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Journal of Innovative Optical Health Sciences 2022年第1期15卷 90-102页

作者： P.A.Dyachenko(Timoshina) A.N.Bashkatov D.A.Alexandrov v.I.Kochubey V.V.Tuchin Saratov State University SaratovRussia Laboratories of Biophotonics and Laser Molecular Imaging and Machine Learning National Research Tomsk State University TomskRussia Saratov State Medical University SaratovRussia Institute of Precision Mechanics and Control Russian Academy of SciencesRussia A.N.Bach Institute of Biochemistry Research Center of Biotechnology of the Russian Academy of Sciences MoscowRussia

The influence of ischemia-reperfusion(I/R)action on pancreatic blood flow(PBF)and the development of acute pancreatitis(AP)in laboratory rats is evaluated in vivo by using the laser speckle contrast imaging(LSCI).Additionally,the optical properties in norm and under condition of AP in rats were assessed using a modied integrating sphere spectrometer and inverse Monte Carlo(IMC)software.The results of the experimental study of microcirculation of the pancreas in 82 rats in the ischemic model are presented.The data obtained conrm the fact that local ischemia and changes in the blood°ow velocity of the main vessels cause and provoke acute pancreatitis.

关键词： Laser speckles contrast of speckle images adaptive algorithm microcirculation blood flow acute pancreatitis pancreas rats optical properties integrating sphere spectroscopy

ALTERATIONS IN AUTOFLUORESCENCE SIGNAL FROM RAT SKIN EX vIvO UNDER OPTICAL IMMERSION CLEARING

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Journal of Innovative Optical Health Sciences 2010年第3期3卷 147-152页

作者： E.v.MIGACHEvA A.B.PRAvDIN V.V.Tuchin Saratov State University 83 Astrakhanskaya str.410012 SaratovRussia

For the first time,the changes in autofluorescence spectra of ex vivo rat skin have been experimentally investigated using the combination of fluorescence spectroscopy and optical immersion clearing.The glucose,glycerol and propylene glycol solutions were used as clearing agents.The optical clearing was performed from the dermal side of skin imitating the in vivo injection of clearing agent under the dermal layers.In this contribution,the common properties of autofluorescence variation during optical immersion clearing were determined.The tendency of autofluorescence signal to decrease with reduction of scattering in tissue was noticed and discussed in detail.However,the differences in the shape of spectral curves under application of different clearing agents showed that optical clearing affects the autofluorescence properties of tissue differently depending on the type of clearing liquid.The results obtained are useful for the understanding of tissue optical clearing mechanisms and for improving techniques such as fluorescence spectroscopy.

关键词： Autofluorescence spectra fluorescence spectroscopy rat skin tissue optical clearing clearing agents

Laser speckle contrast imaging for monitoring of acute pancreatitis at ischemia-reperfusion injury of the pancreas in rats

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创新光学健康科学杂志(英文) 2023年第5期16卷 147-147页

PHOTONIC CRYSTAL WAvEGUIDE BIOSENSOR

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Journal of Innovative Optical Health Sciences 2013年第2期6卷 11-16页

作者： A.A.ZANISHEvSKAYA A.v.MALININ V.V.Tuchin YU.S.SKIBINA I.YU.SILOKHIN Saratov State University 83 Astrakhanskaya Str. Saratov 410012Russia SPE Nanostructured Glass Technology 101 50 let Oktjabrja ave.Saratov 410033Russia Institute of Precise Mechanics and Control RAS 24 Rabochaya Str.Saratov 410028Russia University of OuluP.O.Box 4500Oulu FIN-90014Finland SPE Nanostructured Glass Technology 101 50 let Oktjabrja Ave.Saratov 410033Russia

The hollow core photonic crystal waveguide biosensor is designed and described.The biosensor was tested in experiments for artificial sweetener identifcation in drinks.The photonic crystal waveguide biosensor has a high sensitivity to the optical properties of liquids flling up the hollow core.The compactness,good integration ability to different optical systems and compatibility for use in industrial settings make such biosensor very promnising for v arious biomedical applicat ions.

关键词： Biosensor hollow core photonic crystal fiber biomedical applications artificial sweetener food quality

Multi-layered tissue head phantoms for noninvasive optical diagnostics

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Journal of Innovative Optical Health Sciences 2015年第3期8卷 36-45页

作者： M.S.Wróbel A.P.Popov A.v.Bykov M.Kinnunen M.Jędrzejewska-Szczerska V.V.Tuchin Department of Metrology and Optoelectronics Gdansk University of Technology Gabriela Narutowicza Street 11/1280-233 Gdansk Poland Optoelectronics and Measurement Techniques Laboratory Faculty of Information Technology and Electrical Engineering University of Oulu P.O.Box 4500 FI-90014 OuluFinland Research-Educational Institute of Optics and Biophotonics Saratov State University Saratov 410012Russia Institute of Precise Mechanics and Control Russian Academy of Sciences Saratov 410028Russia

Extensive research in the area of optical sensing for medical diagnostics requires development of tissue phantoms with opt ical properties similar to those of living human tissues.Development and improvement of in vivo optical measurement systems requires the 1use of stable tissue phantoms with known characteristics,which are mainly used for calibration of such systems and testing their performance over time.Optical and mechanical properties of phantoms depend on their purpose.Nevertheless,they must accurately simulate specific tssues they are supposed to mimic.Many tsues and organs including head possess a multi-layered structure,with specifie optical properties of each layer.However,such a structure is not always addressed in the present-day phantoms.In this paper,we focus on the development of a plain-parallel multi-layered phantom with optical properties(reduced scattering oofficientμ'and absorption cofficientμa)corresponding to the human head layers,such as skin,skul,and gray and white matter of the brain tissue.The phantom is intended for use in noninvasive diffuse near-infrared spectroscopy(NIRS)of humnan brain.Optical parameters of the fabricated phantoms are reconstructed using spectrophotometry and inverse adding-doubling calculation method.The results show that polyinyl chloride plastisol(PvCP)and zinc oxide(ZnO)nanoparticles are suitable materials for fabrication of tissue mimicking phantoms with controlled scattering properties.Good matching was found between optical properties of phantoms and the corresponding values found in the literature.

关键词： Tissue-mimicking phantoms optical properties near-infrared spectroscopy head model

The morpho-functional assessment of plasmonic photothermal therapy effects on transplanted liver tumor

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Journal of Innovative Optical Health Sciences 2015年第3期8卷 28-35页

作者： A.B.Bucharskaya G.N.Maslyakova G.A.Afanasyeva* G.S.Terentyuk N.A.Navolokin O.v.Zlobina D.S.Chumakov A.N.Bashkatov E.A.Genina N.G.Khlebtsov B.N.Khlebtsov V.V.Tuchin Saratov State Medical University n.a.v.I.Razumovsky Russia Saratov State University n.a.N.G.Chernyshevsky Russia Institute of Biochemistry and Physiology of Plants and Microorganisms RAS SaratovRussia Institute of Precise Mechanics and Control RAS SaratovRussia Optoelectronics and Measurement Techniques Laboratory University of Oulu OuluFinland

The antitumor efficiency of gold nanorod plasmonic photothermal therapy(PPTT)was evalu-ated experimentally.The rat cholangiocarcinoma line PC-1 was used as a tumor model.Exposureof tumors to S08-nm laser radiation was performed,and the noninvasive temperature monitoring of the tumor tissue was carried out using infrared imager.The growth rate kinetics and mor-phological alterations of transplanted liver tumors,as wll as indicators of lipid peroxidation activity and autointoxication in rat serum,were studied,The activation of lipid peroxidation andthe development of autointoxication were detected after PPTT.The results not only demonstratethe antitumor ficacy of the proposed therapeutic technology but also reveal the side effectsin the presence of peroxidation products in systemic circulation.

关键词： Gold nanorodis plasmonic photothermal therapy laser hyperthermia transplantedliver tumor

Introduction to the Special Issue on Advances in Biophotonics and Biomedical Optics:Part II

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Journal of Innovative Optical Health Sciences 2022年第1期15卷 29-31页

作者： Polina Dyachenko(Timoshina) Tingting Yu Dan Zhu valery v.tuchin Research-Educational Institute of Optics and Biophotonics Saratov State University Saratov 410012Russia Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 P.R.China MoE Key Laboratory for Biomedical Photonics School of Engineering Sciences Huazhong University of Science and Technology Wuhan 430074 P.R.China

The 9th Chinese–Russian Workshop on Biophotonics and Biomedical Optics was held online on 28–30 September 2020.The bilateral workshop brought together both Russian and Chinese scientists,engineers,and clinical researchers from a variety of disciplines engaged in applying optical science,photonics,and imaging technologies to problems in biology and medicine.During the workshop,2 plenary lectures,35 invited presentations,5 oral presentations,and 8 internet reports were presented.This special issue selects some papers from the attendees and includes both research and review articles.

关键词： photonics Russian Biomedical

Photodynamic therapy of brain tumors and novel optical coherence tomography strategies for in vivo monitoring of cerebral°uid dynamics

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Journal of Innovative Optical Health Sciences 2020年第2期13卷 13-32页

作者： A.AbdurashitoV.V.Tuchin O.Semyachkina-Glushkovskaya Saratov State University Saratov 410012 Russian Federation Tomsk State University Tomsk 634050 Russian Federation Institute of Precision Mechanics and Control Russian Academy of Sciences Saratov 410028 Russian Federation

Photodynamic therapy(PDT)is a promising tool for least-invasive alternative methods for the treatment of brain tumors.The newly discovered PDT-induced opening of the blood–brain barrier(BBB)permeability open novel strategies for drug-brain delivery during post-surgical treatment of glioblastoma GBM.Here we discuss mechanisms of PDT-mediated opening of the BBB and age differences in PDT-related increase in BBB permeability,including with formation of brain edema.The meningeal lymphatic system plays a crucial role in the mechanism of brain drainage and clearance from metabolites and toxic molecules.We discuss that noninvasive photonic stimulation of°uid clearance via meningeal lymphatic vessels,and application of optical coherence tomography(OCT)for bed-side monitoring of meningeal lymphatic drainage has the promising perspective to be widely applied in both experimental and clinical studies of PDT and improving guidelines of PDT of brain tumors.

关键词： Photodynamic therapy optical coherence tomography(OCT) brain tumor meningeal lymphatic

Shedding light on biology and healthcare--preface to the special issue on Biomedical Optics

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Light(Science & Applications) 2022年第7期11卷 1315-1317页

作者： Peng Xi Xunbin Wei Junle Qu valery v.tuchin Department of Biomedical Engineering College of Future TechnologyPeking University100871BeijingChina Department of Biomedical Engineering Peking University100081BeijingChina Center for Biomedical Optics and Photonics(CBOP)&College of Physics and Optoelectronic Engineering Key Laboratory of Optoelectronic Devices and Systems of Guangdong Province and Ministry of EducationShenzhen University518060ShenzhenChina Saratov State University 83 Astrakhanskaya str.Saratov410012Russia

During the past decade,there has been an explosion in the development of novel optical techniques in biomedical research and clinical applications.Immense progress has been made in optical imaging and detection to provide necessary biological information for disease diagnosis and in-depth understanding of biological processes.Moreover,recent advances integrating laser technology with biomarkers have enabled novel diagnostic and treatment approaches for different types of diseases.

关键词： optical integrating diagnosis

Introduction to the special issue on celebrating the 15th anniversary of JIOHS and the 70th anniversary of HUST

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Journal of Innovative Optical Health Sciences 2023年第1期16卷 1-4页

作者： Qingming Luo valery v.tuchin Lihong Wang Hainan University P.R.China Wuhan NationalLabforOptoelectronics HUSTP.R.China Institute of Precision Mechanics and Control FRC SSC RASRussia A.N.Bach Institute of Biochemistry FRC Fundamentals of Biotechnology RAS Russia California Institute of Technology USA

Since launching in 2008,Journal of Innovative Optical Health Sciences(JIOHS)has been published for 15 years umtil 2022.Supported by the founding advisor Prof.Britton Chance and other founding Editorial Members,JIOHS was quickly embraced by the biomedical optics community,especially in Asia.Authors submitted some of their high quality papers to JIOHS,which led to a constant Impact Factor(IF)increase frcom the first IF 0.632 to IF 2396(Journal Citation Report 2021).

关键词： founding optics OHS