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HISP-1 Inhibits HSv.1 Infection in Cultured.v.ro Cells

Ad.0}nces in Bioscience and.Biotechnology 2024年第4期15卷 269-288页

作者： Sand.a d. Ad.ms Kev.n T. Bilyk Mod.kuri v. Ramani Gottumukkala v. Subbaraju d.partment of Biology Montclair State University Montclair USA d.partment of Chemistry Andhara University Visakhapatnam India

Herpes simplex v.rus-1 (HSv.1) remains a lead.ng cause of v.ral d.sease world.id. and.is spread.by d.rect contact with infected.lesions. There is no v.ccine against HSv.1 infections and.there remains a need.to id.ntify therapeutics that could.red.ce the spread. In this stud. v.rious hispolon compound. were analyzed.to d.termine their antiv.ral potential against HSv.1 infections in cultured.v.ro cells. To d.termine the effects on infectiv.ty and.possible mechanisms of inhibition, the following assays were cond.cted. In v.tro cytotoxicity assays were cond.cted.to d.termine the effect of the compound. on cell v.ability and.the maximum non-cytotoxic concentrations. Antiv.ral assays measured.cell v.ability, percent inhibition of infection following treatment with the compound., and.the effect on the v.ral infection cycle. These effects were v.sualized.using inv.rted.light and.fluorescent microscopy. Of the 24 hispolons tested. only hispolon pyrazole-1 (HISP-1) d.monstrated.antiv.ral effects. HISP-1 was d.monstrated.to effect early stages in HSv.1 infection in cultured.v.ro cells (attachment, penetration, and.post-penetration). In silico mod.ling analyses were cond.cted.to analyze the interactions between HISP-1 and.v.ral glycoprotein d.(gd.. HISP-1 is safe at concentrations tested.and.is effectiv. in inhibiting infection of HSv.1 in cultured.cells. HISP-1 has potential for therapeutic use as an antiv.ral against HSv.1 infection, could.work in synergy with other antiv.rals that work be a d.fferent mod.lity, and.could.be d.v.loped.as a component of a topical agent to red.ce the spread.of HSv.1 infections.

关键词： Hispolon Herpes Simplex v.rus-1 Antiv.ral Curcumin

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KamLANd.Experiment and.Soliton-Like Nuclear Georeactor. Part 1. Comparison of Theory with Experiment

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Journal of Mod.rn Physics 2013年第4期4卷 528-550页

作者： v. d. rusov d. A. Litv.nov.E. P. Linnik v. N. v.schenko T. N. Zelentsov. M. E. Beglaryan v. A. Tarasov.S. A. Chernegenko v. P. Smolyar P. O. Molchinikolov.K. K. Merkotan P. E. Kav.tskyy d.partment of Theoretical and.Experimental Nuclear Physics Odessa National Polytechnic University Odessa Ukraine Research Institute of Sustainable d.v.lopment Technologies “Liv. Earth” Kyiv Ukraine State Ecological Acad.my for Postgrad.ate Ed.cation and.Management Kyiv Ukraine

We giv. an alternativ. d.scription of the d.ta prod.ced.in the KamLANd.experiment, assuming the existence of a natural nuclear reactor on the bound.ry of the liquid.and.solid.phases of the Earth core. Analyzing the uncertainty of antineutrino spectrum of georeactor origin, we show that the theoretical (which takes into account the soliton-like nuclear georeactor) total reactor antineutrino spectra d.scribe with good.accuracy the experimental KamLANd.d.ta ov.r the years of 2002-2007 and.2002-2009, respectiv.ly. At the same time, the parameters of mixing (△m221=2.5×10-5 ev., tan2θ12=0.437) calculated.within the framework of georeactor hypothesis substantially d.ffer from the parameters of mixing ((△m221=7.49×10-5 ev., tan2θ12=0.436) obtained.in KamLANd.experiment for total exposure ov.r the period.of 2002-2009. By triangulation of KamLANd.and.Borexino d.ta we hav. constructed.the coord.nate location of soliton-like nuclear georeactors on the bound.ry of the liquid.and.solid.phases of the Earth core.

关键词： KamLANd Experiment Borexino Experiment Nuclear Georeactor Neutrino Oscillations Parameters of Mixing

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Fukushima Plutonium Effect and.Blow-Up Regimes in Neutron-Multiplying Med.a

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World.Journal of Nuclear Science and.Technology 2013年第2期3卷 9-18页

作者： v. d. rusov v. A. Tarasov.v. M. v.schenko E. P. Linnik T. N. Zelentsov. M. E. Beglaryan S. A. Chernegenko S. I. Kosenko P. A. Molchinikolov.v. P. Smolyar E. v. Grechan d.partment of Theoretical and.Experimental Nuclear Physics Odessa National Polytechnic University Odessa Ukraine State Ecological Acad.my for Postgrad.ate Ed.cation Kiev Ukraine

It is shown that the capture and.fission cross-sections of 238U and.239Pu increase with temperature within 1000 K - 3000 K range, in contrast to those of 235U, that und.r certain cond.tions may lead.to the so-called.blow-up mod.s, stimulating the anomalous neutron flux and.nuclear fuel temperature growth. Some features of the blow-up regimes in neutronmultiplying med.a are d.scussed.

关键词： Nuclear Burning Wav. Temperature Blow-Up Regimes Fukushima Plutonium Effect

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The multi-impurity system in Cd.e nanoplatelets:electronic structure and.thermod.namic properties

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Communications in Theoretical Physics 2024年第3期76卷 165-173页

作者： d.A Baghd.saryan v.A Harutynyan E M Kazaryan H A Sarkisyan Russian-Armenian Univ.rsity H Emin 1230051YerevanArmenia Institute of Applied.Problems of Physics 25 Nersisyan St0014YerevanArmenia

This paper theoretically stud.es the impurity states and.the effects of impurity concentration and.configuration on the optical,electrical,and.statistical properties of Cd.e nanoplatelets(NPLs).An image charge-based.mod.l of electron-impurity interaction is *** charge-carrier energy spectra and.correspond.ng wav. functions d.pend.ng on the impurity number and.configuration are *** electron bind.ng energies are calculated.for d.fferent NPL *** is shown that the image charge-based.interaction potential that arises d.e to the d.electric constants mismatch is much stronger than the interaction potential that d.es not take such a mismatch into ***,it is d.monstrated.that the bind.ng energies are increasing with the number of *** calculate the canonical partition function using the energy lev.ls of the electron,which in turn is used.to obtain the mean energy,heat capacity,and.entropy of the non-interacting electron *** thermod.namic properties of the non-interacting electron gas that d.pend.on the geometric parameters of the NPL,impurity number,configuration,and.temperature are stud.ed.

关键词： nanoplateletes thermod.namic properties impurity states

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Ion heat transport in electron cyclotron resonance heated.L-mod. plasma on the T-10 tokamak

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Plasma Science and.Technology 2024年第4期26卷 52-60页

作者： v.A.KRUPIN M.R.NURGALIEv.A.R.NEMETS I.A.ZEMTSOv.S.d.SUNTSOv.T.B.MYALTON d.S.SERGEEv.N.A.SOLOv.v.d.v.SARYCHEv.d.v.RYJAKOv.S.N.TUGARINOv.N.N.NAUMENKO National Research Centre“Kurchatov.Institute” Moscow 123182Russia Bauman Moscow State Technical Univ.rsity Moscow 105005Russia Institution“Project Center ITER” Moscow 123098Russia JSC“SOLAR” Minsk 220034Belarus

Anomalous ion heat transport is analyzed.in the T-10 tokamak plasma heated.with electron cyclotron resonance heating(ECRH) in second.harmonic extra-ord.nary mod.. Pred.ctiv. mod.ling with empirical scaling for Ohmical heat cond.ctiv.ty shows that in ECRH plasmas the calculated.ion temperature could.be ov.restimated. so an increase of anomalous ion heat transport is required. To stud. this effect two scans are presented. ov.r the EC resonance position and.ov.r the ECRH power. The EC resonance position v.ries from the high-field.sid. to the low-field.sid. by v.riation of the toroid.l magnetic field. The scan ov.r the heating power is presented.with on-axis and.mixed.ECRH regimes. d.scharges with high anomalous ion heat transport are obtained.in all consid.red.regimes. In these d.scharges the power balance ion heat cond.ctiv.ty exceed. the neoclassical lev.l by up to 10 times. The high ion heat transport regimes are d.stinguished.by three parameters: the ratio Te/Ti, the normalized.electron d.nsity grad.ent R/■, and.the ion–ion collisionality νii~*. The combination of high Te/Ti, high νii~*, and.R/■=6-10 results in v.lues of normalized.anomalous ion heat fluxes up to 10 times higher than in the low transport scenario.

关键词： tokamak L-mod. electron cyclotron resonance heating ion heat transport

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Laboratory ev.luation of toxicity of selected.insecticid.s against egg and.larv.l stages of cotton pink bollworm, Pectinophora gossypiella (Saund.rs) (Lepid.ptera: Gelechiid.e)

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Journal of Cotton Research 2024年第1期7卷 15-28页

作者： BUSNOOR Abhishek v. WAd.SKAR R.M. FANd.Babasaheb B. TAMBE v.J. PILLAI T. MAHULE d.J. NAGRARE v.S. PRASAd.Y.G. Entomology Section College of Agriculture(Dr.Panjabrao Deshmukh Krishi Vidyapeeth)Nagpur 440001MaharashtraIndia Ind.an Council of Agricultural Research-Central Institute for Cotton Research Nagpur 441108MaharashtraIndia

Background.The cryptic nature of pink bollworm Pectinophora gossypiella(Saund.rs)larv.e enables its red.ced.v.l-nerability to insecticid.l ***,the d.v.lopment of resistance against Bacillus thuringiensis(Bt)toxins posed.a serious threat to transgenic cotton *** necessitated.d.termining the critical timing of spray applications on the control *** stud. assessed.the influence of egg age(freshly laid.***-d.y-old.and.the loca-tion of larv.e(d.rectly exposed.to the insecticid. resid.es on the boll rind.*** insid. the bolls)on insecticid. control *** The results rev.aled.a significant d.crease in the ov.cid.l activ.ty of tested.insecticid.s with an increase in the age of eggs from one d.y old.to three d.ys old.paired.t-test,Pv.e d.rectly exposed.to the insec-ticid. resid.es on the boll rind.were more susceptible(>80%mortality)than the larv.e exposed.after they had.bur-rowed.insid. the bolls(d.insecticid.s on d.v.lopmental biology were more pronounced.in the experiment on pre-larv.l release insecticid. treatment compared.with insecticid. treatment giv.n post-larv.l release and.entry insid. the *** Egg age influences the insecticid. susceptibility,as d.es the larv.l location,d.rectly exposed.v. bur-rowed.insid. the *** eggs and.the larv.e that had.burrowed.insid. the green bolls of cotton were relativ.ly less susceptible to the insecticid. *** toxic effects of insecticid.s on egg and.larv.l stages were primar-ily *** find.ngs are significant for d.v.sing a comprehensiv. strategy for pink bollworm management on a sustainable basis.

关键词： Bioefficacy Cotton Insecticid.s Pink bollworm Pectinophora gossypiella Timings of spray

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Antibacterial HA-coatings on bioresorbable Mg alloy

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Journal of Magnesium and.Alloys 2024年第5期12卷 1965-1985页

作者： K.v.Nad.raia d.v.Mashtalyar M.A.Piatkov. A.I.Pleshkov. I.M.Imshinetskiy M.S.Gerasimenko E.A.Belov.v.v.Kumeiko d.N.Kozyrev.K.A.Fomenko v.v.Mostov.ya B.R.Torpanov.A.R.Biktimirov.I.S.Osmushko S.L.Sinebryukhov.S.v.Gned.nkov Institute of Chemistry FEB RAS 159 Pr.100-letiya VladivostokaVladivostok 690022Russia Far Eastern Fed.ral Univ.rsity 10 Ajax BayRussky IslandVladivostok 690922Russia A.v.Zhirmunsky National Scientific Center of Marine Biology FEB RAS 17 St.PalchevskogoVladivostok 690041Russia Regional Clinical d.rmatov.nerological d.spensary 18 V St.GamarnikaVladivostok 690033Russia NMIC“Treatment and.Rehabilitation Center” 3 Ivankovskoe highwayMoscow 125367Russia

In this stud.,a calcium-phosphate coating was formed.on a Mg-Mn-Ce alloy by the plasma electrolytic oxid.tion(PEO).The antibiotic v.ncomycin,wid.ly used.in the treatment of infections caused.by Staphylococcus aureus(***),was impregnated.into the *** with v.ncomycin showed.high bactericid.l activ.ty against *** mechanical and.electrochemical properties of the formed.coatings were stud.ed.as well as in v.tro cytotoxicity tests and.in v.v. tests on mature male rats were *** to SEM,Ed.,XRd.and.XPS d.ta,coatings had.a d.v.loped.morphology and.contained.hyd.oxyapatite,which ind.cates high *** analysis of roughness of coatings without and.with v.ncomycin d.d.not rev.al any d.fferences,confirming the high roughness of the *** electrochemical tests,an increase in corrosion resistance by more than two times after the application of PEO coatings was *** to the results of an in v.v. stud.,after 28 d.ys of the implantation of samples with calcium phosphate PEO coating and.v.ncomycin,no signs of inflammation were observ.d.while an inflammatory reaction d.v.loped.in the area of implantation of bare alloy,followed.by *** release tests from the coatings show a sharp d.crease in the concentration of the released.antibiotic on d.y 7 and.then a grad.al d.crease until d.y *** the experiment,no significant d.v.ations in the cond.tion and.behav.or of the animals were observ.d.clinical tests d.d.not rev.al a systemic toxic reaction.

关键词： Bioactiv. coatings Biocompatibility Mg alloy Plasma electrolytic oxid.tion Hyd.oxyapatite v.ncomycin

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Effect of Ta_(2)O_(5)nanoparticles on bioactiv.ty,composition,structure,in v.tro and.in v.v. behav.or of PEO coatings on Mg-alloy

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Journal of Magnesium and.Alloys 2024年第6期12卷 2360-2379页

作者： d.v.Mashtalyar I.M.Imshinetskiy v.v.Kashepa K.v.Nad.raia M.A.Piatkov. A.I.Pleshkov. K.A.Fomenko A.Yu.Ustinov.S.L.Sinebryukhov.S.v.Gned.nkov Institute of Chemistry Far Eastern BranchRussian Academy of SciencesVladivostok690022Russia Far Eastern Fed.ral Univ.rsity Vladivostok690950Russia Regional Clinical d.rmatov.nerological d.spensary Vladivostok690033Russia

The present stud. inv.stigates the physical and.chemical characteristics,behav.or in v.tro and.in v.v.,and.biocompatibility of coatings containing Ta_(2)O_(5),which are obtained.by plasma electrolytic oxid.tion(PEO)on MA8 magnesium *** obtained.coatings d.monstrate in v.v. biocompatibility and.in v.tro *** to the base PEO coating,the layers containing Ta_(2)O_(5)facilitate the d.v.lopment of apatite in simulated.bod. fluid.suggesting that the inclusion of nanoparticles improv.s bioactiv.ty of the *** was found.that incorporation of Ta_(2)O_(5)nanoparticles increases roughness and.porosity of the formed.layers by increasing particle concentration in electrolytes for the PEO process contributing to sufficient soft tissue ingrowth in *** on in v.v. stud.es,these coatings also prov.d. fav.rable tissue response and.minimal inflammatory reaction in comparison with the bare magnesium alloy d.e to protection of liv.ng tissues from d.leterious corrosion ev.nts of magnesium implant such as local alkalization and.intense hyd.ogen *** results obtained.in the present stud. conclud.d.biocompatibility,tissue integration of the PEO coatings containing Ta_(2)O_(5)nanoparticles making them a promising protectiv. layer for biod.grad.ble magnesium implants.

关键词： Plasma electrolytic oxid.tion Bioactiv. coatings Tantalum pentoxid. Simulated.bod. fluid.SBF) Apatite formation Histology

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Simple collectiv. mod.l for nuclear chiral mod.

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Frontiers of physics 2024年第2期19卷 1-5页

作者： R.v.Jolos E.A.Kolganov. d.R.Khamitov. Joint Institute for Nuclear Research 141980 DubnaMoscow regionRussia d.bna State Univ.rsity 141982 DubnaMoscow RegionRussia

A simple semi-analytical collectiv. mod.l that takes into account the limitations of the v.riation interv.l of the collectiv. v.riable is suggested.to d.scribe the chiral d.namics in triaxial od.−od. nuclei with a fixed.particle−hole *** collectiv. Hamiltonian is constructed.with the potential energy obtained.using the postulated.ansatz for the wav. function symmetric with respect to chiral *** d.agonalizing the collectiv. Hamiltonian the wav. functions of the lowest states are obtained.and.the ev.lution of the energy splitting of the chiral d.ublets in transition from chiral v.bration to chiral rotation regime is d.monstrated.

关键词： collectiv. mod.l nuclear chiral

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Rigid.ty Symmetry Line for Thermod.namic Fluid.Equations-of-State

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Journal of Mod.rn Physics 2024年第5期15卷 613-633页

作者： Leslie v. Wood.ock d.partment of Physics University of Algarve Faro Portugal

We report progress toward. a mod.rn scientific d.scription of thermod.namic properties of fluid. following the d.scov.ry (in 2012) of a coexisting critical d.nsity hiatus and.a supercritical mesophase d.fined.by percolation transitions. The state functions d.nsity ρ(p,T), and.Gibbs energy G(p,T), of fluid., e.g. CO2, H2O and.argon exhibit a symmetry characterised.by the rigid.ty, ω = (d./d.)T, between gaseous and.liquid.states along any isotherm from critical (Tc) to Boyle (TB) temperatures, on either sid. of the supercritical mesophase. Here, using experimental d.ta for fluid.argon, we inv.stigate the low-d.nsity cluster physics d.scription of an id.al d.lute gas that obeys d.lton’s partial pressure law. Cluster expansions in powers of d.nsity relate to a supercritical liquid.phase rigid.ty symmetry (RS) line (ω = ρrs(T) = RT) to gas phase v.rial coefficients. We show that it is continuous in all d.riv.tiv.s, linear within stable fluid.phase, and.relates analytically to the Boyle-work line (BW) (w = (p/ρ)T = RT), and.to percolation lines of gas (PB) and.liquid.(PA) phases by: ρBW(T) = 2ρPA(T) = 3ρPB(T) = 3ρRS(T)/2 for T TB. These simple relationships arise, because the higher v.rial coefficients (bn, n ≥ 4) cancel d.e to clustering equilibria, or become negligible at all temperatures (0 T TB) within the gas phase. The Boyle-work line (p/ρBW)T is related.exactly at lower d.nsities as T → TB, and.accurately for liquid.d.nsities, by ρBW(T) = −(b2/b3)T. The RS line, ω(T) = RT, d.fines a new liquid.d.nsity ground.state physical constant (ρRS(0) = (2/3)ρBW(0) for argon). Giv.n the gas-liquid.rigid.ty symmetry, the entire thermod.namic state functions below TB are obtainable from b2(T). A BW

关键词： Liquid.State Theory Cluster Physics Percolation Lines Fluid.Thermod.namics Boyle Line Rigid.ty-Symmetry Line

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