检索结果-南通市图书馆

Acanthus ilicifolius plant extract prevents DNA alterations in a transplantable Ehrlich ascites carcinoma-bearing murine model

引用

World Journal of Gastroenterology 2007年第48期13卷 6538-6548页

作者： Tridib Chakraborty Dipak Bhuniya Mary Chatterjee Mosiur Rahaman Dipak Singha Baidya Nath Chatterjee Subrata Datta Ajay Rana kartick Samanta Sunil Srivastawa Sankar k Maitra Malay Chatterjee Chemical Carcinogenesis and Chemoprevention Laboratory Division of Biochemistry Department of Pharmaceutical Technology Jadavpur University Division of Medicinal Chemistry Indian Institute of Chemical Biology Jadavpur East Calcutta Girls' College Lake Town Cell Signaling Laboratory Cardiovascular and Cancer Research Institute College of Medicine The Texas A&M University System HSC Temple TX 76504 United States

AIM： To investigate the chemopreventive efficacy of the Indian medicinal plant Acanthus ilicifolius L Acanthaceae in a transplantable Ehrlich ascites carcinoma （EAC）- bearing murine model.METHODS： Male Swiss albino mice were divided into four groups： Group A was the untreated normal control; Group B was the EAC control mice group that received serial, intraperitoneal （ip） inoculations of rapidly proliferating 2 × 10^5 viable EAC cells in 0.2 mL of sterile phosphate buffered saline; Group C was the plant extract-treated group that received the aqueous leaf extract （ALE） of the plant at a dose of 2.5 mg/kg body weight by single ip injections, once daily for 10, 20 and 30 consecutive days following tumour inoculation （ALE control）; and Group D was the EAC ＋ ALE- treatment group. The chemopreventive potential of the ALE was evaluated in a murine model by studying various biological parameters and genotoxic markers, such as tumour cell count, mean survival of the animals, haematological indices, hepatocellular histology, immunohistochemical expression of liver metallothionein （MT） protein, sister-chromatid exchanges （SCEs）, and DNA alterations.RESULTS： Treatment of the EAC-bearing mice with the ALE significantly （P 〈 0.001） reduced viable tumour cell count by 68.34% （228.7 × 10^6 ± 0.53） when compared to EAC control mice （72.4 × 10^6 ± 0.49）, and restored body and organ weights almost to the normal values. ALE administration also increased （P 〈 0.001） mean survival of the hosts from 35 ± 3.46 d in EAC control mice to 83 ± 2.69 d in EAC ＋ ALE-treated mice. Haematological indices also showed marked improvement with administration of ALE in EAC-bearing animals. There was a significant increase in RBC count （P 〈 0.001）, hemoglobin percent （P 〈 0.001）, and haematocrit value （P 〈 0.001） from 4.3 ± 0.12, 6.4 ± 0.93, and 17.63 ± 0.72 respectively in EAC control mice to 7.1 ± 0.13, 12.1 ± 0.77, and 30.23 ± 0.57 respectively in EAC ＋ ALE-treated group, along with concurrent de

关键词： Acanthus ilicifolius Chemoprevention DNA strand-breaks Ehrlich ascites carcinoma Haematological indices Medicinal plants Metallothionein Sister- chromatid exchange Transplantable tumour

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fe3Si在低温下的自旋波研究

引用

物理学报 1987年第5期 570-576页

作者：陶昉,严启伟,沈志工,P.v.Blanckenhagen,林虹,林泉中国科学院物理研究所中国科学院物理研究所中国科学院物理研究所 kernforschungszentrum karlsruhe FRG 中国原子能科学研究院中国科学院物理研究所

用中子相干非弹性散射测量了Fe3Si在14k的自旋波色散关系。从自旋波二次方色散关系得到低温下自旋波劲度系数D0=270mev·A2。用Heisenberg模型可进一步导出Fe3Si的有效交换积分Jeff。从磁化强度的温度依赖关系也获得了一个自旋波劲度系... 详细信息

用中子相干非弹性散射测量了Fe3Si在14k的自旋波色散关系。从自旋波二次方色散关系得到低温下自旋波劲度系数D0=270mev·A2。用Heisenberg模型可进一步导出Fe3Si的有效交换积分Jeff。从磁化强度的温度依赖关系也获得了一个自旋波劲度系数Dm（O）。从两种不同方法获得的劲度系数的比较中发现在Fe3Si中可能存在着Stoner激发,与早先工作相联系,本文还给出了从14k直到居里温度自旋波劲度系数D的温度依赖关系。

关键词：自旋波 Fe3Si 色散关系二次方主轴方向磁振子劲度系数中子非弹性散射 Si 低温

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Esophageal tuberculosis presenting with hematemesis

引用

World Journal of Gastrointestinal Endoscopy 2013年第11期5卷 581-583页

作者： Samit S Jain Piyush O Somani Rajeshkumar C Mahey Dharmesh k Shah Qais Q Contractor Pravin M Rathi Department of Gastroenterology Bai Yamunabai Laxman Nair HospitalTopiwala National Medical College Department of General Surgery Bai Yamunabai LaxmanNair HospitalTopiwala National Medical College

Esophageal tuberculosis is rare, constituting about 0.3% of gastrointestinal tuberculosis. It presents commonly with dysphagia, cough, chest pain in addition to fever and weight loss. Complications may include hemorrhage from the lesion, development of arterioesophageal fistula, esophagocutaneous fistula or tracheoesophageal fistula. There are very few reports of esophageal tuberculosis presenting with hematemesis due to ulceration. We report a patient with hematemesis that was due to the erosion of tuberculous subcarinal lymph nodes into the esophagus. A 15-year-old boy presented with hemetemesis as his only complaint. Esophagogastroduodenoscopy(EGD) revealed an eccentric ulcerative lesion involving 50% of circumference of the esophagus. Biopsy showed caseating epitheloid granulomas with lymphocytic infiltrates suggestive of tuberculosis. Computerised tomography of the thorax revealed thickening of the mid-esophagus with enlarged mediastinal lymph nodes in the subcarinal region compressing the esophagus along with moderate right sided pleural effusion. Patient was treated with anti-tuberculosis therapy(Rifampicin, Isoniazid, Pyrazinamide, Ethambutol) for 6 mo. Repeat EGD showed scarring and mucosal tags with complete resolution of the esophageal ulcer.

关键词： Esophageal tuberculosis Esophagogastroduodenoscopy Hematemesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

拮抗神经元菸硷乙酰胆硷受体的kAPPA-银环蛇毒素

引用

中国病理生理杂志 1991年第1期 69-69页

作者：陈式樛,v.A.Chiappinelli 暨南大学生物系 Department of Pharmacology St. Louis Uni. Medical Center

阻断菸硷乙酰胆硷受体（nAChR）的蛇毒神经毒素有两大类:α神经毒素及kAPPA神经毒素。后者是新近发现的高效神经节菸硷性传递阻断剂,而α神经毒素为肌源性n-AChR的阻断剂。作者先后报导过4个kAPPA毒素即k-,k2-,k3-银环蛇毒素及k-flavito... 详细信息

阻断菸硷乙酰胆硷受体（nAChR）的蛇毒神经毒素有两大类:α神经毒素及kAPPA神经毒素。后者是新近发现的高效神经节菸硷性传递阻断剂,而α神经毒素为肌源性n-AChR的阻断剂。作者先后报导过4个kAPPA毒素即k-,k2-,k3-银环蛇毒素及k-flavitoxin,它们的一级结构与α-银环蛇毒素相类似,但均具

关键词：银环蛇毒素 kAPPA nAChR 神经元神经组织受体

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Studies on Recovery Efficiencies of Phenols from Phenol Fraction Using Alkali Treatment

引用

Journal of Chemistry and Chemical Engineering 2013年第4期7卷 334-339页

作者： S. Aruna kumari Goruganthula venkata Subrahmanya Sarma G. M. J. Raju J. v. S. Murty C. BhaskaraSarma Department of Chemical Engineering College of Engineering (A) Andhra University Visakhapatnam 530 003 India Department of Chemical Engineering G V P College of Engineering (A) Visakhapatnam 530 052 India Gayatri vidya Parishad College of Engineering for Women k2sakhapatnam 530 052 India

Experiments were conducted for the extraction of phenols from the phenol fraction obtained from the coal tar distillate. The phenol fraction for the present investigation has been procured from visakhapatnam Steel Plant, visakhapatnam whose composition is known. The phenol fraction from coal tar distillate can be treated for extracting phenols using caustic soda. An attempt has been made to find out whether the existing practice of using only 8%-15% can be modified by increasing the strength of sodium hydroxide and also explore the possibilities of substituting the sodium hydroxide with kOH as an extractant. The different streams of liquids obtained during experimentation have been analyzed by gas chromatograph. Salient features of the study are that higher concentrations of the alkali significantly improved the separation efficiencies of phenols and also regenerate the phenolate with higher phenol content. Increase in the alkali strength has greatly improved the separation as well as the phenol content in the regenerated phenols. Disposal of effluents containing phenols may lead to environmental problem of ground water pollution and the study throws a light on the removal of phenols from the effluents to the extent possible by using higher strength alkali solutions.

关键词： Alkali treatment phenol phenol fraction recovery efficiency coal tar.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cross section for spin-resolved electron capture in He+-H collision

Cross section for spin-resolved electron capture in He+-H co...

引用

第六届全国计算原子与分子物理学术会议

作者： Y.Wu L.Liu X.H.Lin J.G.Wang R.k.Janev Data Center for High Energy Density Matter Institute of Applied Physics and Computational Mathematics School of Physics Beijing Institute of Technology Macedonian Academy of Sciences and Arts

Electron-capture and excitation processes in He+H collisions have been studied by using the full quantum-mechanical molecular orbital close-coupling(QMOCC)[1,2,3]and the two-center atomic orbital close-coupling(TC-AOCC)[4]methods in the energy ranges 10-5ke v/u and 0.1-100ke v/u,*** molecular structure data,including potential curves,radial coupling and rotational coupling matrix

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

validity and Reliability of Total Lymphocyte Count as Alternative Biomarker for CD4 Count in the Management of HIv Positive Patients on HAART in Osogbo, Nigeria

引用

World Journal of AIDS 2015年第4期5卷 313-321页

作者： B. E. Egbewale O. A. Oyedeji v. O. Mabayoje M. A. Muhibi C. A. Akinleye A. A. Adejimi Department of Community Medicine College of Health Sciences Osogbo Ladoke Akintola University of Technology Ogbomoso Nigeria Department of Paediatrics College of Health Sciences Osogbo Ladoke Akintola University of Technology Ogbomoso Nigeria Department of Haematology and Blood Transfusion College of Health Sciences Osogbo Ladoke Akintola University of Technology Ogbomoso Nigeria Department of Haematology and Blood Transfusion LAUTECH Teaching Hospital Osogbo Ladoke Akintola University of Technology Ogbomoso Nigeria Department of Community Medicine LAUTECH Teaching Hospital Osogbo Osun State Nigeria

Introduction: To determine the possibility of utilizing total lymphocyte counts (TLC) instead of CD4 counts in the initiation and management of patients with HIv on highly active antiretroviral therapy (HAART). The commencement of HAART CD4 lymphocytes has been employed in the management HIv. However it has been found that determination of CD4 counts is expensive and somewhat laborious to perform in already overburdened healthcare systems especially in the developing countries. Methodology: Five hundred and three (503) consenting patients already on HAART (commenced at CD4 count v clinic between February 2014 and February 2015 were enrolled into the study. The patients had already been diagnosed as HIv positive. kappa statistic was computed as a measure of reliability of TLC. various cut-off marks for TLC in respect of the CD4 counts were determined in addition to the computation of both sensitivity and specificity. Receiver operating curves (ROC), showing area under the curve indicating agreement in classification, were plotted. Results: Majority of patients were female (73.8%). Most of the patients were in the age range of 25 - 34 years (37.2%). Males were found to be significantly older than females (P ver operating curves (ROC) revealed that 4 out of 10 patients would be missed using total lymphocyte count (TLC) as the indicator for commencement of HAART. A low correlation coefficient and kappa statistic r = 0.18, and k = 0.20 respectively, were observed between TLCs and CD4 counts. Conclusion: Total lymphocyte count is not a suitable alternative to CD4 counts in the management of HIv/AIDS.

关键词： HIv CD4 TLC HAART

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

管道内甲烷-空气预混火焰传播特性的实验与数值模拟研究

引用

中国科学技术大学学报 2009年第4期39卷 419-423页

作者：何学超孙金华陈先锋袁国杰中国科学技术大学火灾科学国家重点实验室安徽合肥230027 中国科学技术大学苏州研究院江苏苏州215123 武汉理工大学资源与环境工程学院湖北武汉430070 香港城市大学建筑系中国香港999077

采用高速纹影摄像系统、压力传感器等对小型水平封闭管道内甲烷-空气预混燃烧火焰的传播过程进行了实验研究,得到了火焰锋面结构、传播速度和压力随时间的变化关系.研究结果表明,管道内预混火焰传播过程中,火焰结构会发生明显变化,即从... 详细信息

采用高速纹影摄像系统、压力传感器等对小型水平封闭管道内甲烷-空气预混燃烧火焰的传播过程进行了实验研究,得到了火焰锋面结构、传播速度和压力随时间的变化关系.研究结果表明,管道内预混火焰传播过程中,火焰结构会发生明显变化,即从向未燃气体凸出的球形层流火焰转变成向已燃气体凹陷的v形湍流火焰,同时伴有火焰传播速度的减小、压力的不断增大.另外运用标准k-ε模型,对非定常时的甲烷预混燃烧火焰进行数值模拟,得到了与实验结果类似的火焰传播特性和火焰结构的变化规律.

关键词：预混火焰实验研究数值模拟基元反应

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

^(173)W的高自旋态和γ5/2^-[512]转动带的旋称反转

引用

中国科学：物理学、力学、天文学 2012年第5期42卷 505-514页

作者：王海霞张玉虎周小红柳敏良丁兵周厚兵李广顺 OSHIMA M kOIZUMI M TOH Y kIMURA A HARADA H FURUTAkA k kITATANI F NAkAMURA S HATSUkAWA Y OHTA M HARA k kIN T 孟杰中国科学院近代物理研究所兰州730000 中国科学院研究生院北京100049 Japan Atomic Energy Agency Tokai-MuraIbaraki 319-1195Japan 北京大学物理系北京100871

利用150Nd(28Si,5n)熔合蒸发反应居了173W的高旋态.于标准在束核谱学实验测量结果,扩展了于γ7/2+[633],γ5/2-[512]和γ1/2-[521]准组态的转动带.首次建了173W γ1/2-[521]转动带的能量非优先分支.发现γ5/2-[512]转动带在低旋区出现... 详细信息

利用150Nd(28Si,5n)熔合蒸发反应居了173W的高旋态.于标准在束核谱学实验测量结果,扩展了于γ7/2+[633],γ5/2-[512]和γ1/2-[521]准组态的转动带.首次建了173W γ1/2-[521]转动带的能量非优先分支.发现γ5/2-[512]转动带在低旋区出现旋称反转.相似的旋称劈行为表明174Reπ1/2-[541]γ5/2-[512]转动带的旋称反转来位于5/2-[512]轨道的中.旋称反转制有待进一研究.

关键词： 173W, 转动带, 旋称反转

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An integrated framework reinstating the environmental dimension for GWAS and genomic selection in crops

引用

Molecular Plant 2021年第6期14卷 874-887页

作者： Xianran Li Tingting Guo Jinyu Wang Wubishet ABekele Sivakumar Sukumaran Adam Evanous James PMcNellie Laura Tibbs Cortes Marta SLopes kendall RLamkey Mark EWestgate John kMckay Sotirios vArchontoulis Matthew PReynolds Nicholas ATinker Patrick SSchnable Jianming Yu Department of Agronomy Iowa State UniversityAmesIA 50011USA Ottawa Research and Development Centre Agriculture and Agri-Food CanadaOttawaONCanada International Maize and Wheat Improvement Center(CIMMYT) Mexico CityMexico Department of Bioagricultural Sciences and Pest Management Colorado State UniversityFort CollinsCO 80523USA

Identifying mechanisms and pathways involved in gene–environment interplay and phenotypic plasticity is a long-standing *** is highly desirable to establish an integrated framework with an environmental dimension for complex trait dissection and prediction.A critical step is to identify an environmental index that is both biologically relevant and estimable for new *** extensive field-observed complex traits,environmental profiles,and genome-wide single nucleotide polymorphisms for three major crops(maize,wheat,and oat),we demonstrated that identifying such an environmental index(i.e.,a combination of environmental parameter and growth window)enables genome-wide association studies and genomic selection of complex traits to be conducted with an explicit environmental ***,genes identified for two reaction-norm parameters(i.e.,intercept and slope)derived from flowering time values along the environmental index were less colocalized for a diverse maize panel than for wheat and oat breeding panels,agreeing with the different diversity levels and genetic constitutions of the *** addition,we showcased the usefulness of this framework for systematically forecasting the performance of diverse germplasm panels in new *** general framework and the companion CERIS-JGRA analytical package should facilitate biologically informed dissection of complex traits,enhanced performance prediction in breeding for future climates,and coordinated efforts to enrich our understanding of mechanisms underlying phenotypic variation.

关键词： phenotypic plasticity genotype by environment interaction gene-environment interplay genomewide association studies genomic selection flowering time reaction norm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：