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ASSESSMENT OF TISSUE OPTICAL CLEARING AS A FUNCTION OF GLUCOSE CONCENTRATION USING OPTICAL COHERENCE TOMOGRAPHY

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Journal of Innovative Optical Health Sciences 2010年第3期3卷 169-176页

作者： NARENDRAN SUDHEENDRAN MOHAMED MOHAMED MOHAMAD G.GHOSN vALERY v.tuchin KIRILL v.LARIN Department of Electrical and Computer Engineering University of Houston N308 Engineering Building 1 HoustonTX 77204USA Department of Biomedical Engineering University of Houston 2028 SERC Building HoustonTX 77204USA Department of Medicine Baylor College of Medicine HoustonTX 77030USA Institute of Optics and Biophotonics Saratov State University Saratov 410012Russia Institute of Precise Mechanics and Control of RAS Saratov 410056 Russia

One of the major challenges in imaging biological tissues using optical techniques,such as optical coherence tomography(OCT),is the lack of light penetration due to highly turbid structures within the tissue.Optical clearing techniques enable the biological samples to be more optically homogeneous,allowing for deeper penetration of light into the tissue.This study investigates the effect of optical clearing utilizing various concentrations of glucose solution(10%,30%,and 50%)on porcine skin.A gold-plated mirror was imaged beneath the tissue and percentage clearing was determined by monitoring the change in reflected light intensity from the mirror over time.The ratio of percentage clearing per tissue thickness for 10%,30% and 50% glucose was determined to be 4.7±1.6%mm^(−1)(n=6),10.6±2.0%mm^(−1)(n=7)and 21.8±2.2%mm^(−1)(n=5),respectively.It was concluded that while higher glucose concentration has the highest optical clearing effect,a suitable concentration should be chosen for the purpose of clearing,considering the osmotic stress on the tissue sample.

关键词： Glucose porcine skin percent clearing scattering coefficient optical coherence tomography

Photodynamic therapy of brain tumors and novel optical coherence tomography strategies for in vivo monitoring of cerebral°uid dynamics

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Journal of Innovative Optical Health Sciences 2020年第2期13卷 13-32页

作者： A.Abdurashitov.v.tuchin O.Semyachkina-Glushkovskaya Saratov State University Saratov 410012 Russian Federation Tomsk State University Tomsk 634050 Russian Federation Institute of Precision Mechanics and Control Russian Academy of Sciences Saratov 410028 Russian Federation

Photodynamic therapy(PDT)is a promising tool for least-invasive alternative methods for the treatment of brain tumors.The newly discovered PDT-induced opening of the blood–brain barrier(BBB)permeability open novel strategies for drug-brain delivery during post-surgical treatment of glioblastoma GBM.Here we discuss mechanisms of PDT-mediated opening of the BBB and age differences in PDT-related increase in BBB permeability,including with formation of brain edema.The meningeal lymphatic system plays a crucial role in the mechanism of brain drainage and clearance from metabolites and toxic molecules.We discuss that noninvasive photonic stimulation of°uid clearance via meningeal lymphatic vessels,and application of optical coherence tomography(OCT)for bed-side monitoring of meningeal lymphatic drainage has the promising perspective to be widely applied in both experimental and clinical studies of PDT and improving guidelines of PDT of brain tumors.

关键词： Photodynamic therapy optical coherence tomography(OCT) brain tumor meningeal lymphatic

OPTICAL PROPERTIES OF SKIN,SUBCUTANEOUS,AND MUSCLE TISSUES:A REvIEW

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Journal of Innovative Optical Health Sciences 2011年第1期4卷 9-38页

作者： ALEXEY N.BASHKATOv ELINA A.GENINA vALERY v.tuchin Institute of Optics and Biophotonics Saratov State University Saratov 410012Russia Institute of Precise Mechanics and Control of RAS Saratov 410028Russia

The development of optical methods in modern medicine in the areas of diagnostics,therapy,and surgery has stimulated the investigation of optical properties of various biological tissues,since the efficacy of laser treatment depends on the photon propagation and fluence rate distribution within irradiated tissues.In this work,an overview of published absorption and scattering properties of skin and subcutaneous tissues measured in wide wavelength range is presented.Basic principles of measurements of the tissue optical properties and techniques used for processing of the measured data are outlined.

关键词： Absorption coefficient scattering coefficient anisotropy factor reduced scattering coefficient refractive index

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FOREWORD

Journal of Innovative Optical Health Sciences 2009年第3期2卷 I0001-I0002页

作者： Elina A.Genina Kirill v.Larin valery v.tuchin Research-Educational Institute of Optics and Biophotonics Saratov State University Saratov Russia Department of Biomedical Engineering University of Houston Houston USA Research-Educational Institute of Optics and Biophotonics Saratov State University Institute of Precise Mechanics and Control RAS Saratov Russia

Special Issue Optical Technologies in the Study of Tissues and Biological Fluids We are pleased to present this special issue of JIOHS,which focuses on optical technologies in the study of tissues and biological liquids.The selected papers were presented during Saratov Fall Meeting—XII International School for Junior Scientists and Students on Optics,Laser Physics and Biophotonics(September 23–26,2008,Saratov,Russia)in the framework of the following workshops:“Optical Technologies in Biophysics and Medicine,”“Nanostructures and Nanoparticles,”“Microscopic and Low-Coherence Methods in Biomedical Applications,”and“Internet Biophotonics.”All eight papers in this special issue are research papers.

关键词： Junior photonics Russia

Optical clearing mechanisms characterization in muscle

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Journal of Innovative Optical Health Sciences 2016年第5期9卷 82-100页

作者： Luís Oliveira M.Inês Carvalho Elisabete Nogueira valery v.tuchin Physics Department–Polytechnic Institute of Porto School of Engineering Rua Dr.Antonio Bernardino de Almeida 4314200-072 PortoPortugal FEUP–University of Porto Rua Dr.Roberto Frias 4200-465 PortoPortugal CIETI–Centre of Innovation in Engineering and Industrial Technology ISEP Rua Dr.Antonio Bernardino de Almeida4314200-072 PortoPortugal DEEC/FEUP and INESC TEC University of Porto Rua Dr.Roberto Frias 4200-465 PortoPortugal Research-Education Institute of Optics and Biophotonics Saratov National Research State University 83 Astrakhanskaya street Saratov 410012Russia Laboratory of Laser Diagnostics of Technical and Living Systems Institute of Precision Mechanics and Control RAS 24 Rabochaya street Saratov 410028Russia Interdisciplinary Laboratory of Biophotonics Tomsk National Research State University 36 Lenin's avenue Tomsk 634050Russia

Optical immersion clearing is a technique that has been widely studied for more than two decades and that is used to originate a temporary transparency effect in biological tissues.If applied in cooperation with clinical methods it provides optimization of diagnosis and treatment procedures.This technique turns biological tissues more transparent through two main mechanisms-tissue dehydration and refractive index(RI)matching between tissue compo-nents.Such matching is obtained by partial replacement of interstit ial water by a biocompat ible agent that presents higher RI and it can be completely rever sible by natural rehydration in vrivo or by assisted rehydration in ex vivo tissues.Experimental data to characterize and discriminate between the two mechanisms and to find new ones are necessary.Using a simple method,based on collimated transmittance and thickness measurements made from muscle samples under treatment,we have estimated the diffusion properties of glucose,ethylene glycol(EG)and water that were used to perform such char acterization and discrimination.Comparing these properties with data from literature that characterize their diffusion in water we have observed that musde cell membrane permeability limits agent and water diffusion in the muscle.The same experi-mental data has allowed to calculate the optical dearing(OC)eficiency and make an inter-pretation of the internal changes that occurred in muscle during the treatments.The same methodology can now be used to perform similar studies with other agents and in other tissues in order to solve engineering problems at design of inexpensive and robust technologies for a consider.able improvement of optical tomogr aphic techmiques with better contrast and in depth imaging.

关键词： Collimated transmittance agent diffusivity tissue dehydration thickness variation refractive index matching glucose ethylene glycol

INTRODUCTION:SPECIAL ISSUE ON ADvANCES IN BIOPHOTONICS AND BIOMEDICAL OPTICS-PART I

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Journal of Innovative Optical Health Sciences 2013年第2期6卷 16-17页

作者： Dan Zhu valery v.tuchin Qingming Luo Huazhong University of Science and Technology WuhanP.R.China Saratov State University SaratovRussia

The 5th Russian-Chinese Workshop on Biophotonics and Biomedical Optics was hosted in Saratov,Russia on 26-28,September,2012.The bilateral Workshop brought together both Russian and Chinese scientists,engineers and clinical researchers from a variety of disciplines engaged in applying optical science,photonics and imaging technologies to problems in biology and medicine.During the W orkshop,2 plenary lectures,11 invited presentations,4 oral presentations and 13 poster reports were presented.A special Internet session with 5 presentations-1 plenary,2 invited,and 2 posters was also organized.This special issue selects some papers from the attendees,and is made up of 12 original research articles and one review.Seven articles will be presented in vol.6 No.1 of JIOHS,while the remaining five articles will be presented in vol.6 No.2.

关键词： Russian photonics engineer

Glycerol effects on optical,weight and geometrical properties of skin tissue

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Journal of Innovative Optical Health Sciences 2021年第5期4卷 64-74页

作者： vadim D.Genin Elina A.Genina valery v.tuchin Alexey N.Bashkatov Saratov State University(National Research University) 83Astrakhanskaya Str.Saratov 410012Russia Tomsk State University(National Research University) 36Lenina Av.Tomsk 634050Russia Institute of Precise Mechanics and Control of RAS 24Rabochaya Str.Saratov 410028Russia

Complex study of glycerol effects on the skin tissue was performed.The change in optical,weight and geometrical parameters of the rat skin under the action of the glycerol solutions was studied ex vivo.Possible mechanisms of the skin optical clearing under the action of glycerol solutions of different concentrations were discussed.The results can be helpful for refinement of models developed to evaluate the effective diffusion coefficients of glycerol in tissues.

关键词： Glycerol solutions skin optical clearing collimated transmittance dehydration

Foreword to the Special Issue on Optical Technologies in Biophysics and Medicine

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Journal of Innovative Optical Health Sciences 2015年第3期8卷 1-2页

作者： Elina A.Genina Dan Zhu valery v.tuchin Research-Educational Institute of Optics and Biophotonics Saratov State University SaratovRussia Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology(HUST)Wuhan P.R.China Research-Educational Institute of Optics and Biophotonics Saratov State University Institute of Precise Mechanics and Control RAS Saratov Russia

We are pleased to present the third issue of JIOHS,which focuses on optical technologies of diagnosticsand therapy,These are selected papers presented during Saratov Fall Meeting,1t International Sym-posium on Optics and Biophotonics(September 24-28,2013,Saratov,Russia)in the framework of the Workshops:"Optical Technologies in Biophysics_and Medicine,"Nanobiophotonics,"and"Internet Biophotonics."

关键词： Biophys ics photonics

OPTICAL COHER ENCE TOMOGRAPHY OF ADIPOSE TISSUE AT PHOTODYNAMIC/PHOTOTHERMAL TRE ATMENT IN vITRO

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Journal of Innovative Optical Health Sciences 2013年第2期6卷 22-28页

作者： IRINA YU.YANINA NATALIA A.TRUNINA vALERY v.tuchin Physics Department Saratov State UniversitySaratov 83 Astrakhanskay str.410012Russian FederationRussia Physics Department Saratov State UniversitySaratov83 Astrakhanskay str.410012Russian FederationRussia Laboratory of Laser Diagnostics of Technical and Living Systems of Precise Mechanics and Control Institute of the Russian Academy of Sciences 24 Rabochaya Str. Saratov410028Russian FederationRussia Optoelectronics and Measurement Techniques Laboratory University of Oulu P.O.Box 4500 FIN-90014 OuluFinland

Temporal changes in structure and refractive index distribution of adipose tissue at photo-dynamic/photothermal treatment were studied with OCT in vitro.Ethanol-water solutions of indocyanine green(ICG)and brilliant green(BG)were used for fat tissue staining.CW laser diode(808 nm)and LED light source(442 and 597 nm)were used for ir adiation of stained tissue slices.The data received supporting the hypothesis that photodynamic/photothermal treatment,induces fat cell lipolysis during a certain period of time after light exposure.

关键词： Optical coherence tomography adipose tissue effective refractive index photodynamic/photothermal treatment