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Isomeric ratio of the ^(181)Ta(γ,3n)^(178m,g)Ta reaction products at energy Eγmax up to 95 Mev

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Chinese Physics C 2022年第1期46卷 102-109页

作者： O.S.Deiev I.S.Timchenko S.N.Olejnik v.A.Kushnir v.v.mytrochenko S.A.Perezhogin National Science Center"Kharkiv Institute of Physics and Technology" 1 Akademicheskaya St.61108 KharkivUkraine

The photoneutron reaction^(18)Ta(y,3m)(178m,g)Ta was investigated with the beam from the NSC KIPT electron linear accelerator *** measurements were performed using the residual y-activity *** bremsstrahlung flux-averaged cross sections((E_(γmax))>.(r(E_(γmax))>m.values of the averaged cross-sections and isomeric ratio were calculated using the partial cross-sections from the TALYS1.95 code for different level density models LD 1-6..The obtained experimental d(E_(γmax))agree with the data in the lterature,but differ from the theoretical values in ab-solute magnitude and the behavior of the energy dependence.A comparison of the determined averaged cross-sec-tions with the calculated cross sections showed the best agreement for the case of the LD 5 model.

关键词： bremsstrahlung flux-averaged cross-section isomeric ratio bremsstrahlung end-point energy of 35-95 Mev activation and off-line 7-ray spectrometric technique TALYS1.95 GEANT4.9.2

Isomeric pair 95m,g Nb in the photonuclear reactions on natMo at the bremsstrahlung end-point energy of 38–93 Mev

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Chinese Physics C 2023年第12期47卷 64-72页

作者： I.S.Timchenko O.S.Deiev S.M.Olejnik S.M.Potin v.A.Kushnir v.v.mytrochenko S.A.Perezhogin v.A.Bocharov Institute of Physics Slovak Academy of SciencesSK-84511 BratislavaSlovakia National Science Center"Kharkov Institute of Physics and Technology" 1Akademichna St.61108KharkivUkraine CNRS/IJCLAB 15 Rue Georges Clemenceau Str.Orsay91400France

The ^(nat)Mo(γ,xnp)^(95m,g)Nb photonuclear reaction was studied using the electron beam from the NSC KIPT linear accelerator *** experiment was performed using the activation and off-line γ-ray spectrometric *** experimental isomeric yield ratio(IR) was determined for the reaction products ^(95m,g)Nb at the bremsstrahlung end-point energy E_(γmax) range of 38-93 *** obtained values of IR are in satisfactory agreement with the results of other studies and extend the range of previously known *** theoretical values of the yields Y_(m,g)(E_(γmax)) and the IR for the isomeric pair ^(95m,g)Nb from the ^(nat)Mo(γ,xnp) reaction were calculated using the partial cross-sections σ(E) from the TALYS1.95 code for six different level density *** the investigated range of E_(γmax),the theoretical dependence of IR on energy was confirmed-the IR smoothly increases with increasing *** comparison showed a noticeable difference(more than 3.85 times) in the experimental IR relative to all theoretical estimates.

关键词： photonuclear reactions natMo isomeric pair 95m gNb isomeric yield ratio reaction yield bremsstrahlung end-point energy of 38–93 Mev activation and off-lineγ-ray spectrometric technique TALYS1.95 level density model GEANT4.9.2.

Cross-sections of photonuclear reactions ^(65)Cu(γ, n)^(64)Cu and ^(63)Cu(γ, xn)^(63−x)Cu in the energy range E_(γmax) = 35–94 Mev

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Chinese Physics C 2022年第12期46卷 208-216页

作者： O.S.Deiev I.S.Timchenko S.M.Olejnik S.M.Potin v.A.Kushnir v.v.mytrochenko S.A.Perezhogin B.I.Shramenko National Science Center“Kharkov Institute of Physics and Technology” 1Akademichna St.61108KharkivUkraine

The flux-averaged cross-sectionsfor the reactions^(65)Cu(γ,n)^(64)Cu,^(63)Cu(γ,n)^(62)Cu,^(63)Cu(γ,2n)^(61)Cu,and^(63)Cu(γ,3n)^(60)Cu have been measured within the bremsstrahlung end-point energy E_(γmax)range of 35–94 *** experiments were performed with the electron beam from the NSC KIPT linear accelerator LUE-40 with the use of the activation and off-lineγ-ray spectrometric *** calculation of the flux-average cross-sections_(th)was conducted using the cross-sectionσ(E)values from the TALYS1.95 code,run with default *** is shown that the experimental average cross-sections for the reactions^(65)Cu(γ,n)^(64)Cu,^(63)Cu(γ,n)^(62)Cu,and^(63)Cu(γ,2n)^(61)Cu are systematically higher than the theoretical estimates based on the TALYS1.95 *** obtainedvalues supplement the data of different laboratories for the(γ,n)and(γ,2n)reactions of^(63)Cu and^(65)*** the reaction^(63)Cu(γ,3n)^(60)Cu,the values ofwere measured for the first time.

关键词： ^(63)Cu ^(65)Cu photonuclear reactions flux-averaged cross-section bremsstrahlung end-point energies of 35-94 Mev activation and off-lineγ-ray spectrometric techniques TALYS1.95 GEANT4

Autism spectrum disorder:difficulties in diagnosis and microRNA biomarkers

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Neural Regeneration Research 2025年第10期20卷 2776-2786页

作者： Bridget Martinez Philip v.Peplow Department of Pharmacology University of Nevada-RenoRenoNVUSA Department of Medicine University of Nevada-RenoRenoNVUSA Department of Anatomy University of OtagoDunedinNew Zealand

We performed a PubMed search for microRNAs in autism spectrum disorder that could serve as diagnostic biomarkers in patients and selected 17 articles published from January 2008 to December 2023,of which 4 studies were performed with whole blood,4 with blood plasma,5 with blood serum,1 with serum neural cell adhesion molecule L1-captured extracellular vesicles,1 with blood cells,and 2 with peripheral blood mononuclear *** of the studies involved children and the study cohorts were largely *** of the studies had performed microRNA sequencing or quantitative polymerase chain reaction assays to measure microRNA *** five studies had used real-time polymerase chain reaction assay to validate microRNA expression in autism spectrum disorder subjects compared to *** microRNAs that were validated in these studies may be considered as potential candidate biomarkers for autism spectrum disorder and include miR-500a-5p,-197-5p,-424-5p,-664a-3p,-365a-3p,-619-5p,-664a-3p,-3135a,-328-3p,and-500a-5p in blood plasma and miR-151a-3p,-181b-5p,-320a,-328,-433,-489,-572,-663a,-101-3p,-106b-5p,-19b-3p,-195-5p,and-130a-3p in blood serum of children,and miR-15b-5p and-6126 in whole blood of *** important limitations were identified in the studies reviewed,and need to be taken into account in future *** studies are warranted with children and adults having different levels of autism spectrum disorder severity and consideration should be given to using animal models of autism spectrum disorder to investigate the effects of suppressing or overexpressing specific microRNAs as a novel therapy.

关键词： autism spectrum disorder biomarker blood cells blood plasma blood serum diagnosis microRNA peripheral blood mononuclear cells serum neural cell adhesion molecule L1-captured extracellular vesicles whole blood

MicroRNAs as potential diagnostic biomarkers for bipolar disorder

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Neural Regeneration Research 2025年第6期20卷 1681-1695页

Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microRNA profiling in bloodand brain-based materials. From the studies that had validated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had investigated the changes in microRNA expression of patients with bipolar disorder receiving treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedatives, hypnotics, anticonvulsants, and analgesics(drug class C) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serve as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectively, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observed i

关键词： biomarker bipolar disorder blood leukocytes blood plasma blood plasma extracellular vesicles/exosomes blood serum brain tissue brain tissue extracellular vesicles/exosomes lymphoblastoid cell lines microRNA neural progenitor cells whole blood

MicroRNAs as potential biomarkers for diagnosis of post-traumatic stress disorder

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Neural Regeneration Research 2025年第7期20卷 1957-1970页

Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life ***,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with and without post-traumatic stress *** addition,the heterogeneity of clinical presentations of post-traumatic stress disorder and the overlap of symptoms with other conditions can lead to misdiagnosis and inappropriate *** suggests that this condition is a multisystem disorder that affects many biological systems,raising the possibility that peripheral markers of disease may be used to diagnose post-traumatic stress *** performed a PubMed search for microRNAs(miRNAs)in post-traumatic stress disorder(PTSD)that could serve as diagnostic biomarkers and found 18 original research articles on studies performed with human patients and published January 2012 to December *** included four studies with whole blood,seven with peripheral blood mononuclear cells,four with plasma extracellular vesicles/exosomes,and one with serum *** of these studies had also used whole *** studies were excluded as they did not involve microRNA *** of the studies had collected samples from adult male veterans who had returned from deployment and been exposed to combat,and only two were from recently traumatized adult *** measuring miRNA expression levels,many of the studies had used microarray miRNA analysis,miRNA Seq analysis,or NanoString *** six studies had used real time polymerase chain reaction assay to determine/validate miRNA expression in PTSD subjects compared to *** miRNAs that were found/validated in these studies may be considered as potential candidate biomarkers for PTSD and include miR-3130-5p in whole blood;miR-193a-5p,-7113-5p,-125a,-181c,and-671-5p in peripheral blood mononuclear cells;miR-10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and-7641 in plasma extracellular vesicles/

关键词： biomarker diagnosis microRNA peripheral blood mononuclear cells plasma extracellular vesicles/exosomes post-traumatic stress disorder serum exosomes whole blood whole plasma

Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.v.P.Sakamuri Anil Sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： victor v.Chizhikov Igor Y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-valle-Anton and Borrell,2022).

关键词： epithelium Figure center

Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease

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Neural Regeneration Research 2025年第7期20卷 2053-2067页

作者： Milica Zeljkovic Jovanovic Jelena Stanojevic Ivana Stevanovic Milica Ninkovic Tihomir v.Ilic Nadezda Nedeljkovic Milorad Dragic Laboratory for Neurobiology Department of General Physiology and BiophysicsFaculty of BiologyUniversity of BelgradeBelgradeSerbia Medical Faculty of Military Medical Academy University of DefenceBelgradeSerbia

An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's *** therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in *** transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's ***,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain *** purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated *** with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod ***,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate *** intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate *** with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor *** treatment with prolonged intermittent theta burst stimulation,complete motor recovery was *** improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst *** results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)***

关键词： A_(1)R A_(2A)R adenosine receptors adenosine ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling