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v.lidity and Reliability o. To.al Lympho.yte Co.nt as Alternativ. Bio.arker fo. CD4 Co.nt in the Management o. HIv.Po.itiv. Patients o. HAART in o.o.bo. Nigeria

引用

Wo.ld Jo.rnal o. AIDS 2015年第4期5卷 313-321页

作者： B. E. Egbewale o. A. o.edeji v. o. mabayoje M. A. Muhibi C. A. Akinleye A. A. Adejimi Department o. Co.munity Medicine College of Health Sciences Osogbo Ladoke Akintola University of Technology Ogbomoso Nigeria Department o. Paediatrics College of Health Sciences Osogbo Ladoke Akintola University of Technology Ogbomoso Nigeria Department o. Haemato.o.y and Blo.d Transfusio. College of Health Sciences Osogbo Ladoke Akintola University of Technology Ogbomoso Nigeria Department o. Haemato.o.y and Blo.d Transfusio. LAUTECH Teaching Hospital Osogbo Ladoke Akintola University of Technology Ogbomoso Nigeria Department o. Co.munity Medicine LAUTECH Teaching Hospital Osogbo Osun State Nigeria

Intro.uctio.: To.determine the po.sibility o. utilizing to.al lympho.yte co.nts (TLC) instead o. CD4 co.nts in the initiatio. and management o. patients with HIv.o. highly activ. antiretro.0}ral therapy (HAART). The co.mencement o. HAART CD4 lympho.ytes has been emplo.ed in the management HIv. Ho.ev.r it has been fo.nd that determinatio. o. CD4 co.nts is expensiv. and so.ewhat labo.io.s to.perfo.m in already o.0}rburdened healthcare systems especially in the dev.lo.ing co.ntries. Metho.o.o.y: Fiv. hundred and three (503) co.senting patients already o. HAART (co.menced at CD4 co.nt o.attended o.r HIv.clinic between February 2014 and February 2015 were enro.led into.the study. The patients had already been diagno.ed as HIv.po.itiv.. Kappa statistic was co.puted as a measure o. reliability o. TLC. v.rio.s cut-o.f marks fo. TLC in respect o. the CD4 co.nts were determined in additio. to.the co.putatio. o. bo.h sensitiv.ty and specificity. Receiv.r o.erating curv.s (Ro.), sho.ing area under the curv. indicating agreement in classificatio., were plo.ted. Results: Majo.ity o. patients were female (73.8%). Mo.t o. the patients were in the age range o. 25 - 34 years (37.2%). Males were fo.nd to.be significantly o.der than females (P v.r o.erating curv.s (Ro.) rev.aled that 4 o.t o. 10 patients wo.ld be missed using to.al lympho.yte co.nt (TLC) as the indicato. fo. co.mencement o. HAART. A lo. co.relatio. co.fficient and Kappa statistic r = 0.18, and K = 0.20 respectiv.ly, were o.serv.d between TLCs and CD4 co.nts. Co.clusio.: To.al lympho.yte co.nt is no. a suitable alternativ. to.CD4 co.nts in the management o. HIv.AIDS.

关键词： HIv CD4 TLC HAART

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