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Hyperhomocysteinemia and Associated Biological Markers in a Congolese Population of Type 2 Diabetes Mellitus in Brazzaville

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Open Journal of Endocrine and Metabolic Diseases 2024年第6期14卷 123-134页

作者： v. R. Ikia Monde A. L. M. Boumba E. Mokondjimobe H. Poaty G. Loubano-voumbi W. f. Ondongo A. G. Mayindou Kimbangu K. Onanga f. Elilie Mawa Ongoth E. Bouenizabila C. Andres H. G. Monabeka Biochemistry Laboratory Service University Hospital Center Brazzaville Congo faculty of Health Sciences Marien NGOUABI University Brazzaville Congo Research Area of Pointe-Noire National Institute for Research in Health Sciences (IRSSA) Pointe-Noire Congo Microbiology and Molecular Biology Department Loandjili General Hospital Pointe-Noire Congo LOMO Research University Kinshasa DRC Department of Statistics Health Information and Epidemiology Surveillance Departmental Directorate of Health Care and Services Brazzaville Congo Department of Endocrinology University Hospital Center Brazzaville Congo Department of Biochemistry and Molecular Biology Bretonneau Regional University Hospital Tours France

The search for new biomarkers predictive of type 2 diabetes currently constitutes a research avenue in Bioclinical. Total homocysteine remains a preferred target due to its involvement in the occurrence of degenerative complications in type 2 diabetics. The aim of this work was to study hyperhomocysteinemia and other biochemical markers associated with T2D in the Congolese population. This was an analytical case-control study carried out between October 2022 and October 2023. The study population consisted of 150 subjects including 100 T2D patients and 50 control subjects. The main clinical data were collected on a pre-established form. Homocysteine determination was carried out by the sandwich ELISA method. The other biochemical markers were measured by colorimetric enzymatic methods. Hyperhomocysteinemia was present in 27.3% (41/150) of the entire study population. Type 2 diabetics had a frequency of hyperhomocysteinemia of 36% (36/100) and control 10% (5/50) (p = 0.001). The mean hyperhomocysteinemia concentration was 31.9 μmol/l with extremes ranging from 18 to 103 μmol/l. Means of biological markers between diabetics and controls showed a statistically significant difference (p = 0.01). The risk factors associated with this HHcy were: sex (OR = 3.5), age (OR = 9.4), sedentary lifestyle (OR = 3.4) and glycosylated hemoglobin (OR = 12) with a p-value vely. Our results suggest that hyperhomocysteinemia can be considered as a predictive biomarker in the bioclinic of Congolese type 2 diabetic patients.

关键词： Hyperhomocysteinemia Biological Markers T2DM Brazzaville

应用中央前回磁化率定性和定量指标对上运动神经元受损为主的肌萎缩侧索硬化症的诊断准确性

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国际医学放射学杂志 2024年第1期 124-125页

作者： f.Lo Russo v.E.Contarino G.Conte C.Morelli f.Trogu S.Casale 吴梦琳

摘要目的比较定性和定量评估中央前回磁化率在检测以上运动神经元（UMN）损伤为主的肌萎缩侧索硬化症（ALS）的诊断准确性。方法回顾性收集47例ALS病人的临

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Numerical Investigation of a Refractive Index SPR D-Type Optical fiber Sensor Using COMSOL Multiphysics

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Photonic Sensors 2013年第1期3卷 61-66页

作者： D. f. santos A. GUERREIRO J. M. BAPTISTA Centro de Ciēncias Exatas e da Engenharia Universidade da Madeira Funchal Portugal faculdade de Ciēncias da Universidade do Porto Portugal INESC TEC Porto Portugal

Recently, many programs have been developed for simulation or analysis of the different parameters of light propagation in optical fibers, either for sensing or for communication purposes. In this paper, it is shown the COMSOL Multiphysics as a fairly robust and simple program, due to the existence of a graphical environment, to perform simulations with good accuracy. Results are compared with other simulation analysis, focusing on the surface plasmon resonance （SPR） phenomena for refractive index sensing in a D-type optical fiber, where the characteristics of the material layers, in terms of the type and thickness, and the residual fiber cladding thickness are optimized.

关键词： Refractive index sensor optical fiber sensor surface plasmon resonance light propagation simulation COMSOL Multiphysics graphical environment

Photonuclear reactions on stable isotopes of selenium at bremsstrahlung end-point energies of 10-23 Mev

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Chinese Physics C 2024年第2期48卷 91-103页

作者： f.A.Rasulova N.v.Aksenov S.I.Alekseev R.A.Aliev S.S.Belyshev I.Chuprakov N.Yu.fursova A.S.Madumarov J.H.Khushvaktov A.A.Kuznetsov B.S.Yuldashev Joint Institute for Nuclear Research DubnaRussia Institute of Nuclear Physics of the Academy of Sciences of the Republic of Uzbekistan TashkentUzbekistan faculty of Chemistry of Lomonosov Moscow State University MoscowRussia National Research Center"Kurchatov Institute" MoscowRussia Skobeltsyn Institute of Nuclear Physics of Lomonosov Moscow State University MoscowRussia faculty of Physics of Lomonosov Moscow State University MoscowRussia Institute of Nuclear Physics AlmatyRepublic of Kazakhstan

In this study,experiments were performed at bremsstrahlung end-point energies of 10-23 Mev with the beam from the MT-25 microtron using theγ-activation *** experimental values of relative yields were compared with theoretical results obtained on the basis of TALYS with the standard parameters and the combined model of photonucleon *** isospin splitting in the combined model of photonucleon reactions allows describing experimental data on reactions with proton escape in the energy range from 10 to 23 ***,taking into account isospin splitting is necessary for a correct description of the decay of the giant dipole resonance.

关键词： bremsstrahlung photon cross section isospin splitting giant dipole resonance

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The theoretical study of the efficiency of diffusion deposition of nanoaerosols in the extended range of the Peclet numbers

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颗粒学报:英文版 2023年第6期77卷 47-55页

作者： R.f.Mardanov S.K.Zaripov v.f.Sharafutdinov N.I.Lobachevskii Institute of Mathematics and Mechanics Kazan(Volga Region)Federal UniversityKremlevskaya ul.18KazanTatarstan420008Russia

The efficiencies of the diffusion deposition of nanoaerosols for a single fiber for the models of aerosol filter and wire mesh screen are studied numerically in the extended range of the Peclet number *** rectangular periodic cell model for fluid flow and convective-diffusive transport of small aerosol particles is *** of the previous theoretical and experimental studies of single fiber diffusion deposition efficiency were for the case of Pe>*** array with uniform square or chess grid of fibers and of a row of circular cylindrical fibers are considered as the filter and wire mesh screen *** flow and particles transport equations are solved numerically using the Boundary Element *** obtained numerical data are used to derive the approximate formulas for the deposition efficiency in the entire range of the Peclet number for the various porosities of the filter medium or distances between fibers in a wire mesh *** derived dependencies take into account nonlinearity of the deposition efficiency at the low Peclet *** obtained analytical dependencies compare well with the numerical and experimental data.

关键词： Arrayof fibers Row of fibers Periodic cell model Convection-diffusion equation Single fiber efficiency

Non-HfE haemochromatosis

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World Journal of Gastroenterology 2007年第35期13卷 4690-4698页

作者： Daniel f Wallace v Nathan Subramaniam Membrane Transport Laboratory The Queensland Institute of Medical ResearchBrisbaneQueenslandAustralia

Non-HfE hereditary haemochromatosis （HH） refers to a genetically heterogeneous group of iron overload disorders that are unlinked to mutations in the HfE gene. The four main types of non-HfE HH are caused by mutations in the hemojuvelin, hepcidin, transferrin receptor 2 and ferroportin genes. Juvenile haemochromatosis is an autosomal recessive disorder and can be caused by mutations in either hemojuvelin or hepcidin. Ar~ adult onset form of HH similar to HfE-HH is caused by homozygosity for mutations in transferrin receptor 2. The autosomal dominant iron overload disorder ferroportin disease is caused by mutations in the iron exporter ferroportin. The clinical characteristics and molecular basis of the various types of non-HfE haemochromatosis are reviewed. The study of these disorders and the molecules involved has been invaluable in improving our understanding of the mechanisms involved in the regulation of iron metabolism.

关键词： Haemochromatosis Iron overload Non-HfE Juvenile haemochromatosis Hemojuvelin Hepcidin Transferrin receptor 2 ferroportin

Cystic neoplasms of the pancreas: A diagnostic challenge

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World Journal of Gastroenterology 2009年第1期15卷 48-54页

作者： Grant f Hutchins Peter v Draganov Department of Gastroenterology Hepatology and Nutrition University of Florida1600 SW Archer Rd Room HD 602 PO Box 100214 Gainesville Florida 32610 United States

Cystic neoplasms of the pancreas are increasingly recognized due to the expanding use and improved sensitivity of cross-sectional abdominal imaging. Major advances in the last decade have led to an improved understanding of the various types of cystic lesions and their biologic behavior. Despite signifi cant improvements in imaging technology and the advent of endoscopic-ultrasound (EUS)-guided fineneedle aspiration, the diagnosis and management of pancreatic cystic lesions remains a significant clinical challenge. The fi rst diagnostic step is to differentiate between pancreatic pseudocyst and cystic neoplasm. If a pseudocyst has been effectively excluded, the cornerstone issue is then to determine the malignant potential of the pancreatic cystic neoplasm. In the majority of cases, the correct diagnosis and successful management is based not on a single test but on incorporating data from various sources including patient history, radiologic studies, endoscopic evaluation, and cyst fluid analysis. This review will focus on describing the various types of cystic neoplasms of the pancreas, their malignant potential, and will provide the clinician with a comprehensive diagnostic approach.

关键词： Cystic neoplasm Endoscopic ultrasound Pancreas Pancreatic cyst Pancreatitis

Modeling the crystallographic structure of Ho(Ni,Co,Mn)O_(3±δ) perovskite-type manganite

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Journal of Advanced Ceramics 2012年第4期1卷 274-282页

作者： C.Morilla-santos f.f.ferreira W.H.Schreiner O.Peña P.N.Lisboa-filho UNESP-Univ Estadual Paulista POSMAT-Programa de Pós-Graduação em Ciência e Tecnologia de MateriaisBauruBrazil UfABC-Universidade federal do ABC-Centro de Ciências Naturais e Humanas Santo AndréBrazil UfPR-Universidade federal do Paraná Departamento de FísicaCuritibaBrazil Sciences Chimies de Rennes UMR 6226 Universitéde Rennes 1RennesFrance UNESP-Univ Estadual Paulista Faculdade de CiênciasDepartamento de FísicaBauruBrazil

Crystallographic and microstructural properties of Ho(Ni,Co,Mn)O3±dperovskite-type multiferroic material are *** were synthesized with a modified polymeric precursor *** synchrotron X-ray powder diffraction(SXRPD)technique associated to Rietveld refinement method was used to perform structural *** crystallographic structures,as well as microstructural properties,were studied to determine unit cell parameters and volume,angles and atomic positions,crystallite size and strain.X-ray energies below the absorption edges of the transition metals helped to determine the mean preferred atomic occupancy for the substituent ***,analyzing the degree of distortion of the polyhedra centered at the transitions metal atoms led to understanding the structural model of the synthesized phase.X-ray photoelectron spectroscopy(XPS)was performed to evaluate the valence states of the elements,and the tolerance factor and oxygen *** obtained results indicated a small decrease distortion in structure,close to the HoMnO3 basis *** addition,the substituent atoms showed the same distribution and,on average,preferentially occupied the center of the unit cell.

关键词： crystallographic structure X-ray powder diffraction Rietveld refinement manganites

Mesophyll thickness and sclerophylly among Calotropis procera morphotypes reveal water-saved adaptation to environments

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Journal of Arid Land 2019年第6期11卷 795-810页

作者： Marcelo f POMPELLI Keila R MENDES Marcio v RAMOS Jose N B santos Diaa T A YOUSSEf Jaqueline D PEREIRA Laurício ENDRES Alfredo JARMA-OROZCO Rodolfo SOLANO-GOMES Betty JARMA-ARROYO Andre L J SILvA Marcos A santos Werner C ANTUNES Plant Physiology Laboratory Department of BotanyFederal University of PernambucoRecife 50670901Brazil Department of Biochemistry and Molecular Biology Federal University of CearáFortaleza 60020603Brazil Department of Natural Products Faculty of PharmacyKing Abdulaziz UniversityJeddah 21589Saudi Arabia Institute of Botany Federal University of ViçosaRio Paranaíba CampusRio Paranaiba 36570900Brazil Plant Ecophysiology Laboratory Federal University of AlagoasMaceio 57072900Brazil faculty of Agricultural Science University of CórdobaMontería 230002Colombia Instituto Politécnico Nacional Research Interdisciplinary Center for Integrated Rural DevelopmentSanta Cruz XoxocotlanOaxaca 7738Mexico Department of Biology University of MaringáMaringá87020900Brazil

Calotropis procera(Aiton)Dryand(Apocynaceae)is a native species in tropical and subtropical Africa and ***,due to its fast growing and drought-tolerant,it has become an invasive species when it was introduced into Central and South America,as well as the Caribbean ***,*** displays a wide distribution in the *** is important,in particular,because many invasive species exert a high reproductive pressure on the invaded communities or are highly productive in their new distributed *** has been suggested that a very deep root system and a high capacity to reduce stomatal conductance during water shortage could allow this species to maintain the water status required for a normal ***,the true mechanism behind the successful distribution of *** across wet and dry environments is still *** leaves were collected from 12 natural populations in Brazil,Colombia and Mexico,ranging from wet to dry environments during 2014–*** traits of morphology and anatomy from these distinct morphotypes were *** found that *** leaves had a considerable capacity to adjust their morphological,anatomical and physiological traits to different *** magnitude of acclimation responses,i.e.,plasticity,had been hypothesized to reflect the specialized adaptation of plant species to a particular ***,allometric models for leaf area(LA)estimation cannot be grouped as a single *** are narrower and thicker with low amounts of air spaces inside the leaf parenchyma in wet environments,while they are broader and thinner with a small number of palisade cell layers in dry *** on these,we argue that broader and thinner leaves of *** dissipate incident energy at the expense of a higher rate of transpiration to survive in environments in which water is the most limiting factor and to compete in favorable wet environments.

关键词： invasive plant energy budget leaf anatomy morphological trait specific leaf area

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