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Lecanemab Unveiled:Exploring Alzheimer’s Treatment Advancements,Assessing Strengths,Limitations,and Its Therapeutic Landscape Position

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Biomedical and Environmental Sciences 2024年第4期37卷 428-431页

作者： victor abiola adepoju OKECHUKWU Innocent Onyezue SAFAYET Jamil OLALEKAN John Okesanya DON Eliseo Lucero-Prisno Ⅲ Department of HIV and Infectious Diseases Jhpiegoan affiliate of John Hopkins UniversityAbujaNigeria Department of Prevention and Community Directorate APIN Public Health InitiativesAbujaNigeria Department of Public Health Daffodil International UniversityDhaka-1216Bangladesh Department of Public Health and Maritime Transport University of ThessalyVolosGreece Department of Global Health and Development London School of Hygiene and Tropical MedicineLondonUnited Kingdom

In the ever-evolving landscape of Alzheimer’s treatment,lecanemab(Leqembi)has emerged as a promising *** conventional therapies that merely alleviate symptoms,lecanemab is a humanized monoclonal antibody with a distinct *** targets protofibrils,insoluble fibrils,amyloid oligomers,and soluble amyloid-beta protofibrils,which are known to be especially damaging to neurons,with high accuracy.

关键词： Alzheimer amyloid Therapeutic

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Completion of 6-mo isoniazid preventive treatment among eligible under six children:A cross-sectional study,Lagos,Nigeria

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World Journal of Clinical Cases 2023年第1期11卷 104-115页

作者： victor abiola adepoju Ademola Adelekan Aderonke Agbaje Femi Quaitey Tobi Ademola-Kay Ann Uduak Udoekpo Olusola Daniel Sokoya Department of HIV and Infectious Diseases Jhpiego NigeriaFederal Capital TerritoryAbuja 900918Nigeria Department of Research Bluegate Research InstituteIbadan 211271Oyo StateNigeria Clinical Services Institute of Human Virology of NigeriaAbuja 900918Nigeria Department of HIV and Infectious Diseases Jhpiego NigeriaUyo 520108AkwaIbomNigeria Adolescent and Youth Care Youth Development and Empowerment InitiativeLagos 23401Nigeria Monitoring and Evaluation Jhpiego NigeriaUyo 520108AkwaIbomNigeria Lagos State Tuberculosis Buruli Ulcer and Leprosy Control ProgramIkeja 100001LagosNigeria

BACKGROUND Nigeria is one of the thirty high burden countries with significant contribution to the global childhood tuberculosis *** annual risk for children could be as high as 4%particularly in high tuberculosis(TB)prevalent ***(INH)Preventive Therapy has been shown to prevent TB incidence but data on its implementation among children are *** To determine the completion of INH among under six children that were exposed to adults with smear positive pulmonary TB in Lagos,*** This was a hospital-based retrospective cross-sectional review of 265 medical records of eligible children0.005).CONCLUSION This study demonstrated suboptimal INH completion rate among children with only 6 out of 10 children initiated on INH who completed a 6-mo treatment in Lagos,*** huge drop-offs in the first 2 mo of INH calls for innovative strategies such as the use of 60-d INH calen

关键词： Isoniazid Child Tuberculosis Treatment Outcome Completion Latent tuberculosis Dosage

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Acceptability and strategies for enhancing uptake of human immunodeficiency virus self-testing in Nigeria

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World Journal of Methodology 2023年第3期13卷 127-141页

作者： victor abiola adepoju Chidinma Umebido Ademola Adelekan Ali Johnson Onoja Department of HIV and Infectious Diseases Self testing in Africa(STAR)ProjectJhpiego NigeriaAbuja 900901Federal Capital TerritoryNigeria Department of Public Health and Biological Sciences Blue Gate Research InstituteIbadan 200116Oyo StateNigeria Department of Research African Health ProjectAbuja 900901Federal Capital TerritoryNigeria

BACKGROUND In 2019,the Nigerian Ministry of Health published the first operational guidelines for human immunodeficiency virus self-testing(HIVST)to improve access to human immunodeficiency virus(HIV)testing services among undertested populations in the ***,as part of the campaign to increase HIV testing services in Nigeria,the Nigerian Ministry of Health developed standard operating procedures for using HIVST *** To systematically review the acceptability and strategies for enhancing the uptake of HIVST in *** The systematic review was conducted and reported in line with the Preferred Reporting Items for Systematic Reviews and *** databases were searched to get the necessary materials needed for this *** forms developed by the authors were used for data extraction to minimize the risk of bias and ensure that the articles used for the study were properly *** articles were first screened using the titles and their *** full papers were screened,and the similarities of the documents were ***,quantitative,and mixed-method studies were evaluated using the Critical Appraisal Skills Programme and Critical Appraisal Framework *** All the publications reviewed were published between 2015 and 2022,with 33.3%published in ***(77.8%)of the studies were cross-sectional,43.3%were conducted in Lagos State,and 26.3%were conducted among young *** study revealed a high level of acceptability of *** factors,such as gender,sexual activity,and previous testing experience,influence the acceptability of HIV self-testing,with some individuals more likely to *** cost of the kit was reported as the strongest factor for choosing HIVST services,and this ranged from 200 to 4000 Naira(approximately United States Dollar 0.55-11.07),with the majority willing to pay 500 Naira(approximately United States Dollar 1.38).Privately-owned,registered pharmaci

关键词： Acceptability HIV self-testing Uptake Intention-to-use Regulation Linkage to care

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Preferences for oral-vs blood-based human immunodeficiency virus self-testing:A scoping review of the literature

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World Journal of Methodology 2023年第3期13卷 142-152页

作者： victor abiola adepoju Winifred Imoyera Ali Johnson Onoja Department of HIV and Infectious Diseases Jhpiego Nigeriaan affiliate of John Hopkins UniversityAbuja 900901Federal Capital TerritoryNigeria Research African Health ProjectAbuja 900901Federal Capital TerritoryNigeria

BACKGROUND The evidence on preferences for oral-vs blood-based human immunodeficiency virus self-testing(HIVST)has been heterogenous and *** addition,most evaluations have relied on hypothetical or stated use cases using discreet choice experiments rather than actual preferences among experienced users,which are more objective and critical for the understanding of product *** head-to-head comparison of consumer preferences for oral-versus bloodbased HIVST is *** To examine the existing literature on preferences for oral-vs blood-based HIVST,determine the factors that impact these preferences,and assess the potential implications for HIVST *** Databases such as PubMed,Medline,Google Scholar,and Web of Science were searched for articles published between January 2011 to October *** must address preferences for oral-vs blood-based *** study used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist to ensure the quality of the *** The initial search revealed 2424 records,of which 8 studies were finally included in the scoping *** preference for blood-based HIVST was 48.8%(9%-78.6%),whereas pooled preference for oral HIVST was 59.8%(34.2%-91%)across all ***,for male-specific studies,the preference for blood-based HIVST(58%-65.6%)was higher than that for oral(34.2%-41%).The four studies that reported a higher preference for blood-based HIVST were in *** considered blood-based HIVST to be more accurate and rapid,while those with a higher preference for oral HIVST did so because these were considered non-invasive and easy to *** Consistently in the literature,men preferred blood-based HIVST over oral HIVST due to higher risk perception and desire for a test that provides higher accuracy coupled with rapidity,autonomy,privacy,and confidentiality,whereas those with a higher preference for oral HIVST did so because these were considered

关键词： Human immunodeficiency virus self-testing Preferences Oral human immunodeficiency virus self-testing Blood-based human immunodeficiency virus self-testing

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