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Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Cosmology with an Effective Λ-Term in Lyra Manifold

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Chinese Physics Letters 2013年第11期30卷 215-219页

作者： v.k.Shchigolev Department of Theoretical Physics Ulyanovsk State UniversityUlyanovsk 432000Russia

A cosmological model in Lyra's geometry is studied under the assumption that an effective cosmological term appears in the field equations as the result of interaction between the displacement vector field and an auxiliaryΛ*** exact solutions to the model equations are obtained and preliminarily studied for the simplest cases in order to illustrate how such a model works.

关键词： equations exact auxiliary

Effect of Welding Processes on Tensile and Impact Properties,Hardness and Microstructure of AISI 409M Ferritic Stainless Joints Fabricated by Duplex Stainless Steel Filler Metal

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Journal of Iron and Steel Research International 2009年第5期16卷 66-72页

作者： A k Lakshminarayanan k Shanmugam v Balasubramanian Centre for Materials Joining and Research(CEMAJOR) Department of Manufacturing EngineeringAnnamalai University

The effect of welding processes such as shielded metal arc welding, gas metal arc welding and gas tungsten arc welding on tensile and impact properties of the ferritic stainless steel conforming to AISI 409M grade is studied. Rolled plates of 4 mm thickness were used as the base material for preparing single pass butt welded joints. Tensile and impact properties, microhardness, microstructure and fracture surface morphology of the welded joints have been evaluated and the results are compared. From this investigatio.n, it is found that gas tungsten arc welded joints of ferritic stainless steel have superior tensile and impact properties compared with shielded metal arc and gas metal arc welded joints and this is mainly due to the presence of finer grains in fusion zone and heat affected zone.

关键词： ferritic stainless steel shielded metal arc welding gas metal arc welding gas tungsten arc welding tensile impact property

Effect of Autogenous Arc Welding Processes on Tensile and Impact Properties of Ferritic Stainless Steel Joints

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Journal of Iron and Steel Research International 2009年第1期16卷 62-68,16页

作者： A k Lakshminarayanan k Shanmugam v Balasubramanian Centre of Materials Joining and Research (CEMAJOR) Department of Manufacturing EngineeringAnnamalai UniversityAnnamalai Nagar-608002Tamil NaduIndia

The effect of autogeneous arc welding processes on tensile and impact properties of ferritic stainless steel conformed to AISI 409M grade is studied. Rolled plates of 4 mm thickness have been used as the base material for preparing single pass butt welded joints. Tensile and impact properties, microhardness, microstructure, and fracture surface morphology of continuous current gas tungsten arc welding （CCGTAW）, pulsed current gas tungsten arc welding （PCGTAW）, and plasma arc welding （PAW） joints are evaluated and the results are compared. It is found that the PAW joints of ferritic stainless steel show superior tensile and impact properties when compared with CCG-TAW and PCGTAW joints, and this is mainly due to lower heat input, finer fusion zone grain diameter, and higher fusion zone hardness.

关键词： ferritic stainless steel plasma arc welding continuous current gas tungsten arc welding pulsed currentgas tungsten arc welding tensile property impact property

Evaluation of Microstructure and Mechanical Properties of Laser Beam Welded AISI 409M Grade Ferritic Stainless Steel

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Journal of Iron and Steel Research International 2012年第1期19卷 72-78页

作者： A k Lakshminarayanan v Balasubramanian Department of Manufacturing Engineering Annamalai University

The microstructure analysis and mechanical properties evaluation of laser beam welded AISI 409M ferritic stainless steel joints are investigated. Single pass autogeneous welds free of volumetric defects were produced at a welding speed of 3 000 mm/min. The joints were subjected to optical microscope, scanning electron fractographe, microhardness, transverse and longitudinal tensile, bend and charpy impact toughness testing. The coarse ferrite grains in the base metal were changed into dendritic grains as a result of rapid solidification of laser beam welds. Tensile testing indicates overmatching of the weld metal is relative to the base metal. The joints also exhibited acceptable impact toughness and bend strength properties.

关键词： laser beam welding ferritic stainless steel tensile property impact property

Cosmological Models with Fractional Derivatives and Fractional Action Functional

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Communications in Theoretical Physics 2011年第8期56卷 389-396页

作者： v.k.Shchigolev Department of Theoretical Physics Faculty of Physics and EngineeringUlyanovsk State University

Cosmological models of a scalar field with dynamical equations containing fractional derivatives or derived from the Einstein-Hilbert action of fractional order, are constructed. A number of exact solutions to those e... 详细信息

关键词： fractional derivative and integral cosmology

Effect of Heat Input on Fume Generation and Joint Properties of Gas Metal Arc Welded Austenitic Stainless Steel

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Journal of Iron and Steel Research International 2011年第10期18卷 72-79页

作者： k Srinivasan v Balasubramanian Department of Manufacturing Engineering Annamalai University

The effect of heat input on fume and their compositions during gas metal arc welding （GMAW） of AISI 316 stainless steel plates are investigated. Fume generation rate （FGR） and fume percentage were determined by ANSI/AWS F1.2 methods. Particle characterization was performed with SEM-XEDS and XRF analysis to reveal the particle morphology and chemical composition of the fume particles. The SEM analysis reveals the morphology of particles having three distinct shapes namely spherical, irregular, and agglomerated. Spherical particles were the most abundant type of individual particle. All the fume particle size falls in the range of less than 100 nm. Mechanical properties （strength, hardness and toughness） and microstructural analysis of the weld deposits were evaluated. It is found that heat input of 1.15 kJ/mm is beneficial to weld stainless steel by GMAW process due to lower level of welding fume emissions and superior mechanical properties of the joints.

关键词： gas metal arc weldings fume generation rates austenitic stainless steels tensile property scanning electron microscopes X-ray florescence spectrometer

Shape of Compact Toroidal Dimensions T_θ~d and Casimir Effect on M^D×T_θ~d Spacetime

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Communications in Theoretical Physics 2011年第1期55卷 101-110页

作者： v.k.Oikonomou Department of Theoretical Physics Aristotle University of Thessaloniki Technological Education Institute of Serres

We study the influence of the shape of compact a scalar field. We examine both the massive and the massless dimensions to the Casimir energy and Casimir force of scalar field. The total spacetime topology is M^D × Tθ2, where M^D） is the D-dimensional Minkowski spacetime and Tθ2 the twisted torus described by R1, R2, and 8. For the case R1 = R2 we found that the massive bulk scalar field Casimir energy is singular for D=even and this singularity is R-dependent and remains even when the force is calculated. Also the massless Casimir energy and force is regular only for D = 4 （!）. This is very interesting phenomenologically. We examine the energy and force as a function of 8. Also we address the stabilization problem of the compact space. We also briefly discuss some phenomenological implications.

关键词： Casimir energy Casimir force extra dimensions twisted torus shadowing effect zeta dimensions

Measurement-induced nonlocality based on affinity

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Communications in Theoretical Physics 2020年第7期72卷 42-48页

作者： R Muthuganesan v k Chandrasekar Centre for Nonlinear Science&Engineering School of Electrical&Electronics EngineeringSASTRA Deemed UniversityThanjavur—613401Tamil NaduIndia

Measurement-induced nonlocality(MIN),a quantum correlation measure for bipartite systems,is an indicator of maximal global effects due to locally invariant von Neumann projective *** is originally defined as the maximal square of the Hilbert-Schmidt norm of the difference between pre-and post-measurement *** this article,we propose a new form of MIN based on *** quantity satisfies all the criteria of a bona fide measure of quantum correlation *** quantity is evaluated for both arbitrary pure and 2×n dimensional(qubit-qudit)mixed *** operational meaning of the proposed quantity is interpreted in terms of the interferometric power of the quantum *** apply these results on two-qubit mixed states,such as the Werner,isotropic and Bell diagonal states.

关键词： affinity nonlocality quantum correlation local measurements