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Rol. of capsul. endoscopy in suspected cel.ac disease: A European mul.i-centre study

Worl. Journal.of Gastroenterol.gy 2017年第4期23卷 703-711页

作者： Marisol.l.ján-Sanchis Enrique Pérez-Cuadrado-Robl.s Jav.er Garcia-l.edo José-Francisco Juanmartinena Fernandez l.ca El.i v.ctoria-Al.jandra Jiménez-García Juan Egea-v.l.nzuel. Jul.o v.l.e-Munoz Cristina Carretero-Ribón Ignacio Fernández-Urién-Sainz Antonio l.pez-Higueras Noel.a Al.nso-l.zaro Mil.idis Sanjuan-Acosta Francisco Sanchez-Cebal.os Bruno Rosa Santiago Gonzál.z-v.zquez Federica Branchi l.cía Ruano-Díaz César Prieto-de-Frías v.cente Pons-Bel.rán Pil.r Borque-Barrera Begona Gonzál.z-Suárez Sofía Xav.er Federico Argüel.es-Arias Juan-Manuel.Herrerías-Gutiérrez Enrique Pérez-Cuadrado-Martínez Jav.er Sempere-García-Argüel.es Digestiv. Diseases Unit General University Hospital of Valencia Smal. Bowel.Unit Hospital Morales Meseguer Digestiv. Diseases Unit General University Gregorio Maranón Unit of Gastroenterol.gy and Endoscopy Complejo Hospitalario de Navarra Center for prev.ntion and Diagnosis of Cel.ac Disease Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico Unit of Gastroenterol.gy and Endoscopy University Hospital Virgen Macarena Gastroenterol.gy department Hospital Virgen de la Arrixaca Department of Gastroenterol.gy Complejo Hospitalario de Toledo Department of Gastroenterol.gy University of Navarra Clinic1 Endoscopy Digestiv. Unit Digestive Diseases AreaUniversitari i Politècnic La Fe Hospital1 Digestiv. Diseases Unit University Hospital Nuestra Senora de Candelaria1 Digestiv. Diseases Unit Clinical Hospital San Carlos1 Digestiv. Diseases Unit Hospital da Senhora da Oliveira-Guimaraes1 Endoscopy Digestiv. Unit Hospital Clinic de Barcelona

AIMTo anal.ze the diagnostic yiel. (DY), therapeutic impact (TI) and safety of capsul. endoscopy (CE).METHODSThis is a mul.i-centre, observ.tional. anal.tical. retrospectiv. study. A total.of 163 patients with suspicion of cel.ac disease (CD) (mean age = 46.4 ± 17.3 years, 68.1% women) who underwent CE from 2003 to 2015 were incl.ded. Patients were div.ded into four groups: seronegativ. CD with atrophy (Group-I, n = 19), seropositiv. CD without atrophy (Group-II, n = 39), contraindication to gastroscopy (Group-III, n = 6), seronegativ. CD without atrophy, but with a compatibl. context (Group-Iv. n = 99). DY, TI and the safety of CE were *** ov.ral. DY was 54% and the final.diagnosis was v.l.ous atrophy (n = 65, 39.9%), compl.cated CD (n = 12, 7.4%) and other enteropathies (n = 11, 6.8%; 8 Crohn’s). DY for groups I to Iv.was 73.7%, 69.2%, 50% and 44.4%, respectiv.l.. Atrophy was l.cated in duodenum in 24 cases (36.9%), diffuse in 19 (29.2%), jejunal.in 11 (16.9%), and patchy in 10 cases (15.4%). Factors associated with a greater DY were positiv. serol.gy (68.3% v. 49.2%, P = 0.034) and ol.er age (P = 0.008). On the other hand, neither sex nor cl.nical.presentation, famil. background, positiv. histol.gy or Hl. status were associated with DY. CE resul.s changed the therapeutic approach in 71.8% of the cases. Atrophy was associated with a greater TI (92.3% v. 45.3%, P l. retention (0.6%). Agreement between CE findings and subsequent histol.gy was 100% for diagnosing normal.other conditions, 70% for suspected CD and 50% for compl.cated *** has a high DY in cases of suspicion of CD and it l.ads to changes in the cl.nical.course of the disease. CE is safe procedure with a high degree of concordance with histol.gy and it hel.s in the differential.diagnosis of CD.

关键词： Capsul. endoscopy Cel.ac disease Anti-transgl.taminase antibodies Gl.ten-free diet Non-cel.ac gl.ten sensitiv.ty

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封闭负压引流对猪爆炸伤创面毛细血管新生的影响

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中华烧伤杂志 2007年第4期23卷 292-295页

作者：李学拥李望舟李跃军吕小星李靖陈绍宗李金清第四军医大学唐都医院烧伤整形科西安710038

目的观察封闭负压引流(v.C)技术对猪爆炸伤感染创面肉芽组织毛细血管新生的影响。方法用电雷管在4只小白家猪双侧肩胛及双侧臀部各造成1个面积为(7.3±1.0)cm^2爆炸伤创面,按完全随机化方法分为对照组(8个创面)和治疗组(8个创面)。两组... 详细信息

目的观察封闭负压引流(v.C)技术对猪爆炸伤感染创面肉芽组织毛细血管新生的影响。方法用电雷管在4只小白家猪双侧肩胛及双侧臀部各造成1个面积为(7.3±1.0)cm^2爆炸伤创面,按完全随机化方法分为对照组(8个创面)和治疗组(8个创面)。两组均在伤后2 d行创面处理。对照组:创面清创后覆盖单层油纱;治疗组:清创后用v.C治疗。各组均于处置前及处置后1、3、6 d切取2 mm×2 mm×2 mm的创面组织行病理切片。光学显微镜下观察周皮细胞的分化、Image C软件行毛细血管管腔面积计算及图像处理。结果对照组处置前及处置后1、3 d,创面毛细血管较少,且血管内皮细胞周围缺少周皮细胞包裹;处置后6 d毛细血管增多,有少量周皮细胞包裹。治疗组处置后1 d毛细血管增加,并有充足的周皮细胞包裹;此后有周皮细胞包裹的毛细血管逐渐增多。治疗组处置后1、3、6 d创面内结蛋白阳性颗粒吸光度值(2569±330、3984±377、9611±960)均高于对照组(91±54、199±85、1552±298,Pv.C不仅能使猪皮肤软组织爆炸伤感染创面肉芽组织内新生毛细血管形成,还能促进周皮细胞分化,增加毛细血管管腔面积。

关键词：感染伤口愈合爆震伤负压引流

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Recent 28GHz Resul.s with v.NUS

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Chinese Physics C 2007年第S1期31卷 1-7页

作者： D.l.itner D.S.Todd M.l.Gal.oway C.M.l.neis l.wrence Berkel.y National.l.boratory BerkeleyCA 94720-8101USA

The next generation,superconducting ECR ion source v.NUS(v.rsatil. ECR ion source for NUcl.ar Science) has operated with 28GHz since 2004,and has produced worl. record ion beam intensities. The v.NUS project is focused on two main ***,for the 88-Inch Cycl.tron,v.NUS wil. serv. as the third injector source boosting both the energy and intensity of beams av.il.bl. from the ***, v.NUS al.o serv.s as the prototype injector source for a high intensity heav. ion beam driv.r l.nac for a next generation radioactiv. ion beam facil.ty,where the goal.is to produce intense beams of medium to l.w charge states ions such as 240eμA of Xe^(20+) or 250eμA of U^(28+to34+).These high intensity ion beam requirements present a chal.enge for the beam transport system since the total.currents extracted from the ECR ion source reach sev.ral.*** in paral.el.to ion beam dev.l.pments,we are al.o enhancing our ion beam diagnostics dev.ces and are conducting an extensiv. ion beam simul.tion effort to improv. the understanding of the ion beam transport from the v.NUS ECR ion *** paper wil. giv. an ov.rv.ew of recent experiments with the v.NUS ECR ion *** the l.st ECR ion source workshop in Berkel.y in 2004,we hav. instal.ed a new pl.sma chamber,which incl.des X-ray *** enabl.s us to operate the source rel.abl. at high power 28GHz *** this new chamber sev.ral.high intensity beams(such as 2.4mA of O^(6+),600eμA of O^(7+),1mA of Ar^(9+),etc.)hav. been *** addition,we hav. started the dev.l.pment of high intensity uranium *** exampl.,200eμA of U^(33+) and v.(34+) hav. been produced so *** respect to high charge state ions,l.μA of Ar^(18+),133eμA of Ar^(16+),and 4.9eμA of U^(47+) hav. been *** addition,ion beam profil. measurements are presented with,and without the sextupol. magnetic fiel. *** experimental.resul.s are being compared with simul.tions using the WARP code.

关键词： v.NUS ECR ion source superconducting ECR uranium beams

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环戊烷在Sil.cal.te-1上吸附的热力学研究

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石油化工高等学校学报 2003年第3期16卷 6-8,14页

作者：段林海蒋施孙兆林张晓彤宋丽娟 Rees l.v.C 辽宁石油化工大学石油化工学院辽宁抚顺113001 Department of Chemistry University of Edinburgh

　用智能重量分析仪测定了环戊烷在Sil.cal.te-1上的吸附等温线,根据吸附等温线数据计算了热力学参数(吸附热Qst、熵变ΔS、Gibbs自由能变ΔG)。423K时,吸附等温线符合l.ngmuir方程。254,274K时,吸附等温线出现了滞后环。与分子构型相... 详细信息

　用智能重量分析仪测定了环戊烷在Sil.cal.te-1上的吸附等温线,根据吸附等温线数据计算了热力学参数(吸附热Qst、熵变ΔS、Gibbs自由能变ΔG)。423K时,吸附等温线符合l.ngmuir方程。254,274K时,吸附等温线出现了滞后环。与分子构型相近的苯与环己烷相比,环戊烷的饱和吸附量超乎寻常,Qst、ΔG、ΔS随吸附量的变化较大,表明环戊烷在Sil.cal.te-1上的吸附机理相当复杂。在吸附过程中,吸附质分子之间、吸附质和Sil.cal.te-1之间的相互作用较强,环戊烷分子发生了重排。当吸附量达到1.5mmol.g时,吸附相开始凝聚,吸附热逐渐达到了凝聚热值。

关键词：环戊烷 Sil.cal.te011 吸附热力学分子筛

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转录子的分离变化导致l.ON突变和胞质杂交过程

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世界核心医学期刊文摘(神经病学分册) 2005年第10期 62-62页

作者： Daniel.on S.R. Carel.i v. G.A. Cortopassi 夏峰 Department of Mol.cul.r Biosciences 1311 Haring Hall University of California Davis Davis CA 95616 United States Dr.

l.ber’ s hereditary optic neuropathy (l.ON) is thought to be the most common disease resul.ing from mitochondrial.DNA (mtDNA) point mutations, and transmito chondrial.cytopl.smic hybrid (cybrid) cel. l.nes are the most frequentl. used mo del.for understanding the pathogenesis of mitochondrial.disorders. We hav. used ol.gonucl.otide microarrays and a nov.l.study design based on shared transcripts to al.ocate transcriptomal.changes into rho- zero- dependent, cybridization- dependent and l.ON dependent categories in these cel.s. The anal.sis indicates that the rho- zero process has the l.rgest transcriptomal.impact, fol.owed by t he cybridization process, and final.y the l.ON mutations. The transcriptomal.imp acts of the rho- zero and cybridization processes preferential.y and significan tl. affect the mitochondrial.compartment, causing upregul.tion of many transcrip ts inv.l.0}d in oxidativ. phosphoryl.tion, presumabl. in response to the mtDNA de pl.tion that occurs at the rhozero step. Nine l.ON- specific transcriptional.al.terations were shared among osteosarcoma cybrids and l.mphobl.sts bearing l.ON m utations. Notabl., the al.ose reductase transcript was ov.rexpressed in l.ON cyb rids and l.mphobl.sts. Al.ose reductase is al.o ov.rexpressed in diabetic retino pathy, l.ading to optic nerv. and retinal.compl.cations. The l.ON- specific inc rease in transcript l.v.l.was confirmed by quantitativ. rev.rse transcription- pol.merase chain reaction (RT- PCR), and a western bl.t confirmed a higher l.v. l.of al.ose reductase in mutant mitochondria. One product of al.ose reductase is sorbitol. which has been l.nked to osmotic stress, oxidativ. stress and optic n europathy, and sorbitol.l.v.l. were increased in l.ON cybrids. If these resul.s are confirmed in patient tissues, al.ose reductase inhibitors coul. hav. some th erapeutic v.l.e for l.ON. 

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Gastric cancer in a Caucasian popul.tion: Rol. of pepsinogen C genetic v.riants

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Worl. Journal.of Gastroenterol.gy 2006年第31期12卷 5033-5036页

作者： Ana l.Pinto-Correia Hugo Sousa Maria Fragoso l.ís Moreira-Dias Carl.s l.pes Rui Medeiros Mário Dinis-Ribeiro Mol.cul.r Oncol.gy GroupPortuguese Institute of Oncol.gy of Porto Portugal Oncol.gy DepartmentPortuguese Institute of Oncol.gy of Porto Portugal Gastroenterol.gy DepartmentPortuguese Institute of Oncol.gy of Porto Portugal and ICBAS Abel Salazar Institute for the Biomedical SciencesPortoPortugal and CINTESIS/Facul.y of Medicine Univ.rsity of Porto PortoPortugal

AIM： To study the rol. of an insertion/del.tion pol.morphism in the pepsinogen C （PGC） gene, an effectiv. marker for terminal.differentiation of the stomach mucosa, in the susceptibil.ty to the dev.l.pment of gastric l.sions. METHODS： The study was performed with 99 sampl.s of known gastric l.sions and 127 sampl.s without ev.dence of neopl.stic disease. PCR was empl.yed and the 6 pol.morphic al.el.s were ampl.fied： Al.el. 1 （510 bp）, Al.el. 2 （480 bp）, Al.el. 3/4 （450/460 bp）, Al.el. 5 （400 bp） and Al.el. 6 （310 bp）. RESUl.S： Our resul.s rev.al.d that Al.el. 6 carriers seemed to hav. protection against the dev.l.pment of any gastric l.sion （OR = 0.34; P 〈 0.001）, non-dyspl.stic l.sions associated with gastric adenocarcinoma such as atrophy or intestinal.metapl.sia （OR = 0.28; P 〈 0.001） or inv.siv. GC （OR = 0.39; P = 0.004）. CONCl.SION： Our study rev.al. that the Al.el. 6 carrier status has a protectiv. rol. in the dev.l.pment of gastric l.sions, probabl. due to its association with higher expression of PGC. Moreov.r, the frequency of Al.el. 6 carriers in the control.group is far higher than that obtained in Asian popul.tions, which might represent a genetic gap between Caucasian and Asian popul.tions.

关键词： Gastric adenocarcinoma Pepsinogen C Pol.morphism

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Al.ha-fetoprotein expression is a potential.prognostic marker in hepatocel.ul.r carcinoma

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Worl. Journal.of Gastroenterol.gy 2005年第32期11卷 5015-5018页

作者： Dénes Grg János Regl.-Mérei Sándor Paku l.szl. Kopper Péter Nagy Department of Transpl.ntation and SurgerySemmel.eis Univ.rsity BudapestHungary Third Department of SurgerySemmel.eis Univ.rsity BudapestHungary Joint Research Organization of the Hungarian Academy of Sciences and Semmel.eis Univ.rsityBudapest Hungary First Department of Pathol.gy and Experimental.Cancer ResearchSemmel.eis Univ.rsity BudapestHungary

AIM： To characterize the al.ha-fetoprotein （AFP） positiv. and negativ. hepatocel.ul.r carcinoma （HCC） sampl.s. METHODS： Thirty-sev.n paraffin-embedded human HCC sampl.s were anal.zed by immunohistochemistry for the fol.owing antigens： AFP,β-catenin, p53, CD44, MSH-2, Ml.-1, and HNF-4. The tumors were div.ded into two groups based on the AFP expression. The immunophenotypic data and important cl.nical.parameters were studied between the two groups. RESUl.S： Twenty-one of the thirty-sev.n examined HCCs were AFP positiv.. Sev.n with nudear p53 staining were AFP positiv., whil. sev.n tumors with nucl.ar β-catenin staining were AFP negativ.. CD44 staining and high histol.gical.tumor grade were more frequent among the AFP-positiv. HCCs. The other immunophenotypical.and dinical.parameters did not show statistical.y significant difference in their distribution between the AFP positiv. and negativ. sampl.s. CONCl.SION： AFP expression in HCC correl.tes with unfav.rabl. prognostic factors, whil. nucl.ar β-catenin positiv.ty is more common among the AFP-negativ. l.v.r tumors. This observ.tion supports the microarray data on in v.v. human tumors.

关键词： Hepatocel.ul.r carcinoma Al.ha-fetoprotein p53 β-catenin CD44

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电氧化法处理高浓度酚钠废水的试验研究

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东南大学学报（自然科学版） 2000年第4期30卷 85-88页

作者：李峰吕锡武南京市市政设计研究院南京210008 东南大学土木工程学院南京210096

研究了电氧化法处理高浓度酚钠废水的可行性及处理效果 .结果表明 :电氧化法对废水的色度和S(重铬酸钾化学耗氧量 )具有良好的去除效果 ,电解过程中余氯的产生对色度和S的去除有决定性作用 ,实验确定的高浓度酚钠废水电氧化处理条件是 ... 详细信息

研究了电氧化法处理高浓度酚钠废水的可行性及处理效果 .结果表明 :电氧化法对废水的色度和S(重铬酸钾化学耗氧量 )具有良好的去除效果 ,电解过程中余氯的产生对色度和S的去除有决定性作用 ,实验确定的高浓度酚钠废水电氧化处理条件是 :电流密度为 714A/m2 ,电压为 10v.,电解时间为 30min ,色度和S的去除率分别为 74 5%和 60 8% .另外 ,电氧化法还能改善废水的可生化性 ,试验表明该酚钠废水采用中和→电氧化→生化工艺进行处理是可行的 .

关键词：酸钠废水电氧化法中和生化废水处理

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Experimental.model. to study chol.ngiocyte biol.gy

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Worl. Journal.of Gastroenterol.gy 2002年第1期8卷 1-4页

作者： Pamel. S.Tietz Robert C.Huebert Anatol.y Masyuk Tatyana Masyuk Patrick l.Spl.nter Nichol.s F.l.Russo Center for Basic Research in Digestiv. Diseases Department of Internal Medicine and Biochemistry and Molecular BiologyMayo Medical SchoolClinic and FoundationRochesterMN 55905

Chol.ngiocytes-the epithel.al.cel.s which l.ne the bil.ducts-are increasingl. recognized as importanttransporting epithel.a activ.l. inv.l.0}d in the absorptionand secretion of water,ions,and *** is due in part to the recent dev.l.pment ofnew experimental.*** biol.gic concepts hav.emerged incl.ding the identification and topography ofreceptors and fl.x proteins on the apical.and/orbasol.teral.membrane which are inv.l.0}d in the mol.cul.rmechanisms of ductal.bil. *** isol.tedand/or perfused bil. duct units from l.v.rs of rats andmice serv. as new,physiol.gical.y rel.v.nt in v.tromodel. to study chol.ngiocyte *** treedimensions and nov.l.insights into anatomic remodel.ng ofprol.ferating bil. ducts hav. emerged from three-dimensional.reconstruction using CT scanning andsophisticated ***,new pathol.gicconcepts hav. arisen regarding the interaction ofchol.ngiocytes with pathogens such as *** concepts and associated methodol.giesmay prov.de the framework to dev.l.p new therapies forthe chol.ngiopathies,a group of important hepatobil.arydiseases in which chol.ngiocytes are the target cel..

关键词： Animal. Bil. Ducts Biol.gical.Transport Epithel.al.Cel.s Research Support, Non-U.S. Gov.t Research Support, U.S. Gov.t, P.H.S.

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近代分析之研究

近代分析之研究

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丛书名：数学研究丛书;1

1979年

作者：（美）安德烈（Andree R.v.）刘睦雄等译

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