检索结果-南通市图书馆

Genes and genetics in eye diseases: a genomic medicine approach for investigating hereditary and inflammatory ocular disorders

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2018年第1期11卷 117-134页

作者： Mahavir Singh Suresh C tyagi Eye and vision Science Laboratory Department of Physiology University of Louisville School of Medicine

Past 25 y have witnessed an exponential increase in knowledge and understanding of ocular diseases and their respective genetic underpinnings. As a result, scientists have mapped many genes and their variants that can influence vision and health of our eyes. Based on these findings, it is becoming clear that an early diagnosis employing genetic testing can help evaluate patients＇ conditions for instituting treatment plan（s） and follow-up care to avoid vision complications later. For example, knowing family history becomes crucial for inherited eye diseases as it can benefit members in family who may have similar eye diseases or predispositions. Therefore, gathering information from an elaborate examination along with complete assessment of past medical illness by ophthalmologists followed by consultation with geneticists can help create a roadmap for making diagnosis and treatment precise and beneficial. In this review, we present an update on ocular genomic medicine that we believe has tremendous potential towards unraveling genetic implications in ocular diseases and patients＇ susceptibilities. We also discuss translational aspects of genetic ophthalmology and genome engineering that may help advance molecular diagnostics and therapeutics.

关键词： CRISPR/Cas9 precision medicine genetic ophthalmology genome engineering inflammation single nucleotide polymorphism

Optimizing the Pulsed Current Gas Tungsten Arc Welding Parameters

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2006年第6期22卷 821-825页

作者： M.Balasubramanian v.Jayabalan v. Balasubramanian Department of Production Engineering Sathyabama Institute of Science and TechnologyIndia Department of Manufacturing Engineering Anna UniversityIndia Department of Manufacturing Engineering Annamalai UniversityIndia

The selection of process parameter in the gas tungsten arc （GTA） welding of titanium alloy was presented for obtaining optimum grain size and hardness. Titanium alloy （Ti-6Al-4v） is one of the most important non-ferrous metals which offers great potential application in aerospace, biomedical and chemical industries, because of its low density （4.5 g/cm^3）, excellent corrosion resistance, high strength, attractive fracture behaviour and high melting point （1678℃）. The preferred welding process for titanium alloy is frequent GTA welding due to its comparatively easier applicability and better economy. In the case of single pass （GTA） welding of thinner section of this alloy, the pulsed current has been found beneficial due to its advantages over the conventional continuous current process. Many considerations come into the picture and one needs to carefully balance various pulse current parameters to reach an optimum combination. Four factors, five level, central composite, rotatable design matrix were used to optimize the required number of experimental conditions. Mathematical models were developed to predict the fusion zone grain size using analysis of variance （ANOvA） and regression analysis. The developed models were optimized using the traditional Hooke and Jeeve＇s algorithm. Experimental results were provided to illustrate the proposed approach.

关键词： Pulsed current Gas tungsten arc welding Titanium alloy Design of experiments ANOvA, Hooke and Jeeve's algorithm Grain size Hardness

Express Methods for Measurement of Electroconductivity of Semiconductor Layered Crystal

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2015年第11期32卷 114-117页

作者： FILIPPOv v. v. vLASOv A. N. Department of Physics Lipetsk State Pedagogical University Lipetsk 398020 Russian Federation Department of Natural Sciences and Technical Disciplines the Branch in Lipetsk of Moscow State University of Technologies and Management Lipetsk 398006 Russian Federation

We describe theoretically the grounded method of measuring the conductivity of anisotropic layered semiconductor materials. The suggested method implies the use of a four-probe testing device with a linear arrangement of probes. The final expressions for identifying the electrical conductivity are presented in the form of a series of analytic functions. The suggested method is experimentally verified, and practical recommendations of how to apply it are also provided.

关键词： Express Methods for Measurement of Electroconductivity of Semiconductor Layered Crystal

Process Parameter Optimization of the Pulsed Current Argon Tungsten Arc Welding of Titanium Alloy

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2008年第3期24卷 423-426页

作者： M.Balasubramanian v.Jayabalan v.Balasubramanian Department of Mechanical Engineering Maamallan Institute of Technology Department of Manufacturing-Engineering Anna University Department of Manufacturing Engineering Annamalai University

The selection of process parameters for obtaining optimal tensile properties in the pulsed current gas tungsten arc welding is presented. The tensile properties include ultimate tensile strength, yield strength and notch tensile strength. All these characteristics are considered together in the selection of process parameters by modified taguchi method to analyse the effect of each welding process parameter on tensile properties. Experimental results are furnished to illustrate the approach.

关键词： Pulsing current Modified taguchi method Tensile properties

A NEW APPROACH TO SOLvE SYSTEMS OF LINEAR EQUATIONS

在线全文

学校读者我要写书评

暂无评论

Journal of Computational Mathematics 2001年第4期19卷 445-448页

作者： v á squez, Luis v á squez-Poletti, Jos é L. Universidad Complutense 西班牙 E-28040 Universidad Pontificia Comillas 西班牙 E-28015

Presents a study which proposed an iterative approach to solve systems of linear equations. Definition of two families of convergent iterative methods; Features of the iterative method; Application of the method to a ... 详细信息

关键词： Iterative method Linear systems Classical dynamics.

Metalloproteinases as mediators of inflammation and the eyes： molecular genetic underpinnings governing ocular pathophysiology

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2017年第8期10卷 1308-1318页

作者： Mahavir Singh Suresh C tyagi Eye and vision Science Laboratory Department of Physiology University of Louisville School of Medicine Louisville KY 40202 USA

There are many vision threatening diseases of the eye affecting millions of people worldwide. In this article, we are summarizing potential role of various matrix metalloproteinases （MMPs）; the Zn （2＋）-dependent endoproteases in eye health along with pathogenesis of prominent ocular diseases such as macular degeneration, diabetic retinopathy, and glaucoma via understanding MMPs regulation in affected patients, interactions of MMPs with their substrate molecules, and key regulatory functions of tissue inhibitor of metalloproteinases （TIMPs） towards maintaining overall homeostasis.

关键词： age-related macular degeneration choroidal neovascularization diabetes glaucoma metalloproteinases tissue inhibitors of metalloproteinases

Effect of Multiple Martensitic Transformations on Structure of Fe-Ni Alloys

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2013年第3期29卷 279-282页

作者： v.Danilchenko Ie.Dzevin v.Sagaradze G.v.Kurdyumov Institute of Metal Physics NAS of UkraineKievUkraine Institute of Metal Physics Ural Division of RASEkaterinburgRussia

Effect of multiple direct and reverse martensitic transformations on fragmentation of austenitic grains in Fe-Ni alloys have been studied by X-ray diffraction and scanning electron microscopy. An ultra-fine structure was formed by fragmentation inside austenitic grains due to progressing misorientation of austenitic sub-grains during multiple γ-α-γ-martensitic phase transitions. An increase in the number of γ-α-γ-transformations increases misorientation angle between austenitic sub-grains and leads to transformation of an austenitic single crystal into a textured polycrystal. It has been shown that multiple γ-α-γ-martensitic phase transitions change the mechanism of internal stress relaxation from dislocation-based to deformation twinning.

关键词： Austenite Crystal lattice Ultra-fine structure Martensitic transformation

The Radcliffe Wave Parameters from Data on Open Star Clusters

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第3期24卷 106-109页

作者： v.v.Bobylev A.T.Bajkova Pulkovo Astronomical Observatory St-Petersburg 196140Russia

A spectral analysis of the vertical positions and velocities of 374 open star clusters(OSCs)was carried *** took these OSCs from the Hunt and Reffert catalog;they have an average age of about 10 million years,and are located on the galactic plane XY in a narrow zone inclined by 25°to the galactic axis *** following estimates of the parameters of the Radcliffe wave were obtained:(a)the maximum value in periodic perturbations of vertical coordinates Z_(max)=92±10pc with the wavelength of these perturbations λ_(z)=4.82±0.09 kpc;(b)the maximum value of the velocity of vertical disturbances Wmax=4.36±0.12km s^(-1) with disturbance wavelengthλ_(W)=1.78±0.02 *** that the results of the vertical velocity analysis are first-class in accuracy and completely new.

关键词： (Galaxy) local interstellar matter-Galaxy structure-(Galaxy) solar neighborhood

Photoluminescence,structural and antibacterial properties of co-dopedβ-Ca_(3)(PO_(4))_(2)-type phosphates Ca_(8)CuRE(PO_(4))_(7)(RE=Eu-Er)

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2024年第9期42卷 1658-1668,I0002页

作者： Ivan v.Nikiforov Ekaterina v.Iliin Bogdan I.Lazoryak Sergey M.Aksenov Pavel v.Slukin Dina v.Deyneko Department of Chemistry Lomonosov Moscow State University119991MoscowRussia Laboratory of Arctic Mineralogy and Material Sciences Kola Science CentreRussian Academy of Sciences184209ApatityRussia Geological Institute Kola Science CentreRussian Academy of Sciences184209ApatityRussia State Scientific Center of Applied Microbiology and Biotechnology of Rospotrebnadzor 24 Block A142279ObolenskRussia

Novel Ca_(8)CuRE(PO_(4))_(7)where RE^(3+)=Eu^(3+),Tb^(3+),Dy^(3+),Ho^(3+)and Er^(3+)were synthesized by a solid-state method in *** structures of the samples were characterized by powder X-ray diffraction using Rietveld refinement to determine the occupation of crystal *** samples are found to have a centrosymmetric structure with space group R3c,as shown by dielectric *** synthesized Ca_(8)CuRE(PO_(4))_(7)samples have multifunctional *** Cu^(2+)ions provide antibacterial properties,while the rare earth elements ions exhibit luminescence properties,and theβ-Ca_3(PO_(4))_(2)-type host is *** photoluminescence properties of RE^(3+)ions were studied and compared with other simmilar Ca_(8)MRE(PO_(4))_(7)phosphates,where M is a divalent *** photoluminescence intensity quenching in terms of energy transfer from RE^(3+)to Cu^(2+)is *** bioactive properties were studied in relation to antibacterial activity against *** and *** syntesized Ca_(8)CuRE(PO_(4))_(7)samples demonstrate very high and stable inhibition of bacteria *** correlation between crystal structure and properties is *** combining multiple approaches to the directio nal design of such materials,several important properties within a single chemical compound to achieve biovisualization and bioactive properties simultaneously can be combined.

关键词： β-Ca_(3)(PO_(4))_(2) Whitlockite-type structure Bioactive phosphates TCP Photoluminescence Rare earths