioactive molecules of different types of EOs and their pharmacological activities such as antioxidant,antifungal and antimicrobial effects on crop protection were also *** major compounds of EOs represent potential antioxidant,antimicrobial and antifungal activities through various *** types of EOs such as tea tree oil,lemon oil,clove oil,cinnamon oil and thyme oil from various traditional plants,have significantly showed better antimicrobial and antioxidant activities,and also effectively increased the shelf lives of the cereal products and increased the quality of food *** major groups of EOs such as terpenes and aromatic volatile compounds,play a key role in food safety without affecting the *** to their various activities including antioxidant and antimicrobial activities,EOs could be used as alternative preservatives to increase the shelf lives of cereals and crops.

关键词： Essential oils Terpenes Phenol Food spoilage Preservatives Antimicrobial activity

Monkeypox: A Viral Zoonotic Disease of Rising Global Concern

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Infectious Diseases & Immunity 2024年第3期4卷 121-131页

作者： Sukumaran Ani Betsy Joseph Mary Thomas vishnupriya K.Sweety Nandita Suresh Tumos Waltimo Department of Dentistry Oral Health InstituteHamad Medical CorporationPost Box 3050DohaQatar College of Dental Medicine Qatar UniversityPost Box 2713DohaQatar Department of Periodontology Saveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennai 600077India Department of Oral and Maxillofacial Diseases Helsinki University and University HospitalHelsinki 00014Finland Pushpagiri Institute of Medical Sciences and Research Centre MedicityPerumthuruthyTiruvallaKerala 689101India Clinic for Oral Health and Medicine University Center for Dental Medicine Basel UZBUniversity of Basel4058 BaselSwitzerland.

Monkeypox(mpox)is a rare viral zoonotic disease,endemic to Central and West Africa,caused by the monkeypox virus,an orthopoxvirus similar to the variola virus(smallpox).Although sporadic travel-associated cases have historically occurred outside Africa,in May 2022,mpox began spreading globally in multiple nonendemic countries across several *** 2024,there has been an increase in globally reported confirmed cases of mpox and deaths from mpox,making it a public health emergency of international *** reasons for the unusual global spread are under investigation but likely relate to increased travel and waning population immunity to *** now appears to be mainly through close,intimate contact,especially among men who have sex with *** is usually a self-limited *** limited approved antiviral treatments are available,such as tecovirimat,which the European Medicines Agency approved in January 2022 for the treatment of mpox,their widespread availability and effectiveness in the current outbreak remain to be *** health control measures include surveillance,case identification/isolation,contact tracing,and targeted vaccination of contacts at high risk of ***,challenges remain in curtailing the current unprecedented *** knowledge gaps include animal reservoir(s)responsible for initial spillover events,viral mutations that may enhance transmissibility,optimal diagnostics for noninvasive specimens,effective antiviral therapies,next-generation vaccines providing longer-term immunity,and building global capacity for outbreak *** review summarizes the current literature on mpox virology,epidemiology,pathogenesis,clinical manifestations,diagnostics,treatment,prevention,and public health control *** investigation and research are needed to better understand mpox’s evolving epidemiology,pathogenicity,transmissibility,and ecology to guide strategies for containin

关键词： Antiviral agents Disease outbreaks Epidemiology Mpox Smallpox vaccine Zoonoses

CAG and GGN Repeat Length Polymorphisms of Androgen Receptor Gene in Women with Breast Cancer: A Case-Control Study from South India

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Journal of Cancer Therapy 2012年第5期3卷 741-748页

作者： Durgadatta Tosh Bineet Panda Tipirisetti Nageswar Rao Arvind Babu vishnupriya Satti Digumarti Raghnadharao Lalji Singh Lakshmi Rao Centre for Cellular and Molecular Biology Hyderabad India Department of Genetics Osmania University Hyderabad India Department of Medical Oncology Nizams Institute of Medical Sciences Hyderabad India

Aim: The Androgen Receptor (AR) is a ligand-dependent transcriptional activator and the AR gene contains a highly polymorphic trinucleotide repeat CAG and GGN in the first exon. Given the lack of information AR-CAG and GGN repeat polymorphism and its potential correlation with breast cancer in South Indian women, we conducted a case-control study to observe the effects of CAG & GGN repeat length polymorphism and risk of breast cancer. Methods: Polymorphisms for AR-CAG and GGN repeat length was detected by Gene Scan analysis in the genomic DNA from cases with breast cancer and controls. Results: Association between AR genotype was calculated by categorising alleles as short (S) and long (L) and taking median value as the cut-off. LL genotype of CAG repeat was found to be associated with breast cancer (OR, 4.58;95% CI, 10.61-1.98;p—0.0004). GGN repeat having ≥21 was found in most of the cases and none of the cases showed 20 repeats thus indicate that alleles having homozygous repeat 20 may be protective towards breast cancer. Also, SS genotype was observed in 56.84% of cases and in 73.03% of controls (OR, 0.48;95% CI, 0.26-0.89;p value, 0.02). Conclusion: Our results indicate that longer CAG and GGN repeat may be associated with breast cancer whereas, the shorter GGN repeat length genotype of AR are protective.

关键词： Breast Cancer Androgen Receptor CAG GGN

The epidemiology and prevalence of Ulcerative colitis in the South of India

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Open Journal of Immunology 2012年第4期2卷 144-148页

作者： Sivaram Gunisetty Santosh Kumar Tiwari Avinash Bardia Meka Phanibhushan vishnupriya Satti Mohammed Aejaz Habeeb Aleem Ahmed Khan Centre for Liver Research and Diagnostics Deccan College of Medical Sciences Hyderabad India Department of Genetics Osmania University Hyderabad India Society for Translational and Regenerative Medicine Secunderabad India

Ulcerative colitis is considered frequent in majority of European and North American population and exceptional in most of the developing Asian countries. There is a dearth of reported data from South India on the incidence of the disease and its prevalence. Hence the present study was designed to estimate the prevalence of ulcerative colitis in a tertiary care hospital of Hyderabad, South India. The study population consisted of 157 Ulcerative colitis and 204 healthy subjects. All subjects were interviewed by means of a questionnaire for general demographical details and socioeconomic conditions, health related quality of life and history of UC. Patients were categorized based on disease severity;moderate: 95, and severe: 62 and disease manifestation: 73 (46.5%) pancolitis, 60 (38.2%) left-sided colitis and 24 (15.3%) had proctosigmoiditits. Disease prevalence was high in patients

关键词： Ulcerative Colitis Epidemiology Prevalence South India