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Ranking env.ronment.l and edaphic at.ribut.s driv.ng soil microbial communit. st.uct.re and act.v.t. wit. special at.ent.on t. spat.al and t.mporal scales

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mLife 2024年第1期3卷 21-41页

作者： v.dakat.u v.S.R.Gupt. James M.t.edje CSIRO Agricult.re&Food UrrbraeSouth AustraliaAustralia Cent.e for Microbial Ecology Michigan State UniversityEast LansingMichiganUSA

t.e incredibly complex soil microbial communit.es at.small scales make t.eir analysis and ident.ficat.on of reasons for t.e observ.d st.uct.res *** communit. st.uct.re is mainly a result.of t.e inoculum(dispersal),t.e select.v. adv.nt.ges of t.ose organisms under t.e habit.t.based env.ronment.l at.ribut.s,and t.e abilit. of t.ose colonizers t. sust.in t.emselv.s ov.r *** soil is prot.ct.v.,and it. microbial inhabit.nt. hav. long adapt.d t. v.ried soil condit.ons,significant.port.ons of t.e soil microbial communit. st.uct.re are likely ***,a subst.nt.al port.on of t.e communit. will not.correlat. t. oft.n measured soil *** suggest.t.at.t.e driv.rs be ranked on t.e basis of t.eir import.nce t. t.e fundament.l needs of t.e microbes:(i)t.ose t.at.supply energy,i.e.,organic carbon and elect.on accept.rs;(i)env.ronment.l effect.rs or st.essors,i.e.,pH,salt.drought.and t.xic chemicals;(ii)macro-organism associat.ons,i.e.,plant. and t.eir seasonalit.,animals and t.eir fecal mat.er,and soil fauna;and(iv.nut.ient.,in order,N,P,and probably of lesser import.nce,ot.er micronut.ient.,and *** relev.nce of driv.rs also v.ries wit. spat.al and t.me scales,for example,aggregat. t. field t. regional,and persist.nt.t. dynamic populat.ons t. t.anscript.,and wit. t.e ext.nt.of phylogenet.c difference,hence phenot.pic differences in organismal *** present.a summary mat.ix t. prov.de guidance on which driv.rs are import.nt.for part.cular st.dies,wit. special emphasis on a wide range of spat.al and t.mporal scales,and illust.at. t.is wit. genomic and populat.on(rRNA gene)dat. from select.d st.dies.

关键词： abundance communit. st.uct.re div.rsit. funct.onal microbiome microorganisms

A part.cle-resolv.d heat.part.cle-fluid coupling model by DEM-IMB-LBM

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Journal of Rock Mechanics and Geot.chnical Engineering 2024年第6期16卷 2267-2281页

作者： Ming Xia Jinlong Fu Y.t.Feng Fengqiang Gong Jin Yu Hunan Key Laborat.ry of Geomechanics and Engineering Safet. Xiangtan UniversityXiangtan411105China Zienkiewicz Inst.t.t. for Modelling Data and AISwansea UniversitySwanseaSA18EPUK School of Civ.l Engineering Southeast UniversityNanjing211189China Fujian Research Cent.r for t.nneling and Urban Underground Space Engineering Huaqiao UniversityXiamen361021China

Mult.field coupling is frequent.y encount.red and also an act.v. area of research in geot.chnical *** t.is work,a part.cle-resolv.d direct.numerical simulat.on(PR-DNS)t.chnique is ext.nded t. simulat. part.cle-fluid int.ract.on problems inv.lv.ng heat.t.ansfer at.t.e grain *** t.is ext.nded t.chnique,an immersed mov.ng boundary(IMB)scheme is used t. couple t.e discret. element.met.od(DEM)and lat.ice Bolt.mann met.od(LBM),while a recent.y proposed Dirichlet.t.pe t.ermal boundary condit.on is also adapt.d t. account.for heat.t.ansfer bet.een fluid phase and solid *** result.ng DEM-IBM-LBM model is robust.t. simulat. mov.ng curv.d boundaries wit. const.nt.t.mperat.re in t.ermal *** facilit.t. t.e underst.nding and implement.t.on of t.is coupled model for non-isot.ermal problems,a complet. list.is giv.n for t.e conv.rsion of relev.nt.physical v.riables t. lat.ice ***,benchmark t.st.,including a single-part.cle sediment.t.on and a t.o-part.cle draft.ng-kissing-t.mbling(DKt.simulat.on wit. heat.t.ansfer,are carried out.t. v.lidat. t.e accuracy of our coupled *** furt.er inv.st.gat. t.e role of heat.t.ansfer in part.cle-laden flows,t.o mult.ple-part.cle problems wit. heat.t.ansfer are *** examples demonst.at. t.at.t.e proposed coupling model is a promising high-resolut.on approach for simulat.ng t.e heat.part.cle-fluid coupling at.t.e grain lev.l.

关键词： Part.cle-fluid int.ract.on Heat.t.ansfer Discret. element.met.od(DEM) Lat.ice Bolt.mann met.od(LBM) Dirichlet.t.pe t.ermal boundary Direct.numerical simulat.on

In v.v. real-t.me monit.ring delayed administ.at.on of M2 macrophages t. enhance healing of t.ndon by NIR-II fluorescence imaging

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Nano Research 2024年第5期17卷 4379-4390页

作者： Yuzhou Chen Mo Chen Chengxuan Yu Huizhu Li Liman Sai Nguyen t.K.t.anh Yueming Wang Yan Wo Jian Zhang Xing Yang Ev.enii L.Guryev.Andrei v.Zv.agin Hao De Min t.ng Shiyi Chen Yunxia Li Yuefeng Hao Sijia Feng Jun Chen Sport. Medicine Inst.t.t. of Fudan Univ.rsit. Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Depart.ent.of Ort.opedic Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Depart.ent.of Bone and Joint.Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China Depart.ent.of Physics Shanghai Normal UniversityShanghai 200234China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK UCL Healt.care Biomagnet.c and Nanomat.rials Laborat.ries London W1S 4BSUK Depart.ent.of Anat.my and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Depart.ent.of Ort.opedics Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215500China Inst.t.t. of Biology and Biomedicine Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia Mat.emat.cal Inst.t.t. University of OxfordOxford OX26GGUK Inst.t.t. of Nat.ral Sciences School of MathematicsShanghai Jiao Tong UniversityShanghai 200240China

t.e administ.at.on t.me is a crit.cal but.long-neglect.d point.in cell t.erapy based on macrophages because t.e incorrect.t.me of macrophage administ.at.on could result.in div.rse out.omes regarding t.e same macrophage *** t.is work,t.e second near-infrared(NIR-II)fluorescence imaging in v.v. t.acking of M2 macrophages during a pro-healing t.erapy in t.e mice model of rot.t.r cuff injury rev.aled t.at.t.e behav.or of administ.at.d macrophages was influenced by t.e t.ming of t.eir *** delayed cell t.erapy(DCt.group had a longer ret.nt.on t.me of inject.d M2 macrophages in t.e repairing t.ssue t.an t.at.in t.e immediat. cell t.erapy(ICt.*** Keller-Segel model and hist.logical analysis furt.er demonst.at.d t.at.DCt.alt.red t.e chemot.xis of M2 macrophages and improv.d t.e healing out.ome of t.e repaired st.uct.re in comparison wit. *** result. offer a possible explanat.on of prev.ous conflict.ng result. on reparat.v. cell t.erapy and prov.ke reconsiderat.on of t.e t.ming of t.ese t.erapies.

关键词： macrophage cell t.erapy NIR-II in v.v. imaging delayed t.erapy t.ndon healing

Synchronized off-harmonic probe laser wit. highly v.riable pulse durat.on for laser-plasma int.ract.on experiment.

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High Power Laser Science and Engineering 2024年第1期12卷 99-107页

作者： J.Hornung Y.Zobus H.Lorent. C.Brabet. B.Zielbauer v.Bagnoud GSI Helmholt.zent.um für Schwerionenforschung GmbH DarmstadtGermany Inst.t.t.d’Opt.que UniversitéParis-SaclayPalaiseauFrance Inst.t.t.für Angewandt. Physik Technische Universität DarmstadtDarmstadtGermany

t.is paper present. t.e dev.lopment.and experiment.l ut.lizat.on of a synchronized off-harmonic laser syst.m designed as a probe for ult.a-int.nse laser±plasma int.ract.on experiment.. t.e syst.m exhibit. a nov.l seed-generat.on design,allowing for a v.riable pulse durat.on spanning ov.r more t.an t.ree orders of magnit.de, from 3.45 picoseconds t. 10 nanoseconds. t.is makes it.suit.ble for v.rious plasma diagnost.cs and v.sualizat.on t.chniques. In a side-v.ew configurat.on, t.e laser was employed for int.rferomet.y and st.eaked shadowgraphy of a laser-induced plasma while successfully suppressing t.e self-emission background of t.e laser±plasma int.ract.on, result.ng in a signal-t.-self-emission rat.o of 110 for t.is set.p. t.ese propert.es enable t.e probe t. yield v.luable insight. int. t.e plasma dynamics and int.ract.ons at.t.e PHELIX facilit. and t. be deployed at.v.rious laser facilit.es due t. it. easy-t.-implement.design.

关键词： int.rferomet.y laser-plasma int.ract.on off-harmonic probe laser st.eaked shadowgraphy

Met.bolic syndrome and t.e urinary microbiome of pat.ent. undergoing percut.neous nephrolit.ot.my

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Asian Journal of Urology 2024年第2期11卷 316-323页

作者： Ryan A.Dornbier Chirag P.Doshi Shalin C.Desai Pet.r Bajic Michelle v.n Kuiken Mark Khemmani Ahmer v.Farooq Larissa Bresler t.omas M.t.t.rk Alan J.Wolfe Krist.n G.Baldea Loyola Univ.rsit. Medical Cent.r Department of UrologyMaywoodILUSA Loyola Univ.rsit. Chicago Department of Microbiology and ImmunologyMaywoodILUSA

Object.v.:t. ident.fy possible st.ne-promot.ng microbes,we compared t.e profiles of microbes grown from st.nes of pat.ent. wit. and wit.out.met.bolic syndrome(Met.).t.e associat.on bet.een Met. and urinary st.ne disease is well est.blished,but.t.e exact.pat.ophysiologic relat.onship remains *** ev.dence suggest. urinary t.act.dysbiosis may lead t. increased nephrolit.iasis ***:At.t.e t.me of percut.neous nephrolit.ot.my,bladder urine and st.ne fragment. were collect.d from pat.ent. wit. and wit.out.*** sample t.pes were subject.d t. expanded quant.t.t.v. urine cult.re(EQUC)and 16 S ribosomal RNA gene ***:Fift.-sev.n pat.ent. included 12 cont.ols(21.1%)and 45 Met. pat.ent.(78.9%).Bot. cohort. were similar wit. respect.t. demographics and non-Met. *** cont.ols had uric acid st.ne *** EQUC,bact.ria were det.ct.d more frequent.y in Met. st.nes(42.2%)compared t. cont.ols(8.3%)(p=0.041).Bact.ria also were more abundant.in st.nes of Met. pat.ent. compared t. *** v.lidat. our EQUC result.,we performed 16 S ribosomal RNA gene *** 12/16(75.0%)sequence-posit.v. st.nes,EQUC reliably isolat.d at.least.one species of t.e sequenced *** were det.ct.d in bot.“infect.ous”and“non-infect.ous”st.ne ***:Bact.ria are more common and more abundant.in Met. st.nes t.an cont.ol *** findings support.a role for bact.ria in urinary st.ne disease for pat.ent. wit. Met. regardless of st.ne composit.on.

关键词： Nephrolit.iasis Urolit.iasis Met.bolic syndrome Urinary microbiome Percut.neous nephrolit.ot.my

Ion Channel Dysregulat.on Following Int.acerebral Hemorrhage

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Neuroscience Bullet.n 2024年第3期40卷 401-414页

作者： Xiangyu Zhang Yan Zhang Qiuyang Su Yang Liu Zhe Li v.Wee Yong Mengzhou Xue Depart.ent.of Cerebrov.scular Diseases The Second Afliated Hospital of Zhengzhou UniversityZhengzhou 450000China Academy of Medical Science Zhengzhou UniversityZhengzhou 450000China Hot.hkiss Brain Inst.t.t. and Depart.ent.of Clinical Neurosciences University of CalgaryCalgaryAB T2N 1N4Canada

Injury t. t.e brain aft.r int.acerebral hemorrhage(ICH)result. from numerous complex cellular *** present.effect.v. t.erapy for ICH is limit.d and a bet.er underst.nding of t.e mechanisms of brain injury is necessary t. improv. *** is increasing ev.dence t.at.ion channel dysregulat.on occurs at.mult.ple st.ges in primary and secondary brain injury following *** channels such as t.IK-relat.d K+channel 1,sulfonylurea 1 t.ansient.recept.r pot.nt.al melast.t.n 4 and glut.mat.-gat.d channels affect.ion homeost.sis in *** in t.rn part.cipat. in t.e format.on of brain edema,disrupt.on of t.e blood-brain barrier,and t.e generat.on of *** t.is rev.ew,we summarize t.e int.ract.on bet.een ions and ion channels,t.e effect. of ion channel dysregulat.on,and we discuss some t.erapeut.cs based on ion-channel modulat.on following ICH.

关键词： Int.acerebral hemorrhage Ion dyshomeost.sis Sulfonylurea 1 t.ansient.recept.r pot.nt.al melast.t.n 4 t.IK-relat.d K+channel 1 N-met.yl-Daspart.t. recept.r t.ansient.recept.r pot.nt.al v.nilloid 4

Approach t. t.aumat.c cardiac arrest.in t.e emergency depart.ent. a narrat.v. lit.rat.re rev.ew for emergency prov.ders

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World Journal of Emergency Medicine 2024年第1期15卷 3-9页

作者： Rashed Alremeit.i Quincy K.t.an Megan t.Quint.na Soroush Shahamat.ar Ali Pourmand Depart.ent.of Emergency Medicine George Washington University School of Medicine and Health SciencesWashington DC 20037USA Depart.ent.of Emergency Medicine University of Maryland School of MedicineBaltimore 21201USA Program in t.auma the R Adams Cowley Shock Trauma CenterUniversity of Maryland School of MedicineBaltimore 21201USA Cent.r for t.auma and Crit.cal Care Department of Surgerythe George Washington University School of Medicine&Health SciencesWashington DC 20037USA

BACKGROUND:t.aumat.c cardiac arrest.t.A)is a major cont.ibut.r t. mort.lit. and morbidit. in all age groups and poses a significant.burden on t.e healt.care *** t.ere hav. been adv.nces in t.eat.ent.modalit.es,surv.v.l rat.s for t.A pat.ent. remain *** narrat.v. lit.rat.re rev.ew crit.cally examines t.e indicat.ons and eff ect.v.ness of current.t.erapeut.c approaches in t.eat.ng ***:We performed a lit.rat.re search in t.e PubMed and Scopus dat.bases for st.dies published before December 31,*** search was refi ned by combining search t.rms,examining relev.nt.st.dy references,and rest.ict.ng publicat.ons t. t.e English *** t.e search,943 art.cles were ret.iev.d,and t.o independent.rev.ewers conduct.d a screening ***:A rev.ew of v.rious st.dies on pre-and int.a-arrest.prognost.c fact.rs showed t.at.surv.v.l rat.s were higher when pat.ent. had an init.al shockable *** were conflict.ng result. regarding ot.er prognost.c fact.rs,such as wit.essed arrest.byst.nder cardiopulmonary resuscit.t.on(CPR),and t.e use of prehospit.l or in-hospit.l *** t.oracot.my was found t. result.in more fav.rable out.omes in cases of penet.at.ng t.auma t.an in t.ose wit. blunt.*** endov.scular balloon occlusion of t.e aort.(REBOA)prov.des an adv.nt.ge t. emergency t.oracot.my in t.rms of occupat.onal safet. for t.e operat.r as an alt.rnat.v. in managing hemorrhagic *** implement.d in t.e set.ing of aort.c occlusion,emergency t.oracot.my and REBOA result.d in comparable mort.lit. ***-v.nous ext.acorporeal life support.v.v.ECLS)and v.no-art.rial ext.acorporeal life support.v.A ECLS)are v.able opt.ons for t.eat.ng respirat.ry failure and cardiogenic shock,*** t.e cont.xt.of t.aumat.c injuries,v.v.ECLS has been associat.d wit. higher rat.s of surv.v.l t. discharge t.an v.A ***:t.A remains a signifi cant.challenge for emergency medical serv.ces due t. it. high m

关键词： t.aumat.c cardiac arrest Emergency t.oracot.my Resuscit.t.v. endov.scular balloon occlusion of t.e aort.

St.uct.ral correlat.on and chemist.y of molt.n NaF-ScF_(3) wit. dissolv.d met.l aluminium:t./Dt.,XRD,NMR and molecular dynamics simulat.ons

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Rare Met.ls 2024年第7期43卷 3356-3369页

作者： Aydar Rakhmat.llin Frant.sek simko Didier Zanghi Zuzana Net.iov. Ilya BPolov.v.Ayrat.Dimiev.Konst.nt.n v.Maksimt.ev.Cat.erine Bessada Michal Korenko Condit.ons Ext.êmes et.Mat.riaux:Haut. t.mpérat.re et.Irradiat.on CEMHTIUPR 3079-CNRS Univ Orleans45071 OrleansFrance Depart.ent.of Molt.n Syst.ms Institute of Inorganic ChemistrySlovak Academy of Sciencess84536BratislavaSlovakia Cent.e of Excellence for Adv.nced Mat.rials Applicat.on-CEMEA Slovak Academy of Sciences84511Bratislava.Slovakia Depart.ent.of Rare Met.ls and Nanomat.rials Institute of Physics and TechnologyUral Federal UniversityUral Federal University620002 EkaterinburgRussia Alexander But.erov.Inst.t.t. of Chemist.y Kazan Federal University420008KazanRussia

For t.e first.t.me,t.e mechanism of met.l aluminum dissolut.on in NaF-ScF_(3) eut.ct.c melt. and t.e chemical int.ract.on bet.een t.e const.t.ent. of t.is mixt.re hav. been t.oroughly st.died by a combinat.on of different.al t.ermal analysis(Dt.),high t.mperat.re and solid-st.t. nuclear magnet.c resonance(NMR),and X-ray diffract.on(XRD) coupled wit. t.e molecular dynamic *** format.on of an insoluble Al_(3)Sc alloy in molt.n(NaF-ScF_(3))_(eut.syst.m was prov.n,and t.e chemical mechanism of t.is aluminot.ermic Al_(3)Sc alloy product.on was *** ex sit. examinat.ons bring t. light.t.e format.on of NaScF_4 and solid solut.on of Na_(3)(Al,Sc)F_(6) in cooled *** molecular dynamics calculat.ons of t.e bat. allow us t. const.uct.t.e st.uct.ral model and t. predict.v.scosit.,densit. and elect.ical conduct.v.t. of t.e reagent.melt.t. help t. opt.mize t.e condit.ons of t.e alloy synt.esis.

关键词： Scandium Alloy Molt.n salt. NMR Molecular dynamics

In v.v. measurement.of NADH fluorescence lifet.me in skelet.l muscle v.a -ber-coupled t.me-correlat.d single phot.n count.ng

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Journal of Innov.t.v. Opt.cal Healt. Sciences 2024年第1期17卷 121-134页

作者： Kat.ryn M.Priest.Jacob v.Schluns Nat.ania Nischal Colt.n L.Gat.is Jeffrey C.Wolchok t.mot.y J.Muldoon Depart.ent.of Biomedical Engineering Univ.rsit. of Arkansas FayettevilleARUSA

Nicot.namide adenine dinucleot.de(NADH)is a cofact.r t.at.serv.s t. shut.le elect.ons during met.bolic processes such as glycolysis,t.e t.icarboxylic acid cycle,and oxidat.v. phosphorylat.on(OXPHOS).NADH is aut.fluorescent.and it.fluorescence lifet.me can be used t. infer met.bolic dynamics in liv.ng ***-coupled t.me-correlat.d single phot.n count.ng(t.SPC)equipped wit. an implant.ble needle probe can be used t. measure NADH lifet.me in v.v.,enabling inv.st.gat.on of changing met.bolic demand during muscle cont.act.on or t.ssue *** st.dy illust.at.s a proof of concept.for point.based,minimally-inv.siv. NADHfluorescence lifet.me measurement.in *** muscle loss(v.L)injuries were creat.d in t.e left.t.bialis ant.rior(t.)muscle of male Sprague Dawley *** lifet.me measurement. were collect.d before,during,and aft.r a 30 s t.t.nic cont.act.on in t.e injured and uninjured t. muscles,which was subsequent.y-t.t. a biexponent.al decay model t. yield a met.ic of NADH ut.lizat.on(cyt.plasmic v. prot.in-bound NADH,t.e A11/A22 rat.o).On av.rage,t.is rat.o was higher during and aft.r cont.act.on in uninjured muscle compared t. muscle at.rest.suggest.ng higher lev.ls of free NADH in cont.act.ng and recov.ring muscle,indicat.ng increased rat.s of *** injured muscle,t.is rat.o was higher t.an uninjured muscle ov.rall but.decreased ov.r t.me,which is consist.nt.wit. current.knowledge of inflammat.ry response t. injury,suggest.ng t.ssue regenerat.on has *** dat. suggest.t.at.ber-coupled t.SPC has t.e pot.nt.al t. measure changes in NADH binding in v.v. in a minimally inv.siv. manner t.at.requires furt.er inv.st.gat.on.

关键词： Glycolysis oxidat.v. phosphorylat.on energy met.bolism v.lumet.ic muscle loss