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Large-scale genome-wide SnP analysis reveals the rugged(and ragged)landscape of global ancestry,phylogeny,and demographic history in chicken breeds

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 324-340页

作者： natalia v.DEMEnTIEvA Yuri S.SHCHERBAKOv Olga I.STAnISHEvSKAYA Anatoly B.vAKHRAMEEv Tatiana A.LARKInA Artem P.DYSIn Olga A.nIKOLAEvA Anna E.RYABOvA Anastasiia I.AZOvTSEvA Olga v.MITROFAnOvA Grigoriy K.PEGLIvAnYAn natalia R.REInBACH Darren K.GRIFFIn Michael n.ROMAnOv Russian Research Institute of Farm Animal Genetics and Breeding-Branch of the L.K.Ernst Federal Research Centre for Animal Husbandry.Pushkin St.Petersburg196601Russia School of Biosciences University of KentCanterburyCT27NJUK L.K.Ernst Federal Research Center for Animal Husbandry DubrovitsyPodolskMoscow Oblast142132Russia

The worldwide chicken gene pool encompasses a remarkable,but shrinking,number of divergently selected breeds of diverse *** study was a large-scale genome-wide analysis of the landscape of the complex molecular architecture,genetic variability,and detailed structure among 49 *** populations represent a significant sample of the world's chicken breeds from Europe(Russia,Czech Republic,France,Spain,UK,etc.),Asia(China),north America(USA),and Oceania(Australia).Based on the results of breed genotyping using the Illumina 60K single nucleotide polymorphism(SnP)chip,a bioinformatic analysis was carried *** included the calculation of heterozygosity/homozygosity statistics,inbreeding coefficients,and effective population *** also included assessment of linkage disequilibrium and construction of phylogenetic *** multidimensional scaling,principal component analysis,and ADMIXTURE-assisted global ancestry analysis,we explored the genetic structure of populations and subpopulations in each *** overall 49-population phylogeny analysis was also performed,and a refined evolutionary model of chicken breed formation was proposed,which included egg,meat,dual-purpose types,and ambiguous *** a large-scale survey of genetic resources in poultry farming using modern genomic methods is of great interest both from the viewpoint of a general understanding of the genetics of the domestic chicken and for the further development of genomic technologies and approaches in poultry *** general,whole genome SnP genotyping of promising chicken breeds from the worldwide gene pool will promote the further development of modern genomic science as applied to poultry.

关键词： Chicken genome diversity Single nucleotide polymorphism(SnP)analysis Gene pool Global ancestry Phylogeny Demographic history

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Promotion of structural plasticity in area v2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene navarro-Lobato Mariam Masmudi-Martín Manuel F.López-Aranda Juan F.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey Sinforiano Posadas María E.Quiros-Ortega Zafar U.Khan Laboratory of neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades neurodegenerativas(CIBERnED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of neurobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area v2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of *** this study,we demonstrated that the same treatment with RGS14414in visual area v2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDnF).A knockdown of BDnF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM *** findings suggest that BDnF-mediated neuronal structural plasticity in area v2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area v2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

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排卵期女性用自然周期、改良自然周期或人工子宫内膜制剂进行一次冷冻胚胎移植后活产率的临床研究

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中国临床药理学杂志 2024年第16期40卷 2456-2456页

作者： HO v n A PHAM T D nGUYEn n T 孟海峰

本研究为一项随机、开放标签研究,研究对象为18~45岁的排卵期女性,受试者按照1:1:1的比例被随机分为自然周期组、改良自然周期组或人工周期组。由于研究干预措施的性质特殊,故本试验不设盲。自然周期组不使用雌激素、孕酮或人绒毛膜促... 详细信息

本研究为一项随机、开放标签研究,研究对象为18~45岁的排卵期女性,受试者按照1:1:1的比例被随机分为自然周期组、改良自然周期组或人工周期组。由于研究干预措施的性质特殊,故本试验不设盲。自然周期组不使用雌激素、孕酮或人绒毛膜促性腺激素(hCG);改良自然周期组使用hCG来触发排卵;人工周期组使用口服戊酸雌二醇(从月经第2~4天开始,每天8mg)和阴道孕酮(从子宫内膜厚度≥7mm开始,每天800mg)。

关键词：人工周期戊酸雌二醇子宫内膜厚度活产率自然周期冷冻胚胎移植排卵期孕酮

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Metal-modulated epitaxy of Mg-doped Al_(0.80)In_(0.20)n-based layer for application as the electron blocking layer in deep ultraviolet light-emitting diodes

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Journal of Semiconductors 2024年第5期45卷 80-89页

作者： Horacio Irán Solís-Cisneros Carlos Alberto Hernández-Gutiérrez Enrique Campos-González Máximo López-López Optomechatronics Group Tecnológico Nacional de México Campus Tuxtla Gutiérrezcarretera Panamericana 1080C.P.29050Tuxtla GutiérrezChiapasMéxico Departamento de Física Instituto Nacional de Investigaciones NuclearesCarretera México-Toluca s/nC.P.52750La Marquesa OcoyoacacMéxico Departamento de Física Centro de Investigación y estudios Avanzados del Instituto Politécnico NacionalAv.Instituto Politécnico Nacional 2508San Pedro ZacatencoGustavo A.Madero07360 Ciudad de MéxicoCDMXMéxico

This work reports the growth and characterization of p-AlInn layers doped with Mg by plasma-assisted molecular beam epitaxy(PAMBE).AlInn was grown with an Al molar fraction of 0.80 by metal-modulated epitaxy(MME)with a thickness of 180 nm on Si(111)substrates using Aln as buffer *** substrate temperatures were used to enhance the incorporation of indium atoms into the alloy without clustering,as confirmed by X-ray diffraction(XRD).Cathodoluminescence measurements revealed ultraviolet(Uv)range ***,Hall effect measurements indicated a maximum hole mobility of 146 cm^(2)/(v∙s),corresponding to a free hole concentration of 1.23×10^(19)cm^(−3).The samples were analyzed by X-ray photoelectron spectroscopy(XPS)estimating the alloy composition and extracting the Fermi level by valence band ***-doped AlInn layers were studied for use as the electron-blocking layer(EBL)in LED *** varied the Al composition in the EBL from 0.84 to 0.96 molar fraction to assess its theoretical effects on electroluminescence,carrier concentration,and electric field,using SILvACO *** results from this study highlight the importance and capability of producing high-quality Mg-doped p-AlInn layers through *** simulations suggest that an Al content of 0.86 is optimal for achieving desired outcomes in electroluminescence,carrier concentration,and electric field.

关键词： metal-modulated epitaxy AlInn DUv-LED EBL simulation

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Evaluation of Mandibular Deprogramming Using TEnS (Transcutaneous Electrical nerve Stimulation) in Patients at the Specialty Clinic of the Juarez Autonomous University of Tabasco from 2022 to 2024

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Journal of Biosciences and Medicines 2024年第7期12卷 245-251页

作者： Christian C. Aguilar-Caamal Landy v. Limonchi-Palacio Crystell G. Guzmán-Priego Jeannette Ramírez-Mendoza José M. Lehmann-Mendoza Miguel A. López-Alvarado Xavier E. Moreno-Enriquez Jorda A. Albarrán-Melzer Academic Division of Health Sciences Juarez Autonomous University of Tabasco Villahermosa Tabasco Mxico Cardiometabolism Laboratory Academic Division of Health Sciences Juarez Autonomous University of Tabasco Villahermosa Tabasco Mxico

Temporomandibular disorders (TMD) negatively affect quality of life, causing pain and restricted jaw movements. This study evaluates the effectiveness of Transcutaneous Electrical nerve Stimulation (TEnS) on TMD patients before orthodontic treatment at the Juarez Autonomous University of Tabasco. A quantitative, quasi-experimental study was conducted with 30 patients who met the inclusion criteria: aged 18 to 65 years, with TMJ pain symptoms, diagnosed with temporomandibular disorders using the Helkimo index, and who had provided informed consent for the study. The range of mandibular movement and the visual Analog Scale (vAS) were measured to record values before therapy. The electrodes of the TEnS therapy were positioned on both sides of the jaw in the preauricular area and the masseter muscle, the therapy was administered for 40 minutes, utilizing a frequency of 2 - 4 Hz and a pulse duration of 300 microseconds. Following this, the range of mandibular movement and the vAS were reassessed to evaluate the outcomes., significantly improved maximum mouth opening (37.7 ± 6.4 mm to 44.6 ± 5.88 mm), right laterality (3.86 ± 1.57 mm to 5.43 ± 1.21 mm), left laterality (3.13 ± 1.63 mm to 4.53 ± 1.61 mm), protrusion (4.01 ± 1.7 mm to 5.36 ± 1.32 mm), and pain perception (4.56 ± 2.045 to 2.03 ± 1.5) (P nS therapy enhances mandibular movement and reduces pain, making it a well-tolerated, non-invasive complementary treatment for TMD.

关键词： TEnS Opening Deprogramming Electrostimulation TMJ (Temporomandibular Joint)

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Adaptive-optical 3D microscopy for microfluidic multiphase flows

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Light(Advanced Manufacturing) 2024年第3期5卷 105-119页

作者： Clemens Bilsing Erik nützenadel Sebastian Burgmann Jürgen Czarske Lars Büttner Laboratory of Measurement and Sensor System Techniques TUD Dresden University of Technology01069 DresdenGermany Chair of Fluid Mechanics Bergische Universitát Wuppertal42119 WuppertalGermany BIOLAS Laboratory of Measurement and Sensor System Techniques01069 DresdenGermany

Measurements based on optical microscopy can be severely impaired if the access exhibits variations of the refractive *** the case of fluctuating liquid-gas boundaries,refraction introduces dynamical aberrations that increase the measurement *** is prevalent at multiphase flows(***,film flows)that occur in many technical applications as for example in coating and cleaning processes and the water management in fuel *** this paper,we present a novel approach based on adaptive optics for correcting the dynamical aberrations in real time and thus reducing the measurement *** shape of the fluctuating water-air interface is sampled with a reflecting light beam(Fresnel Guide Star)and a Hartmann-Shack sensor which makes it possible to correct its influence with a deformable mirror in a closed ***-dimensional flow measurements are achieved by using a double-helix point spread *** measure the flow inside a sessile,oscillating 50-μl droplet on an opaque gas diffusion layer for fuel cells and show that the temporally varying refraction at the droplet surface causes a systematic underestimation of the flow field magnitude corresponding to the first droplet eigenmode which plays a major role in their detachment *** demonstrate that the adaptive optics correction is able to reduce this systematic ***,the adaptive optics system can pave the way to a deeper understanding of water droplet formation and detachment which can help to improve the efficiency of fuels cells.

关键词： Double-Helix point spread function Adaptive optics Particle tracking velocimetry Aberration correction Depth-resolving microscopy Closed-loop control

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Failure to Rescue as a Quality Metric in Congenital Heart Surgeries in a High-Complexity Service Provider Institution Located in a Middle-Income Country

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Congenital Heart Disease 2024年第2期19卷 207-218页

作者： Gustavo Cruz Santiago Pedroza Juan F.vélez Jessica Largo Juan F.Tejada Jorge H.Mejía-Mantilla Departamento de Anestesiología Fundación Valle del LiliCali760032Colombia Centro de Investigaciones Clínicas Fundación Valle del LiliCali760032Colombia Departamento de Cardiología Pediátrica Fundación Valle del LiliCali760032Colombia Facultad de Medicina Universidad IcesiCali760031Colombia Unidad de Cuidado Intensivo Fundación Valle del LiliCali760032Colombia

Background:Failure to rescue has been an effective quality metric in congenital heart ***,mor-bidity and mortality depend greatly on non-modifiable individual factors and have a weak correlation with better-quality *** aim to measure the complications,mortality,and risk factors in pediatric patients undergoing congenital heart surgery in a high-complexity institution located in a middle-income country and compare it with other institutions that have conducted a similar ***:A retrospective observational study was conducted in a high-complexity service provider institution,in Cali,*** pediatric patients undergoing any congenital heart surgery between 2019 and 2022 were *** main outcomes evaluated in the study were complication,mortality,and failure to rescue *** and multivariate logistic regression analysis was performed with mortality as the outcome ***:We evaluated 308 congenital heart *** the outcomes,201(65%)complications occurred,23(7.5%)patients died,and the FTR of the entire cohort was 11.4%.The presence of a postoperative complication(OR 14.88,CI 3.06–268.37,p=0.009),age(OR 0.79,CI 0.57–0.96,p=0.068),and urgent/emergent surgery(OR 8.14,CI 2.97–28.66,pnificant variables in predicting ***:Failure to rescue is an effective and comparable quality measure in healthcare institutions and is the major contributor to postoperative mortality in congenital heart *** our higher mortality and complication rate,we obtained a comparable failure to rescue rate to high-income countries’health institutions.

关键词： Congenital heart surgery complication mortality failure to rescue quality metric

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Hydroxyapatite composites with carbon allotropes:Preparation,properties,and applications

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Particuology 2024年第5期88卷 239-265页

作者： Boris I.Kharisov Oxana v.Kharissova Lucy T.González Yolanda Peña Méndez Igor E.Uflyand Idalia Gómez de la Fuente Universidad Autónoma de nuevo León Ave.UniversidadCiudad UniversitariaSan Nicolás de los GarzaNuevo León 66455Mexico Tecnologico de Monterrey Escuela de Ingeniería y CienciasMonterreyNuevo Leon 64890Mexico Department of Chemistry Southern Federal UniversityRostov-on-DonRussia

Hydroxyapatite(HA)and its composites with inorganic additives,dopants,and polymers is a rapidly developing branch in the materials *** particular,carbon allotropes are widely used in these composites being widely applied for medical *** a gap of insufficient generalization of recent achievements in the field of the HA/Carbon composites,in this review we present the state of the art of the field of HA composites and hybrids with classic carbon allotropes and *** composites are known for carbon nanotubes,nanofibers,graphene and its oxidized forms,as well as,in a lesser grade,for graphite,fullerenes,nanodiamonds,carbon nanofoams,*** composites can be fabricated by a variety of classic and less-common methods,such as co-precipitation(with or without ultrasonic treatment),CvD,hot isostatic pressing,hydrothermal,spark plasma sintering,biomimetic mineralization,thermal and plasma spray,electrochemical and electrophoretic deposition,self-assembling,3D printing,electrospinning,and lyophilisation,among *** of various synthesis techniques can be also carried out for composite *** or synthetic HA can be used as it is for further interaction with carbon allotropes or it can be first prepared and then reacted with carbon counterpart;similarly,carbon allotropes can be introduced into the interaction with HA directly or they can be first synthesized,in particular from *** biocompatible composites can be produced in the form of coatings,powders,and scaffolds and can additionally contain quantitative amounts of third phases,frequently natural or synthetic *** these composites,especially with O-containing functionalizing groups,HA disadvantages could be considerably decreased with simultaneous enhancement of mechanical properties,becoming similar to human bone,chemical stability and biocompatibility,as well as possessing antibacterial ***→G reduction and higher HA decoration were obs

关键词： Hydroxyapatite Carbon nanotubes Graphene Quantum dots Fullerenes nanodiamonds

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Performance Analysis of Thermoacoustic Refrigerator of 10 W Cooling Power Made up of Poly-vinyl-Chloride for Different Parallel Plate Stacks by Using Helium as a Working Fluid

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Journal of Thermal Science 2021年第6期30卷 2037-2055页

作者： n v Shivakumara BHEEMSHA Arya Department of Mechanical Engineering BMS College of EngineeringBengaluru 560019India Department of Mechanical Engineering Government PolytechnicChannasandraBengaluru 560067India

Refrigerants are usually provided in the conventional refrigeration system although the refrigerants produce Chlorofluorocarbons(CFCs)and Hydro-chlorofluorocarbons(HCFCs),which are hazardous to the ***,these disadvantages can be overcome by using air or inert gas in the thermoacoustic refrigeration *** the present experimental work,helium is used as a working gas with an operating pressure range of 0.2 MPa to 1.0 MPa in order to study the performance of thermoacoustic refrigerator(TAR)which is fabricated using Poly-vinyl-Chloride(PvC).The parallel plate stacks with different porosity ratios have been considered to study the performance of *** temperature difference between the hot and cold heat exchanger and acoustic dynamic pressure were recorded by using Bruel and Kjaer data acquisition system under different operating *** effect of different operating parameters such as operating frequency(200 Hz to 600 Hz),cooling load(2 W to 10 W)and drive ratio(0.6%to 1.6%)have also been considered to study the performance of *** TAR also modeled in DeltaEC software and the results are compared with the experimental outcomes and found to be in good *** experimental results show that-2.1℃is the lowest temperature measured at cold heat exchanger by achieving the highest temperature difference of about 32.9℃.An improvement is around 36%as compared to that of previous experiments that used aluminium *** highest Coefficient of Performance(COP)and the Relative Coefficient of Performance(COPR)are found to be 2.024 and 0.217,respectively.

关键词： thermoacoustic refrigerator parallel plate stack porosity ratio temperature difference COP COPR

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Scientific guidelines for preclinical research on potentised preparations manufactured according to current pharmacopoeias-the PrePoP guidelines

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Journal of Integrative Medicine 2024年第5期22卷 533-544页

作者： Alexander L.Tournier Leoni v.Bonamin Susann Buchheim-Schmidt Steven Cartwright Christoph Dombrowsky Paul Doesburg Carla Holandino Maria Olga Kokornaczyk Everine Bvan de Kraats Jesús Antonio López-Carvallo Papiya nandy JoséManuel Mazón-Suástegui Fateme Mirzajani Bernard Poitevin Claudia Scherr Karin Thieves Sandra Würtenberger Stephan Baumgartner Institute of Complementary and Integrative Medicine University of Bern3010 BernBernSwitzerland Institute of Integrative Medicine Witten/Herdecke University58455 WittenNorth Rhine–WestphaliaGermany Homeopathy Research Institute London SW74EFUnited Kingdom Graduate Program on Environmental and Experimental Pathology Paulista UniversitySão Paulo 01504-000São PauloBrazil Department of Medical Science Deutsche Homöopathie-Union DHU-Arzneimittel GmbH&Co.KG76227 KarlsruheBaden-WürttembergGermany Cherwell Laboratory for Fundamental Research in Homeopathy Oxford OX28NUOxforeshireUnited Kingdom Society for Cancer Research Hiscia Research Institute4144 ArlesheimBaselSwitzerland Laboratório Multidisciplinar de Ciências Farmacêuticas Universidade Federal do Rio de JaneiroRio de Janeiro 21941-902Rio de JaneiroBrazil World Water Community Rotterdam 3029AKthe Netherlands Departamento de Acuicultura Facultad de Ciencias del MarUniversidad Católica del Norte1790437 CoquimboElquiChile Centre for Interdisciplinary Research and Education KolkataWest Bengal 700068West BengalIndia Laboratorio de Homeopatía Acuícola y Semillas Marinas Centro de Investigaciones Biológicas del NoroesteLa Paz 23096Baja California SurMexico Protein Research Center Shahid Beheshti UniversityTehran ***Iran Department of Medical Laboratory Science College of ScienceKnowledge University44001 ErbilErbilIraq SociétéSavante d’Homéopathie 75009 ParisFrance Sola Salus Institute for Homeopathic Research52511 GeilenkirchenNorth Rhine–WestphaliaGermany Scientific Society for Homeopathy 06366 KöthenSaxony-AnhaltGermany

Objective Pharmacopoeias regulate the manufacture of potentised pharmaceutical preparations used in different branches of complementary and integrative *** physicochemical properties and biological activity of these preparations are often investigated in preclinical research,yet no guidelines for experimental research currently exist in this *** present PrePoP guidelines aim to provide recommendations to promote high-quality,statistically sound,and reproducible preclinical research on potentised *** Input was gathered from researchers nominated by the relevant scientific societies using a simplified Delphi consensus approach covering the most relevant aspects of basic research methodology in the field including appropriate controls,sample preparation and handling,and *** three rounds of feedback,a consensus was finally reached on the most important aspects and considerations for conducting high-quality research on potentised *** We present a series of recommendations on a range of topics including experimental controls,system stability,blinding and randomisation,environmental influences,and procedures for the preparation of potentised samples and controls,and we address some specific challenges of this research *** This expert consensus process resulted in a robust set of methodological guidelines for research on potentised preparations and provides a valuable framework that will inform and improve the quality of subsequent research in this emerging field.

关键词： Research guidelines Fundamental research Basic research Complementary and integrative medicine Potentisation Potentised preparations

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