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Evaluation of Two Highly Porous Microcrystalline Biphasic Calcium Phosphate-Based Bone Grafts for Bone Regeneration: An Experimental Study in Rabbits

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Journal of Materials Science and Chemical Engineering 2020年第6期8卷 8-30页

作者： Miguel Ángel Garcés-villalá Sergio David Rico Sergio Gustavo nazar Mariano Escudero-Pinel víctor galván-josa José Luis Calvo-Guirado Department of Implant and Biomaterial Research Fundación Corazón de Jesús San Juan Argentina Facultad de Matemática Astronomía y Física Universidad Nacional de Córdoba Córdoba Argentina Department of Oral Surgery and Implant Dentistry Faculty of Health Sciences Universidad Católica San Antonio de Murcia Murcia Spain

A biphasic bone grafting biomaterial based on a mixture of calcium phosphates and beta-tricalcium phosphate (β-TCP) phases with high nanoporosity was synthesized. The synthesis route was based on calcium phosphate composition and the incorporation of glycolic acid as a pore former, giving a material composed of 97% β-TCP and 3% calcium orthophosphates (CaPO4). An in vitro study of the purity, microstructure, crystalline domain, and pores size for the material obtained was performed by SEM analysis as well as full structural characterization. The region of interest related to the surface was determined by the specific surface area measured with the BET method. In vivo evaluation of bone response was performed by implanting the new low-cost biphasic manufacturing material synthesized in this work, which was compared with a biphasic material of similar chemical and microstructural composition existing in the commercial market and with higher cost called Synergy Odontit® β-TCP. The materials were implanted separately into 5 mm diameter defects in the tibias of new Zealand White rabbits at 30, 60, and 90 days. The results obtained showed that the host tissue well accepted the new biphasic material;the presence of new bone formation was observed. A more complete resorption was observed for the new microcrystalline biphasic material compared to for a commercial β-TCP material.

关键词： Microcrystalline Beta-Tricalcium Phosphate Ceramic Bone Graft Glycolic Acid

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