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Cellular & Molecular Immunology 2021年第10期18卷 2457-2459页

作者： gema Frühbeck victoria Catalán víctor valentí Rafael Moncada Javier gómez-Ambrosi Sara Becerril Camilo Silva Piero Portincasa Javier Escalada Amaia Rodríguez Metabolic Research Laboratory Clínica Universidad de NavarraPamplonaSpain CIBER Fisiopatología de la Obesidad y Nutrición(CIBEROBN) Instituto de Salud Carlos IIIMadridSpain Obesity and Adipobiology group Instituto de Investigación Sanitaria de Navarra(IdiSNA)PamplonaSpain Department of Endocrinology and Nutrition Clínica Universidad de NavarraPamplonaSpain Department of Surgery Clínica Universidad de NavarraPamplonaSpain Department of Anesthesia Clínica Universidad de NavarraPamplonaSpain Department of Biomedical Sciences and Human Oncology Clinica Medica“A.Murri”University of Bari Medical SchoolPoliclinico HospitalBariItaly.

A sedentary lifestyle and obesity are important risk factors for severe COvID-19 complications and death[1,2].Excessive adipose tissue(AT)might contribute to more extensive viral spread with increased shedding,immune activation,and cytokine amplification[3].Several factors secreted by contracting muscle,termed myokines,mediate the beneficial effects of exercise in a wide range of diseases,including obesity[4].Thus,we conducted a study to explore the potential role of myokines of the fibronectin type III domain-containing family,FNDC4 and FNDC5,in mechanisms underlying the increased susceptibility to COvID-19 complications in obesity.

关键词： FNDC5 obesity FND

A virtual model of the retina based on histological data as a tool for evaluation of the visual fields

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Annals of Eye Science 2017年第1期2卷 113-126页

作者： Francisco-Javier Carreras Ángel v.Delgado José.L.garcía-serrano Department of Surgery Medical School2Department of Applied PhysicsSchool of SciencesUniversity of GranadaGranadaSpain Hospital Clínico San Cecilio University of GranadaGranadaSpain School of Computer Science Department of Computer Science and Artificial IntelligenceUniversity of GranadaGranadaSpain

Background:To settle the fundamentals of a numerical procedure that relates retinal ganglion-cell density and threshold sensitivity in the visual *** sensitivity of a generated retina and visual pathways to virtual stimuli are simulated,and the conditions required to reproduce glaucoma-type defects both in the optic-nerve head(ONH)and visual fields are ***:A definition of selected structural elements of the optic pathways is a requisite to a translation of clinical knowledge to computer programs for visual field *** program is able to generate a database of normalized visual *** relationship between the number of extant receptive fields and threshold sensitivity is plotted for background sensitivity and corresponding automated perimetry.A solution in two planes to the 3D distribution of axons in the ONH is *** fields with induced damage in the optic disc are comparable in pattern and quantity to glaucomatous ***:The two-level simulation of the ONH facilitates the analysis of optic-cup/retinal *** can generate the virtual optic pathways tailored to the age and morphology of the patient’s eye,and it is possible to reproduce glaucomatous damage by“reverse engineering”*** virtual cortical model renders a quantitative relationship between visual defect and neural ***:A two-level computing of the retina/optic nerve facilitates the analysis of neuroretinal defects and can be incorporated to automatic perimeters to facilitate visual field analysis.

关键词： Computer modeling early optic pathways neuroretinal defects threshold sensitivity visual fields

Hepatobiliary manifestations in inflammatory bowel disease: The gut,the drugs and the liver

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World Journal of gastroenterology 2013年第42期19卷 7327-7340页

作者： María Rojas-Feria Manuel Castro Emilio Suárez Javier Ampuero Manuel Romero-gómez Unit for Medical and Surgical Management of Digestive Diseases and CIBERehd Valme University HospitalUniversity of SevilleE-41014 SevillaSpain

Abnormal liver biochemical tests are present in up to30%of patients with inflammatory bowel disease(IBD),and therefore become a diagnostic *** and biliary tract diseases are common extraintestinal manifestations for both Crohn’s disease and ulcerative colitis(UC),and typically do not correlate with intestinal *** sclerosing cholangitis(PSC)is the most common hepatobiliary manifestation of IBD,and is more prevalent in *** 5%of patients with UC develop PSC,with the prevalence reaching up to 90%.Cholangiocarcinoma and colon cancer risks are increased in these *** common disorders include autoimmune hepatitis/PSC overlap syndrome,Igg4-associated cholangiopathy,primary biliary cirrhosis,hepatic amyloidosis,granulomatous hepatitis,cholelithiasis,portal vein thrombosis,liver abscess,and non-alcoholic fatty liver *** B reactivation during immunosuppressive therapy is a major concern,with screening and vaccination being recommended in serologically negative cases for patients with *** prophylaxis with entecavir or tenofovir for 6to 12 mo after the end of immunosuppressive therapy is mandatory in patients showing as hepatitis B surface antigen(HBsAg)positive,independently from viral *** negative and anti-HBc positive patients,with or without anti-HBs,should be closely monitored,measuring alanine aminotransferase and hepatitis B virus DNA within 12 mo after the end of therapy,and should be treated if the viral load *** the other hand,immunosuppressive therapy does not seem to promote reactivation of hepatitis C,and hepatitis C antiviral treatment does not influence IBD natural history *** of the drugs used for IBD treatment may induce hepatotoxicity,although the incidence of serious adverse events is *** in liver biochemical tests associated with aminosalicylates are uncommon and are usually not clinically *** hepatotoxicity has been describ

关键词： Inflammatory bowel disease Hepatobiliary disorders Extraintestinal manifestations Primary sclerosing cholangitis Drug-induced liver injury Hepatotoxicity Hepatitis B Hepatitis C

Empirically supported psychological treatments:The challenges of comorbid psychiatric and behavioral disorders in people with intellectual disability

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World Journal of Psychiatry 2021年第11期11卷 1039-1052页

作者： Laura E gómez Patricia Navas MiguelÁngel verdugo Marc J Tassé Department of Psychology University of OviedoOviedo 33011AsturiasSpain Department of Personality Evaluation and Psychological TreatmentsInstitute on Community IntegrationUniversity of SalamancaSalamanca 37005SalamancaSpain Department of Psychology and Psychiatry The Ohio State University Nisonger Center-UCEDDColumbusOH 43210-1257United States

This paper reviews the current state of knowledge on psychological interventions with empirical evidence of efficacy in treating common psychiatric and behavioral disorders in people with intellectual disability(ID)at all stages of their *** begin with a brief presentation of what is meant by psychiatric and behavioral disorders in this population,along with an explanation of some of the factors that contribute to the increased psychosocial vulnerability of this group to present with these *** then conduct a review of empirically supported psychological therapies used to treat psychiatric and behavioral disorders in people with *** review is structured around the three generations of therapies:Applied behavior analysis(e.g.,positive behavior support),cognitive behavioral therapies(e.g.,mindfulness-based cognitive therapy),and contextual therapies(e.g.,dialectical behavior therapy).We conclude with some recommendations for professional practice in the fields of ID and psychiatry.

关键词： Behavior disorder Intellectual disability Psychiatry Applied behavior analysis Cognitive behavioral therapies Contextual therapies

Surface integrity of ball burnished bioresorbable magnesium alloy

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Advances in Manufacturing 2023年第2期11卷 342-362页

作者： g.v.Jagadeesh Srinivasu gangi Setti Department of Mechanical Engineering National Institute of Technology RaipurChhattisgarh492010India

Magnesium alloys are potential biodegradable and biocompatible implant materials because of their excellent biological properties. Recently, interest in these alloys as a promising alternative for temporary orthopedic implants has grown owing to their desirable biological, mechanical, and physical properties. However, the application of magnesium alloys is hindered by their rapid degradation and low corrosion resistance in physiological fluids, leading to the failure of implants. Thus, the current challenge is to enhance the corrosion resistance and control the degradation rate of magnesium under physiological conditions. The rapid degradation of magnesium alloys can be controlled by improving their surface integrity, such as surface roughness and microhardness. The present study aims to improve the surface integrity of the Mg Ze41A alloy by the ball burnishing technique. The surface roughness improved by 94.90% from 0.941 μm to 0.048 μm with a burnishing force of 50 N, burnishing speed of 1 300 r/min, burnishing feed of 130 mm/min, and three passes. Similarly, the microhardness improved by 50.62% from 75.2 Hv to 113.27 Hv with a burnishing force of 60 N, burnishing speed of 1 100 r/min, burnishing feed of 100 mm/min, and five passes. The variations in microhardness, which were observed up to 400 μm beneath the surface, exhibited a linear nature. These variations may be attributed to the movement of dislocations, formation of new dislocations, nanocrystal structures, metastable phases and subgrains, and lattice distortion or grain refinement. The surface features obtained from optical images demonstrated the fundamental mechanisms involved in the ball burnishing process. The concept of burnishing maps and zones will assist in the design of the ball burnishing parameters of a material with an equivalent yield strength of 140 MPa. The significant improvement in the surface integrity of the Mg Ze41A alloy by the ball burnishing technique is expected to improve its func

关键词： Magnesium alloy Bioresorbable Orthopedic implants Surface integrity Ball burnishing

Stability of Macroscopic Binary Systems

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Communications in Theoretical Physics 2019年第11期71卷 1335-1340页

作者： g.g.Adamian N.v.Antonenko H.Lenske v.v.Sargsyan Joint Institu te for Nuclear Research 141980 DubnaRussia Ins titut fur Theore tische Physik der Jus tus-Liebig—Uni versit Nt D-35392 GiessenGermany

The Darwin instability effect in the binary systems(di-planets, di-stars, and di-galaxies) is analyzed within the model based on the Regge-like laws. All possible binary stars are found satisfying the Darwin instability condition that requires to search for other mechanism triggering the merger of the contact binary objects. New analytical formulas are obtained for the orbital rotation period and the relative distance between components of the binary system. The decreasing and increasing periods as functions of mass asymmetry are related, respectively, with the non-overlapping and overlapping stage of the binary object evolution.

关键词： Regge laws binary stars and galaxies Darwin instability effect

Synthesis of Pharmaceutical Intermediates by Toluene Benzylation over Heteropoly Acids on Different Support

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Journal of Natural gas Chemistry 2007年第2期16卷 186-192页

作者： v. v. Bokade g. D. Yadav Catalysis Division National Chemical LaboratoryPune 411008India University Institute of Chemical TechnologyMumbai-19India University Institute of Chemical Technology Mumbai-19India

Selective formation of pharmaceutical intermediates like diphenylmethane, dimethyldiphenylmethane, benzyl toluene and benzoic acid by liquid phase, toluene benzylation with benzyl chloride as a benzylating agent, was systematically studied over plane clay （K-10, montmorillonite）, plane H-Beta, plane MFI structured titanosilicate （TS-1） and heteropoly acids [HPA, namely dodecatungstophosphoric acid [H3PO4.12WOa-xH2O] （TPA）, dodeca-molybdo phosphoric acid ammonium salt hydrate [H12Mo12N3040P＋aq] （DMAA）, sodium tungstate hydrated purified [Na12WO4.2H2O] （STH）] supported on clay, H-beta and TS-1. The 20%TPA/Clay, 30%TPA/H-Beta and 30%TPA/TS-1, were observed to be the best catalyst samples over plane clay, plane H-Beta and plane TS-1. The catalyst samples are compared with respect to benzyl chloride conversion and selectivities for diphenylmethane, dimethyl-diphenylmethane, benzyl toluene and benzoic acid. The reaction follows the pseudo-first order rate power law model. The apparent rate constants are calculated and compared with the reported ones.

关键词： toluene benzylation benzyl chloride heteropolyacid diphenylmethane dimethyl-diphenyl methane benzyl toluene benzoic acid

Coherent Bremsstrahlung at Beijing Electron-Positron Collider

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Chinese Physics Letters 1999年第8期16卷 557-559页

作者： DINg Yi-bing v.g.Serbo graduate School University of Science and Technology of China at BeijingChinese Academy of SciencesBeijing 1000393 Novosibirsk State University 630090 NovosibirskRussia Department of Physics University of MilanINFN20133 MilanItaly

The main characteristics of coherent bremsstrahlung (CBS) for the Beijing Electron-Positron Collider are calculated. At this collider dNγ~3 x 10^(8) dE_(γ)/E_(γ) photons of CBS will be emitted for a single collision of the beams in the energy range E_(γ)v. It seems that CBS can be a potential tool for optimizing collisions and measuring beam parameters. Indeed, the bunch length σz can be found from the CBS spectrum because critical energy Ec ∝ 1/σz;the horizontal transverse bunch size σx is related to dNγ∝1/σ^(2)_(x). In addition, CBS may be very useful for a fast control over an impact parameter R between the colliding bunch axes.

关键词： parameters. Electron coherent

On the possible ultrasonic inspection of micro-bubbles generated by the optical fiber tip

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Journal of Innovative Optical Health Sciences 2016年第5期9卷 22-29页

作者： v.v.Kazakov A.g.Sanin v.A.Kamensky Institute of Applied Physics of the Russian Academy of Sciences 46 Ul'yanov Street 603950Nizhny NovgorodRussia

We demonstrate the possibility of detection and monitoring of bubbles emerging near the tip of an optical fiber by means of ultrasonic *** excitation of bubbles at their resonant frequencies is performed using short ultrasonic pulses having a wide frequency range simulta-neously with their modulation by means of a long pulse of a monochromatic *** method allows detection of bubbles of various *** signal processing method,which allows increased bubble detection accuracy,is proposed for ressearch in envir onments of biological-like medium which show continuous variations in structure and properties when exposed to optical *** method has been demonstrated on model objects:in a liquid and in a biological tissue phantom using various methods of bubble generation(hydrolysis and optical enission).We studied bubble formation by the tip of a fiber of the surgical laser LSP-007/10 "IRE Polus"with a wavelength of 0.97μm coated with a highly absorbing graphite layer.

关键词： Bubble generation ultrasonic inspection of bubbles subharmonic ultrasound modulation laser surgery.

Insulin resistance and hepatitis C

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World Journal of gastroenterology 2006年第44期12卷 7075-7080页

作者： Manuel Romero-gómez Unit for the Clinical Management of Digestive Diseases. Hospital Universitario de valme. Ctra de Cádiz s/n 41014 Sevilla Spain

Insulin resistance is the major feature of the metabolic syndrome and depends on insulin secretion and insulin sensitivity. In chronic hepatitis C, insulin resistance and type 2 diabetes mellitus are more often seen than in healthy controls or chronic hepatitis B patients. Hepatitis C virus （HCv） infection promotes insulin resistance, mainly by increased TNF production together with enhancement of suppressor of cytokine （SOC-3）; both events block PI3K and Akt phosphorylation. Two types of insulin resistance could be found in chronic hepatitis C patients＇. ＂viral＂ and ＂metabolic＂ insulin resistance. Insulin resistance in chronic hepatitis C is relevant because it promotes steatosis and fibrosis. The mechanisms by which insulin resistance promotes fibrosis progression include：（1） steatosis, （2） hyperleptinemia, （3） increased TNF production, （4） impaired expression of PPARy receptors. Lastly, insulin resistance has been found as a common denominator in patients difficult-to-treat like cirrhotics, overweight, HIv coinfected and Afro-American. Insulin resistance together with fibrosis and genotype has been found to be independently associated with impaired response rate to peginterferon plus ribavirin. Indeed, in genotype 1, the sustained response rate was twice （60%） in patients with HOMA ≤ 2 than patients with HOMA 〉 2. In experiments carried out on Huh-7 cells transfected by full length HCvRNA, interferon alpha blocks HCv replication. However, when insulin （at doses of 128 μU/mL, similar that seen in the hyperinsulinemic state） was added to interferon, the ability to block HCv replication disappeared, and the PKR synthesis was abolished. In summary, hepatitis C promotes insulin resistance and insulin resistance induces interferon resistance, steatosis and fibrosis progression.

关键词： Diabetes mellitus Homeostasis model of assessment Fibrosis Steatosis Sustained response Peginterferon Ribavirin