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Frontiers in Energy 2012年第3期6卷 304-310页

作者： k. vENkATESWARLU B. S. R. MURTHY v. v. SUBBARAO k. vijaya kUMAR Mechanical Engineering Department K.L University Guntur 522502India Mechanical Engineering Department Q.I.S College of Engineering and Technology Ongole 523272 India Mechanical Engineering Department J.N.T.U Kakinada Kakinada533033 India

Cetane improvers reduce the ignition delay, which in turn reduces the combustion temperatures thereby reduce NOx emissions. Exhaust gas recirculation （EGR） proved to be an effective way to reduce the NOx emissions. In this present experimental work, a combination of exhaust gas recirculation and cetane improver ethyl hexyl nitrate （EHN） is used to investigate the performance and exhaust emissions of a single cylinder four stroke naturally aspirated direct injection and air cooled diesel engine. Test results show that the brake thermal efficiency increases with the increase in the percentage of EGR which is accompanied by a reduction in brake specific fuel consumption and exhaust gas temperatures, and that bio- diesel with cetane improver under 20% EGR reduces NOx emissions by 33% when compared to baseline fuel without EGR. However carbon monoxide （CO）, hydro carbon （HC） and smoke emissions increase with an increase in percentage of EGR.

关键词： additive exhaust gas recirculation (EGR),emissions ethyl hexyl nitrate (EHN) performance

Metaheuristic Based Clustering with Deep Learning Model for Big Data Classification

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Computer Systems Science & Engineering 2023年第1期44卷 391-406页

作者： R.krishnaswamy kamalraj Subramaniam v.Nandini k.vijayalakshmi Seifedine kadry Yunyoung Nam Department of Electronics and Communication Engineering University College of Engineering AriyalurAriyalur621704India Department of Biomedical Engineering Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore641021India Department of Computer Science and Engineering Sona College of TechnologySalem636005India Department of Electronics and Communication Engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesChennai600077India Deparmtent of Applied Data Science Noroff University CollegeKristiansandNorway Department of Computer Science and Engineering Soonchunhyang UniversityAsanKorea

Recently,a massive quantity of data is being produced from a distinct number of sources and the size of the daily created on the Internet has crossed two *** the same time,clustering is one of the efficient techniques for mining big data to extract the useful and hidden patterns that exist in ***-based clustering techniques have gained significant attention owing to the fact that it helps to effectively recognize complex patterns in spatial *** data clustering is a trivial process owing to the increasing quantity of data which can be solved by the use of Map Reduce *** this motivation,this paper presents an efficient Map Reduce based hybrid density based clustering and classification algorithm for big data analytics(MR-HDBCC).The proposed MR-HDBCC technique is executed on Map Reduce tool for handling the big *** addition,the MR-HDBCC technique involves three distinct processes namely pre-processing,clustering,and *** proposed model utilizes the Density-Based Spatial Clustering of Applications with Noise(DBSCAN)techni-que which is capable of detecting random shapes and diverse clusters with noisy *** improving the performance of the DBSCAN technique,a hybrid model using cockroach swarm optimization(CSO)algorithm is developed for the exploration of the search space and determine the optimal parameters for density based ***,bidirectional gated recurrent neural network(BGRNN)is employed for the classification of big *** experimental validation of the proposed MR-HDBCC technique takes place using the benchmark dataset and the simulation outcomes demonstrate the promising performance of the proposed model interms of different measures.

关键词： Big data data classification clustering mapreduce dbscan algorithm

Evodiamine activates cellular apoptosis through suppressing PI3k/AkT and activating MAPk in glioma

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中国药理学与毒理学杂志 2018年第4期32卷 342-343页

作者： Feng Zhi Rong WANG Dan-hi DENG Nai-yuan SHAO Yuan XU Lian XUE Ya PENG Ya-tian LIU Department of Neurosurgery The First People's Hospital of Changzhou Changzhou China Modern Medical Research Center The Third Affiliated Hospital of Soochow UniversityChangzhou 213003 China Department of Radiation Oncology Jiangsu Cancer Ho

OBJECTIvE Glioblastoma multiforme(GBM) is the most malignant primary tumor of the central nervous system and is associated with a very poor *** further improvements in outcomes have been reported since radiotherapy-temozolomide therapy was ***,*** new agents to treat GBM is *** study aimed to evaluate the anti-tumor effect of evodiamine(Evo) on GBM cells,and to determine the underlying mechanisms *** U251,LN229,HEB and PC12 cells were treated with various concentrations of evodiamine for 24 and48 hours,cell viability was measured by MTT *** U251 and LN229 cells were treated with ***(0-10 μmol·L^(-1)) for 24 h,and then stained with Hoechst *** Annexin v-FITC Apoptosis Detection kit was used to detect apoptosis in the *** oxygen species(ROS) production was detected using dichlorofluorescein diacetate(DCFH-DA) *** changes in mitochondrial *** potential(MMP) were assessed by JC-1 after cells were treated with *** *** levels of p-PI3k,PI3k,p-Akt,Akt,Bax,Bcl-2,p-p38,p38,p-JNk,JNk,p-ERk,ERk,Cytochrome c,Caspase-3,cleaved Caspase-3,PRAP,and cleaved PARP were measured by Western blot *** According to MTT assay results,Evo significantly inhibited the cell proliferation in a time-and dose-dependent *** microscopy and flow cytometry analyses revealed that Evo induced cell apoptosis in a concentration-dependent ***,Evo induced reactive oxygen species(ROS) production and mitochondrial membrane potential(MMP) ***,Evo induced apoptosis in cancer cells by suppressing PI3k/AkT signaling and inducing MAPk ***(p38 and JNk,but not ERk) to regulate apoptotic proteins(Bax,Bcl-2,Cytochrome c,***-3,and PARP).CONCLUSION In summary,Evo inhibits cell proliferation by inducing cellular apoptosis via suppressing PI3k/AkT and activating MAPk in GBM;these results indicate that Evo may be regarded as a ne

关键词：胶质母细胞瘤治疗方法肿瘤临床分析

Dysfunction of the adhesion G protein-coupled receptor latrophilin 1(ADGRL1/LPHN1)increases the risk of obesity

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten Schöneberg AndréNguyen Dietzsch Hadi Al-Hasani Joachim Altschmied katharina Bottermann Jana Brendler Judith Haendeler Susanne Horn Isabell kaczmarek Antje körner kerstin krause kathrin Landgraf Diana Le Duc Laura Lehmann Stefan Lehr Stephanie Pick Albert Ricken Rene Schnorr Angela Schulz Martina Strnadová Akhil velluva Heba Zabri Torsten Schöneberg Doreen Thor Simone Prömel Rudolf Schönheimer Institute of Biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for Clinical Biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German Center for Diabetes Research(DZD e.v.) Munich-NeuherbergGermany Cardiovascular Degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Research Institute(CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Center for Pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Helmholtz Institute for Metabolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany Department of Endocrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human Genetics Leipzig University Medical CenterLeipzigGermany Institute of Cell Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of Medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide *** the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity.G protein-coupled receptors(GPCRs)are among the main modulators of metabolism and energy ***,for instance,regulate appetite and satiety in certain hypothalamic neurons,as well as glucose and lipid metabolism and hormone secretion from *** in some GPCRs,such as the melanocortin receptor type 4(MC4R),have been associated with early-onset ***,we identified the adhesion GPCR latrophilin 1(ADGRL1/LPHN1)as a member of the regulating network governing food intake and the maintenance of energy *** of the highly conserved receptor in mice results in increased food consumption and severe obesity,accompanied by dysregulation of glucose ***,we identified a partially inactivating mutation in human ADGRL1/LPHN1 in a patient suffering from ***,we propose that LPHN1 dysfunction is a risk factor for obesity development.

关键词： obesity metabolism intake

Comparative LIDT measurements of optical components for high-energy hiLASE lasers

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high Power Laser Science and Engineering 2016年第1期4卷 75-83页

作者： Jan vanda Jan evcík Egidijus Pupka Mindaugas ciuka Andrius Melninkaitis Martin Divoky venkatesan Jambunathan Stefano Bonora václav koda Antonio Lucianetti Danijela Rostohar Tomas Mocek valdas Sirutkaitis hilase Institute of Physics AS CR LIDARIS Ltd. Laser Research Center Vilnius University LUXOR Laboratory CNR IFN Crytur Ltd.

Further advancement of high-energy pulsed lasers requires a parallel development of appropriate optical *** different optical components, such as mirrors and antireflection-coated windows, which are essential for the design of hi LASE high average power lasers were tested. The following paper summarizes results on the measurements of laser-induced damage threshold of such components, and clearly shows their capabilities and limitations for such a demanding application.

关键词： diode-pumped solid-state laser and applications laser-induced damage

Anatomic Correlates of Mitral Systolic Anterior Motion in Transposition of the Great Arteries Following Atrial Switch Operation

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Congenital Heart Disease 2023年第3期18卷 267-277页

作者： Norman Aiad Mark v.Sherrid Adam J.Small Youssef Elnabawi Jodi Feinberg Leon Axel Ralph Mosca T.k.Susheel kumar Michael Argilla Dan G.Halpern Cardiovascular Division Leon H.Charney Division of CardiologyNYU Langone HealthSchool of MedicineNew York University GrossmanNew YorkUSA Department of Cardiovascular Disease Medical SchoolThe University of MinnesotaMinneapolisUSA The Lillehei Heart Institute MinneapolisMNUSA Radiology Department NYU Langone HealthSchool of MedicineNew York University GrossmanNew YorkUSA Cardiothoracic Surgery Department NYU Langone HealthSchool of MedicineNew York University GrossmanNew YorkUSA Pediatric Cardiology Division NYU Langone HealthSchool of MedicineNew York University GrossmanNew YorkUSA Department of Internal Medicine NYU Langone HealthSchool of MedicineNew York University GrossmanNew YorkUSA

Introduction:We sought to investigate whether the development of sub-pulmonic systolic anterior motion(SAM)may be inherent to the anatomy of the the mitral valve(Mv)or affected by external factors,such as a dilated right ventricle or chest abnormalities in d-looped transposition of the great arteries post atrial switch operation(d-TGA/AtS).Methods:Analysis was performed of clinical and cardiac imaging studies acquired on 19 adult patients with d-TGA/AtS(age 42±6 years old,56%male)between 2015–*** data included mitral apparatus anatomy,and CT/MRI data included biventricular dimensions,function,and Haller index(hi)for pectus ***:Patients with leaflet SAM(n=6)compared to patients without SAM(n=13)had higher Mv protrusion height(2.3±0.5 vs.1.5±0.4 cm,p≤0.01)and longer anterior Mv leaflet length(3.1±0.4 cm vs.2.6±0.3 cm p≤0.05),when compared to those ***/MRI showed higher sub-pulmonic left ventricular ejection fraction(LvEF)in the SAM group(71%±8%vs.54%±7%,respectively).Rv size and function,significant chest deformity(hi>3.5),presence of a ventricular lead pacemaker,and septal thickness did not play a role in development of ***:An elongated mitral apparatus is associated with the development of SAM,and the development of left ventricular outflow tract obstruction(LvOTO),in d-TGA/*** hyperkinesia is associated with *** Rv dimensions,septal thickness,and degree of chest deformity did not differ significantly between subjects with SAM and those without.

关键词： d-loop transposition of the great arteries mustard operation senning operation systolic anterior motion of the mitral valve echocardiography cardiac MRI

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响应面法优化稻壳中木聚糖的提取工艺

食品与机械 2011年第6期27卷 114-118页

作者：韩丹妮谢定长沙理工大学化学与生物工程学院湖南长沙410114

为提高稻壳中木聚糖的提取率,稻壳经3%的硫酸预处理后再用碱法进行木聚糖的提取,采用响应面法优化工艺条件,先对提取温度、NaOH浓度、固液比、提取时间4个因素进行单因素试验。根据单因素试验结果设计中心组合试验,以木聚糖提取率为考... 详细信息

为提高稻壳中木聚糖的提取率,稻壳经3%的硫酸预处理后再用碱法进行木聚糖的提取,采用响应面法优化工艺条件,先对提取温度、NaOH浓度、固液比、提取时间4个因素进行单因素试验。根据单因素试验结果设计中心组合试验,以木聚糖提取率为考察指标,采用响应面分析法确定最优工艺参数。结果表明:提取温度69.8℃、NaOH浓度10.7%、固液比1∶13(m∶v)、提取时间5.1h。该条件下,木聚糖提取率可达76.57%。

关键词：稻壳木聚糖响应面法

A scenario for high accuracy τ mass measurement at BEPC-Ⅱ

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Chinese Physics C 2012年第7期36卷 573-577页

作者： M. N. Achasov v. E. Blinov 蔡啸傅成栋 F. A. Harris Q. Liu 莫晓虎 N. Yu. Muchnoi I. B. Nikolaev 秦庆 A. G. Shamov k. Yu. Todyshev 王贻芳张建勇 Budker Institute of Nuclear Physics Siberian Branch of the Russian Academy of Sciences11 Lavrentyev Novosibirsk 630090 Russia Institute of high Energy Physics Chinese Academy of Sciences University of Hawaii HonoluluHI 96822 USA

Scenarios for the τ mass measurement at the upgraded Beijing Electron-Positron Collider （BEPC- II ） are studied. A nested minimization procedure is used to optimize the data taking plan. It is found that by using five energy points with the total integrated luminosity of 100 pb-1, the τ mass can be determined with a statistical error of 50 kev.

关键词： τ mass scan optimization uncertainty

短暂性左室心尖球形综合征(Takotsubo心肌病)是永久性起搏器植入的并发症

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世界核心医学期刊文摘(心脏病学分册) 2007年第9期 49-50页

作者： Chun S.G. kwok v. Pang D.k. Lau T.k. 郭俊 Department of Medicine University of Hawaii John A. Burns School of Medicine Honolulu hi United States

背景:Takotsubo心肌病是新近描述的一种罕见临床疾病,以无血管造影显著冠状动脉疾病证据的短暂性左室心尖球形改变及运动不能为特征,主要见于绝经后女性。该病于2004年在美国首次证实,且仅在日本患者和白人患者中曾被报道。病例报道:1... 详细信息

背景:Takotsubo心肌病是新近描述的一种罕见临床疾病,以无血管造影显著冠状动脉疾病证据的短暂性左室心尖球形改变及运动不能为特征,主要见于绝经后女性。该病于2004年在美国首次证实,且仅在日本患者和白人患者中曾被报道。病例报道:1例77岁的夏威夷

关键词：心尖球形综合征左室心肌病心肌疾病 Takotsubo 短暂性

Overview of the hiLASE project: high average power pulsed DPSSL systems for research and industry

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high Power Laser Science and Engineering 2014年第2期2卷 1-10页

作者： M.Divoky M.Smrz M.Chyla P.Sikocinski P.Severova O.Novak J.Huynh S.S.Nagisetty T.Miura J.Pila O.Slezak M.Sawicka v.Jambunathan J.vanda A.Endo A.Lucianetti D.Rostohar P.D.Mason P.J.Phillips k.Ertel S.Banerjee C.Hernandez-Gomez J.L.Collier T.Mocek hiLASE Institute of Physics AS CR v.v.i. Na Slovance 2 182 21 Prague Czech Republic STFC Rutherford Appleton Laboratory Didcot OX11 0QX United Kingdom

An overview of the Czech national R&D project hiLASE(high average power pulsed laser) is presented. The project focuses on the development of advanced high repetition rate, diode pumped solid state laser(DPSSL) systems with energies in the range from mJ to 100 J and repetition rates in the range from 10 Hz to 100 kHz. Some applications of these lasers in research and hi-tech industry are also presented.

关键词： DPSSL Yb3+:YAG thin-disk multi-slab pulsed high average power laser