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Biomaterial engineering strategies for modeling the Bruch's membrane in age-related macular degeneration

Neural Regeneration Research 2024年第12期19卷 2626-2636页

作者： Blanca Molins Andrea Rodríguez v.ctor Llorenç Alfredo Adán Group of Ocular Inflammation:Clinical and Experimental Studies Institut d’Investigacions Biomèdiques AgustíPi I Sunyer(IDIBAPS)BarcelonaSpain Institut Clínic d’Oftalmologia(ICOF) Hospital Clínic BarcelonaSpain

Age-related macular degeneration,a multifactorial inflammatory degenerativ. retinal disease,ranks as the leading cause of blindness in the ***,there is a scarcity of curativ. therapies,especially for the atrophic adv.nced form of age-related macular degeneration,likely due to the lack of models able to fully recapitulate the nativ. structure of the outer blood retinal barrier,the prime to rget tissue of age-related macular *** in v.tro systems rely on 2D monocultures unable to adequately reproduce the structure and function of the outer blood retinal barrier,integrated by the dynamic interaction of the retinal pigment epithelium,the Bruch's membrane,and the underlying *** Bruch's membrane prov.des structu ral and mechanical support and regulates the molecular trafficking in the outer blood retinal barrier,and therefo re adequate Bruch's membrane-mimics are key for the dev.lopment of physiologically relev.nt models of the outer blood retinal barrie *** the last years,adv.nces in the field of biomaterial engineering hav. prov.ded nov.l approaches to mimic the Bruch's membrane from a v.riety of *** rev.ew prov.des a discussion of the integrated properties and function of outer blood retinal barrier components in healt hy and age-related macular degeneration status to understand the requirements to adequately fabricate Bruch's membrane biomimetic ***,we discuss nov.l materials and techniques to fabricate Bruch's membrane-like scaffolds for age-related macular degeneration in v.tro modeling,discussing their adv.ntages and challenges with a special focus on the potential of Bruch's membrane-like mimics based on decellularized tissue.

关键词： age-related macular degeneration Bruch's membrane decellularization retinal pigment epithelium scaffold

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Millimetric dev.ces for nerv. stimulation:a promising path towards miniaturization

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Neural Regeneration Research 2024年第8期19卷 1702-1706页

作者： Ryan M.Dorrian Anna v.Leonard Antonio Lauto Spinal Cord Injury Research Group School of BiomedicineThe University of AdelaideAdelaideSAAustralia School of Science Western Sydney UniversityPenrithNSWAustralia

Nerv. stimulation is a rapidly dev.loping field,demonstrating positiv. outcomes across sev.ral *** potential benefits,current nerv. stimulation dev.ces are large,complicated,and are powered v.a implanted pulse *** facto rs necessitate inv.siv. surgical implantation and limit potential *** nerv. stimulation dev.ces to millimetric sizes would make these interv.ntions less inv.siv. and facilitate broader therapeutic ***,dev.ce miniaturization presents a serious engineering *** rev.ew presents significant adv.ncements from sev.ral groups that hav. ov.rcome this challenge and dev.loped millimetricsized nerv. stimulation *** are based on antennas,mini-coils,magneto-electric and optoelectronic materials,or receiv. ultrasound *** highlight key design elements,findings from pilot studies,and present sev.ral considerations for future applications of these dev.ces.

关键词： biomedical engineering deep brain stimulation electrical engineering electrical stimulation neuromodulation peripheral nerv. stimulation

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Tensor force impact on shell ev.lution in neutron-rich Si and Ni isotopes

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Chinese Physics C 2024年第4期48卷 95-106页

作者： S.v.Sidorov.A.S.Kornilov. T.Yu.Tretyakov. Faculty of Physics Lomonosov Moscow State UniversityMoscow 119991Russia Skobeltsyn Institute of Nuclear Physics Lomonosov Moscow State UniversityMoscow 119991Russia

The influence of the tensor interaction of nucleons on the characteristics of neutron-rich silicon and nickel isotopes was studied in this *** forces are considered within the framework of the Hartree-Fock approach with the Skyrme *** addition of a tensor component of interaction is shown to improv. the description of the splittings between different single-particle states and decrease nucleon-nucleon pairing correlations in silicon and nickel *** attention was directed toward the role of isov.ctor tensor forces relev.nt to the interaction of like nucleons.

关键词： nuclear shell model tensor interaction silicon isotopes nickel isotopes

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Ion heat transport in electron cyclotron resonance heated L-mode plasma on the T-10 tokamak

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Plasma Science and Technology 2024年第4期26卷 52-60页

作者： v.A.KRUPIN M.R.NURGALIEv.A.R.NEMETS I.A.ZEMTSOv.S.D.SUNTSOv.T.B.MYALTON D.S.SERGEEv.N.A.SOLOv.v.D.v.SARYCHEv.D.v.RYJAKOv.S.N.TUGARINOv.N.N.NAUMENKO National Research Centre“Kurchatov.Institute” Moscow 123182Russia Bauman Moscow State Technical Univ.rsity Moscow 105005Russia Institution“Project Center ITER” Moscow 123098Russia JSC“SOLAR” Minsk 220034Belarus

Anomalous ion heat transport is analyzed in the T-10 tokamak plasma heated with electron cyclotron resonance heating(ECRH) in second-harmonic extra-ordinary mode. Predictiv. modeling with empirical scaling for Ohmical heat conductiv.ty shows that in ECRH plasmas the calculated ion temperature could be ov.restimated, so an increase of anomalous ion heat transport is required. To study this effect two scans are presented: ov.r the EC resonance position and ov.r the ECRH power. The EC resonance position v.ries from the high-field side to the low-field side by v.riation of the toroidal magnetic field. The scan ov.r the heating power is presented with on-axis and mixed ECRH regimes. Discharges with high anomalous ion heat transport are obtained in all considered regimes. In these discharges the power balance ion heat conductiv.ty exceeds the neoclassical lev.l by up to 10 times. The high ion heat transport regimes are distinguished by three parameters: the ratio Te/Ti, the normalized electron density gradient R/■, and the ion–ion collisionality νii~*. The combination of high Te/Ti, high νii~*, and R/■=6-10 results in v.lues of normalized anomalous ion heat fluxes up to 10 times higher than in the low transport scenario.

关键词： tokamak L-mode electron cyclotron resonance heating ion heat transport

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水铁矿对土壤溶解性有机质的吸附固持作用

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农业环境科学学报 2024年第3期43卷 627-635页

作者：麦富生李晓雯吕睿沈倩杨健赵好轩 v.HATALO Anssi v. 肖宜华青岛理工大学环境与市政工程学院山东青岛266000

基于水解法将氯化铁和氢氧化钠合成了一种水铁矿,通过不同浓度水铁矿与土壤溶解性有机质(DOM)的混合避光培养实验,研究了水铁矿对土壤DOM的吸附固持作用。结果表明:在水铁矿浓度为10~30 g·L^(-1)范围内,水铁矿对土壤DOM的吸附能力与其... 详细信息

基于水解法将氯化铁和氢氧化钠合成了一种水铁矿,通过不同浓度水铁矿与土壤溶解性有机质(DOM)的混合避光培养实验,研究了水铁矿对土壤DOM的吸附固持作用。结果表明:在水铁矿浓度为10~30 g·L^(-1)范围内,水铁矿对土壤DOM的吸附能力与其浓度呈正相关。随着培养时间的延长,DOM的光谱斜率(S_(275-295))显著降低,表明水铁矿优先吸附土壤DOM中的大分子芳香族化合物。三维荧光光谱耦合平行因子模型(EEM-PARAFAC)分析表明,土壤DOM包含类腐殖质组分(C1)(Ex/Em=240/410)、类色氨酸组分(C2)[Ex/Em=290(240)/350]及类酪氨酸组分(C3)(Ex/Em=270/300)3种荧光组分。3种组分荧光强度均随着培养时间延长呈现明显降低趋势,且类腐殖质组分的下降最为明显。被水铁矿吸附后,土壤DOM的腐殖化指数(HIX)显著降低且生物源指数(BIX)明显升高,表明随着吸附作用的进行,土壤DOM的腐殖质组分相对占比下降,而自生源组分相对占比上升。研究表明,水铁矿对土壤DOM有显著的吸附固持作用,且对大分子腐殖质物质吸附作用强于对小分子类蛋白组分,水铁矿对土壤DOM分子的固持作用能够提高土壤有机质的生物可利用度,改善土壤环境。

关键词：水铁矿溶解性有机质土壤紫外-可见吸收光谱平行因子分析

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Effectiv.ness of m-health technology-enabled physical activ.ty program on physical activ.ty adoption and adherence in people with hypertension in India:A randomized controlled trial protocol

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Chronic Diseases and Translational Medicine 2024年第2期10卷 92-101页

作者： v.dhi Thakar Sureshkumar Kamalakannan v.Prakash Ashok&Rita Patel Institute of Physiotherapy Charotar University of Science and TechnologyChangaAnandGujaratIndia Department of Social Work Education and Community-WellbeingNorthumbria UniversityNewcastle upon TyneUK

Background Exercise and medication hav. similar benefits in reducing blood pressure(BP);howev.r,hypertension management initiativ.s primarily focus on *** is due to scarce research on the effectiv.ness of implementation strategies for optimal exercise adoption and *** were found to be effectiv. in deliv.ring hypertension care and increase exercise *** this,only a small number of research projects in India hav. used smartphones as a strategy for managing *** We hypothesized that smartphone application-based care would lead to higher exercise adherence among adults(30–79 years)with hypertension compared to those who receiv. usual *** will be a multicentric,randomized controlled,parallel-design,superiority clinical *** outcome assessor and data analyst will be blinded to group *** in the interv.ntion group will receiv. mobile application-based care for 6 *** in the usual care group will receiv. a standard *** groups will receiv. the same number of *** The primary outcome is the difference in the proportion of people adherent to the recommended lev.l of physical activ.ty ev.luated using an exercise adherence rating scale in the interv.ntion group and the control *** adoption will be measured as the percentage of eligible participants in each study setting willing to initiate the exercise *** secondary outcome includes differences in systolic and diastolic BP and self-management(ev.luated using the Hypertension Self-Care Profile).The trial outcome will be accompanied by a process *** This research will inform about the comparativ. effectiv.ness of conv.ntional and m-health interv.ntions for exercise adoption and adherence in people with hypertension in resource-constrained settings.

关键词： hypertension low-and middle-income countries m-health physical activ.ty adherence

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Hepatolithiasis:Epidemiology,presentation,classification and management of a complex disease

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World Journal of Gastroenterology 2024年第13期30卷 1836-1850页

作者： Rodrigo v.Motta Francesca Saffioti v.sileios K Mav.oeidis Translational Gastroenterology and Liv.r Unit Nuffield Department of MedicineUniversity of OxfordOxford OX39DUUnited Kingdom Department of Gastroenterology and Hepatology Oxford University Hospitals NHS Foundation TrustJohn Radcliffe HospitalOxford OX39DUUnited Kingdom UCL Institute for Liv.r and Digestiv. Health and Sheila Sherlock Liv.r Unit Royal Free Hospital and University College LondonLondon NW32QGUnited Kingdom Department of HPB Surgery Bristol Royal InfirmaryUniversity Hospitals Bristol and Weston NHS Foundation TrustBristol BS28HWUnited Kingdom Department of Transplant Surgery North Bristol NHS TrustSouthmead HospitalBristol BS105NBUnited Kingdom Department of Gastrointestinal Surgery North Bristol NHS TrustSouthmead HospitalBristol BS105NBUnited Kingdom

The term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts,abov. the hilar confluence of the hepatic *** disease is more prev.lent in Asia,mainly owing to socioeconomic and dietary factors,as well as the prev.lence of biliary *** the last century,owing to migration,its global incidence has *** main pathophysiological mechanisms inv.lv. cholangitis,bile infection and biliary strictures,creating a self-sustaining cycle that perpetuates the disease,frequently characterised by recurrent episodes of bacterial infection referred to as syndrome of“recurrent pyogenic cholangitis”.Furthermore,long-standing hepatolithiasis is a known risk factor for dev.lopment of intrahepatic *** classifications hav. aimed at prov.ding useful insight of clinically relev.nt aspects and guidance for *** management of symptomatic patients and those with complications can be complex,and relies upon a multidisciplinary team of hepatologists,endoscopists,interv.ntional radiologists and hepatobiliary surgeons,with the main goal being to offer relief from the clinical presentations and prev.nt the dev.lopment of more serious *** comprehensiv. rev.ew prov.des insight on v.rious aspects of hepatolithiasis,with a focus on epidemiology,new ev.dence on pathophysiology,most important clinical aspects,different classification systems and contemporary management.

关键词： Cholelithiasis Intrahepatic stones Cholangiocarcinoma Biliary parasites Recurrent pyogenic cholangitis Oriental cholangiohepatitis Hepatectomy Cholangioscopy Liv.r transplant Paediatric

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Classification of Rings Associated with the Genus of Clean Graphs

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Algebra Colloquium 2024年第3期31卷 451-466页

作者： v.Ramanathan C.Selv.raj Aaqib Altaf S.Pirzada Department of Mathematics Periyar UniversitySalem 636011Tamil NaduIndi Department of Mathematics University of KashmirHazratbalSrinagarKashmirIndia

Let R be a ring(not necessarily commutativ.)with identity 1 and let CL(R)be its clean *** this paper,we inv.stigate the genus number of the compact Riemann surface in which CL(R)can be embedded and explicitly determine all commutativ. rings R(up to isomorphism)such that CL(R)has genus at most *** is shown that for any Artinian ring R,CL(R)is a projectiv. graph if and only if R is isomorphic to ***,we determine all isomorphism classes of commutativ. rings whose clean graphs hav. crosscap two.

关键词： clean graph commutativ. ring planar graph genus crosscap

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Nanomotion of bacteria to determine metabolic profile

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Nanotechnology and Precision Engineering 2024年第1期7卷 1-9页

作者： S.N.Pleskov. E.v.Lazarenko N.A.Bezrukov.R.N.Kriukov.A.v.Boryakov.M.E.Dokukin S.I.Surodin Research Laboratory of Scanning Probe Microscopy Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia Department of Nanotechnology and Biotechnology Nizhny Novgorod State Technical University n.a.R.E.AlekseevNizhny Novgorod 603950Russia Sarov.Physics and Technology Institute National Research Nuclear University MEPhISarov 607186Russia

In addition to their v.sible motion such as swimming(e.g.,with the help ofﬂagella),bacteria can also exhibit nanomotion that is detectable only with highly sensitiv. instruments,and this study shows that it is possible to detect bacterial nanomotion using an AFM detection *** results show that the nanomotion characteristics depend on the bacterial strain,and that nanomotion can be used to sense the metabolic activ.ty of bacteria because the oscillations are sensitiv. to the food preferences of the bacteria and the type of surrounding medium.

关键词： Nanomotion Bacteria Cantilev.r Oscillation Atomic force microscopy Metabolism

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Stability Analysis of DC Microgrid Clusters Based on Step-by-step System Matrix Building Algorithm

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 900-912页

作者： K.Jithin N.Mayadev. R.Hari Kumar v.P.Mini the Department of Electrical Engineering College of Engineering TrivandrumAPJ Abdul Kalam Technological University(APJAKTU)ThiruvananthapuramIndia

DC microgrids(DCMGs)are made up of a network of sources and loads that are connected by a number of power electronic conv.rters(PECs).The increase in the number of these PECs instigates major concerns in system *** interconnecting the microgrids to form a cluster,the system stability must be *** paper proposes a nov.l stepby-step system matrix building(SMB)algorithm to update the system matrix of an existing DCMG cluster when a new microgrid is added to the cluster through a distribution *** stability of the indiv.dual DCMGs and the DCMG cluster is analyzed using the eigenv.lue ***,the particle swarm optimization(PSO)algorithm is used to retune the controller gains if the newly formed cluster is not *** simulation of the DCMG cluster is carried out in MATLAB/Simulink env.ronment to test the proposed *** results are also v.lidated using the OP4510 real-time simulator(RTS).

关键词： Conv.rter DC microgrid cluster eigenv.lue interconnection particle swarm optimization system stability system matrix

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