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中华实验外科杂志 2001年第4期18卷 307-308页

作者：秦仁义 Abdullah s Ahmed 邹声泉吴在德裘法祖华中科技大学同济医学院附属同济医院外科武汉430030

目的　探讨胰腺缺血再灌注加微球栓塞对鼠胰腺癌血清肿瘤坏死因子 (TNF) α、白细胞介素 1(IL 1)和λ 干扰素 (IFN λ)含量及肿瘤生长的影响。方法　大鼠胰腺尾部胰腺肿瘤形成后 ,阻断及开放胰腺尾部主要供血血管脾下动脉各 30min ,... 详细信息

目的　探讨胰腺缺血再灌注加微球栓塞对鼠胰腺癌血清肿瘤坏死因子 (TNF) α、白细胞介素 1(IL 1)和λ 干扰素 (IFN λ)含量及肿瘤生长的影响。方法　大鼠胰腺尾部胰腺肿瘤形成后 ,阻断及开放胰腺尾部主要供血血管脾下动脉各 30min ,并经脾下动脉注入微球栓塞微血管 ,然后结扎脾下动脉。分别于术前及术后 14d采用酶联免疫吸附法测定血清TNF α、IL 2和IFN λ的含量及观察胰腺肿瘤体积的变化。结果　胰腺肿瘤缺血再灌注加微球栓塞组 (E组 )术前血清TNF α、IFN λ和IL 2的含量和胰腺肿瘤体积与阳性对照组 (B组 )和胰腺肿瘤缺血组 (C组 )及胰腺肿瘤缺血再灌注组 (D组 )之间比较差异均无显著性 (P >0 .0 5 )。术后 14dE组血清TNF α、IFN λ和IL 2的含量〔( 79.5± 8.7)ng/L、( 10 6.0± 10 .8)ng/L、( 34 6.1± 13.1)ng/L〕明显高于B组〔( 30 .5± 3.5 )ng/L、( 76.7± 5 .8)ng/L、( 137.5± 8.1)ng/L〕、C组〔( 5 3.6± 6.3)ng/L、( 91.4±7.3)ng/L、( 2 0 3.4± 7.9)ng/L〕和D组 ( P <0 .0 1) ;且D、E组肿胰腺瘤体积也明显小于B、C组。结论　胰腺肿瘤缺血再灌注加微球栓塞可导致鼠胰腺肿瘤血清TNF α、IFN λ和IL 2含量明显升高 ,并可使胰腺肿瘤体积明显缩小 ,其效果明显优于单纯的胰腺肿瘤缺血或胰腺?

关键词：胰腺肿瘤缺血再灌注细胞活素类肿瘤体积微球栓塞血清细胞因子

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原发性开角型青光眼患者5种特征个性评估

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世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 53-54页

作者： Mabuchi F. Yoshimura K. Kashiwagi K. s. Tsukahara 张少娟 Department of Ophthalmology Faculty of Medicine University of Yamanashi 1110 Shimokato Tamaho- cho Nakakoma-gun Yamanashi 409- 3898 Japan

Purpose: several characteristic personality types have been reported for glaucoma patients in previous studies. However, none of the previous studies used a common structural theory of personality. In this study, we conducted a multicenter cross-sectional case-control study using the recently established five-factor model of personality structure. Methods: Personality was evaluated using the Neuroticism Extraversion Openness Five-Factor Inventory (NEO-FFI), which is a questionnaire specifically designed to test the five-factor model of personality: neuroticism (N), extraversion (E), openness (O), agreeableness (A), and conscientiousness (C). Eligible questionnaires were obtained from 196 patients with primary open-angle glaucoma (POAG) (99 men, 97 women) and 223 reference subjects with no ocular disease except cataract (87 men, 136 women). The mean score of each NEO-FFI factor for POAG patients was compared to the scores for the reference subjects. Results: Compared with the reference subjects, the mean N score was significantly higher (P=0.013), the mean scores for A and C were significantly lower (P=0.007 and P=0.001, respectively), and the mean E score tended to be lower (P=0.055) in male POAG patients. The mean E score was significantly lower (P=0.023) in female POAG patients. Conclusions: Characteristic personality traits were noted in POAG patients, and a more significant relationship was found between personality and glaucoma in men than in women.

关键词：眼部疾病问卷调查平均分值最新设计病例对照研究

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在二尖瓣峡部进行线性消融的技术和结果

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世界核心医学期刊文摘（心脏病学分册） 2005年第4期1卷 42-42页

作者： J.s P. Hocini M. Hsu L.-F. 杜媛 Hop. Haut-Leveque 33604 Bordeaux-Pessac France Dr.

Background -This prospective clinical study evaluates the feasibility and eff icacy of combined linear mitral isthmus ablation and pulmonary vein(Pv) isolatio n in patients with paroxysmal atrial fibrillation(AF). Methods and Results -One hundred consecutive patients(13 women; age 55±10 years)-with drug-refractory , symptomatic paroxysmal AF underwent Pv isolation and linear ablation of the ca votricuspid isthmus and the mitral isthmus(lateral mitral annulus to the left in ferior Pv). They were compared with 100 consecutive patients(14 women; age, 52± 10 years) undergoing Pv isolation and cavotricuspid ablation without mitral isth mus ablation. Bidirectional mitral isthmus block was confirmed by demonstrating( 1) a parallel corridor of double potentials during coronary sinus(Cs) pacing,(2) an activation detour by pacing either side of the line, and(3) differential pac ing techniques. Isolation of all Pvs and cavotricuspid isthmus ablation were per formed successfully in all. Mitral isthmus block was achieved in 92 patients aft er 20±10 minutes of endocardial radiofrequency application and an additional 5 ±4 minutes of epicardial radiofrequency application from within the Cs in 68, r esulting in a conduction delay of 151±26 ms during Cs pacing. Thirty-two patie nts with mitral isthmus ablation compared with 49 without had recurrent atrial a rrhythmia (P=0.02) requiring further ablation. At 1 year after the last procedur e, 87 patients with mitral isthmus ablation and 69 without(P=0.002) were arrhyth mia free without antiarrhythmic drugs, mitral isthmus ablation being the only fa ctor associated with long-term success(RR for AF recurrence, 0.2; CI, 0.1 to 0. 4; Psions -Catheter ablation of the mitral isthmus results cons istently in demonstrable conduction block and is associated with a high cure rat e for paroxysmal AF.

关键词：二尖瓣峡部线性消融起搏技术阵发性房颤抗心律失常药物射频消融术传导阻滞分离术冠状窦和阵

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