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Comparative study on glutathione transferases of rat brain and testis under the stress of phenobarbitol and β-methylcholanthrene

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2005年第8期6卷 759-769页

作者： THYAGARAJU k HEMAVATHI B vasundhara k RAO A.D DEVI k.N Department of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP India

A comparative study was made on the tissue specific expression of glutathione transferases (GST) in brain and testis after exposure of rat to phenobarbitol (PB) and β-methylcholanthrene (MC). Glutathione transferases, a family of multifunctional proteins are involved in intracellular transport processes and in detoxication of electrophilic xenobiotics by catalyzing reactions such as conjugation, isomerization, reduction and thiolysis. On purification, the yield of GST proteins by affinity chromatography was 39% in testis and 32% in brain. The affinity purified testis GSTs were resolved by chromatofocusing into six anionic and four cationic isozymes, and in brain glutathione transferases were resolved into four anionic and three cationic isozymes, suggesting the presence of multiple isozymes with Yc, Yb, Yβ and Yδ in both of them. In testis and brain, these isozymes at identical pI values showed variable functions with a battery of substrates and the cationic isozymes of brain and testis showed identical properties in CHP (cumene hydroperoxide) at pH values of above 7.0. Substrate specificity studies and immunoblot analysis of testis and brain proteins revealed that they play a predominant role in the detoxication of phenobarbitol or β-methylcholanthrene. Expression of the isozymes in testis and brain on exposure to PB and MC indicated elevated subunit variation. In both testis and brain, Yδ of π class was expressed on PB treatment and Yc of α class and Yβ of μ class was expressed in MC treated testis and only Yc was predominantly expressed in MC treated brain. Thus these subunits expression is considered as markers for carcinogenesis and specific to chemical toxicity under phenobarbitol and β-methylcholanthrene stress.

关键词： Glutathione transferases Testis Brain Phenobarbitol β-Methylcholanthrene

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支链氨基酸代谢在枫糖尿病中的作用

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中国优生与遗传杂志 2024年第2期32卷 221-227页

作者：胡莹莹 Srivastava vasundhara 刘云霞新加坡国立大学新加坡169857 复旦大学附属妇产科医院妇科上海200090

枫糖尿病(MSUD)也称支链酮酸尿症,它是由于一组支链α酮酸脱氢酶复合体(BCkDC)基因突变而引起BCkD复合体活性缺乏的常染色体隐性遗传的代谢紊乱疾病。MSUD患者中支链氨基酸(BCAA)代谢紊乱,导致血浆、组织和尿液中积累大量的支链氨基酸... 详细信息

枫糖尿病(MSUD)也称支链酮酸尿症,它是由于一组支链α酮酸脱氢酶复合体(BCkDC)基因突变而引起BCkD复合体活性缺乏的常染色体隐性遗传的代谢紊乱疾病。MSUD患者中支链氨基酸(BCAA)代谢紊乱,导致血浆、组织和尿液中积累大量的支链氨基酸和支链酮酸(BCkA)。MSUD患者主要临床表现为进行性神经功能恶化,伴有运动迟缓、共济失调、智力障碍和精神症状的病理生理学特征,其主要是由于氨基酸代谢失衡而导致脑中蛋白质和神经递质合成缺失。而高BCAA/BCkA水平大幅度加重神经系统症状,表明BCAA/BCkA具有神经毒性。目前大量来自人类和动物模型实验数据证实,BCAA/BCkA特别是亮氨酸和α-kIC在MSUD脑损伤的发病机制中起到非常重要的作用。这篇综述主要介绍BCAA/BCkA代谢紊乱在MSUD患者神经失调中起到的潜在病理机制。BCAA/BCkA代谢失调不仅影响其他中性氨基酸水平的显著下降从而减少蛋白质和神经递质合成,还导致线粒体中能量代谢失调从而影响脑的正常功能,这些病理机制可能导致MSUD患者的神经系统后遗症。我们希望通过了解MSUD具体的病理机制,为MSUD治疗提供新的治疗策略和药物靶点。

关键词：枫糖尿病支链氨基酸支链酮酸支链α酮酸脱氢酶复合体中性氨基酸

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Application of light emitting diodes (LEDs) for food preservation, post-harvest losses and production of bioactive compounds: a review

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Food Production, Processing and Nutrition 2022年第1期4卷 85-94页

作者： Amrita Poonia Surabhi Pandey vasundhara Department of Dairy Science and Food Technology Institute of Agricultural SciencesBanaras Hindu UniversityVaranasiUttar Pradesh221005India

Light-emitting diode (LED) technology is a new non-thermal food preservation method that works by converting light energy into heat. LED has potential to revolutionize crop production, protection and preservation. This technology is economical and environmentally friendly. LEDs have been shown to improve the nutritive quality and shelf life of foods, control the ripening of fruits, induce the synthesis of bioactive compounds and antioxidants and reduce the microbial contamination. This technology also has great scope in countries, where safety, hygiene, storage and distribution of foods are serious issues. While comparing this technology with other lighting technologies, LEDs can bring numerous advantages to food supply chain from farm to fork. In case of small growing amenities which exploit only LEDs, energy expenditure has been successfully reduced while producing nutritious food. LEDs can be used to give us better understanding and control over production and preservation of food with relation to spectral composition of light. LEDs also play significant role in food safety by inactivating the food borne pathogens. Therefore, LED lighting is a very effective and promising technology for extending shelf life of agricultural produce by increasing disease resistance and with increased nutritional values.

关键词： Light emitting diodes Food preservation Anti-microbial Bioactive compounds Non-thermal

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Thermal and FT-IR Properties of Semiconducting SnO2-PbO-V2O5Glass System

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New Journal of Glass and Ceramics 2015年第3期5卷 53-58页

作者： Ponnada Tejeswara Rao Balireddy vasundhara Department of Physics GITAM Institute of Technology GITAM University Visakhapatnam India

Melt quenched “SnO2(50-x)PbO:50V2O5” glass system containing x = 5, 10, 15 in molar ratio has been investigated. Effects of heating rate, glass transition, crystallization, melting temperature and infrared spectra of SnO2 substituted PbO-V2O5 glass system are reported. XRD results show that perfect vitrification has been achieved for all the glass samples after annealing at 150°C. DSC results have indicated that eutectic composition of the lead metavanadate has been maintained for all the glass systems up to 15 mole% of substitution. IR spectra for a SnO2 substitution of 5 mole% V=O stretching frequency occur at 966 cm-1 without appearance of any additional peak. But for 10 mole% and 15 mole% SnO2 substituted samples, additional peaks appear at 1023 and 1005 cm-1 indicating the effect of SnO2 in the vanadate crystalline matrix such that there is an elongation of V=O bond. Since the crystalline matrix is affected, we can expect similar effect in the glass matrix also.

关键词： DSC XRD FT-IR Lead Vanadate Glasses

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The Experimental Measurements of Total Mass Attenuation Coefficients in Arsenic Oxide

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World Journal of Nuclear Science and Technology 2016年第3期6卷 125-130页

作者： B. vasundhara P. Tejeswararao Department of Engineering Physics GITAM Institute of Technology GITAM University Visakhapatnam India

Measurements of k-shell mass attenuation coefficients are reported for the first time in Arsenic oxide (As2O3). Experiments are performed using Arsenic Oxide extended range HPGe detector. To achieve measurements at many small and regular energy intervals, secondary X-ray emission technique using “Seventeen Scatters” is employed. The results are in agreement with the proposed theoretical estimates. No evidence could, however be gained in favor of microscopic theories such as RRS and EXAFS, insofar as there are no energy points within a range of 100eV on either side of the k-edge.

关键词： Mass Attenuation Arsenic Oxide k-Shell Energy Intervals

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中西医治疗颈椎病方法

中西医治疗颈椎病方法

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作者： Madhavee vasundhara Siriwardhana Herath 北京中医药大学

学位级别：硕士

背景:本论文论述了中、西医对颈椎病的诊断、分型和治疗。颈椎病是临床最常见的疾病之一。这是一种慢性的椎间盘退行性改变,由年龄增长、外伤或其他疾病引起。传统中医疗法在中国被很多中医医院证实为行之有效的,故中西医学结合治疗颈... 详细信息

背景:本论文论述了中、西医对颈椎病的诊断、分型和治疗。颈椎病是临床最常见的疾病之一。这是一种慢性的椎间盘退行性改变,由年龄增长、外伤或其他疾病引起。传统中医疗法在中国被很多中医医院证实为行之有效的,故中西医学结合治疗颈椎病本文中亦有所论述。目的:本文首先论述了中医学与西医学中颈椎病的各种类型,同时详细论述了中西医结合治疗颈椎病的方法,对中医的疗法的介绍紧随在西医疗法之后。在颈椎病的治疗中,中医不仅可以与西医疗法结合应用,亦可作为单一的疗法独立使用。本文对中医疗法的论述重点在于针灸与推拿。其次,本文展示了在颈椎病的治疗中,中医的针灸与推拿治疗是确有成效的,并附加了数篇病案加以论证。方法:我们系统回顾了 59篇关于颈椎病治疗的不同方法的文献资料。本文的参考文献以针灸、推拿为关键词检索自以下数据库:美国国立医学图书馆PEDro,Google Scholar,Web of knowledge,Sciencedirect,Medscape,Library of the VUB,Medline、PubMed、考科兰图书馆The Cochrane Library、中国知网CNkI、Embase、一个主要的日本数据库、顶级的韩国针灸杂志以及中国医学网站上主要的中文杂志。本文的重点在于颈椎病的针灸、推拿、拔罐、刮痧疗法。因此,本文同样论及了对在国医堂中医门诊使用中医疗法治疗颈椎病的一些医案的研究。结果:诸多关于中医作为单一疗法或中西医结合疗法治疗颈椎病的研究表明,其可以有效减轻颈椎病的疼痛及与疼痛有关的其他症状。在几乎所有的研究与临床观察中中医疗法与西医疗法在疗效上都有显著的差异。与西医治疗相比,中医疗法有副作用更小的特点。本文中引用的病例展示了中医治疗颈椎病的良好的的效果反馈。结论:我们认为一些中医疗法如针灸等,其本身的特性如灵活、副作用小等特点使得其对于治疗颈椎病是有效的。越来越多的研究表明针灸对治疗颈椎病是确有成效的。

关键词：颈椎病西医中医针灸推拿

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Role of PET-CT (Positron Emission Tomography-Computed Tomography) in Cancer Evaluation and Treatment

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World Journal of Nuclear Science and Technology 2022年第1期12卷 11-20页

作者： Balireddy vasundhara Pottumuthu Hemalatha Pakalapati Satya Sarath kumar Raju Department of Physics GITAM Institute of Science GITAM University Visakhapatnam India Department of Nuclear Medicine & PETCT Omega Hospitals Hyderabad India

Context: Positron emission tomography is a nuclear medicine imaging that deals with physiological function using radioisotopes. With the most PET (Positron Emission Tomography) scanners in integration with the CT scanners of late, this technology has registered phenomenal growth. The small amount of radioactive material is called Radiotracers. Objective: Like 18F- Fluro-deoxy-2-glucose has widely used. In this article, the author introduced clinical applications of PET out of 25 patients who studied hypermetabolic lesions in lymph nodes. Methods: PET imaging is coincidence imaging which is different from the other imaging technique PET image formed from multiple rings of detector crystals. Each decay positron travel in tissue annihilation reaction is going on. FDG is the most commonly used radiotracer to detect and stage various types of malignancies. Result: The field of PET/CT imaging cares for many oncology patients. PET improved localization of malignant lesions. It improved staging biopsy and therapy. Conclusion: Finally, studies to data showed 4% to 10% improvement in the overall accuracy of staging/restaging in lesions. If we use Monte Carlo simulation, OLINDA/EXM software may improve further with widely used.

关键词： Positron Emission Tomography Radio Isotopes Lymphoma Neo-Plasmas

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Synthesis and Characterization of Nano-Acetamiprid—New Plant Safeguard Nanomaterial

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American Journal of Analytical Chemistry 2020年第5期11卷 197-204页

作者： P. Padmavathi N. vasundhara Swathi kovvuri N. V. S. Venugopal Department of Chemistry Institute of Science GITAM University Visakhapatnam India

In present days many types of materials are used to reduce the environmental pollution in the world which includes nanomaterials. Nanopesticides increase the efficacy, durability and reduction in the amount of active constituent. The potential applications of nanotechnology in pesticides are quick decomposition in soil or plant, targeted delivery, apparent solubility and controlled release. In this communication the author reported a neonicatonoid insecticide called as Nano-acetamiprid and it is widely used to control fungal infections in different crops like cotton, leafy vegetables, citrus fruits, pome etc. The author reported a facile method i.e. a new Nano-acetamiprid for plant disease control and its subsequent characterization of encapsulated complex using polycaprolactone as an encapsulated agent. Nano-acetamiprid encapsulated particles were characterized by dynamic light scattering (DLS), ultraviolet spectroscopy and scanning electron microscopy (SEM). To ascertain the formation and the stability of nanoencapsulated acetamiprid pesticide, the maximum absorption spectra formulated at 421 nm and unformulated pesticide at 520 nm were observed. The size distribution was noted at 40 - 50 nm. The bioactivity study was conducted against various Aspergillus niger. The performance of nano particles was many fold times effective when compared to the original parental particles. The bio-assay of Nano-acetamiprid shows better results when compared to the normal commercial acetamiprid.

关键词： Acetamiprid Nano Encapsulation Polycaprolactone Antifungal Studies

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对未接受过化疗的晚期卵巢癌患者行吉西他滨、紫杉醇和顺铂联合化疗的多中心Ⅱ期研究

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世界核心医学期刊文摘（妇产科学分册） 2005年第10期1卷 46-46页

作者： Gupta S.k JohnS Naik R B.S. Awasthy 侯巍 Dharamshila Cancer Hospital Vasundhara Enclave Delhi 110096 India

Objectives. The objectives of this multicenter phase II study were to evaluate the effects of gemcitabinepaclitaxel- cisplatin combination chemotherapy on response rate, survival, and toxicity in patients with advanced epithelial ovarian cancer (AEOC). Methods. Chemonaive AEOC patients with bidimensionally measurable disease or an elevated serum cancer antigen 125 level received cisplatin (70 mg/m2)onday 1 and paclitaxel (80 mg/m 2) and gemcitabine (1000 mg/m2)pacli- on days 1 and 8, every 3 weeks. Results. Between October 2000 and September 2001, 46 patients were enrolled. Sixteen patients underwent debulking surgery prior to chemotherapy. In 45 evaluable patients, overall response rate was 64.4% (7 CR and 22 PR). Median time- to- progression was 13.4 months (95% CI, 9.6- 17.4 months); median progression- free survival was 12.3 months (95% CI, 8.8- 15.6 months); median overall survival was 26.0 months (95% CI, 18 months- not reached); and 1- year survival was 74% (95% CI, 60- 88% ). The relative dose intensities of gemcitabine, paclitaxel, and cisplatin were 81.4% , 80.2% , and 89.8% , respectively. Grade 3/4 neutropenia was the predominant hematologic toxicity observed (73.9% of patients) followed by grade 3/4 leukopenia (56.5% ), anemia (45.7% ), thrombocytopenia (23.9% ), and febrile neutropenia/neutropenic sepsis (26.1% ). The predominant grade 3 nonhematologic toxicities were alopecia (43.5% ) and diarrhea (19.6% ). Grade 4 nonhematologic toxicities were nausea/vomiting, constipation, and uremia (2.2% each). Two treatment- related deaths occurred (neutropenic sepsis and uremia). Conclusion. Gemcitabine- paclitaxel- cisplatin combination chemotherapy is active with manageable toxicity in chemonaive patients with advanced ovarian cancer and should be explored in larger phase III trials.

关键词：晚期卵巢癌顺铂联合化疗肿瘤细胞减灭术卵巢上皮癌晚期癌抗原肿瘤进展存活时间存活期血液毒性

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