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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-núñez María Fernanda González Ana María Avalos Lisette Leyton cellular communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced center for chronic Diseases(AccDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(cD90)

Three-dimensional mixed convection stagnation-point fow past a vertical surface with second-order slip velocity

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Applied Mathematics and Mechanics(English Edition) 2023年第4期44卷 641-652页

作者： A.v.ROScA n.c.ROScA I.POP Department of Statistics-Forecasts-Mathematics Faculty of Economics and Business AdministrationBabes-Bolyai UniversityCluj-Napoca 400084Romania Department of Mathematics Faculty of Mathematics and Computer ScienceBabes-Bolyai UniversityCluj-Napoca 400084Romania Academy of Romanian Scientists 3 Ilfov StreetBucharest 050044Romania

This study is concerned with the three-dimensional(3D)stagnation-point for the mixed convection flow past a vertical surface considering the first-order and secondorder velocity *** the authors’knowledge,this is the first study presenting this very interesting *** partial differential equations for the flow problem are transformed into nonlinear ordinary differential equations(ODEs)by using appropriate similarity *** ODEs with the corresponding boundary conditions are numerically solved by utilizing the bvp4c solver in MATLAB programming *** effects of the governing parameters on the non-dimensional velocity profiles,temperature profiles,skin friction coefficients,and the local nusselt number are presented in detail through a series of graphs and ***,it is reported that the reduced skin friction coefficient decreases for the assisting flow situation and increases for the opposing flow *** numerical computations of the present work are compared with those from other research available in specific situations,and an excellent consensus is *** exciting feature for this work is the existence of dual *** important remark is that the dual solutions exist for both assisting and opposing flows.A linear stability analysis is performed showing that one solution is stable and the other solution is not *** notice that the mixed convection and velocity slip parameters have strong effects on the flow *** effects are depicted in graphs and discussed in this *** obtained results show that the first-order and second-order slip parameters have a considerable effect on the flow,as well as on the heat transfer characteristics.

关键词： three-dimensional(3D)mixed convection flow stagnation point flow first-order slip velocity second-order slip velocity numerical solution stability analysis

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs víctor cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk Laura nadal Marta Tomàs carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza Unitat d’Histologia i neurobiologia(UHneurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and c(PKA and PKc)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75nTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKc activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the n-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

The role of deformations and orientations in an alpha ternary fission of Thorium

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nuclear Science and Techniques 2022年第6期33卷 1-8页

作者： A.v.Mahesh Babu n.Sowmya H.c.Manjunatha n.Dhananjaya Department of Physics BMSIT&MAffiliated to VTUBangaloreKarnataka 560064India Department of Physics Government College for WomenKolarKarnataka 563101India

The alpha ternary fission half-lives of thorium isotopes have been studied using the coulomb and proximity potential *** role of the deformation effects and the angle of orientation were included during the evaluation of the total *** combinations were identified using cold valley plots of the driving *** half-lives and yields were evaluated using the penetration *** dependence of the logarithmic half-lives on different angles of orientation was *** evaluated alpha ternary fission yield was compared with that of the available experiments with and without *** half-lives obtained in the present work were compared with those of the available *** alpha ternary fission fragments were identified in the isotopes of *** alpha ternary fission half-lives were compared to the binary fission *** binary fission half-lives are dominant in the ^(209-225)Th nuclei,and the ternary fission half-lives are dominant in the isotopes of the ^(226-238)Th nuclei.

关键词： Alpha ternary fission Yield Half-lives Driving potential

control strategy for seamless transition from islanded to interconnected operation mode of microgrids

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Journal of Modern Power Systems and clean Energy 2017年第2期5卷 169-176页

作者： c.n.PAPADIMITRIOU v.A.KLEFTAKIS n.D.HATZIARGYRIOU Department of Electrical and computer Engineering National Technical University of Athens(NTUA)AthensGreece

Microgrids can operate either interconnected to the utility grid or disconnected forming an island. The transition between these modes can cause transient overcurrents or power oscillations jeopardizing the equipment safety or the system stability. This paper proposes a local multi agent control method for a seamless transfer between the islanded and interconnected modes of operation with agents implemented into the microgrid central switch(McS) and into the microsources inverters. The McS agent supervises the grid status and controls the switch for the transition of the microgrid through the different operation modes, while it communicates locally with the inverter agents of the microsources. The inverter agents undertake the synchronization process in case of reconnecting and change the inverter control mode depending on the grid status. Simulation and experimental results are presented to show the performance and feasibility of the proposed strategy.

关键词： Microgrid Islanding Reconnection Agents Synchronization control hardware-in-the-loop(cHIL)

Biomass Industrial Effluent Effect on carbohydrates,Aminoacids,nitrite and nitrite Enzyme Activities of Arachis hypogaea L.

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Agricultural Sciences in china 2009年第2期8卷 203-215页

作者： P c nagajyoti n Dinakar S Suresh Y Udaykiran c Suresh T n v K v Prasad T Damodharam Department of Environmental Sciences Sri Venkateswara University national Institute of nutrition Hyderabad Regional Agricultural Research Station N.G. Ranga Agriculture University

The objectives of the present investigations are to see the effects of biomass power plant effluent on the carbohydrates, aminoacids, nitrite and nitrite enzyme activitiesand proline of Arachis hypogaea L. var TcGS 320 under controlled pot culture methods. Plants were cultivated with 25, 50, 75 and 100% of the effluent and a control without the effluent. The treatment of the crop with 25% of the effluent has shown stimulatory effect on all the biochemical parameters studied. carbohydrates, starch, aminoacids, protein, nitrate and nitrite reductase enzymatic activities have increased in 10, 15, 20 DAS （days after sowing）. In 25 and 30 DAS all biochemical parameters have decreased, due to environmental factors （rainfall, temperature, humidity, etc.）. The present investigation clearly indicated that the biomass power plant effluent has stimulatory effect on all the biochemical contents at lower concentration, and at higher concentration they have deleterious effects.

关键词： biomass power plant effluent biochemical parameters Arachis hypogaea stimulatory effect

A new Method of Synthesis of Azo Schiff Base Ligands with Azo and Azomethine Donors： Synthesis of n-4-Methoxybenzylidene-2-（3-hydroxyphenylazo）-5-hydroxyaniline and Its nickel（Ⅱ） complex

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chinese Journal of chemistry 2007年第6期25卷 869-871页

作者： OFORKA, n. c. MKPEnIE, v. n. Department of Pure and Industrial chemistry University of Port Harcourt P. M. B. 5323 Port Harcourt Nigeria

A new method for the synthesis of azo Schiff an base ligand in which the azo and azomethine groups are coordination sites was developed through a Schiff base precursor. The precursor, n-4-methoxybenzylidene-3-hydroxyphenylamine （SB） derived from 3-aminophenol was regioselectively coupled with a diazonium ion para to the hydroxyl group of the amine component of the Schiff base. The para selectivity was controlled by the directing effect of the hydroxyl group. The ligand and its nickel（Ⅱ） complex were characterized by elemental analyses, IR and Uv-vis spectroscopy. The analytical and spectral data supported the mononuclear formulation of the complex with metal to ligand ratio （M ： L = 1 ： 2） and suggested a square planar geometry for the complex.

关键词： synthesis azo compound Schiff base ligand azo and azomethine donor

Protozoan colonization on artificial substrates in relation to water quality in a tropical Indian harbour

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Journal of Environmental Sciences 2001年第2期13卷 143-147页

作者： v.R.Bharati R.n.Khan c.Kalavati A.v.Raman Department of Zoology Andhra UniversityVisakhapatnam 530003India.

A field study was conducted to evaluate the protozoan colonization patterns on artificial substrates in relation to organic pollution within a tropical harbour. The composition of protozoans and their succession rates on artificial substrates(polyurethane foam units) were compared between two field stations(A and B), and their presence were considered with regards to the prevailing water quality conditions at the study sites. Altogether 44 genera of flagellates and ciliates were documented. The common genera of flagellates encountered included Monas, Polytoma, and chromalina. Among the ciliates, the predominant genera were Tetrahymena, vorticella, Lagynophyra, and Heloiphyra. These groups exhibited characteristic successional patterns in relation to ambient water quality. At Station A, located close to the sewage outfall, the water quality parameters included poor Secchi disc transparency(0.48m), dissolved oxygen of 1.93 mg/ml, salinity of 18 psu, and temperature 31.3 ℃. Here, the nanoflagellates( spumella ) colonized first, followed by microcilliate( Tetrahymena ) and sessile form( vorticella ). Station B, located on the seaward side, was characterized by relatively less stressed environmental conditions with transparency 1.85m and dissolved oxygen value of 6 04 mg/ml. Salinity of 27.27 psu, and mean temperature of 30 ℃ were recorded at “B'. At this station, the nanoflagellate Polytoma was first documented to colonize on the substrates, followed by microcilliate( Lagynophrya ) and suctorid( Heliophyra ). These findings support the use of protozoans as indicator species for evaluating the hazards posed by organic pollution to natural estuarine communities.

关键词： Protozoan colonization on artificial substrates in relation to water quality in a tropical Indian harbour

Ordered exponential and its features in Yang-Mills effective action

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communications in Theoretical Physics 2023年第8期75卷 119-127页

作者： A v Ivanov n v Kharuk St.Petersburg Department of Steklov Mathematical Institute of Russian Academy of Sciences 27 FontankaSt.Petersburg 191023Russia Leonhard Euler International Mathematical Institute 10 Pesochnaya nab.St.Petersburg 197022Russia

In this paper,we discuss some non-trivial relations for ordered exponentials on smooth Riemannian *** an example of application,we study the dependence of the four-dimensional quantum Yang–Mills effective action on the special gauge transformation with respect to the background ***,we formulate some open questions about a structure of divergences for a special type of regularization in the presence of the background field formalism.

关键词： Yang-Mills effective action ordered exponential heat kernel Green's function short-distance asymptotics cutoff regularization Synge's world function