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Effects of temperature on the mechanical properties of Ti6Al4v powder compacts prepared by magnetic pulse compaction

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Rare Metals 2010年第3期29卷 302-307页

作者： LI mini YU Haiping LI Chunfeng School of Materials Science and Engineering Harbin Institute of Technology Harbin 150001 China

The effects of temperature （0-500°C） on the compressive strength,hardness,average relative density,and microstructure of Ti6Al4v powder green compacts prepared by magnetic pulse compaction were *** results show that with increasing heating temperature,the compressive strength first increases and then decreases with the maximum value of 976.74 Mpa at 400°*** average relative density and hardness constantly increase,and their values reach 96.11% and HRA 69.8 at 500°C,*** increase of partial welding is found among the junctions of particles inside the compacts; there is no obvious grain growth inside the compacts within the temperature range.

关键词： powder metallurgy powder compaction magnetic pulse compaction heating temperature relative density electromagnetic forming

Liquid biopsy in colorectal cancer:No longer young,but not yet old

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World Journal of Gastroenterology 2022年第15期28卷 1503-1507页

作者： Giandomenico Roviello Daniele Lavacchi Lorenzo Antonuzzo Martina Catalano Enrico mini Department of Health Sciences Section of Clinical Pharmacology and OncologyUniversity of FlorenceFirenze 50139Italy Clinical Oncology Unit AOU CareggiFirenze 50134Italy Department of Experimental and Clinical Medicine University of FirenzeFirenze 50134Italy School of Human Health Sciences University of FlorenceFlorence 50134Italy

Colorectal cancer(CRC)is one of the most prevalent cancers and the second leading cause of cancer-related deaths *** treatment strategy employed in CRC patients is becoming highly dependent on molecular characteristics present at diagnosis and during *** biopsy is an emerging field in the management of this cancer,and its relevance as a potential diagnostic,prognostic,monitoring,and therapeutic tool makes it a viable strategy in the clinical management of CRC *** biopsy also has certain limitations,but these limitations seem to be at the reach of near-future technological *** this letter,we focus on the clinical perspectives of liquid biopsy in CRC with particular regard to the various biomarkers recently identified that have been shown to be potentially useful in multiple aspects of early stage or metastatic CRC.

关键词： Colorectal cancer Liquid biopsy Circulating tumor DNA Diagnosis prognosis Targeted therapy

Genomic and genetic alterations influence the progression of gastric cancer

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World Journal of Gastroenterology 2011年第3期17卷 290-299页

作者： Stefania Nobili Lorenzo Bruno Ida Landini Cristina Napoli paolo Bechi Francesco Tonelli Carlos A Rubio Enrico mini Gabriella Nesi Department of preclinical and Clinical pharmacology University of Florence Department of Critical Care Medicine and Surgery University of Florence Department of Clinical physiopathology University of Florence Department of pathology Karolinska Institute and University Hospital Division of pathological Anatomy Department of Critical Care Medicine and SurgeryUniversity of Florence

Gastric cancer is one of the leading causes of cancerrelated deaths worldwide, although the incidence has gradually decreased in many Western countries. Two main gastric cancer histotypes, intestinal and diffuse, are recognised. Although most of the described genetic alterations have been observed in both types, different genetic pathways have been hypothesized. Genetic and epigenetic events, including 1q loss of heterozygosity (LOH), microsatellite instability and hypermethylation, have mostly been reported in intestinal-type gastric carcinoma and its precursor lesions, whereas 17p LOH, mutation or loss of E-cadherin are more often implicated in the development of diffuse-type gastric *** this review, we summarize the sometimes contradictory findings regarding those markers which influence the progression of gastric adenocarcinoma.

关键词： Gastric cancer Gene alterations prognosis Molecular pathology

The Basic Components of Software-Hardware System for Modeling and Control of the Toroidal plasma by Epsilon-Nets on Heterogeneous mini-Supercomputers

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Communications in Computational physics 2018年第6期24卷 1-26页

作者： Fedor S.Zaitsev Alexei G.Shishkin Andrei A.Lukianitsa Egor p.Suchkov Sergei v.Stepanov Fedor A.Anikeev Scientific Research Institute of System Development Russian Academy of SciencesNakhimovsky prosp.26 b.1117218MoscowRussia Moscow State University Department of Computational Mathematics and CyberneticsLenin’s Hills119991MoscowRussia.

A significant step towards the comprehensive solution of the important new fundamental control problems of high-temperature plasma of toroidal configuration is made by utilizing heterogeneous mini-supercomputers of NIISI RAS(Scientific Research Institute of System Development,Russian Academy of Science).The basic components of hardware and software modeling system and automatic real-time plasma feedback control are developed and *** system is named HASp CS(Hardware-Software plasma Control System).It is based on a fundamentally new,more accurate and reliable control algorithm using a solution with a given accuracy of a number of inverse diagnostic problems by ∈-*** possibility of an application of the proposed technique during discharge time to provide feedback control of the boundary and internal plasma parameters is *** is shown that the complex allows investigating the processes in currently operated and designed fusion devices and solving problems of fusion application for energy *** recommendations to the engineering implementation of plasma control systems are *** directions for further research are formulated.

关键词： Control problem ∈-net plasma tokamak modeling

Behavioral and physiological flexibility are used by birds to manage energy and support investment in the early stages of reproduction

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Current Zoology 2010年第6期56卷 767-792页

作者： Franois vZINA Katrina G. SALvANTE Département de Biologie chimie et géographieGroupe de recherche sur les environnements nordiques BORASUniversité du Québec à Rimouski Department of Biological Sciences Simon Fraser University

Interest in phenotypic flexibility has increased dramatically over the last decade, but flexibility during reproduction has received relatively little attention from avian scientists, despite its possible impact on fitness. Because most avian species maintain atrophied reproductive organs when not active, reproduction in birds requires major tissue remodeling in preparation for breeding. Females undergo rapid （days） recrudescence and regression of their reproductive organs at each breeding attempt, while males grow their organs ahead of time at a much slower rate （weeks） and may maintain them at maximal size throughout the breeding season. Reproduction is associated with significant metabolic costs. Egg production leads to a 22%-27% increase in resting metabolic rate （RMR） over non-reproductive values. This is partly due to the activity of the oviduct, an organ that may allow females to adjust reproductive investment by modulating egg size and quality. In males, gonadal recrudescence may lead to a 30% increase in RMR, but the data are inconsistent and general conclusions regarding energetic costs of reproduction in males will require more research. Recent studies on captive female zebra finches describe the impacts of these costs on daily energy budgets and highlight the strategies used by birds to maintain their investment in reproduction when energy is limited. Whenever possible, birds use behavioral flexibility as a first means of saving energy. Decreasing locomotor activity saves energy during challenges such as egg production or exposure to cold temperatures and is an efficient way to buffer variation in individual daily energy budgets. However, when behavioral flexibility is not possible, birds must rely on flexibility at the physiological level to meet energy demands. In zebra finches breeding in the cold, this results in a reduced pace of laying, likely due to down-regulation of both reproductive and non-reproductive function, allowing females to defend mini

关键词： phenotypic plasticity phenotypic flexibility BMR Energy budget Organ Egg size physiological tradeoff Fitness

A historical literature review of coronary microvascular obstruction and intra-myocardial hemorrhage as functional/structural phenomena

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The Journal of Biomedical Research 2023年第4期37卷 268-289页

作者： Leonid N.Maslov Natalia v.Naryzhnaya Sergey v.popov Alexandr v.Mukhomedzyanov Ivan A.Derkachev Boris K.Kurbatov Andrey v.Krylatov Feng Fu Jianming pei vyacheslav v.Ryabov Evgenii v.vyshlov Svetlana v.Gusakova Alla A.Boshchenko Akpay Sarybaev Laboratory of Experimental Cardiology Cardiology Research InstituteTomsk National Research Medical Center of the Russian Academy of SciencesTomskTomsk Region 634012Russia Department of physiology and pathophysiology National Key Discipline of Cell BiologySchool of Basic Medicinethe Fourth Military Medical UniversityXi'anShaanxi 710032China Siberian State Medical University TomskTomsk Region 634050Russia National Center of Cardiology and Internal Medicine Bishkek 720040Kyrgyzstan.

The analysis of experimental data demonstrates that platelets and neutrophils are involved in the no-reflow phenomenon,also known as microvascular obstruction(MvO).However,studies performed in the isolated perfused hearts subjected to ischemia/reperfusion(I/R)do not suggest the involvement of microembolization and microthrombi in this *** intracoronary administration of alteplase has been found to have no effect on the occurrence of MvO in patients with acute myocardial ***,the major events preceding the appearance of MvO in coronary arteries are independent of microthrombi,platelets,and *** cells appear to be the target where ischemia can disrupt the endothelium-dependent vasodilation of coronary ***,reperfusion triggers more pronounced damage,possibly mediated by *** and intra-myocardial hemorrhage contribute to the adverse post-infarction myocardial ***,pharmacological agents used to treat MvO should prevent endothelial injury and induce relaxation of smooth *** conditioning protocols have been shown to prevent MvO,with L-type Ca2+channel blockers appearing the most effective in treating MvO.

关键词： heart ischemia reperfusion microvascular obstruction intra-myocardial hemorrhage

Millimetric devices for nerve stimulation:a promising path towards miniaturization

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Neural Regeneration Research 2024年第8期19卷 1702-1706页

作者： Ryan M.Dorrian Anna v.Leonard Antonio Lauto Spinal Cord Injury Research Group School of BiomedicineThe University of AdelaideAdelaideSAAustralia School of Science Western Sydney UniversityPenrithNSWAustralia

Nerve stimulation is a rapidly developing field,demonstrating positive outcomes across several *** potential benefits,current nerve stimulation devices are large,complicated,and are powered via implanted pulse *** facto rs necessitate invasive surgical implantation and limit potential *** nerve stimulation devices to millimetric sizes would make these interventions less invasive and facilitate broader therapeutic ***,device miniaturization presents a serious engineering *** review presents significant advancements from several groups that have overcome this challenge and developed millimetricsized nerve stimulation *** are based on antennas,mini-coils,magneto-electric and optoelectronic materials,or receive ultrasound *** highlight key design elements,findings from pilot studies,and present several considerations for future applications of these devices.

关键词： biomedical engineering deep brain stimulation electrical engineering electrical stimulation neuromodulation peripheral nerve stimulation

Differences between delusional disorder and schizophrenia:A mini narrative review

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World Journal of psychiatry 2022年第5期12卷 683-692页

作者： Alexandre González-Rodríguez Mary v Seeman Department of Mental Health Mutua Terrassa University HospitalUniversity of BarcelonaBarcelona 08280Spain Department of psychiatry University of TorontoToronto M5P 3L6OntarioCanada

psychotic syndromes are divided into affective and non-affective *** among the non-affective forms,substantial differences *** aim of this relatively brief review is to synthesize what is known about the differences between two non-affective psychoses,schizophrenia and delusional disorder(DD),with respect to clinical,epidemiological,sociodemographic,and treatment response characteristics.A pubMed literature search revealed the following:in schizophrenia,hallucinations,negative symptoms and cognitive symptoms are *** are rare in *** to schizophrenia patients,individuals with DD maintain relatively good function,and their delusions are believable;many are beliefs that are widely held in the general *** are generally similar in these two forms of psychosis,with the exception that antidepressants are used more frequently in DD and,for acute treatment,effective antipsychotic doses are lower in DD than in *** is with the hope that the contrasts between these two conditions will aid in the provision of safe and effective treatment for both that this review has been conducted.

关键词： Non-affective psychosis Delusional disorder Schizophrenia Epidemiology Symptoms Treatment response

pOLARIZATION IN B DECAYS

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Chinese physics C 2016年第10期40卷 759-762页

作者： A. v. Gritsan Johns Hopkins University

We review the notation used in polarization measurements in particle production and decay, with a particular emphasis on the B decays and the Cp-violating observables in polarization measurements. We look at several examples of vector-vector and vector-tensor B meson decays, while more details about the theory and experimental results in B decays can be found in a separate mini-review [1] in this Review.

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