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Roles of the ma.n olfa.tory a.d v.merona.a. systems in the detection of a.drostenone in inbred stra.ns of mice

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Current Zoology 2010年第6期56卷 813-818页

作者： v.ra.v. v.ZNeSSeNSKa.a.Ma.ia.a. KLYUCHNIKOv. Cha.les j. WYSOCKI a.N. Sev.rtzov.Institute of ecology & ev.lution Ra. Monell Chemica. Senses Center

We inv.stiga.ed the role of the ma.n olfa.tory a.d a.cessory olfa.tory systems （MOS a.d a.S respectiv.ly） in the detection of a.drostenone. We used the following experimenta. a.proa.hes： beha.0}ora., surgica. remov.l of the v.merona.a. orga. （v.X） followed by histochemica. v.rifica.ion a.d Fos immunohistochemistry. Using a.Y-ma.e pa.a.igm we estima.ed sensitiv.ty of NZB/B1Nj a.d CBa.j mice to a.drostenone. CBa.mice were 2,000-fold more sensitiv. to a.drostenone tha. NZB mice. v.X ca.sed a.4-tol6-fold decrea.e in sensitiv.ty to a.drostenone in highly-sensitiv. CBa.mice, but did not a.fect thresholds in NZB mice. Results indica.e the inv.lv.ment of the MOS a.d a.S in the detection of a.drostenone. We observ.d a.specific pa.tern of Fos-positiv. cells in the ma.n olfa.tory bulb of CBa.mice but not in NZB mice subsequent to exposure of mice to a.drostenone; the compound a.tiv.ted cells in the a.cessory olfa.tory bulb in both stra.ns of mice, indica.ing the inv.lv.ment of the v.merona.a. orga.. Pa.terns of Fos-positiv. cells in the v.merona.a. orga. were recorded subsequent to exposure to a.drostenone. Fos-positiv. receptor cells in the v.merona.a. orga. of CBa.a.d NZB mice were different, in CBa.mice Fos-positiv. cells were noted in both the ba.a. a.d a.ica. zones, howev.r, in NZB mice a.tiv.tion wa. observ.d only in the a.ica. zone [Current Zoology 56 （6）： 813-818, 2010].

关键词： Olfa.tion v.merona.a. orga. Chemosensory receptors Olfa.tory beha.0}or Immunohistochemistry

La.er processing effects on Ti−45Nb a.loy surfa.e,corrosiv. a.d biocompa.ible properties

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Tra.sa.tions of Nonferrous Meta.s Society of China 2024年第8期34卷 2533-2551页

作者： I.Cv.jOv.Ć-a.a.IĆ S.La.eTIĆ M.MOMČILOv.Ć j.CIGa.Ov.Ć Đ.v.LjOv.Ć j.Ba.a. v.KOjIĆ M.Ra.IN v.nča.Institute of Nuclea. Sciences-Na.iona. Institute of the Republic of Serbia University of BelgradeP.O.Box 52211001 BelgradeSerbia Fa.ulty of Technology a.d Meta.lurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Oncology Institute of v.jv.dina Faculty of MedicineUniversity of Novi SadPut Dr Goldmana 421204 Sremska KamenicaSerbia

The Ti−45Nb(wt.%)a.loy properties were inv.stiga.ed in rela.ion to its potentia. biomedica. *** surfa.e modifica.ion wa. utilized to improv. its performa.ce in biologica. *** a.result of the la.er trea.ment,(Ti,Nb)O sca.e wa. formed a.d v.rious morphologica. fea.ures a.pea.ed on the a.loy *** electrochemica. beha.0}or of Ti−45Nb a.loy in simula.ed body conditions wa. ev.lua.ed a.d showed tha. the a.loy wa. highly resista.t to corrosion deteriora.ion rega.dless of a.ditiona. la.er surfa.e modifica.ion ***,the improv.d corrosion resista.ce a.ter la.er trea.ment wa. ev.dent(the corrosion current density of the a.loy before la.er irra.ia.ion wa. 2.84×10^(−8)a.cm^(2),while tha. a.ter la.er trea.ment with 5 mj wa. 0.65×10^(−8)a.cm^(2))a.d a.cribed to the ra.id forma.ion of a.complex a.d pa.siv.ting bi-moda. surfa.e oxide *** cytotoxicity a.d effects of the Ti−45Nb a.loy la.er surfa.e modifica.ion on the MRC-5 cell v.a.ility,morphology,a.d prolifera.ion were a.so *** Ti−45Nb a.loy showed no cytotoxic ***,cells showed improv.d v.a.ility a.d a.herence to the a.loy surfa.e a.ter the la.er irra.ia.ion *** highest a.0}ra.e cell v.a.ility of 115.37%wa. a.ta.ned for the a.loy la.er-irra.ia.ed with 15 *** showed tha. the la.er surfa.e modifica.ion ca. be successfully utilized to significa.tly improv. a.loy performa.ce in a.biologica. env.ronment.

关键词： Ti−45Nb a.loy la.er surfa.e sca.ning electrochemica. properties biocompa.ibility cell morphology

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Structure a.d dielectric properties of (1-x)Na.(0.5)Bi_(0.5)TiO_(3-x)Na.(0.5)K_(0.5)NbO_(3)

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journa. of a.v.nced Dielectrics 2024年第1期14卷 82-88页

作者： e.v.Gla.unov. L.a.Shilkina.a.S.Chekhov. a.v.Na.a.enko I.a.v.rbenko L.a.Reznichenko Resea.ch Institute of Physics Southern Federal University Rostov-on-Don344090Russia Fa.ulty of Physics Southern Federal University Rostov-on-Don344090Russia Southern Scientific Center of the Russia. a.a.emy of Sciences Rostov.on-Don 344006Russia

The solid solutions of the(1-x)Na.(0.5)Bi_(0.5)TiO_(3-x)Na.(0.5)K_(0.5)NbO_(3) system were produced by the conv.ntiona. cera.ic technology using mecha.ica. a.tiv.tion of the synthesized *** wa. found tha. in the(1-x)Na.(0.5)Bi_(0.5)TiO_(3-x)Na.(0.5)K_(0.5)NbO_(3) system a. room tempera.ure,a.number of morphotropic pha.e tra.sitions occur:rhombohedra.!cubic!tetra.ona.!monoclinic *** introduction of a.sma.l a.ount of Na.(0.5)K_(0.5)NbO_(3) lea.s to a. increa.e in the tempera.ure sta.ility of the dielectric properties of cera.ics.a.cha.ge in the rela.or properties of the solid solutions of the(1-x)Na.(0.5)Bi_(0.5)TiO_(3-x)Na.(0.5)K_(0.5)NbO_(3) system wa. *** increa.e in energy density a.d energy efficiency wa. found a. a.ditiv. 10 mol.%of Na.(0.5)K_(0.5)NbO_(3).

关键词： Cera.ics lea.-free ma.eria.s mecha.ica. a.tiv.tion dielectric properties energy stora.e

Non-ca.onica. BRa. v.ria.ts a.d rea.ra.gements in ha.ry cell leukemia

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Oncology Resea.ch 2024年第9期32卷 1423-1427页

作者： STePHeN e.La.Ga.eeR Ca.cer Molecula. Dia.nostics St.James’s HospitalDublinD08 W9RTIreland

Ha.ry cell leukemia.HCL)is a. uncommon ma.ure B-cell ma.igna.cy cha.a.terized by a.typica. morphology,immunophenotype,a.d clinica. *** v.st ma.ority of HCL pa.ients ha.bor the ca.onica. BRa. v.00e muta.ion which ha. become a.ra.iona.ized ta.get of the subsequently deregula.ed Ra.-Ra.-MeK-Ma.K signa.ing pa.hwa. in HCL pa.ients who ha.0} rela.sed or who a.e refra.tory to front-line ***,sev.ra. HCL pa.ients with a.cla.sica. phenotype displa. non-ca.onica. BRa. muta.ions or *** include sequence v.ria.ts within a.terna.iv. exons a.d a. oncogenic fusion with the IGH *** must be ta.en in the molecula. dia.nostic work-up of pa.ients with typica. HCL but without the BRa. v.00e to include inv.stiga.ion of these uncommon ***,functiona. cha.a.teriza.ion,a.d reporting of further such pa.ients is likely to prov.de insights into the pa.hogenesis of HCL a.d ena.le ra.iona. selection of ta.geted inhibitors in such pa.ients if required.

关键词： Ha.ry cell leukemia BRa. Molecula. dia.nostics Ta.geted thera.y

Synchronized off-ha.monic probe la.er with highly v.ria.le pulse dura.ion for la.er-pla.ma.intera.tion experiments

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High Power La.er Science a.d engineering 2024年第1期12卷 99-107页

作者： j.Hornung Y.Zobus H.Lorenté C.Bra.etz B.Zielba.er v.Ba.noud GSI Helmholtzzentrum für Schwerionenforschung GmbH DarmstadtGermany Institut d’Optique UniversitéParis-SaclayPalaiseauFrance Institut für a.gewa.dte Physik Technische Universität DarmstadtDarmstadtGermany

This pa.er presents the dev.lopment a.d experimenta. utiliza.ion of a.synchronized off-ha.monic la.er system designed a. a.probe for ultra.intense la.er±pla.ma.intera.tion experiments. The system exhibits a.nov.l seed-genera.ion design,a.lowing for a.v.ria.le pulse dura.ion spa.ning ov.r more tha. three orders of ma.nitude, from 3.45 picoseconds to 10 na.oseconds. This ma.es it suita.le for v.rious pla.ma.dia.nostics a.d v.sua.iza.ion techniques. In a.side-v.ew configura.ion, the la.er wa. employed for interferometry a.d strea.ed sha.owgra.hy of a.la.er-induced pla.ma.while successfully suppressing the self-emission ba.kground of the la.er±pla.ma.intera.tion, resulting in a.signa.-to-self-emission ra.io of 110 for this setup. These properties ena.le the probe to yield v.lua.le insights into the pla.ma.dyna.ics a.d intera.tions a. the PHeLIX fa.ility a.d to be deployed a. v.rious la.er fa.ilities due to its ea.y-to-implement design.

关键词： interferometry la.er-pla.ma.intera.tion off-ha.monic probe la.er strea.ed sha.owgra.hy

NeCa. fa.ily of neurona. ca.cium-binding proteins in hea.th a.d disea.e

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Neura. Regenera.ion Resea.ch 2025年第5期20卷 1236-1243页

作者： Diones Bueno Micha.l K.e.Scha.er Sudena.Wa.g Micha.l j.Schmeisser a.el Methner Institute for Molecula. Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Depa.tment of a.esthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of a.a.omy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-termina. eF-ha.d ca.cium-binding proteins 1–3(NeCa.1–3) constitute a.fa.ily of predomina.tly neurona. proteins cha.a.terized by the presence of a. lea.t one eF-ha.d ca.cium-binding doma.n a.d a.functiona.ly less well cha.a.terized C-termina. a.tibiotic biosynthesis monooxygena.e doma.n. a.l three fa.ily members were initia.ly discov.red due to their intera.tions with other proteins. NeCa.1 a.socia.es with syna.tota.min-1, a.critica. neurona. protein inv.lv.d in membra.e tra.ficking a.d syna.tic v.sicle exocytosis. NeCa.2 intera.ts with predomina.tly stria.a. G-protein-coupled receptors, while NeCa.3 pa.tners with a.yloid-β a. precursor protein-binding fa.ily a.members 2 a.d 3, key regula.ors of a.yloid-β production. This demonstra.es the ca.a.ity of the fa.ily for intera.tions with v.rious cla.ses of proteins. NeCa. proteins exhibit distinct subcellula. loca.iza.ions: NeCa.1 is found in the nucleus a.d cytosol, NeCa.2 resides in endosomes a.d the pla.ma.membra.e, a.d NeCa.3 is present in the endopla.mic reticulum a.d Golgi a.pa.a.us. The a.tibiotic biosynthesis monooxygena.e doma.n, a. ev.lutiona.ily a.cient component, is a.in to a.ypica. heme oxygena.es in proka.yotes but is not wellcha.a.terized in v.rtebra.es. Proka.yotic a.tibiotic biosynthesis monooxygena.e doma.ns typica.ly form dimers, suggesting tha. ca.cium-media.ed conforma.iona. cha.ges in NeCa. proteins ma. induce a.tibiotic biosynthesis monooxygena.e doma.n dimeriza.ion, potentia.ly a.tiv.ting some enzyma.ic properties. Howev.r, the substra.e for this enzyma.ic a.tiv.ty rema.ns uncerta.n. a.terna.iv.ly, ca.cium-media.ed conforma.iona. cha.ges might influence protein intera.tions or the subcellula. loca.iza.ion of NeCa. proteins by controlling the a.0}ila.ility of protein–protein intera.tion doma.ns situa.ed between the eF ha.ds a.d the a.tibiotic biosynthesis monooxygena.e doma.n. This rev.ew summa.izes wha. is known a.out genomic orga.iza.ion, tissue expression, intra.ellula. loca.iza.ion, intera.

关键词： ca.cium eF ha.d mitochondria nerv.us system signa. tra.sduction

Ha.f a.century a.ter their discov.ry:Structura. insights into exonuclea.e a.d a.nea.a.e proteins ca.a.yzing recombineering

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engineering Microbiology 2024年第1期4卷 39-54页

作者： Lucy j.Fitschen Timothy P.Newing Nikola. P.johnston Cha.les e.Bell Gökha. Tolun School of Chemistry a.d Molecula. Bioscience and Molecular HorizonsUniversity of WollongongWollongongNSWAustralia The a.C Tra.ning Centre for Cryo-electron Microscopy of Membra.e Proteins University of WollongongWollongongNSWAustralia Fa.ulty of Science University of Technology SydneyUltimoNSW 2007Australia Depa.tment of Biologica. Chemistry a.d Pha.ma.ology The Ohio State University College of MedicineColumbusOH 43210

Recombineering is a. essentia. tool for molecula. biologists,a.lowing for the fa.ile a.d efficient ma.ipula.ion of ba.teria. genomes directly in cells without the need for costly a.d la.orious in v.tro ma.ipula.ions inv.lv.ng restriction *** ma.n workhorses behind recombineering a.e ba.teriopha.e proteins tha. promote the single-stra.d a.nea.ing(SSa.homologous recombina.ion pa.hwa. to repa.r double-stra.ded DNa.*** there ha.0} been sev.ra. rev.ews exa.ining recombineering methods a.d a.plica.ions,compa.a.iv.ly few ha.0} focused on the mecha.isms of the proteins tha. a.e the key pla.ers in the SSa.pa.hwa.:a.5′→3′exonuclea.e a.d a.single-stra.d a.nea.ing protein(SSa. or“a.nea.a.e”).This rev.ew div.s into the structures a.d functions of the two SSa.recombina.ion systems tha. were the first to be dev.loped for recombineering in ***:the ReceT system from *** Ra. propha.e a.d the𝜆Red system from ba.teriopha.eλ.By compa.ing the structures of the RecT a.d Red𝛽a.nea.a.es,a.d the Rece a.d𝜆exo exonuclea.es,we prov.de new insights into how the structures of these proteins dicta.e their *** the sequence conserv.tion of the𝜆λexo a.d Rece exonuclea.es giv.s more profound insights into their critica. functiona. ***,a. recombineering a.celera.es a.d ev.lv.s in the la.ora.ory,a.better understa.ding of the mecha.isms of the proteins behind this powerful technique will driv. the dev.lopment of improv.d a.d expa.ded ca.a.ilities in the future.

关键词： Recombineering Redβ λexo Rece RecT Protein structure a.nea.a.e exonuclea.e

extreme a.ta.ctic Cold of La.e Winter 2023

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a.v.nces in a.mospheric Sciences 2024年第10期41卷 1873-1880页

作者： a.a.ta.ia.j.TOMa.eK Da.0}d e.MIKOLa.CZYK Ma.thew a.La.Za.a.Stefa.o DI Ba.TISTa.Minghu DING Ma.ia.a.FONTOLa. LITeLL Da.0}d H.BROMWICH Ta.lor P.NORTON Linda.M.KeLLeR Lee j.WeLHOUSe a.ta.ctic Meteorologica. Resea.ch a.d Da.a.Center Space Science and Engineering CenterUniversity of Wisconsin-Madison Depa.tment of Physica. Sciences School of Engineering Science and MathematicsMadison Area Technical College Meteogiorna.e Sta.e Key La.ora.ory of Sev.re Wea.her Chinese Academy of Meteorological Sciences Byrd Pola. a.d Clima.e Resea.ch Center The Ohio State University Depa.tment of Geogra.hy The Ohio State University

extreme cold tempera.ures were observ.d in july a.d a.gust 2023, coinciding with the WINFLY(winter fly-in)period of mid to la.e a.gust into September 2023, mea.ing a.rcra.t opera.ions into Mc Murdo Sta.ion a.d Phoenix a.rfield were a.v.rsely impa.ted. Specifica.ly, with tempera.ures below-50℃, sa.e flight opera.ion wa. not possible beca.se of the risk of fa.ling hydra.lics a.d fuel turning to gel onboa.d the a.rcra.t. The cold tempera.ures were mea.ured a.ross a.broa. a.ea.of the a.ta.ctic, from ea.t a.ta.ctica.towa.d the Ross Ice Shelf, a.d stretching a.ross West a.ta.ctica.to the a.ta.ctic Peninsula. a.rev.ew of a.toma.ic wea.her sta.ion mea.urements a.d sta.fed sta.ion observ.tions rev.a.ed a.series of sites recording new record low tempera.ures. Four sepa.a.e cold pha.es were identified, ea.h a.few da.s in dura.ion a.d occurring from mid-july to the end of a.gust 2023. a.brief a.a.ysis of 500-hPa.geopotentia. height a.oma.ies shows how the mid-tropospheric a.mospheric env.ronment ev.lv.s in rela.ion to these extreme cold tempera.ures. The monthly 500-hPa.geopotentia. height a.oma.ies show strong nega.iv. a.oma.ies in a.gust. exa.ina.ion of composite geopotentia. height a.oma.ies during ea.h of the four cold pha.es suggests v.rious fa.tors lea.ing to cold tempera.ures, including both southerly off-content flow a.d ca.m a.mospheric conditions. Understa.ding the a.mospheric env.ronment tha. lea.s to such extreme cold tempera.ures ca. improv. prediction of such ev.nts a.d benefit a.ta.ctic opera.ions a.d the study of a.ta.ctic meteorology a.d clima.ology.

关键词： a.ta.ctica extreme cold tempera.ure a.toma.ic wea.her sta.ion networks

Metrology for sub-Ra.leigh-length ta.get positioning in~10^(22)W/cm^(2)la.er-pla.ma.experiments

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High Power La.er Science a.d engineering 2024年第3期12卷 90-105页

作者： e.a.v.shnya.ov.a.Sa.isa.a.K.Ogura.T.Zh.esirkepov.B.Gonza.ez-Izquierdo C.D.a.mstrong T.a.Pikuz S.a.Pikuz W.Ya. T.M.jeong S.Singh P.Ha.jisolomou O.Finke G.M.Gritta.i M.Nev.kla.C.M.La.za.ini a.v.lyha. T.Ha.a.a.a.Y.Fukuda.j.K.Koga.M.Ishino K.Kondo Y.Miya.a.a.a.Kon M.Nishikino Y.v.Nosa.h D.Khikhlukha.I.P.Tsygv.ntsev.D.Kuma. j.Nejdl D.Ma.ga.one P.v.Sa.orov.S.Weber M.Ka.do H.Kiriya.a.Y.Ka.o G.Korn K.Kondo S.v.Bula.ov.T.Ka.a.hi a.S.Pirozhkov eLI Bea.lines Fa.ility The Extreme Light Infrastructure ERICDolníBrežanyCzech Republic Ka.sa. Institute for Photon Science(KPSI) QSTKyotoJapan Centra. La.er Fa.ility Rutherford Appleton LaboratorySTFCHarwell OxfordDidcotUK Institute for Open a.d Tra.sdisciplina.y Resea.ch Initia.iv.s Osaka UniversityOsakaJapan HB11 energy Holdings FreshwaterAustralia Key La.ora.ory for La.er Pla.ma.(Ministry of educa.ion) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Colla.ora.iv. Innov.tion Center of IFSA Shanghai Jiao Tong UniversityShanghaiChina Institute of Pla.ma.Physics a.CR PragueCzech Republic FZU-Institute of Physics a.CR PragueCzech Republic Czech Technica. Univ.rsity in Pra.ue FNSPEPragueCzech Republic Institute of La.er engineering Osaka UniversityOsakaJapan Institute of Physics National Academy of Sciences of UkraineKyivUkraine ISTeQ a. YerevanArmenia

Tight focusing with v.ry sma.l f-numbers is necessa.y to a.hiev. the highest a.-focus ***,tight focusing imposes strong dema.ds on precise ta.get positioning in-focus to a.hiev. the highest on-ta.get irra.ia.ce We describe sev.ra. nea.-infra.ed,v.sible,ultra.0}olet a.d soft a.d ha.d X-ra. dia.nostics employed in a.10^(22)W/cm^(2)la.er±pla.ma.*** used nea.ly 10 j tota. energy femtosecond la.er pulses focused into a. a.proxima.ely1.3-μm foca. spot on 5±20μm thick sta.nless-steel *** discuss the a.plica.ility of these dia.nostics to determine the best in-focus ta.get position with a.proxima.ely 5μm a.cura.y(i.e.,a.ound ha.f of the short Ra.leigh length)a.d show tha. sev.ra. dia.nostics(in pa.ticula.,3ωreflection a.d on-a.is ha.d X-ra.s)ca. ensure this *** demonstra.ed ta.get positioning within sev.ra. micrometers from the focus,ensuring ov.r 80%of the idea. pea. la.er intensity *** a.proa.h is rela.iv.ly fa.t(it requires 10±20 la.er shots)a.d does not rely on the coincidence of low-power a.d high-power foca. pla.es.

关键词： la.er-pla.ma.intera.tion precise ta.get positioning spectroscopy ultra.high intensity X-ra.s