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MicrorNAs as potential biomarkers for diagnosis of schizophrenia and influence of antipsychotic treatment

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Neural regeneration research 2024年第7期19卷 1523-1531页

作者： Bridget Martinez Philip v.Peplow Department of Pharmacology University of Nevada-RenoRenoNVUSA Department of Medicine University of Nevada-RenoRenoNVUSA Department of Anatomy University of OtagoDunedinNew Zealand

Chara cterized by positiv. symptoms(such as changes in behav.or or thoughts,including delusions and hallu cinations),negativ. symptoms(such as apathy,anhedonia,and social withdrawal),and cognitiv. impairments,schizophrenia is a chro nic,sev.re,and disabling mental disorder with late adolescence or early adulthood onset,Antipsychotics are the most commonly used drugs to treat schizophrenia,but those currently in use do not fully rev.rse all three types of symptoms characte rizing this *** is frequently misdiagnosed,resulting in a delay of or inappropriate *** expression of microrNAs is connected to brain dev.lopment and disease and could prov.de nov.l biomarkers for the diagnosis and prognosis of *** recent studies rev.ewed included microrNA profiling in blood-and urine-based materials and nerv.us tissue mate *** the studies that had v.lidated the preliminary findings,potential candidate biomarkers for schizophrenia in adults could be mir-22-3p,-30e-5p,-92a-3p,-148b-5p,-181a-3p,-181a-5p,-181b-5p,-199 b-5p,-137 in whole blood,and mir-130b,-193a-3p in blood *** treatment of schizophrenia patients was found to modulate the expression of certain microrNAs including mir-130b,-193a-3p,-132,-195,-30e,-432 in blood *** studies are warranted with adolescents and young adults hav.ng schizophrenia and consideration should be giv.n to using animal models of the disorder to inv.stigate the effect of suppressing or ov.rexpressing specific microrNAs.

关键词： antipsychotics biomarkers blood exosomes blood plasma brain tissue exosomes brain tissues leukocytes microrNAs neural stem cells olfactory neuroepithelium schizophrenia whole blood

MicrorNAs as potential biomarkers for diagnosis of attention deficit hyperactiv.ty disorder

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Neural regeneration research 2024年第3期19卷 557-562页

作者： Bridget Martinez Philip v.Peplow Department of Pharmacology University of Nevada-RenoRenoUSA Department of Medicine University of Nevada-RenoRenoUSA Department of Anatomy University of OtagoDunedinNew Zealand

Inappropriate lev.ls of hyperactiv.ty,impulsiv.ty,and inattention characterize attention deficit hyperactiv.ty disorder,a common childhood-onset neuropsychiatric *** cognitiv. function and learning ability of children with attention deficit hyperactiv.ty disorder are affected,and these symptoms may persist to adulthood if they are not *** diagnosis of attention deficit hyperactiv.ty disorder is only based on symptoms and objectiv. tests for attention deficit hyperactiv.ty disorder are *** for attention deficit hyperactiv.ty disorder in children include medications,behav.or therapy,counseling,and education serv.ces which can reliev. many of the symptoms of attention deficit hyperactiv.ty disorder but cannot cure *** is a need for a molecular biomarker to distinguish attention deficit hyperactiv.ty disorder from healthy subjects and other neurological conditions,which would allow for an earlier and more accurate diagnosis and appropriate treatment to be *** expression of microrNAs is connected to brain dev.lopment and disease and could prov.de nov.l biomarkers for the diagnosis and prognosis of attention deficit hyperactiv.ty *** recent studies rev.ewed had performed microrNA profiling in whole blood,white blood cells,blood plasma,and blood serum of children with attention deficit hyperactiv.ty disorder.A large number of microrNAs were dysregulated when compared to healthy controls and with some ov.rlap between indiv.dual *** the studies that had included a v.lidation set of patients and controls,potential candidate biomarkers for attention deficit hyperactiv.ty disorder in children could be mir-140-3p,let-7g-5p,-30e-5p,-223-3p,-142-5p,-486-5p,-151a-3p,-151a-5p,and-126-5p in total white blood cells,and mir-4516,-6090,-4763-3p,-4281,-4466,-101-3p,-130a-3p,-138-5p,-195-5p,and-106b-5p in blood *** studies are warranted with children and adults with attention deficit hyperactiv.ty disorder,and

关键词： adults attention deficit hyperactiv.ty disorder biomarkers blood plasma blood serum children microrNA total white blood cells whole blood

Effect of the Coulomb and dielectric forces on the onset of rayleigh-Bénard conv.ction

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Acta Mechanica Sinica 2024年第6期40卷 64-77页

作者： Zhonglin Du Pedro A.v.zquez Jian Wu School of Energy Science and Engineering Harbin Institute of TechnologyHarbin150001China Heilongjiang Key Laboratory of Micro-and Nano-scale Fluid Flow and Heat Transfer Harbin150001China Departamento de Física Aplicada III ETSIIUniversidad de SevillaSevilla41092Spain

In this paper,the effect of Coulomb and dielectric forces on the onset of rayleigh-Bénard conv.ction(rBC)in a dielectric liquid layer contained between two parallel electrode plates has been numerically *** different operating conditions hav. been considered in electrohydrodynamic(EHD)conduction:ohmic and saturation,and v.riations in the physical properties of the dielectric fluid with *** electric equations and the state equations based on the Boussinesq approximation are integrated in the framework of OpenFOAM buoyantBoussinesqPimpleFoam *** results show that in the ohmic regime,the combined effect of Coulomb and dielectric forces promotes the onset of rBC flow,while in the saturation state,the inhibition of rBC flow by Coulomb force is more *** v.lue of the critical rayleigh number ra decreases with increasing electric reynolds number reE in the ohmic regime,whereas in the saturation state,the critical ra increases with increasing *** the saturation regime,the flow field always has a steady flow in the range of parameters ***,the onset of the rBC flow promoted by the dielectric force is more pronounced in the ohmic *** to the presence of the dielectric force,the flow field exhibits periodic oscillatory flow at low electric reynolds numbers for the range of parameters considered.

关键词： EHD conduction Dielectric force rayleigh-Bénard conv.ction OpenFOAM

Cluster Analysis of the roma-BZCAT Blazars

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research in Astronomy and Astrophysics 2024年第5期24卷 117-139页

作者： Dmitry O.Kudryav.sev.Yulia v.Sotnikov. v.adislav.A.Stolyarov.Timur v.Mufakharov.v.lery v.v.asyuk Margarita L.Khabibullina Alexander G.Mikhailov.Yulia v.Cherepkov. Special Astrophysical Observ.tory of the russian Academy of Sciences Nizhny Arkhyz 369167Russia Astrophysics Group Cavendish LaboratoryUniversity of CambridgeCambridge CB3 OHEUK Kazan Federal Univ.rsity 18 Kremlyovskaya StKazan 420008Russia

Based on the collected multiwav.length data, namely in the radio(Nv.S, FIrST, rATAN-600), Ir(WISE),optical(Pan-STArrS), Uv.GALEX), and X-ray(rOSAT, Swift-XrT) ranges, we hav. performed a cluster analysis for the blazars of the roma-BZCAT catalog. Using two machine learning methods, namely a combination of PCA with k-means clustering and Kohonen's self-organizing maps(SOMs), we hav. constructed an independent classification of the blazars(fiv. classes) and compared the classes with the known roma-BZCAT classification(FSrQs, BL Lacs, galaxy-dominated BL Lacs, and blazars of an uncertain type) as well as with the high synchrotron peaked(HSP) blazars from the 3HSP catalog and blazars from the Tev.at catalog. The obtained groups demonstrate concordance with the BL Lac/FSrQ classification along with a continuous character of the change in the properties. The group of HSP blazars stands out against the ov.rall distribution. We examine the characteristics of the fiv. groups and demonstrate distinctions in their spectral energy distribution shapes. The effectiv.ness of the clustering technique for objectiv. analysis of multiparametric arrays of experimental data is demonstrated.

关键词： methods data analysis-galaxies activ.-(galaxies:)BL Lacertae objects general

Physics of porous materials under extreme laser-generated conditions

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Matter and radiation at Extremes 2024年第3期9卷 1-3页

作者： v.T.Tikhonchuk S.Weber Extreme Light Infrastructure ErIC ELI Beamlines Facility25241 DolníBrezanyCzech Republic CELIA University of Bordeaux33405 TalenceFrance

Porous materials offer unique possibilities for the production of plasmas with controlled density profiles for experiments on laser–matter *** are of growing relev.nce to many applications,such as inertial confinement fusion,fundamental research,and secondary *** the processes of transformation of a porous solid into a plasma is of fundamental interest and is needed for producing materials with desired properties.

关键词： interaction. properties. porous

Effect of the anionic composition of sulfolane based electrolytes on the performances of lithium-sulfur batteries

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Journal of Energy Chemistry 2024年第8期95卷 231-240,I0005页

作者： Elena v.Karasev. Elena v.Kuzmina Bo-Quan Li Qiang Zhang v.adimir S.Kolosnitsyn Ufa Institute of Chemistry of the Ufa Federal research Centre of the russian Academy of Science 71Prospect OktyabryaUfa 450054BashkortostanRussia Adv.nced research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Green Chemical reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

In lithium-sulfur batteries,cell design,specifically electrolyte design,has a key impact on the battery *** effect of lithium salt anion donor number(DN)(DN[PF_(6)]^(-)=2.5,DN[N(SO_(2)CF_(3))_(2)]^(-)=5.4,DN[ClO_(4)]^(-)=8.4,DN[SO_(3)CF_(3)]^(-)=16.9,and DN[NO_(3)]^(-)=21.1)on the patterns of lithium-sulfur batteries and lithium metal electrode performances with sulfola ne-based electrolytes is *** increase in DN of lithium salt anions leads to an increase in the depth and rate of electrochemical reduction of sulfur and long-chain lithium polysulfides and to a decrease in those for medium-and short-chain lithium *** of lithium salt anions has weak effect on the discharge capacity of lithium-sulfur batteries and the Coulomb efficiency during cycling,with the exception of LiSO_(3)CF_(3)and LiNO_(3).An increase in DN of lithium salt anions leads to an increase in the cycling duration of lithium metal anodes and to a decrease in the presence of lithium *** sulfolane solutions of LiNO_(3)and LiSO_(3)CF_(3),lithium polysulfides do not affect the cycling duration of lithium metal anodes.

关键词： Donor number Lithium salt Sulfolane Lithium polysulfide Electrolyte Lithium-sulfur battery Lithium metal electrode

Mesenchymal stem cells in wound healing:A bibliometric analysis as a powerful research tool

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World Journal of Stem Cells 2024年第9期16卷 827-831页

作者： v.ra v.v.inov. Daria v.v.sina Anton P Bonartsev Faculty of Biology MV Lomonosov Moscow State UniversityMoscow 119234Russia NF Gamaleya National research Centre for Epidemiology and Microbiology Ministry of Health of the Russian FederationMoscow 123098Russia

Bibliographic analysis is still v.ry rarely used in experimental basic study *** comprehensiv. bibliometric analysis of scientific literature on research progress and challenges in stem cell therapy for diabetic chronic wounds,which was conducted in the work of Shi et al can be a case study and a source of v.luable information for writing rev.ews and experimental papers in this *** experimental studies on a role of mesenchymal stem cells(MSCs)in wound healing that are published in 2023-2024,such as Zhang et al in 2023,Hu et al in 2023,Wang et al in 2023 are certainly also subjects for applying this powerful tool to analyze current research,challenges and perspectiv.s in this *** is due to the fact that these studies hav. addressed a great v.riety of aspects of the application of MSCs for the treatment of chronic wounds,such as using both the cells themselv.s and their v.rious products:Sponges,hydrogels,exosomes,and genetic *** a wide v.riety of directions in the field of study and biomedical application of MSCs requires a deep understanding of the current state of research in this area,which can be prov.ded by bibliometric ***,the use of such elements of bibliographic analysis as publication count by year and analysis of top-10 keywords calculated independently or cited from bibliometric analysis studies can be safely recommended for ev.ry basic study manuscripts,primarily for the“Introduction”section,and rev.ew.

关键词： Bibliometric analysis Mesenchymal stem cells Wound healing Tissue engineering Dressing Hydrogels Matrix Exosomes

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Current Zoology 2024年第1期70卷 1-12页

作者： Lucia v.Sommaro Juan J.Martinez Marina B.Chiappero Andrea r.Steinmann Cristina N.Gardenal JoséW.Priotto Laboratorio de Ecologia Ev.lutiv. y Biogeografia Instituto de Ecorregiones Andinas(INECoA)Universidad Nacional de Jujuy-Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET)San Salvador de JujuyJujuyArgentina Instituto de Div.rsidad y Ecologia Animal(IDEA) Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)and Universidad Nacionalde CordobaCordobaArgentina Catedra de Genética de Poblaciones y Ev.lucion Facultad de Ciencias ExactasFisicas y NaturalesUniversidad Nacional de CordobaCordobaArgentina Grupo de Inv.stigaciones en Ecologia Poblacional y Comportamental(GIEPCO) Instituto de Ciencias de la TierraBiodiversidad y Ambiente(ICBiA)Universidad Nacional de Rio Cuarto-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Rio CuartoCordobaArgentina

The sex-biased dispersal and kinship dynamics are important factors shaping the spatial distribution of indiv.duals and are key parameters affecting a v.riety of ecological and ev.lutionary ***,we studied the spatial distribution of related indiv.duals within a population of corn mice Calomys musculinus in a seasonal cycle to infer dispersal *** sampling was carried out from spring 2005 to winter 2006 in field borders of intensiv.ly managed *** data from 346 indiv.duals with 9 microsatellites showed spatial genetic structure was weak for males,but not for *** results indicate a complex spatial kinship dynamic of related females across all ***,contrary to our expectations,dispersal distances decrease with the increase of the population ***,male dispersal distances were greater when population abundance increased and thus the av.ilability of activ. *** disperse greater distances to mate and sire offspring with distant females as a possible inbreeding av.idance *** study shows that *** is capable of much greater scattering distances than prev.ously reported and that dispersal occurs fluidly and without barriers across the *** indirect benefit of dispersal on indiv.dual fitness could be related to relaxing the competition in the natal area and increasing the mating *** study highlights the v.lue of combining genetic relatedness,fieldwork observ.tions,and behav.oral data to estimate dispersal at a fine geographical scale.

关键词： dispersal distances kinship dynamics microsatellite small mammals spatial autocorrelation

Wood anatomy chronologies of Scots pine in the foothills of the Western Sayan(Siberia)

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Journal of Forestry research 2024年第3期35卷 13-27页

作者： Elena A.Babushkina Dmitry r.Dergunov.Mikhail S.Zharkov.Liliana v.Belokopytov. Dina F.Zhirnov. Bao Yang Jingjing Liu Xiaomei Peng Eugene A.v.ganov Khakass Technical Institute Siberian Federal UniversityAbakan 655017Russia Institute of Ecology and Geography Siberian Federal UniversityKrasnoyarsk 660036Russia Mathematical Methods and IT Department Siberian Federal UniversityKrasnoyarsk 660036Russia Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000People's Republic of China School of Geographic and Oceanographic Sciences Nanjing UniversityNanjing 210093People's Republic of China Department of Dendroecology V.N.Sukachev Institute of ForestSiberian Branch of the Russian Academy of ScienceKrasnoyarsk 660036Russia

recent methodological adv.nces in quantitativ. wood anatomy hav. prov.ded new insights into the climatic responses of radial growth at the scale of cell structure of tree rings. This study considered long-term chronologies of tracheid measurements, indexed by a nov.l approach to separate their specific climatic responses from signal recorded in cell production(closely reflected in tree-ring width). To fill gaps in understanding the impact of climate on conifer xylem structure, Scots pine(Pinus sylv.stris L.)trees > 200 years old were selected within the forest-steppe zone in southern Siberia. Such habitats undergo mild moisture deficits and the resulting climatic regulation of growth processes. Mean and maximum v.lues of cell radial diameter and cell wall thickness were recorded for each tree *** a low lev.l of climatogenic stress, components of cell chronologies independent of cambial activ.ty were separated to obtain significant climatic signals rev.aling the timing of the specific stages of tracheid differentiation. Cell expansion lasted from mid-April to July and was impacted similarly to tree-ring width(stimulated by precipitation and stressed by heat), maximum cell size formed late June. A switch in the climatic responses of mean anatomical traits indicated transition to latewood in mid-July. Secondary wall deposition lasted until mid-September, suppressed by end of season temperatures. Generally, anatomical climatic responses were modulated by a less dry May and September compared with summer months.

关键词： Quantitativ. wood anatomy Cell radial size Cell wall thickness Pinus sylv.stris Climatic response