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BIOCELL 2022年第12期46卷 2525-2530页

作者： MONICA SAVIO VALENTINA MINOIA PAOLA FULGHIERI LUCIA ANNA STIVALA virginie sottile Department of Molecular Medicine University of PaviaPavia27100Italy

The nutraceutical resveratrol is associated with a range of biological effects,from antibiotic to antiinflammatory *** major axis of research has sought to harness its anti-tumour potential,with promising preclinical results and early clinical trials.A second strong interest relies on the anti-ageing effects ascribed to the compound and its application to stem cell *** is becoming clear however that these possible favourable effects are conditioned by a set concentration range not easily controllable in *** we evoke novel developments in the field that could lead to more reliable conditions for the translational use of resveratrol-based compounds.

关键词： Resveratrol Nutraceutical Cancer Cell Differentiation Dihydroxystilbene

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New models of adipogenic differentiation highlight a cell-autonomous response to temperature

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BIOCELL 2020年第4期44卷 501-512页

作者： KSENIJA VELICKOVIC HILDA ANAID LUGO LEIJA SARAH MCGINLAY MICHAEL ESYMONDS virginie sottile School of Medicine The University of NottinghamNottinghamUK Faculty of Biology The University of BelgradeBelgradeSerbia The Early Life Research Unit Academic Division of Child HealthObstetrics and Gynaecologyand Nottingham Digestive Disease Centre and Biomedical Research CentreThe School of MedicineThe University of NottinghamNottinghamUK Department of Molecular Medicine The University of PaviaPaviaItaly

Temperature is a key regulator of brown adipose tissue(BAT)function,acting through central sensory inputs to influence metabolism and energy *** animal models have produced a wealth of information on the pathways,effectors and responses mediating the physiological response of adipose tissue to temperature in vivo,the use of cell culture models now offers evidence of an additional cell-autonomous response to temperature changes,in the absence of neural *** particular,stem cell models provide new insight into the regulation of adipogenic differentiation and the induction of browning features in *** the basis for adipogenic responsiveness to low temperature is discussed,together with different human cell models available to outline the benefits of cell-based approaches for future BAT research.

关键词： Adipose tissue Cell differentiation Temperature Cell autonomous response Transient receptor potential (TRP) channels

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