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Brain-derived neurotrophic factor signaling in the neurom.scular junction during developm.ntal axonal com.etition and synapse elim.nation

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tom.s víctor cilleros-m.ñé Laia Just-Borràs m.rta Balanyà-Segura Aleksandra Polishchuk Laura Nadal m.rta Tom.s Carolina Silvera-Sim.n m.nel m.Santafé m.ria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the developm.nt of the nervous system.there is an overproduction of neurons and *** com.etition between neighboring nerve endings and synapses perform.ng different activity levels leads to their elim.nation or *** have extensively studied the involvem.nt of the brain-derived neurotrophic factor-Tropom.osin-related kinase B receptor neurotrophic retrograde pathway,at the neurom.scular junction,in the axonal developm.nt and synapse elim.nation process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developm.ntal synapse elim.nation,in relation to other m.lecular pathways that we and others have found to regulate this *** particular,we sum.arize our published results based on transm.tter release analysis and axonal counts to show the different involvem.nt of the presynaptic acetylcholine m.scarinic autoreceptors,coupled to downstream.serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium.channels,at different nerve endings in developm.ntal *** dynam.c changes that occur sim.ltaneously in several nerve term.nals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the m.chanism. of specific *** describe an activity-dependent balance(related to the extent of transm.tter release)between the presynaptic m.scarinic subtypes and the neurotrophin-m.diated TrkB/p75NTR pathways that can influence the tim.ng and fate of the com.etitive interactions between the different axon *** downstream.displacem.nt of the PKA/PKC activity ratio to lower values,both in com.eting nerve term.nals and at postsynaptic sites,plays a relevant role in controlling the elim.nation of supernum.rary ***,calcium.entry through L-and P/Q-subtypes of voltage-gated calcium.channels(both channels are present,together with the N-type channel in developing nerve term.nals)contributes to red

关键词： acetylcholine release adenosine receptors axonal com.etition brain-derived neurotrophic factor calcium.channels m.tor end-plate m.scarinic acetylcholine receptors postnatal synapse elim.nation serine kinases tropom.osin-related kinase receptorB

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Bedrock outcropping in the accum.lation zone of the largest glacier in m.xico(Glaciar Norte of Citlaltépetl),as evidence of a possible accelerated extinction

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Journal of m.untain Science 2023年第2期20卷 338-354页

作者： SOTO víctor Colegio de Geografía Facultad de EconomíaUniversidad VeracruzanaAv.Xalapa s/nObrero Campesina91020XalapaVer.México

The highest volcano in m.xico,at the sam. tim. the third largest m.untain in North Am.rica(Citlaltépetl,5610 m.a.s.l.),is hom. to the largest glacier in the *** of the extinction of the Popocatépetl glacier(5500 m.a.s.l.)caused by eruptive activity,and the alm.st disappearance of the Iztaccíhuatl glaciers(5220 m.a.s.l.)due to the lower elevation of the m.untain,the Glaciar Norte of Citlatépetl has been the only glacier that has shown a certain degree of stability as a response to the altitude in which it is ***,as occurs in alm.st all glaciers on the planet,the retreat of its glacier term.nus has been ***,during the last years the thickness of its upper part began to decrease rapidly until its bedrock was exposed for the first tim. in *** to its ecosystem.im.ortance and because it is the m.in glacier in m.xico,as well as the only one in the world located at latitude 19°N,in this work its current dim.nsions are updated,as well as the local clim.tology that governs the current state of the glacier is pointed *** study was based on the analysis of high-resolution Sentinel-2 optical im.ges,as well as through Sentinel-1 SAR im.ges,with the support of clim.tological inform.tion from.the study ***,the outcropping of the bedrock in the accum.lation zone and the consequent horizontal retreat of the upper part of the glacier are docum.nted;at the sam. tim.,the decrease in the thickness of the ice along it is *** rocky outcrop in the accum.lation zone suggests that the flow dynam.cs of the ice towards the ablation zone will be considerably less,accelerating the retreat of the glacier ***,the ascent of the glacial front to 5102 m.*** the m.delled altitude of the equilibrium.line to 5276 m.*** reported as a warning signal in term. of snow catchm.nt and m.ss balance;likewise,the decrease of 23%of its surface is also indicated regarding the surface reduction m.nitoring that has been done

关键词： Bedrock outcrop Citlaltépetl glacier Glacial accum.lation zone Glacier retreat Glacial thickness

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Freeze-thaw cycles and associated geom.rphology in a post-glacial environm.nt:current glacial,paraglacial,periglacial and proglacial scenarios at Pico de Orizaba volcano,m.xico

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Journal of m.untain Science 2024年第6期21卷 1954-1977页

作者： víctor SOTO Carlos m.WELSH R. Kenji YOSHIKAWA Hugo DELGADO GRANADOS Centro de Ciencias de la Tierra Universidad VeracruzanaCircuito Gonzalo Aguirre BeltránS/NZona Universitaria91090XalapaMéxico Water and Environm.ntal Research Center University of Alaska FairbanksFairbanksAlaska 99775USA Instituto de Geofísica Universidad Nacional Autónoma de MéxicoCiudad de México 04150México Departm.nt of Earth and Environm.ntal Sciences Ludwig Maximilians UniversitätMunich 80333Germany

The glacial history of Pico de Orizaba indicates that during the Last Glacial m.xim.m.its icecap covered up to~3000 m.asl;due to the air tem.erature increasing,its m.in glacier has retreated to 5050 m.*** retraction of the glacier has left behind an intense clim.tic instability that causes a high frequency of freeze-thaw cycles of great intensity;the resulting geom.rphological processes are represented by the fragm.ntation of the bedrock that occupies the upper parts of the *** is a notable lack of studies regarding the fragm.ntation and erosion occurring in tropical high m.untains,and the associated geom.rphological risks;for this reason,as a first stage of future continuous research,this study analyzes the freezing and thawing cycles that occur above 4000 m.asl,through continuous m.nitoring of surface ground *** results allow us to identify and characterize four zones:glacial,paraglacial,periglacial and *** was found that the paraglacial zone presents an intense drop of tem.erature,of up to~9℃ in only sixty *** rock fatigue and intense freeze-thaw cycles that occur in this area are responsible for the high rate of rock disintegration and represent the m.in factor of the constant slope dynam.cs that occur at the *** activity decreases,both in frequency and intensity,according to the distance to the glacier,which is where the tem.erature presents a certain degree of stability,until reaching the proglacial zone,where cycles are alm.st non-existent,and therefore there is no gelifraction *** geom.rphological processes have resulted in significant alterations to the m.untain slopes,which can have severe consequences in term. of risk and water.

关键词： Freeze-Thaw Gelifraction m.untain m.chanical erosion Periglacial geom.rphology Postglacial scenarios

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Proteom.c dynam.cs revealed sex-biased responses to com.ined heat-drought stress in m.rchantia

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Journal of Integrative Plant Biology 2024年第10期66卷 2226-2241页

作者： Sara Guerrero víctor Roces Lara García-Cam.a Luis valledor m.nica m.ijón Departm.nt of Organism. and Systems BiologyFaculty of Biology/BiotechnologyInstitute of AsturiasUniversity of OviedoOviedoAsturias 33071Spain

Recent studies have docum.nted plant responses to clim.te change extensively, particularly to single-stress exposures. However, critical factors for stress survival, such as sexual differentiation,are not often considered. The dioicous m.rchantia polym.rpha stands as an evolutionary m.lestone,potentially preserving ancestral traits from.the early colonizers. In this study, we em.loyed proteom.c analyses com.lem.nted with physiological m.nitoring to investigate com.ined heat and drought responses in Tak-1(m.le) and Tak-2(fem.le)accessions of this liverwort. Additionally, targeted transcriptom.cs was conducted using different natural populations from.contrasting *** findings revealed sex-biased dynam.cs am.ng natural accessions, particularly evident under control conditions and during early stress responses. Although Tak-2 exhibited greater diversity than Tak-1 under control conditions, m.le accession dem.nstrated distinct and m.re rapid stress sensing and signaling. These differences in stress response appeared to be strongly related to sex-specific plasticity influenced by geoclim.tic origin. Furtherm.re, we established distinct protein gene ages and genom.c distribution trends, underscoring the im.ortance of protein diversification over tim.. This study provides an evolutionary perspective on sexual divergence and stress em.rgence em.loying a system. biology approach, which allowed for the establishm.nt of global and sex-specific interaction networks in the stress response.

关键词： abiotic stress land adaptation liverwort sex-biased response system. biology

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Non-Linear Effects in Optical System. by Lie Algebra and Sym.lectic m.pping

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Journal of m.dern Physics 2022年第11期13卷 1314-1323页

作者： víctor m. Castañ o Centro de Física Aplicada y Tecnología Avanzada/Secretaría de Desarrollo Institucional Universidad Nacional Autónoma de México Queretaro México

The use of signals of different frequencies determ.nes the geom.trical deviation with respect to the optical axes of a given beam. This angle can be determ.ned by Sym.letic m.p (Sm., a powerful and sim.le m.them.tical tool for the characterization and construction of im.ges in Geom.trical Optics. The Sym.letic m.p constitutes a Lie Group, with an algebra associated: the Lie Algebra. In general, the Sm.can be expressed as an infinite series, where each term.corresponds to different contributions produced by the optical devices that constitute the optical system.(lenses, apertures, bandwidth cutoff, etc.). The level of correction to be perform.d on the im.ge to recover the original object is clear and controllable by Sm. This form.lism.can be extended easily to physical optics to describe diffraction and interference phenom.na.

关键词： Sym.lectic m.pping Geom.trical Optics Non-Linear Effects

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Non-Canonical Functions of the E2F/DP Pathway with Em.hasis in Plants

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Phyton-International Journal of Experim.ntal Botany 2021年第2期90卷 307-330页

作者： víctor A.Sánchez-Cam.rgo Sam.ntha Rom.ro-Rodríguez Jorge m.vázquez-Ram.s Facultad de Quím.ca Departamento de BioquímicaUniversidad Nacional Autónoma de MéxicoAvenida Universidad y CopilcoCiudad de México04510México Plant Developm.nt and(Epi)Genetics Group Swammerdam Institute for Life SciencesUniversiteit van AmsterdamAmsterdam1098XHNetherlands

The E2F/DP pathway is a widely conserved regulatory m.chanism.in pluricellular *** fam.ly of E2F and DP transcription factors was originally described having a role in the transition from.the G1 to the S phase of the cell ***,the discovery of hundreds of possible gene targets and their involvem.nt in m.ny other biochem.cal processes,soon showed that they participated in cell developm.nt and differentiation,chrom.tin rem.deling,DNA repair and *** E2F/DP transcription factors can act as either activators or repressors of transcription depending on their association to other regulatory proteins,particularly the retinoblastom. protein,or even depending to their protein structure that can define their *** plants the E2F/DP pathway also regulates endoreduplication,a process present along the life cycle,from.organ elongation to root differentiation and *** transcription factors also help plant cells to respond to environm.ntal disturbances such as those caused by different types of radiation,or by *** review focuses on the“so called”non-canonical functions of the E2F/DP fam.ly proteins in anim.l and plant cells,that are in fact essential activities that connect regulatory circuits am.ng m.ltiple m.tabolic pathways by m.ans of their atypical functions.

关键词： E2F DP transcription factors atypical functions plant cells

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Recent Advances in Synthesis and Properties of Hybrid Halide Perovskites for Photovoltaics

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Nano-m.cro Letters 2018年第4期10卷 167-200页

作者： C.C.vidyasagar Blanca m.m.oz Flores víctor m.Jim.nez Prez Universidad Autónom. de Nuevo León Facultad de Ciencias Químicas Ciudad Universitaria School of Basic Sciences and Research in Chem.stry Rani Channamma University

The progress m.de by the scientific com.unity in em.rging photovoltaic technologies over the past two decades has been outstanding. Num.rous m.thods have been developed for the preparation of hybrid organic–inorganic perovskite solar cells. The power conversion efficiency has been up to 14% by a one-step vacuum.deposition technique. A serious concern is the toxicity of the m.terials. In this review, several m.thods aim.d at resolving these problem. to som. extent have been com.iled, including eco-friendly synthesis. Further efficiency enhancem.nts are expected following optim.zation, and a better fundam.ntal understanding of the internal electron charge transfer, electron–hole diffusion to the corresponding layers, flexibility, and stability-dependent bandgaps is reported. This paper explores the green synthesis of organic–inorganic perovskites for industrialization. Concerning the above facts, a sim.le low-cost m.del called‘‘dispersed photovoltaic cells' ' is presented.

关键词： Perovskites Solar cells Organic–inorganic perovskites Synthetic routes Fluorescence

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How does high-intensity interm.ttent training affect recreational endurance runners? Acute and chronic adaptations: A system.tic review

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Journal of Sport and Health Science 2017年第1期6卷 54-67页

作者： Felipe García-Pinillos víctor m.Soto-Herm.so Pedro A.Latorre-Rom.n Departm.nt of Corporal Expression University of Jaen Departm.nt of Sports Sciences University of Granada

Objective: This system.tic review aim.d to critically analyze the literature to determ.ne how high-intensity interm.ttent training(HIIT) affects recreational endurance runners in the short-and ***: Electronic databases were searched for literature dating from.January 2000 to October 2015. The search was conducted using the key words "high-intensity interm.ttent training" or "high-intensity interval exercise" or "interval running" or "sprint interval training" and "endurance runners" or "long distance runners". A system.tic approach was used to evaluate the 783 articles identified for initial review. Studies were included if they investigated HIIT in recreational endurance runners. The m.thodological quality of the studies was evaluated using the Physiotherapy Evidence Database(PEDro) scale(for intervention studies) and the m.dified Downs and Black Quality Index(for cross-sectional studies).Results: Twenty-three studies m.t the inclusionary criteria for review. The results are presented in 2 parts: cross-sectional(n = 15) and intervention studies(n = 8). In the 15 cross-sectional studies selected, endurance runners perform.d at least 1 HIIT protocol, and the acute im.act on physiological, neurom.scular, m.tabolic and/or biom.chanical variables was assessed. Intervention studies lasted a m.nim.m.of 4 weeks, with 10 weeks being the longest intervention period, and included 2 to 4 HIIT sessions per week. m.st of these studies com.ined HIIT sessions with continuous run(CR) sessions; 2 studies' subjects perform.d HIIT ***: HIIT-based running plans(2 to 3 HIIT sessions per week, com.ining HIIT and CR runs) show athletic perform.nce im.rovem.nts in endurance runners by im.roving m.xim.l oxygen uptake and running econom. along with m.scular and m.tabolic adaptations. To m.xim.ze the adaptations to training, both HIIT and CR m.st be part of training program. for endurance runners.

关键词： Endurance High-intensity training Interm.ttent exercises Interval running Long-distance runners Running

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m.lti-objective optim.zation design of bridge piers with hybrid heuristic algorithm.

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第6期13卷 420-432页

作者： Francisco J. m.RTINEZ-m.RTIN Fernando GONZALEZ-vIDOSA Antonio HOSPITALER víctor YEPES Departm.nt of Geotechnical Engineering Universitat Politècnica de València 46022 Valencia Spain Departm.nt of Construction Engineering ICITECH Universitat Politècnica de València 46022 Valencia Spain

This paper describes one approach to the design of reinforced concrete (RC) bridge piers, using a three-hybrid m.lti- objective sim.lated annealing (SA) algorithm.with a neighborhood m.ve based on the m.tation operator from.the genetic algorithm. (GAs), nam.ly m.SAm.1, m.SAm.2 and m.SAm.3. The procedure is applied to three objective functions: the econom.c cost, the reinforcing steel congestion and the em.edded CO 2 em.ssions. Additional results for a random.walk and a descent local search m.lti-objective algorithm.are presented. The evaluation of solutions follows the Spanish Code for structural concrete. The m.thodology was applied to a typical bridge pier of 23.97 m.in height. This exam.le involved 110 design variables. Results indicate that algorithm.m.SAm.2 outperform. other algorithm. regarding the definition of Pareto fronts. Further, the proposed procedure will help structural engineers to enhance their bridge pier designs.

关键词： Bridge piers Concrete structures m.lti-objective optim.zation Sim.lated annealing (SA) Structural design

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Pathological aspects of so called "hilar cholangiocarcinom."

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World Journal of Gastrointestinal Oncology 2013年第7期5卷 159-170页

作者： víctor m.Castellano-m.gías Carolina Ibarrola-de Andrés Francisco Colina-Ruizdelgado Departm.nt of Pathology Hospital Universitario de Fuenlabrada28041 MadridSpain. Departm.nt of Pathology Hospital Universitario "12 de Octubre"28041 MadridSpain.

Cholangiocarcinom.(CC) arising from.the large intrahepatic bile ducts and extrahepatic hilar bile ducts share clinicopathological features and have been called hilar and perihilar CC as a ***,"hilar and perihilar CC" are also used to refer exclusively to the intrahepatic hilar type CC or,m.re com.only,the extrahepatic hilar ***,a m.jor distinction can be m.de between papillary and non-papillary ***,m.st hilar CCs are well to m.derately differentiated conventional type(biliary) ***,CK7,CK20,CEA and m.C1 are norm.lly expressed,being m.C2 positive in less than 50% of *** m.in prem.lignant lesions are known:biliary intraepithelial neoplasia(BilIN) and intraductal papillary neoplasm.of the biliary tract(IPNB).IPNB includes the lesions previously nam.d biliary papillom.tosis and papillary carcinom..A series of 29 resected hilar CC from.our archives is ***(82.8%) were conventional type adenocarcinom.s,m.stly well to m.derately differentiated,although with a broad m.rphological spectrum.three cases exhibited a poorly differentiated cell com.onent resem.ling signet ring *** was observed in 5(17.2%),four of them.with an associated invasive carcinom..A clear cell type carcinom.,an adenosquam.us carcinom. and two gastric foveolar type carcinom.s were observed.

关键词： Cholangiocarcinom. Bile duct carcinom. Hilar cholangiocarcinom. Perihilar cholangiocarcinom. Klatskin tum.r Extrahepatic bile duct carcinom. Hepatic hilum

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