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Apoptogenic activity of ethyl acetate extract of leaves of Memecylon edule on human gastric carcinoma cells via mitochondrial dependent pathway

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Asian Pacific Journal of Tropical Medicine 2013年第5期6卷 337-345页

作者： vgm.naidu Bandari Uma Mahesh Ashwini Kumar Giddam Kuppan Rajendran Dinesh Babu Jian Ding K Suresh babu B Ramesh Rajeswara Rao Pragada Gopalakrishnakone P Venom & Toxin Research Programme Department of AnatomyYong Loo Lin School of Medicine4 Medical DriveNational University of SingaporeSingapore-117597 Currently affiliated to Department of Pharmacology & Toxicology National Institute of Pharmaceutical Education & Research(NIPER)BalanagarHyderabadA.PIndia-500037 Department of pharmacology A.U.College of pharmaceutical SciencesAndhra universityVishakhapatnamAndhra PradeshIndia-530003 Natural Products Laboratory Indian Institute of Chemical TechnologyUppal RoadHyderabad 500 607India

Objective:To evaluate the anti-proliferative and apoptogenic activity of ethyl acetate extract from the leaves of Memecylon edule(EtAc-LME) in MKN-74,NUGC gastric cancer cells and non cancerous gastric mucous cells(GES-1),and to explore the mechanism of EtAc-LME induced ***:The mechanism of EtAc-LME induced apoptosis was explored by analysing the activation of pro-caspases,PARP cleavage,expression of cytochrome-c (Cyt-c) was determined by western blotting,mRNA expression of Bcl-2,Bax by RT-PCR,loss of mitochondrial potential using DiOC6 dye,annexin binding assay and its influence on cell cycle arrest by flow ***:The results indicated that EtAc-LME inhibited the gastric cancer cell growth in dose-dependent manner and cytotoxicity was more towards the gastric cancer cells(NUCC and MKN-74) compared to normal gastric cells(GES-1),suggesting more specific cytotoxicity to the malignant *** expression of Cyt-c and subsequent activation of caspases-3 and down regulation of Bcl-2 and loss in mitochondrial potential in EtAc-LME treated MKN-74 and NUGC cells suggested that EtAc-LME induced apoptosis by mitochondrial dependent ***:The present findings suggest that ethyl acetate extract of Memecylon edule induces apoptosis selectively in gastric cancer cells emphasizing the importance of this traditional medicine for its potential in the treatment of gastric cancer.

关键词： Memecylon edule Anti-cancer Gastric cancer Apoptosis

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Multi-scale analysis of carbon mineralization in lime-treated soils considering soil mineralogy

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2296-2309页

作者： Dhanalakshmi Padmaraj Chinchu Cherian Dali naidu Arnepalli Department of Civil Engineering Indian Institute of Technology MadrasChennai600036India University of Northern British Columbia Prince GeorgeBCV2N4Z9Canada

Mineral carbonation is emerging as a reliable CO_(2) capture technology that can mitigate climate *** lime-treated clayey soils,mineral carbonation occurs through the carbonation of free lime and cementitious products derived from pozzolanic *** kinetics of the reactions in lime-treated clayey soils are variable and depend primarily on soil *** present study demonstrates the role of soil mineralogy in CO_(2) capture and the subsequent changes caused by carbon mineralization in terms of the unconfined compressive strength(UCS)of lime-treated soils during their service *** clayey soils(kaolin,bentonite,and silty clay)with different mineralogical characteristics were treated with 4%lime content,and the samples were cured in a controlled environment for 7 d,90 d,180 d,and 365 *** the specified curing periods,the samples were exposed to CO_(2) in a carbonation cell for 7 *** non-carbonated samples purged with N2 gas were used as a benchmark to compare the mechanical,chemical-mineralogical,and microstructure changes caused by carbonation *** investigations indicated that exposure to CO_(2) resulted in an average increase of 10%in the UCS of limetreated bentonite,whereas the strength of lime-treated kaolin and silty clay was reduced by an average of 35%.The chemical and microstructural analyses revealed that the precipitated carbonates effectively filled the macropores of the treated bentonite,compared to the inadequate cementation caused by pozzolanic reactions,resulting in strength *** contrast,strength loss in lime-treated kaolin and silty clay was attributed to the carbonation of cementitious phases and partly to the tensile stress induced by carbonate *** terms of carbon mineralization prospects,lime-treated kaolin exhibited maximum carbonation due to the higher availability of unreacted *** results suggest that,in addition to the increase in compressive strength,adequate calcium-b

关键词： Clays Mineralogy Carbon capture Lime Strength Pore structure

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Coupled bio-chemo-hydro-mechanical modeling of microbially induced calcite precipitation process considering biomass encapsulation using a micro-scale relationship

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2775-2789页

作者： Pavan Kumar Bhukya Nandini Adla Dali naidu Arnepalli Department of Civil Engineering Indian Institute of Technology MadrasChennai600036Tamil NaduIndia

Geomaterials with inferior hydraulic and strength characteristics often need improvement to enhance their engineering *** ground improvement techniques require enormous mechanical effort or synthetic *** stabilization technique such as microbially induced calcite precipitation(MICP)utilizes bacterial metabolic processes to precipitate cementitious calcium *** reactive transport of biochemical species in the soil mass initiates the precipitation of biocement during the MICP *** precipitated biocement alters the hydro-mechanical performance of the soil ***,the flow,deformation,and transport phenomena regulate the biocementation technique via coupled bio-chemo-hydro-mechanical(BCHM)*** all,one crucial phenomenon controlling the precipitation mechanism is the encapsulation of biomass by calcium *** encapsulation can potentially reduce the biochemical reaction rate and decelerate *** examination of the encapsulation process demands a thorough analysis of associated coupled *** this,a numerical model can assist in capturing the coupled processes influencing encapsulation during the MICP ***,most numerical models did not consider biochemical reaction rate kinetics accounting for the influence of bacterial *** this,the current study developed a coupled BCHM model to evaluate the effect of encapsulation on the precipitated calcite content using a micro-scale semiempirical ***,the developed BCHM model was verified and validated using numerical and experimental observations of soil column ***,the encapsulation phenomenon was investigated in the soil columns of variable maximum calcite crystal *** results depict altered reaction rates due to the encapsulation phenomenon and an observable change in the precipitated calcite content for each maximum crystal ***,the permeability and defor

关键词： Biocementation process Bio-chemo-hydro-mechanical(BCHM) model Reactive transport Encapsulation Micro-scale

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Coupled multiphysical model for investigation of influence factors in the application of microbially induced calcite precipitation

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2232-2249页

作者： Xuerui Wang Pavan Kumar Bhukya Dali naidu Arnepalli Shuang Chen Gesellschaft für Anlagen-und Reaktorsicherheit(GRS)GGmbH Braunschweig38122Germany Department of Civil Engineering Indian Institute of Technology MadrasChennai600036India Federal Institute for Geosciences and Natural Resources(BGR) Hannover30655Germany

The study presents a comprehensive coupled thermo-bio-chemo-hydraulic(T-BCH)modeling framework for stabilizing soils using microbially induced calcite precipitation(MICP).The numerical model considers relevant multiphysics involved in MICP,such as bacterial ureolytic activities,biochemical reactions,multiphase and multicomponent transport,and alteration of the porosity and *** model incorporates multiphysical coupling effects through well-established constitutive relations that connect parameters and variables from different physical *** was implemented in the open-source finite element code OpenGeoSys(OGS),and a semi-staggered solution strategy was designed to solve the couplings,allowing for flexible model ***,the developed model can be easily adapted to simulate MICP applications in different *** numerical model was employed to analyze the effect of various factors,including temperature,injection strategies,and application ***,a TBCH modeling study was conducted on the laboratory-scale domain to analyze the effects of temperature on urease activity and precipitated calcium *** understand the scale dependency of MICP treatment,a large-scale heterogeneous domain was subjected to variable biochemical injection *** simulations conducted at the field-scale guided the selection of an injection strategy to achieve the desired type and amount of ***,the study emphasized the potential of numerical models as reliable tools for optimizing future developments in field-scale MICP *** present study demonstrates the potential of this numerical framework for designing and optimizing the MICP applications in laboratory-,prototype-,and field-scale scenarios.

关键词： Multiphysics Microbially induced calcite precipitation(MICP) Coupled thermo-bio-chemo-hydraulic(TBCH) model OpenGeoSys(OGS) Influence factors

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Atypical presentation of a posterior fossa tumour:A case report

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World Journal of Clinical Cases 2024年第13期12卷 2281-2285页

作者： Alisha Narotam Mikara Archary Poobalan Naidoo Yeshkhir Naidoo Vanesha naidu Department of Internal Medicine King Edward VIII Hospital-University of Kwazulu-NatalDurban 4001Kwa-Zulu NatalSouth Africa Department of Internal Medicine Nelson R MandelaSchool of MedicineUniversity of Kwa-Zulu NatalDurban 4001Kwa-Zulu NatalSouth Africa Department of Radiology King Edward VIII Hospital-University of Kwazulu-NatalDurban 4001Kwazulu-NatalSouth Africa

BACKGROUND We described a case of a patient with a meningioma in the posterior fossa presenting atypically with an isolated unilateral vocal cord palsy causing severe respiratory *** is of interest as the patient had no other symptomatology,especially given the size of the mass,which would typically cause a pressure effect leading to neurological and auditory *** SUMMARY This case report described a 48-year-old male who was married with two children and employed as a car *** had a medical history of asthma for the past 10 years controlled with an as-needed beta 2 agonist metered dose *** initially presented to our facility with severe respiratory *** reported a 1-wk history of shortness of breath and wheezing that was not relieved by his *** had no constitutional symptoms or impairment of *** clinical examination,the patient’s chest was“silent.”Our initial assessment was status asthmaticus with type 2 respiratory failure,based on the history of asthma,a“silent chest,”and the arterial blood gas *** A posterior fossa meningioma of such a large size and with extensive infiltration rarely presents with an isolated unilateral vocal cord *** patient’s chief presenting feature was severe respiratory distress,which combined with his background medical history of asthma,was *** should thus consider meningioma as a differential diagnosis for a unilateral vocal cord palsy even without audiology involvement.

关键词： Respiratory distress Meningioma Unilateral vocal cord palsy Posterior fossa tumour Neurosurgery Neurology Radiology Case report

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Crosstalk between degradation and bioenergetics: how autophagy and endolysosomal processes regulate energy production

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Neural Regeneration Research 2025年第3期20卷 671-681页

作者： Angelid Pabon Jagannatham naidu Bhupana Ching-On Wong Department of Biological Sciences Rutgers UniversityNewarkNJUSA

Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy production, and metabolic reprogramming stipulates a shift in such balance to optimize both bioenergetic efficiency and anabolic requirements. Failure in switching bioenergetic dependence can lead to maladaptation and pathogenesis. While cellular degradation is known to recycle precursor molecules for anabolism, its potential role in regulating energy production remains less explored. The bioenergetic switch between glycolysis and mitochondrial respiration involves transcription factors and organelle homeostasis, which are both regulated by the cellular degradation pathways. A growing body of studies has demonstrated that both stem cells and differentiated cells exhibit bioenergetic switch upon perturbations of autophagic activity or endolysosomal processes. Here, we highlighted the current understanding of the interplay between degradation processes, specifically autophagy and endolysosomes, transcription factors, endolysosomal signaling, and mitochondrial homeostasis in shaping cellular bioenergetics. This review aims to summarize the relationship between degradation processes and bioenergetics, providing a foundation for future research to unveil deeper mechanistic insights into bioenergetic regulation.

关键词： autophagy bioenergetics endolysosome energy production glycolysis metabolic reprogramming mitochondria

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Non-enzymatic methods for isolation of stromal vascular fraction and adipose-derived stem cells:A systematic review

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World Journal of Methodology 2024年第2期14卷 134-144页

作者： Vamsi Krishna Mundluru MJ naidu Ravi Teja Mundluru Naveen Jeyaraman Sathish Muthu Swaminathan Ramasubramanian Madhan Jeyaraman Department of Orthopaedics MJ Naidu Super Speciality HospitalVijayawada 520002Andhra PradeshIndia Department of Regenerative Medicine StemC ClinicsVijayawada 520002Andhra PradeshIndia Department of Orthopaedics ACS Medical College and HospitalDr.MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Orthopaedics Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Orthopaedics Government Medical College and HospitalKarur 639004Tamil NaduIndia Department of Biotechnology Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia

BACKGROUND Adipose-derived stem cells(ADSCs)and the stromal vascular fraction(SVF)have garnered substantial interest in regenerative medicine due to their potential to treat a wide range of *** enzymatic methods for isolating these cells face challenges such as high costs,lengthy processing time,and regulatory *** This systematic review aimed to assess the efficacy and practicality of nonenzymatic,mechanical methods for isolating SVF and ADSCs,comparing these to conventional enzymatic *** Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines,a comprehensive literature search was conducted across multiple *** were selected based on inclusion criteria focused on non-enzymatic isolation methods for SVF and ADSCs from adipose *** risk of bias was assessed,and a qualitative synthesis of findings was performed due to the methodological heterogeneity of the included *** Nineteen studies met the inclusion criteria,highlighting various mechanical techniques such as centrifugation,vortexing,and ultrasonic *** review identified significant variability in cell yield and viability,and the integrity of isolated cells across different non-enzymatic methods compared to enzymatic *** some advantages of mechanical methods,including reduced processing time and avoidance of enzymatic reagents,the evidence suggests a need for optimization to match the cell quality and therapeutic efficacy achievable with enzymatic *** Non-enzymatic,mechanical methods offer a promising alternative to enzymatic isolation of SVF and ADSCs,potentially simplifying the isolation process and reducing regulatory ***,further research is necessary to standardize these techniques and ensure consistent,high-quality cell yields for clinical *** development of efficient,safe,and reproducible non-enzymatic isolation methods could signi

关键词： Adipose-derived stem cells Stromal vascular fraction Regenerative medicine Non-enzymatic isolation Mechanical separation techniques

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A new two-degree of freedom combined PID controller for automatic generation control of a wind integrated interconnected power system

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Protection and Control of Modern Power Systems 2022年第1期7卷 300-315页

作者： Appala naidu Karanam Binod Shaw Department of Electrical Engineering National Institute of TechnologyRaipurIndia

Frequency control of an interconnected power system in the presence of wind integration is complex since wind speed/power variations also affect system frequency in addition to load ***,improving existing control schemes is necessary to maintain a stable frequency in such complex power system *** this paper,a new 2-degree of freedom combined proportional-integral and derivative control scheme is applied to a wind integrated interconnected power *** designing the controller,several inputs used for a secondary frequency control loop are considered along with the merits of the existing *** combined controller provides better control action than existing controllers in the presence of wind as is evidenced by the wide variety of results *** tuning of the controller gains,a crow search optimization algorithm(CRSOA)is *** are obtained via the MATLAB/Simulink software.

关键词： Load frequency control 2-DOF-PID controller Crow search optimization algorithm

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Pan evaporation modeling in different agroclimatic zones using functional link artificial neural network

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Information Processing in Agriculture 2021年第1期8卷 134-147页

作者： Babita Majhi Diwakar naidu Department of CSIT Guru Ghasidas VishwavidyalayaCentral UniversityBilaspur 495009India BRSM College of Agricultural Engineering and Technology and Research Station Indira Gandhi Krishi VishwavidyalayaMungeliIndia

Pan evaporation is an important climatic variable for developing efficient water resource management *** the past,many machine learning models are reported in the literature for pan evaporation modeling using the different combinationof available climatic *** order to develop a novel model with improved accuracy and reduced computational complexity,the functional link artificial neural network(FLANN)is chosen as an architecture to estimate daily pan evaporation in three agro-climatic zones(ACZs)of Chhattisgarh state in east-central *** neuron and single layer in its structure make it less complex as compared to other multilayer neural networks and neuro-fuzzy based hybrid *** results obtained with the FLANN model are compared with those obtained by multi-layer artificial neural networks(MLANN)and two empirical methods using the same raw data and corresponding *** indices like root mean square error(RMSE),mean absolute error(MAE)and efficiency factor(EF)is also computed to evaluate the model *** is demonstrated that pan evaporation estimates obtained with the proposed FLANN models provide an improved estimation of pan evaporation(RMSE=0.85 to 1.27 mm d^(-1),MAE=0.63 to 0.95 mm d^(-1) and EF=0.70 to 0.89)as compared to MLANN(RMSE=0.94 to 1.58 mm d^(-1),MAE=0.73 to 1.14 mm d^(-1) and EF=0.62 to 0.88)and empirical(RMSE=1.19 to 2.19 mm d^(-1),MAE=0.91 to 1.62 mm d^(-1) and EF=0.49 to 0.88)models in different ACZs.

关键词： Low complexity Pan evaporation estimation Functional link artificial neural network model Multi-layer artificial neural network model Empirical models

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Minimisation of electric field stress at triple junction of a functionally graded cone type spacer in a gas insulated busduct with metal inserts

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High Voltage 2017年第2期2卷 110-118页

作者： Yerra Swamy naidu Gundavarapu Venkata Nagesh Kumar Department of EEE Vizag Institute of TechnologyVisakhapatnamIndia Department of EEE Vignan's Institute of Information TechnologyVisakhapatnamIndia

Insulation integrity of supporting insulator plays a vital role for determining the continuity of service of the gas insulated substation which depends upon the electric field stress distribution on the surface of the *** junction formed by the conductor,SF6 gas and support insulator is another critical area where the field stress is to be maintained at minimum *** control is a technique employed for obtaining uniform field stress along the surface of the spacer but this technique may sometimes leads to very uneven *** this study,a functional graded material is designed for the standard cone type spacer to obtain uniform field stress along the surface of spacer to overcome the above *** grading of spacer is done with different *** field is computed for three cases namely grading to high,grading to low and U *** metal inserts were tuned and stress is obtained in account of lower fields at the triple point junction and an improved uniform field distribution along the surface is obtained.

关键词： stress graded field

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