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Journal of Ocean University of China 2019年第1期18卷 69-79页

作者： DENG Fangjing JIANG Wensheng valle-levinson arnoldo FENG Shizuo Physical Oceanography Laboratory/CIMST Ocean University of China and Qingdao National Laboratory for Marine Science and Technology Laboratory of Marine Environment and Ecology Ocean University of China Department of Civil and Coastal Engineering University of Florida

In this study, we examine the results obtained by the Finite-volume Coastal Ocean Circulation Model(FVCOM) regarding the effects of eddy viscosity and bathymetry on the three-dimensional(3 D) Lagrangian residual velocity(LRV) in a narrow bay. The results are cast in terms of two nondimensional numbers: the ratio of friction to local acceleration(δ) and the ratio of the minimum depth over shoals to the maximum depth in the channel(ε). The ratio δ depends on the eddy viscosity and mean depth. For a given eddy viscosity, when ε > 0.5, the along-estuary LRV tends to be vertically sheared and when ε < 0.5, the exchange is laterally sheared. When ε << 1, the structure of the 3 D, depth-integrated, and breadth-averaged LRV changes only slightly as δ increases. For ε values between 0.33 and 0.5, the structure of the 3 D LRV is mainly laterally sheared. In the same ε range, the 3 D and depth-integrated LRV exhibit reversed structures from high to low δ values. In addition, the breadth-averaged LRV weakens the typical twolayered circulation when δ decreases. When ε is 1, the two-layered vertical structure reverses direction, and a three-layered vertical structure develops in the outer bay as δ decreases.

关键词： eddy viscosity bathymetric effects Lagrangian residual velocity 3D narrow bay

Loculated pericardial hematoma diagnosed with point-of-care ultrasound

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World Journal of Emergency Medicine 2024年第3期15卷 241-242页

作者： Joaquín valle Alonso Esther Montoro Leandro Noblia Emergency Department Royal Bournemouth HospitalBournemouth 14450UK Emergency Department Hospital Santa LuciaCartagena 30202Spain

Pericardial hematoma is a rare but potentially lifethreatening consequence following cardiac surgery that requires prompt recognition and *** can present with symptoms such as chest pain,dyspnea,tachycardia,and hypotension,which may mimic other post-operative *** pericardial hematoma compressing the atria might be difficult to *** and hematoma are more common in patients receiving early anticoagulant therapy.A focused cardiac ultrasound (Fo CUS) plays a pivotal role in the diagnosis,revealing the presence of pericardial effusion and signs of cardiac *** aim of this report was to provide a prompt diagnosis of loculated pericardial hematoma via Fo CUS in the emergency department (ED).

关键词： hematoma diagnosis cardiac

Lack of evidence for germline WWP1 pathogenic variants in gastrointestinal polyposis and other phenotypes suggestive of PTEN-hamartoma-tumor syndrome

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Genes & Diseases 2024年第2期11卷 524-527页

作者： Noemi Gonzalez-Abuin Tirso Pons Teresa Fuster Isabel Quintana Mariona Terradas Gemma Aiza Joan Brunet Gabriel Capellá Heather Hampel Laura valle Hereditary Cancer Program Catalan Institute of OncologyOncobell ProgramIDIBELLHospitalet de LlobregatBarcelona 08908Spain Department of Immunology and Oncology National Center for BiotechnologySpanish National Research Council (CNB-CSIC)Madrid 28049Spain Centro de Investigación Biomédica en Red de Cáncer (CIBERONC) Madrid 28029Spain Catalan Institute of Oncology IDIBGiGirona 17007Spain Division of Clinical Cancer Genomics Department of Medical Oncology & Therapeutic ResearchCity of Hope National Cancer CenterDuarteCA 91010USA

Germline activating variants in WWP1,which encodes an E3 ubiquitin ligase that antagonizes PTEN tumor suppressive function,have been proposed as an alternative mechanism of PTEN inactivation in PTEN-hamartoma-tumor syndrome(PHTS)-like patients with wildtype PTEN.1 More specifically,heterozygous,potentially activating wwP1 variants were first identified by Lee et al in patients affected with gastrointestinal oligopolyposis,including adenomatous,hyperplastic/serrated,and hamartomatous polyps,and occasionally with colorectal cancer(Table 1).Subsequently,based on the PHTS phenotypic features,wWP1 mutational screening was performed in patients with thyroid nodules,2 or normocephalic autism spectrum disorder(ASD),3 where germline WWP1 variants were also identified(Table S1).

关键词： WWP1 gastrointestinal polyposis

Reduction Discoloration of Reactive Dyed Cotton Waste and Chemical Recycling via Ionic Liquid

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Journal of Renewable Materials 2024年第9期12卷 1557-1571页

作者： Aline Ferreira Knihs Larissa Klen Aragão Miguel Angelo Granato Andrea Cristiane Krause Bierhalz Rita de Cassia Siqueira Curto valle Department of Textile Engineering Federal University of Santa CatarinaBlumenau89036-256Brazil

The textile industry generates large volumes of waste throughout its production process. Most of this waste is colored, therefore, discoloration is an important step toward recycling and reusing this waste. This study focused on the chemical reductive discoloration of textile waste composed of cotton dyed with reactive dye. The experimental design demonstrated the significant influence of the concentration of reducing agent and time of reaction on the degree of whiteness of the cotton fibers. The concentration of the alkaline agent was not significant in the process. The optimization of the reaction conditions lead to Berger degree of 50.5 ± 3.5. The discolored cotton was chemically recycled through dissolution in ionic liquid 1-ethyl-3-methylimidazolium chloride and regeneration in film form in water. The microstructure of the regenerated cellulose films was evaluated by Scanning Electron Microscopy (SEM) indicating complete dissolution and uniform regeneration. The discoloration process reduced the polymerization degree and crystallinity index of the cotton fibers but retained the cellulose I structure. The dissolution and cellulose regeneration process results in transparent films with an amorphous structure. The thermal behavior, evaluated by thermogravimetric analysis, indicated that residues and regenerated film presented a main decomposition step. The maximum decomposition rate temperature of the regenerated films was approximately 40°C lower than the cotton fibers, which correlates well with the reduction in polymerization degree and amorphous structure. In general, the study demonstrated that textile cotton waste dyed with reactive dyes can be chemically discolored to form transparent and amorphous films, contributing to the development of sustainable strategies for the textile industry.

关键词： Reactive dyed cotton waste reactive discoloration ionic liquid dissolution and regeneration recycling and reusing

A Hybrid Model Evaluation Based on PCA Regression Schemes Applied to Seasonal Precipitation Forecast

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Atmospheric and Climate Sciences 2024年第3期14卷 328-353页

作者： Pedro M. González-Jardines Aleida Rosquete-Estévez Maibys Sierra-Lorenzo arnoldo Bezanilla-Morlot Center for Atmospheric Physics Institute of Meteorology Havana Cuba

Possible changes in the structure and seasonal variability of the subtropical ridge may lead to changes in the rainfall’s variability modes over Caribbean region. This generates additional difficulties around water resource planning, therefore, obtaining seasonal prediction models that allow these variations to be characterized in detail, it’s a concern, specially for island states. This research proposes the construction of statistical-dynamic models based on PCA regression methods. It is used as predictand the monthly precipitation accumulated, while the predictors (6) are extracted from the ECMWF-SEAS5 ensemble mean forecasts with a lag of one month with respect to the target month. In the construction of the models, two sequential training schemes are evaluated, obtaining that only the shorter preserves the seasonal characteristics of the predictand. The evaluation metrics used, where cell-point and dichotomous methodologies are combined, suggest that the predictors related to sea surface temperatures do not adequately represent the seasonal variability of the predictand, however, others such as the temperature at 850 hPa and the Outgoing Longwave Radiation are represented with a good approximation regardless of the model chosen. In this sense, the models built with the nearest neighbor methodology were the most efficient. Using the individual models with the best results, an ensemble is built that allows improving the individual skill of the models selected as members by correcting the underestimation of precipitation in the dynamic model during the wet season, although problems of overestimation persist for thresholds lower than 50 mm.

关键词： Seasonal Forecast Principal Component Regression Statistical-Dynamic Models

Neuroprotective effects of G9a inhibition through modulation of peroxisome-proliferator activator receptor gamma-dependent pathways by miR-128

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Neural Regeneration Research 2024年第11期19卷 2532-2542页

作者： Aina Bellver-Sanchis Pedro AAvila-López Iva Tic David valle-García Marta Ribalta-Vilella Luis Labrador Deb Ranjan Banerjee Ana Guerrero Gemma Casadesus Coralie Poulard Mercè Pallàs Christian Grinán-Ferré Department of Pharmacology and Therapeutic Chemistry Institut de Neurociències-Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Molecular Genetics Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Institute of Biotechnology National Autonomous University of MexicoCuernavacaMexico Department of Pharmacology and Therapeutics Health Science Center-University of FloridaGainesvilleFLUSA Department of Chemistry National Institute of Technology DurgapurM G AvenueDurgapurWest BengalIndia Cancer Research Cancer Lyon Universitéde LyonLyonFrance Inserm U1052 Centre de Recherche en Cancérologie de LyonLyonFrance CNRS UMR5286 Centre de Recherche en Cancérlogie de LyonLyonFrance Centro de Investigación en Red Enfermedades Neurodegenerativas(CIBERNED)Instituto de Salud Carlos IIIMadridSpain Neuroimmunology Department National Institute of Neurology and Neurosurgery“Manuel Velasco Suárez”Mexico CityMexico

Dysregulation of G9a,a histone-lysine N-methyltransferase,has been observed in Alzheimer’s disease and has been correlated with increased levels of chronic inflammation and oxidative ***,microRNAs are involved in many biological processes and diseases playing a key role in pathogenesis,especially in multifactorial diseases such as Alzheimer’s ***,our aim has been to provide partial insights into the interconnection between G9a,microRNAs,oxidative stress,and *** better understand the biology of G9a,we compared the global microRNA expression between senescence-accelerated mouse-prone 8(SAMP8)control mice and SAMP8 treated with G9a inhibitor *** found a downregulation of miR-128 after a G9a inhibition treatment,which interestingly binds to the 3′untranslated region(3′-UTR)of peroxisome-proliferator activator receptor γ(PPARG)***,Pparg gene expression levels were higher in the SAMP8 group treated with G9a inhibitor than in the SAMP8 control *** also observed modulation of oxidative stress responses might be mainly driven Pparg after G9a *** confirm these antioxidant effects,we treated primary neuron cell cultures with hydrogen peroxide as an oxidative *** this setting,treatment with G9a inhibitor increases both cell survival and antioxidant ***,up-regulation of PPARγby G9a inhibitor could also increase the expression of genes involved in DNA damage responses and *** addition,we also described that the PPARγ/AMPK axis partially explains the regulation of autophagy markers ***,PPARγ/GADD45αpotentially contributes to enhancing synaptic plasticity and neurogenesis after G9a ***,we propose that pharmacological inhibition of G9a leads to a neuroprotective effect that could be due,at least in part,by the modulation of PPARγ-dependent pathways by miR-128.

关键词： aging cognitive decline epigenetics G9a inhibition microRNAs miR-128 peroxisome-proliferator activator receptorγ(PPARγ) PPARG SAMP8

Lane changing and congestion are mutually reinforcing?

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Communications in Transportation Research 2023年第1期3卷 140-149页

作者： Yang Gao David levinson School of Civil Engineering The University of SydneySydney2006Australia

This study presents a comprehensive analysis of the relationship between congestion and lane changing,using vehicle trajectory data from the M1 motorway in *** establish a connection between the distribution of travel time and lane changing frequency and employ a Poisson process to describe the intensity of lane changing occurrences in different travel time *** an individual perspective,lane changing does not bring significant speed benefits in most cases,except when the speed range is between 45 and 50 km/*** a system perspective,the relationship between lane change rate and speed depends on the purpose of the lane *** merging,diverging,and lane restriction areas,for instance,mandatory lane changes *** most sections of the motorway,discretionary lane changes are motivated by the expectation of improving speed and/or ***,we demonstrate a mutual causality relationship between lane changing and congestion through the Granger causality *** relationship is more pronounced in general areas during peak periods and contributes to the deterioration of the driving environment.

关键词： Lane changing Congestion Poisson process Granger causality

南大西洋湾内风暴增水半日扰动现象的数值模拟实验

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南大西洋湾内风暴增水半日扰动现象的数值模拟实验

Comparative Analysis of Stability and Electromagnetic Transient Studies for HVDC Multi-infeed Systems

第十八届中国海洋（岸）工程学术讨论会

作者：冯曦 Maitaine Olabarrieta arnoldo valle-levinson 河海大学港口航道和近海工程学院 Civil and Coastal Engineering Department University of Florida

美国东海岸的潮汐记录揭示了出现在南大西洋湾频繁的风暴增水半日扰动现象。热带气旋被认为是这些风暴增水半日扰动事件的主要诱发条件之一。该风暴增水半日扰动的振幅以南大西洋湾的顶点为中心达到最大,沿海岸向南和向北均有扩散。依... 详细信息

美国东海岸的潮汐记录揭示了出现在南大西洋湾频繁的风暴增水半日扰动现象。热带气旋被认为是这些风暴增水半日扰动事件的主要诱发条件之一。该风暴增水半日扰动的振幅以南大西洋湾的顶点为中心达到最大,沿海岸向南和向北均有扩散。依据在南大西洋湾海岸观测到的潮汐和风暴潮交互作用的实例为参照,设计理想化过程实验,进一步探讨了热带气旋的各因子对风暴增水半日扰动现象的影响。虽然在历史记录里平行于海岸的飓风路径最为常见,但实验分析中发现,风暴潮与潮汐的交互作用在气旋路径与海岸线正交时最剧烈。风暴增水半日扰动的剧烈程度与气旋的风力强度、最大风速半径正相关,而与气旋的平移速度负相关。对于平行于海岸线移动的气旋,当气旋引起的超过17.5 m/s风速的沿岸风(根据Saffir-Simpson的飓风分类等级,这时风力达到热带风暴强度R17)臂长达到最长时,相应的风暴增水半日扰动现象也最持久且振幅最大。

关键词：风暴潮潮汐半日震动风暴涌动热带气旋潮汐与风暴潮交互作用南大西洋湾

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CSEE Journal of Power and Energy Systems 2017年第3期3卷 253-259页

作者： Marcio Szechtman Maria Jose Ximenes arnoldo Rodrigo Saavedra Dual Consulting Rio de JaneiroBrazil ONS-National System Operator of Brazil Rio de JaneiroBrazil Electel Engineering Rio de JaneiroBrazil

In previous papers,the authors presented various electromagnetic transient(EMT)results for multi-infeed configurations focusing on possible effects from failures in one link being transferred to others in terms of induced commutation failures(CF),either during the fault events or after fault clearing in the recovery ***,the AC system networks in these cases were represented by simplified *** interesting conclusions arose from these publications without enabling a much-detailed analysis of overall system effects,which is only possible when the network is modeled in full *** paper aims at complementing and comparing simulation results on HVDC multi-infeed configurations using both dynamic stability and electromagnetic transient,while establishing some basic proposals for optimal use of both *** identifies the limitations from each type of study so that a comprehensive and useful analysis of HVDC multi-infeed systems can be obtained.

关键词： AC/DC interactions commutation failures HVDC multi-infeed configurations

Debate about TGFBR1 and the susceptibility to colorectal cancer

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World Journal of Gastrointestinal Oncology 2012年第1期4卷 1-8页

作者： Laura valle Hereditary Cancer Program Catalan Institute of Oncology IDIBELL 08908 Hospitalet de Llobregat Spain

Recent years have witnessed enormous progress in our understanding of the genetic predisposition to colorectal cancer (CRC). Estimates suggest that all or most genetic susceptibility mechanisms proposed so far, ranging from high-penetrance genes to low-risk alleles, account for about 60% of the population-attributable fraction of CRC predisposition. In this context, there is increasing interest in the gene encoding the transforming growth factor β receptor 1 (TGFBR1 ); first when over a decade ago a common polymorphism in exon 1 (rs11466445, TGFBR1 *6A/9A) was suggested to be a risk allele for CRC, then when linkage studies identified the chromosomal region where the gene is located as susceptibility locus for familial CRC, and more recently when the allele-specific expression (ASE) of the gene was proposed as a risk factor for CRC. Published data on the association of TGFBR1 with CRC, regarding polymorphisms and ASE and including sporadic and familial forms of the disease, are often contradictory. This review gives a general overview of the most relevant studies in order to clarify the role of TGFBR1 in the field of CRC genetic susceptibility.

关键词： Transforming growth factor β receptor 1 Transforming growth factor β receptor 1*6A 9q linkage peak Allele-specific expression Colorectal cancer risk