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作者： v.arakelian M.R. Smith Departement GMA INSA de Rennes 20 Avenue des Buttes de Co(e|¨)smes CS 14315 35043 Rennes Cedex France Department of Mechanical Materials and Manufacturing Engineering (retired) University of Newcastle Newcastle upon Tyne NE1 7RU UK

This paper deals with a solution of the problem of shaking moment minimization of fully force-balanced linkages. The conditions for reduction of shaking moment are formulated by the minimization of the root mean square (r.m.s.) value of the shaking moment. The method is realized by displacements of the axes of rotation of the counterweights mounted on the frame. The efficiency of the suggested solution is illustrated by a numerical example in which an 80% reduction in the shaking moment of fully force-balanced six-bar linkage is achieved.

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An enhanced chemopreventive effect of methyl donor S-adenosylmethionine in combination with 25-hydroxyvitamin D in blocking mammary tumor growth and metastasis

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Bone Research 2020年第3期8卷 300-311页

作者： Niaz Mahmood Ani arakelian William J.Muller Moshe Szyf Shafaat A.Rabbani Department of Medicine McGill University Health CentreMontrealQC H4A3J1Canada Department of Biochemistry McGill UniversityMontrealQC H3A 1A3Canada Department of Pharmacology and Therapeutics McGill UniversityMontrealQC H3G 1V6Canada

Therapeutic targeting of metastatic breast cancer still remains a challenge as the tumor cells are highly heterogenous and exploit multiple pathways for their growth and metastatic spread that cannot always be targeted by a single-agent monotherapy ***,a rational approach through simultaneous targeting of several pathways may provide a better anti-cancer therapeutic effect We tested this hypothesis using a combination of two nutraceutical agents S-adenosylmethionine(SAM)and vitamin D(vit.D)prohormone[25-hydroxyvitamin D;/25(OH)D,]that are individually known to exert distinct changes in the expression of genes involved in tumor growth and *** results show that both SAM and 25(OH)D monotherapy significantly reduced proliferation and clonogenic survival of a panel of breast cancer cell lines in vitro and inhibited tumor growth,lung metastasis,and breast tumor cell colonization to the skeleton in ***,these effects were significantly more pronounced in the combination ***-Sequencing revealed that the transcriptomic footprint on key cancer-related signaling pathways is broader in the combination setting than any of the ***,comparison of the differentially expressed genes from our transcriptome analyses with publicly available cancer-related dataset demonstrated that the combination treatment upregulates genes from immune-related pathways that are otherwise downregulated in bone metastasis in *** SAM and vit.D are both approved nutraceuticals with known safety profiles,this combination treatment may serve as a novel strategy to reduce breast cancer-associated morbidity and mortality。

关键词： metastasis vitamin inhibited

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Laser Synthesis of Metal Oxide Crystals with the Use of Carbon Nanotubes

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Open Journal of Composite Materials 2013年第2期3卷 16-20页

作者： Dmitrii v. Abramov Sergei M. arakelian Dmitrii A. Kochuyev Stepan A. Makov valerii G. Prokoshev Kirill S. Khorkov Department of Physics and Applied Mathematics Vladimir State University Vladimir Russia.

The results of experimental studies in the direction of the laser forming of nanostructured arrays of metal oxide crystals are presented in this paper. Laser synthesis of crystals of titanium oxide and aluminum oxide was investigated. Carbon nanotubes have been used to control the process of crystal growth. Formation of structures was carried out under the action of CW ytterbium fiber laser with intensity on the order 105 W/cm2. Laser irradiation of the initial target occurred with applying an external accelerating electric field. various forms of metal oxide crystals were obtained. Whiskers with cross dimensions on the order of 100 nm have been found among the formed structures.

关键词： Laser Synthesis Titanium Oxide Aluminum Oxide Carbon Nanotubes Whiskers

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