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Dolomitization of the lower cretaceous carbonate reservoir in the Euphrates Graben,Syria

Petroleum Science 2021年第5期18卷 1342-1356页

作者： Yousef Ibrahem v.P.Morozov v.sudakov Institute of Geology and Petroleum Technologies Kazan Federal UniversityKazan420008Russian Federation

Results of this study are based on core materials description,thin sections,Cathodoluminescence(CL),and Scanning Electron Microscope(SEM)*** Lower Cretaceous over the Euphrates Graben area was characterized by carbonate sedimentation in shallow marine *** low energy lagoonal to inner shelf sediments of the Judea Formation includes micritic mudstone to wackestone texture,dolomitic limestones and *** types of dolomites recognized in the carbonates of the Judea Formation,the preserving microcrystalline dolomites which commonly founded in the partially dolomitized micritic limestones,and the destructive coarsely crystalline dolomites which commonly founded in the dolostones and dolomitic *** examinations indicate that the preserving microcrystalline dolomites represent subtidal cycles developed in a shoal to open marine depositional environments,they probably formed under conditions of the shallow burial *** destructive coarsely crystalline dolomites may develop in more basinward,open marine environments under conditions of the deep burial diagenesis that accompanied by rising in temperature,pressure,and burial *** is believed that evolution of the diagenetic history of the Judean Formation sediments occurred in two diagenetic stages;the shallow burial diagenesis,and the deep burial *** processes,early fracturing,micritization,early calcite,and the early phase of dolomitization were part of the multiple diagenetic alterations during the shallow burial *** deep burial diagenesis was marked by dissolution,late stage of dolomitization and replacement,mechanical and chemical compaction,and the late calcite *** is believed that dolomitization of the Judea Formation carbonates in the Euphrates Graben has contributed to improving the reservoir properties by increasing the porosity and thus the permeability.

关键词： Dolomitization Carbonate Diagenesis Burial history Euphrates graben Syria

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Sedimentary diagenesis and pore characteristics for the reservoir evaluation of Domanik formations(Semiluksk and Mendymsk)in the central part of volga-Ural petroleum province

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Petroleum Research 2022年第1期7卷 32-46页

作者： Yousef Ibrahem v.P.Morozov v.sudakov I.Idrisov A.N.Kolchugin Kazan Federal University Institute of Geology and Petroleum Technologies420008Russian Federation

The Upper Devonian Semiluksk(Domanik)and Mendymsk carbonate successions have been identified as the most promising unconventional oil and gas deposits in Russia's volga-Ural petroleum *** lithofacies were identified:limestones,organic matter-rich siliceous carbonate,and dolomitic limestones/*** sediments are thought to have accumulated in the relatively deep-sea shelf depositional *** to X-ray analysis,calcite is the most common mineral phase in the *** siliceous carbonate rocks'major mineral phases were identified to be quartz,followed by *** rocks have relatively poor reservoir qualities,with porosity ranging from 0.1 to 5%and permeability ranging from 0.01 to 10 *** examination of thin sections reveals four major types of pores:*** pores,which are abundant in all of the examined lithofacies;*** pores formed between dolomite crystals and the very fine components of the siliceous carbonate *** as a result of leaching,and *** as a result of tectonic and/or diagenetic *** the obtained data from the petrographically examined thin sections on the ternary pore plot diagram resulted in the identification of six pore facies and their related diagenetic *** facies 1 depicts the pores that formed during the depositional *** facies 4 displays moldic *** vugs are represented by pore facies *** facies 2 is a mixture between pore facies 1 and pore facies *** facies 3 is a mixture between pore facies 1 and pore facies *** facies 5 is a mixture between pore facies 4 and pore facies *** the petrographic results and the identified pore facies show that pore facies 6 have touching pores and they played the most important role in improving the reservoir *** pore facies 4 which have separate pores have the most influence in the reduction of the reservoir *** diagenetic origin secondary pores are the most

关键词： Domanik formations Shale oil Lithofacies Diagenesis Reservoir characteristics Central part of volga-ural

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Microfacies analysis and depositional environment of the Upper Devonian Dankovo-Lebedyansky sediments,Tatarstan,volga-Ural Basin,Russia

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Petroleum Research 2023年第2期8卷 244-255页

作者： Ibrahem Yousef v.P Morozov A.N Kolchugin v.sudakov I.Idrisov A.Leontev Kazan Federal University Institute of Geology and Petroleum Technologies420008Russian Federation

The Upper Devonian,Middle Famennian Dankovo-Lebedyansky sediments in Southeast Tatarstan territory are a carbonate sequence composed of limestone and dolomite,which is important hydrocarbon reservoir units,therefore,it is necessary to conduct in-depth study on its microfacies and depositional *** this study,a multidisciplinary approach that combines core observation with thin section examination is *** limestone contains abundant skeletal grains(echinoderms,foraminifera,algae,gastropods,and calcispheres),as well as non-skeletal grains(intraclasts and peloids).On the basis of detailed petrographic investigations,six sedimentary microfacies can be identified,including(i)peloidal grainstone(MF 1),(ii)cemented bioclastic peloidal grainstone(MF 2),(iii)echinodermconcentrated packstone(MF 3),(iv)algae packstone(MF 4),(v)bioclastic wackestone(MF 5),(vi)whole-fossil wackestone(MF 6),as well as dolomite or dolostone as diagenetic facies(MF 7).Based on microfacies analysis,the Dankovo-Lebedyansky sediments were deposited in three distinct sedimentary facies belts(shoal,lagoon and open marine environment).In order to reflect dispositional energy condition,the microfacies were grouped into facies associations:(i)low-energy microfacies associations including MF 5 and MF 6,(ii)moderate energy microfacies associations including MF 1,MF 2,MF 3,and MF *** dolomite,or diagenetic facies(MF 7),is the result of slightly to extensively dolomitization of limestone in the Dankovo-Lebedyansky *** of frequent dolostone types are euhedral planar-e and subhedral *** to petrographic characteristic of the dolostone,a seepage reflux model can be used to explain the dolomitization process of Dankovo-Lebedyansky sediments.

关键词： Microfacies Depositional environments Carbonate Dolomitization Upper devonian Dankovo-lebedyansky volga-ural basin

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Autism spectrum disorder:difficulties in diagnosis and microRNA biomarkers

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Neural Regeneration Research 2025年第10期20卷 2776-2786页

作者： Bridget Martinez Philip v.Peplow Department of Pharmacology University of Nevada-RenoRenoNVUSA Department of Medicine University of Nevada-RenoRenoNVUSA Department of Anatomy University of OtagoDunedinNew Zealand

We performed a PubMed search for microRNAs in autism spectrum disorder that could serve as diagnostic biomarkers in patients and selected 17 articles published from January 2008 to December 2023,of which 4 studies were performed with whole blood,4 with blood plasma,5 with blood serum,1 with serum neural cell adhesion molecule L1-captured extracellular vesicles,1 with blood cells,and 2 with peripheral blood mononuclear *** of the studies involved children and the study cohorts were largely *** of the studies had performed microRNA sequencing or quantitative polymerase chain reaction assays to measure microRNA *** five studies had used real-time polymerase chain reaction assay to validate microRNA expression in autism spectrum disorder subjects compared to *** microRNAs that were validated in these studies may be considered as potential candidate biomarkers for autism spectrum disorder and include miR-500a-5p,-197-5p,-424-5p,-664a-3p,-365a-3p,-619-5p,-664a-3p,-3135a,-328-3p,and-500a-5p in blood plasma and miR-151a-3p,-181b-5p,-320a,-328,-433,-489,-572,-663a,-101-3p,-106b-5p,-19b-3p,-195-5p,and-130a-3p in blood serum of children,and miR-15b-5p and-6126 in whole blood of *** important limitations were identified in the studies reviewed,and need to be taken into account in future *** studies are warranted with children and adults having different levels of autism spectrum disorder severity and consideration should be given to using animal models of autism spectrum disorder to investigate the effects of suppressing or overexpressing specific microRNAs as a novel therapy.

关键词： autism spectrum disorder biomarker blood cells blood plasma blood serum diagnosis microRNA peripheral blood mononuclear cells serum neural cell adhesion molecule L1-captured extracellular vesicles whole blood

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MicroRNAs as potential diagnostic biomarkers for bipolar disorder

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Neural Regeneration Research 2025年第6期20卷 1681-1695页

Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microRNA profiling in bloodand brain-based materials. From the studies that had validated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had investigated the changes in microRNA expression of patients with bipolar disorder receiving treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedatives, hypnotics, anticonvulsants, and analgesics(drug class C) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serve as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectively, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observed i

关键词： biomarker bipolar disorder blood leukocytes blood plasma blood plasma extracellular vesicles/exosomes blood serum brain tissue brain tissue extracellular vesicles/exosomes lymphoblastoid cell lines microRNA neural progenitor cells whole blood

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MicroRNAs as potential biomarkers for diagnosis of post-traumatic stress disorder

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Neural Regeneration Research 2025年第7期20卷 1957-1970页

Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life ***,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with and without post-traumatic stress *** addition,the heterogeneity of clinical presentations of post-traumatic stress disorder and the overlap of symptoms with other conditions can lead to misdiagnosis and inappropriate *** suggests that this condition is a multisystem disorder that affects many biological systems,raising the possibility that peripheral markers of disease may be used to diagnose post-traumatic stress *** performed a PubMed search for microRNAs(miRNAs)in post-traumatic stress disorder(PTSD)that could serve as diagnostic biomarkers and found 18 original research articles on studies performed with human patients and published January 2012 to December *** included four studies with whole blood,seven with peripheral blood mononuclear cells,four with plasma extracellular vesicles/exosomes,and one with serum *** of these studies had also used whole *** studies were excluded as they did not involve microRNA *** of the studies had collected samples from adult male veterans who had returned from deployment and been exposed to combat,and only two were from recently traumatized adult *** measuring miRNA expression levels,many of the studies had used microarray miRNA analysis,miRNA Seq analysis,or NanoString *** six studies had used real time polymerase chain reaction assay to determine/validate miRNA expression in PTSD subjects compared to *** miRNAs that were found/validated in these studies may be considered as potential candidate biomarkers for PTSD and include miR-3130-5p in whole blood;miR-193a-5p,-7113-5p,-125a,-181c,and-671-5p in peripheral blood mononuclear cells;miR-10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and-7641 in plasma extracellular vesicles/

关键词： biomarker diagnosis microRNA peripheral blood mononuclear cells plasma extracellular vesicles/exosomes post-traumatic stress disorder serum exosomes whole blood whole plasma

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Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.v.P.Sakamuri Anil Sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

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Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： victor v.Chizhikov Igor Y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-valle-Anton and Borrell,2022).

关键词： epithelium Figure center

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Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease

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Neural Regeneration Research 2025年第7期20卷 2053-2067页

作者： Milica Zeljkovic Jovanovic Jelena Stanojevic Ivana Stevanovic Milica Ninkovic Tihomir v.Ilic Nadezda Nedeljkovic Milorad Dragic Laboratory for Neurobiology Department of General Physiology and BiophysicsFaculty of BiologyUniversity of BelgradeBelgradeSerbia Medical Faculty of Military Medical Academy University of DefenceBelgradeSerbia

An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's *** therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in *** transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's ***,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain *** purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated *** with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod ***,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate *** intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate *** with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor *** treatment with prolonged intermittent theta burst stimulation,complete motor recovery was *** improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst *** results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)***

关键词： A_(1)R A_(2A)R adenosine receptors adenosine ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling

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Impact of time between meniscal injury and isolated meniscus repair on post-operative outcomes:A systematic review

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World Journal of Clinical Cases 2025年第7期13卷 39-45页

作者： Kashif Javid Xavier Akins Nicole G Lemaster Amer Ahmad Austin v Stone Department of Orthopaedic Surgery and Sports Medicine University of KentuckyLexingtonKY 40504United States

BACKGROUND Meniscal tears are one of the most common knee *** the diagnosis of a meniscal tear has been made,there are several factors physicians use to guide clinical *** influence of time between injury and isolated meniscus repair on patient outcomes is not well *** this relationship is important as it may influence clinical decision-making and can add to the preoperative patient education *** hypothesized that increasing the time from injury to meniscus surgery would worsen postoperative *** To investigate the current literature for data on the relationship between time between meniscus injury and repair on patient *** PubMed,Academic Search Complete,MEDLINE,CINAHL,and SPORTDiscus were searched for studies published between January 1,1995 and July 13,2023 on isolated meniscus *** criteria included concomitant ligament surgery,incomplete outcomes or time to surgery data,and *** demographics,time to injury,and postoperative outcomes from each study were abstracted and *** Five studies met all inclusion and exclusion *** were 204(121 male,83 female)patients *** of five(60%)studies determined that time between injury and surgery was not statistically significant for postoperative Lysholm scores(P=0.62),Tegner scores(P=0.46),failure rate(P=0.45,P=0.86),and International Knee Documentation Committee scores(P=0.65).Two of five(40%)studies found a statistically significant increase in Lysholm scores with shorter time to surgery(P=0.03)and a statistically significant association between progression of medial meniscus extrusion ratio(P=0.01)and increasing time to *** Our results do not support the hypothesis that increased time from injury to isolated meniscus surgery worsens postoperative ***-making primarily based on injury interval is thus not recommended.

关键词： Meniscus Meniscal Meniscus repair Meniscectomy Patient reported outcomes Postoperative outcomes Time to surgery Injury interval

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