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Phylogeny,genetics,and the partial life cycle of Oncomegas wageneri in the Gulf of mexico

current Zoology 2020年第3期66卷 275-283页

作者： Andrés martinez-AQUINO víc.or m.vidal-martinez F.Sara cEccARELLI Oscar mENDEZ Lilia c.SOLER-JImENEZ m.Leopoldina AGUIRRE-mAcEDO Facultad de ciencias Universidad Autonoma de Baja CaliforniaCarretera Transpeninsular 3917Fraccionamiento PlayitasEnsenadaBaja California 22860Mexico Laboratorio de Patologia Acuatica Departamento de Recursos del MarCentro de Investigacion y de Estudios Avanzados del Instituto Politecnico NacionalUnidad MeridaCordemexCarretera Antigua a Progreso Km.6MeridaYucatan 97310Mexico Departamento de Biologia de la conservacion CONACYT-Centro de Investigacion Cientifica y de Educacion Superior de EnsenadaCarretera Ensenada-TjuanaEnsenadaBaja California 22860Mexico Laboratorio de Hidrobiologia Facultad de Biologia-XalapaUniversidad VeracruzanaCircuito Gonzalo Aguirre Beltran S/N Zona UniversitariaXalapaVeracruz 91090Mexico

Despite the diversity and ecological importance of cestodes,there is a paucity of studies on their life stages(i.e.,complete lists of intermediate,paratenic,and definitive hosts)and genetic *** example,in the Gulf of mexico(Gom)98 species of cestodes have been reported to date;however,data on their intraspecific genetic variation and population genetic studies are *** trypanorhynch cestode,Oncomegas wageneri,is found(among other places)off the American Western Atlantic coast,including the Gom,and has been reported as an adult from stingrays and from several teleost species in its larval form(as plerocerci).This study represents the first report of 2 previously unregistered definitive hosts for ***,namely the Atlantic sharpnose shark Rhizoprionodon terraenovae and the southern stingray Hypanus *** this work,partial sequences of the 28S(region D1-D2)ribosomal DNA were analyzed to include *** within an eutetrarhynchoid phylogenetic *** *** individuals(which included plerocerci and adults)were recovered as monophyletic and Oncomegas celatus was identified as the sister species of ***,population genetic analyses of *** from the southern Gom were carried out using DNA sequences of the mitochondrial cytochrome c oxi-dase subunit 1(cOI)gene,which reflected high genetic variation and a lack of genetic structure among the 9 oceanographic sampling *** on these results,*** is panmictic in the southern *** extensive sampling along the species entire distribution is necessary to make more accurate inferences of population genetics of ***.

关键词： barcode cyclopsetta chittendeni population genetics Hypanus americanus Oncomegas Rhizoprionodon terraeno-vae 28S rDNA(D1-D2)

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An Agent-Based Solution Framework for Inter-Block Yard crane Scheduling Problems

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International Journal of Transportation Science and Technology 2012年第2期1卷 109-130页

作者： Omor Sharif Nathan Huynh mashrur chowdhury Jose m.vidal Department of civil and Environmental Engineering University of South CarolinaColumbiaSC 29208USA Glenn Department of civil Engineering Clemson UniversityClemsonSC 29634USA Department of computer and Science Engineering University of South CarolinaColumbiaSC 29208USA

The efficiency of yard operations is critical to the overall productivity of a container terminal because the yard serves as the interface between the landside and waterside *** container terminals use yard cranes to transfer containers between the yard and trucks(both external and internal).To facilitate vessel operations,an efficient work schedule for the yard cranes is necessary given varying work volumes among yard blocks with different planning *** paper investigated an agent-based approach to assign and relocate yard cranes among yard blocks based on the forecasted work *** goal of our study is to reduce the work volume that remains incomplete at the end of a planning *** offered several preference functions for yard cranes and blocks which are modeled as *** preference functions are designed to find effective schedules for yard *** addition,we examined various rules for the initial assignment of yard cranes to *** analysis demonstrated that our model can effectively and efficiently reduce the percentage of incomplete work volume for any real-world sized problem.

关键词： Yard crane scheduling container terminals multi-agent systems deferred acceptance algorithm

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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfac.ory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： maría Norte-muñoz maría Portela-Lomba Paloma Sobrado-calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega mar Pérez Josémcabrera-maqueda Javier Sierra manuel vidal-Sanz maría Teresa moreno-Flores marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfac.ory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfac.ory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic fac.or,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfac.ory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfac.ory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfac.ory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(mHcII) neuroprotection olfac.ory ensheathing glia retinal ganglion cells

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Photoelectrochemical activity of ZnO:Ag/rGO photo-anodes synthesized by two-steps sol-gel method

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chinese Physics B 2022年第5期31卷 691-702页

作者： D Ben Jemia m Karyaoui m A Wederni A Bardaoui m v martinez-Huerta m Amlouk R chtourou Laboratory of Nanomaterials and Renewable Energy Systems LANSER Research and Technology Center of EnergyBorj-Cedria Science and Technology ParkBP 952050 Hammam-LifTunisia Faculty of Science of Tunis University of Tunis El ManarTunisia Laboratory of Physics of materials and Nanomaterials Applied to the Environment(LaPhymNE) Faculty of Sciences of GabesCite ErriadhUniversity of Gabes6079 GabesTunisia lnstitute of catalysis and Petrochemistry CSICin MadridSpain Laboratory of Nanomaterials Nanotechnology and Energy(L2NE)University of Tunis El ManarTunisia

This work investigated the influence of silver plasmon and reduced graphene oxide(r GO)on the photoelectrochemical performance(PEc)of Zn O thin films synthesized by the sol-gel *** physicochemical properties of the obtained photo-anodes were systematically studied by using several characterization *** x-ray diffraction analysis showed that all samples presented hexagonal wurtzite structure with a polycrystalline *** and energy dispersive x-ray(EDX)studies confirmed the existence of both Ag and r GO in Zn O:Ag/r GO thin *** estimated grain size obtained from scanning electron microscopy(SEm)analysis decreased with Ag doping,then increased to a maximum value after r GO *** Uv-vis transmission spectra of the as-prepared Zn O:Ag and Zn O:Ag/r GO thin films have shown a reduction in the visible range with a redshift at the absorption *** bandgaps were estimated to be around 3.17 e v,2.7 e v,and 2.52 e v for Zn O,Zn O:Ag,and Zn O:Ag/r GO,***,the electrical measurements revealed that the charge exchange processes were enhanced at the Zn O:Ag/r GO/electrolyte interface,accompanied by an increase in the(PEc)performance compared to Zn O and Zn O:Ag ***,the photocurrent density of Zn O:Ag/r GO(0.2 m A·cm^(-2)) was around 4 and 2.22 times higher than photo-anodes based on undoped Zn O(0.05 m A·cm^(-2)) and Zn O:Ag(0.09 m A·cm^(-2)),***,from the flat band potential and donor density,deduced from the mott-Schottky,it was clear that all the samples were n-type semiconduc.ors with the highest carrier density for the Zn O:Ag/r GO photo-anode.

关键词： zinc oxide reduced graphene oxide silver doping sol-gel photoelectrochemical performance

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Pre-mRNA modifications and their role in nuclear processing

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Frontiers of Electrical and Electronic Engineering in china 2018年第3期6卷 210-227页

作者： Nicole m martinez Wendy v Gilbert Department of molecular Biophysics ＆ Biochemistry Yale UniversityNew HavenCT 06520USA

Background： cellular non-coding RNAs are extensively modified post-transcriptionally, with more than 100 chemically distinct nucleotides identified to date. In the past five years, new sequencing based methods have revealed widespread decoration of eukaryotic messenger RNA with diverse RNA modifications whose functions in mRNA metabolism are only beginning to be known. Results： Since most of the identified mRNA modifying enzymes are present in the nucleus, these modifications have the potential to function in nuclear pre-mRNA processing including alternative splicing. Here we review recent progress towards illuminating the role of pre-mRNA modifications in splicing and highlight key areas for future investigation in this rapidly growing field. conclusions： Future studies to identify which modifications are added to nascent pre-mRNA and to interrogate the direct effects of individual modifications are likely to reveal new mechanisms by which nuclear pre-mRNA processing is regulated.

关键词： mRNA modification pre-mRNA modification splicing RNA-modifying enzymes

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Neurogenesis dynamics in the olfac.ory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfac.ory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfac.ory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfac.ory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfac.ory bulb plays a pivotal role in regulating olfac.ory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfac.ory memories by modulating cellular connectivity within the olfac.ory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfac.ory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfac.ory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfac.ory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfac.ory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfac.ory neurogenesis contribute to enhancing the adaptability of the olfac.ory system. These mechanisms are thought to support olfac.ory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfac.ory bulb olfac.ory learning olfac.ory memory synaptic plasticity

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Isla San Pedro Nolasco as a Late miocene intrusive record at the eastern margin of the Gulf of california:Insights from geological,geochemical and geochronological studies

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Geoscience Frontiers 2022年第3期13卷 100-114页

作者： L.A.velderrain-Rojas J.R.vidal-Solano L.m.Alva-valdivia R.vega-Granillo m.López-martinez Departamento de Geología División de Ciencias Exactas y NaturalesUniversidad de SonoraC.P.83000 HermosilloSonoraMexico Laboratorio de Paleomagnetismo Instituto de GeofísicaUniversidad Nacional Autónoma de MéxicoCircuito de la Investigación CientíficaC.P.04510 MéxicoD.F.Mexico Departamento de Geología División de Ciencias de la TierraCentro de Investigación Científica y de Educación Superior de EnsenadaBaja CaliforniaMexico

Isla San Pedro Nolasco(ISPN)is a structural high bounded by inactive dextral oblique-slip faults in the east-central part of the Gulf of california rift zone and is composed of intrusive rocks not exposed on other Gulf of california *** we present the reconnaissance results from geological mapping,as well as first geochemical and geochronological data for the ISPN intrusive *** intrusive rocks compose a sheet-like body of intermediate and felsic composition intruded by an intermediate and acidic dike *** intrusive rocks(host and dikes)range in age from ca.9 ma to 10 ma(^(40)Ar/^(39)Ar)and show a hydrous ferromagnesian mineral association(amphibole and biotite)with a calc-alkalic and transitional *** hydrated mineralogical association has not been recognized in the coeval rocks along the onshore western margin of the North American plate(coastal Sonora).However,such hydrous mineralogical association is found in the coeval rift transitional volcanic rocks from the Baja california microplate at Santa Rosalía and Bahía de LosÁngeles–Bahía de LasÁ*** ISPN continental block,at least 40 km long,has been pulled apart by transtensional faulting of the late miocene Gulf of california shear zone before the westward migration of the North America-Pacific plate boundary at ca.3–2 ***,ISPN became isolated as an island during the late miocene flooding of the Gulf of california seaway.

关键词： PAc-NAm plate boundary Gulf of california Intrusive rocks Isla San Pedro Nolasco

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Altered mic.orNA expression in animal models of Huntington’s disease and potential therapeutic strategies

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Neural Regeneration Research 2021年第11期16卷 2159-2169页

作者： Bridget martinez Philip v.Peplow Physical chemistry and Applied Spectroscopy Chemistry DivisionLos Alamos National LaboratoryLos AlamosNMUSA Department of medicine St.Georges University School of MedicineGrenada Department of Anatomy University of OtagoDunedinNew Zealand

A review of recent animal models of Huntington’s disease showed many mic.orNAs had altered expression levels in the striatum and cerebral cortex,and which were mostly *** the altered mic.orNAs were miR-9/9*,miR-29b,miR-124a,miR-132,miR-128,miR-139,miR-122,miR-138,miR-23b,miR-135b,miR-181(all downregulated)and miR-448(upregulated),and similar changes had been previously found in Huntington’s disease *** the animal cell studies,the altered mic.orNAs included miR-9,miR-9*,miR-135b,miR-222(all downregulated)and miR-214(upregulated).In the animal models,overexpression of miR-155 and miR-196a caused a decrease in mutant huntingtin mRNA and protein level,lowered the mutant huntingtin aggregates in striatum and cortex,and improved performance in behavioral *** performance in behavioral tests also occurred with overexpression of miR-132 and *** the animal cell models,overexpression of miR-22 increased the viability of rat primary cortical and striatal neurons infected with mutant huntingtin and decreased huntingtin-enriched foci of≥2μ***,overexpression of miR-22 enhanced the survival of rat primary striatal neurons treated with 3-nitropropionic *** expression of miR-214,miR-146a,miR-150,and miR-125b decreased endogenous expression of huntingtin mRNA and protein in HdhQ111/HdhQ111 *** studies with animal models of Huntington’s disease are warranted to validate these findings and identify specific mic.orNAs whose overexpression inhibits the production of mutant huntingtin protein and other harmful processes and may provide a more effective means of treating Huntington’s disease in patients and slowing its progression.

关键词： animal model cerebral cortex huntingtin Huntington’s disease mic.orNA neurodegeneration striatum therapeutic strategies

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SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KcD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OTIFI Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(Gc)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathways play pivotal roles in Gc progression,making them attractive targets for therapeutic ***:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KcD *** and SNU-5 Gc cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KcD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(Ic_(50))value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KcD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm,respectively.A significant elevation in the early phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KcD kinases for treating Gc and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(Gc) Dual inhibition JAK2 PI3KcD SBL-JP-0004 molecular docking molecular dynamics simulation

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mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo centro de Biología molecular Severo Ochoa(cBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

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