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N-acetylcysteine attenuates alcohol-induced oxidative stess in rats

World Journal of Gastroenterology 2003年第4期9卷 791-794页

作者： Resat Ozaras Veysel Tahan Seval Aydin hafize uzun Safiye Kaya Hakan Senturk Department of Infectious Diseases and Clinical Microbiology University of IstanbulIstanbulTurkey Department of Internal Medicine University of IstanbulIstanbulTurkey Department of Biochemistry University of IstanbulIstanbulTurkey

AIM: To investigate free-radical scavenger effect of nacetylcysteine in rats intragastrically fed with ***: Twenty-four rats divided into three groups were fed with ethanol (6 g/kg/day, Group 1), ethanol and nacetylcysteine (1 g/kg, Group 2), or isocaloric dextrose (control group, Group 3) for 4 weeks. Then animals were sacrificed under ether anesthesia, and intracardiac blood and liver tissues were obtained. Measurements were made in both serum and homogenized liver *** (MDA) level was measured by TBARS method. Glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) levels were studied by commercial ***-Wallis test was used for statistical ***: ALT and AST in Group 1 (154 U/L and 302 U/L,respectively) were higher than those in Group 2 (94 U/L and 155 U/L) and Group 3 (99 U/L and 168 U/L) (P=0.001for both). Serum and tissue levels of MDA in Group 1 (1.84nmol/mL and 96 nmol/100 mg-protein) were higher than that in Group 2 (0.91 nmol/mL and 64 nmol/100 mg protein)and Group 3 (0.94 nmol/mL and 49 nmol/100 mg-protein)(P＜0.001 for both). On the other hand, serum GSH-Px level in Group 1 (8.21 U/g Hb) was lower than that in Group 2(16 U/g Hb) and Group 3 (16 U/g-Hb) (P＜0.001). Serum and liver tissue levels of SOD in Group 1 (11 U/mL and 26U/100 mg-protein) were lower than that in Group 2 (18 U/mL and 60 U/100 mg protein) and Group 3 (20 U/mL and 60 U/100 mg-protein) (P＜0.001 for both).CONCLUSION: Ethanol-induced liver damage was associated with oxidative stress, and co-administration of n-acetylcysteine attenuates this damage effectively in rat model.

关键词： N-乙酰半胱氨酸酒精氧化损伤动物实验氧自由基超氧化物歧化酶谷胱苷肽过氧化酶肝功能

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N-acetylcysteine attenuates alcohol-induced oxidative stress in the rat

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World Journal of Gastroenterology 2003年第1期9卷 125-128页

AIM: There is increasing evidence that alcohol-induced liverdamage may be associated with increased oxidative *** aimed to investigate free-radical scavenger effect of n-acetylcysteine in rats intragastrically fed with ***: Twenty-four rats divided into three groups werefed with ethanol (6 g/kg/day, Group 1), ethanol and n-acetylcysteine (1 g/kg, Group 2), or isocaloric dextrose(control group, Group 3) for 4 weeks. Then animals weresacrificed under ether anesthesia, intracardiac blood andliver tissues were obtained. Measurements were performedboth in serum and in homogenized liver *** (MDA) level was measured by TBARSmethod. Glutathione peroxidase (GSH-Px) and superoxidedismutase (SOD) levels were studied by commercial ***-Wallis test was used for statistical ***: ALT and AST in Group 1 (154 U/Land 302 U/L,respectively) were higher than those in Group 2 (94 U/L and155 U/L) and Group 3 (99 U/L and 168 U/L) (P＝0.001 forboth). Serum and tissue levels of MDA in Group 1 (1.84 nmol/mL and 96 nmol/100 mg-protein) were higher than Group 2(0.91 nmol/mL and 64 nmol/100 mg-protein) and Group 3(0.94 nmol/mL and 49 nmol/100 mg-protein) (P＜0.001 forboth). On the other hand, serum GSH-Px level in Group 1(8.21 U/g-Hb) was lower than Group 2 (16 U/g-Hb) andGroup 3 (16 U/g-Hb) (P＜0.001). Serum and liver tissue levelsof SOD in Group 1 (11 U/mL and 26 U/100 mg-protein)were lower than Group 2 (18 U/mL and 60 U/100 mg-protein)and Group 3 (20 U/mL and 60 U/100 mg-protein) (P＜0.001for both).CONCLUSION: This study demonstrated that ethanol-induced liver damage is associated with oxidative stress,and co-administration of n-acetylcysteine attenuates thisdamage effectively in rat model.

关键词： N-乙酰半胱氨酸氧化损伤乙醇动物实验肝功能氧自由基

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Potential effects of L-NAME on alcohol-induced oxidative stress

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World Journal of Gastroenterology 2005年第4期11卷 600-604页

作者： hafize uzun Gonul Simsek Seval Aydin Ethem Unal Yesari Karter Nermin Karaturan Yelmen Suphi Vehid Asl Curgunlu Safiye Kaya Department of Biochemistry Istanbul University Cerrahpapa School of MedicineIstanbulTurkey Department of Physiology Istanbul University Cerrahpapa School of MedicineIstanbulTurkey Department of General Surgery Istanbul University Cerrahpapa School of MedicineIstanbulTurkey Department of Internal Medicine Istanbul University Cerrahpapa School of MedicineIstanbulTurkey Department of Physiology Istanbul University Cerrahpapa School of MedicineIstanbul Turkey Department of Public Health Istanbul University Cerrahpapa School of MedicineIstanbulTurkey

AIM: Nitric oxide (NO) is a highly reactive oxidant synthesized from L-arginine by nitric oxide synthase (NOS). NO may cause injury through the generation of potent radicals. Nwnitro-L-arginine methyl ester (L-NAME) is a non-selective inhibitor of NOS. We aimed to evaluate whether L-NAME treatment had protective effects against oxidative stress in rats intragastrically fed with ethanol during a 4 ***: Thirty-six male Wistar rats were divided into 3 equal groups: group 1 (control group-isocaloric dextrose was given), group 2 (6 g/kg.d ethanol-induced group) and group 3 (both ethanol 6 g/kg.d and L-NAME 500 mg/L in drinking water-given group). Animals were sacrificed at the end of 4 wk-experimental period, and intracardiac blood and liver tissues were obtained. Biochemical measurements were performed both in plasma and in homogenized liver tissues. Alanine amino transferase (ALT), aspartate amino transferase (AST), malondialdehyde (MDA), NO, superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) levels were measured by ***: ALT and AST in group 2 (62 U/L and 128 U/L,respectively) were higher than those in group 1 (24 U/L and 38 U/L) and group 3 (37 U/L and 81 U/L) (P＜0.001 for both).Plasma and tissue levels of MDA in group 2 (4.66 μmol/L and 0.55 nmol/mg protein) were higher than in group 1 (2.65 μmol/L and 0.34 nmol/mg protein) and group 3 (3.43 μmol/L and 0.36 nmol/mg protein) (P＜0.001 for both). Plasma and liver tissue levels of NO in group 2 (54.67 μmol/L and 586.50 nmol/mg protein) were higher than in group 1 (34.67 μmol/L and 435.33 nmol/mg protein)and group 3 (27.50 μmol/L and 412.75 nmol/mg protein )(P＜0.001 for both). Plasma and liver tissue SOD activities in group 2 (15.25 U/mL and 5.38 U/ mg protein,respectively) were lower than in group 1 (20.00 U/mL and 8.13 U/mg protein) and group 3 (19.00 U/mL and 6.93 U/mg protein) (P＜0.001 for both). Plasma and liver tissue CAT activities in group 2 (145 U/mL and 37 U/ mg

关键词： L-NAME 酒精肝诱导作用氧化作用精氨酸

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Oxidative stress in portal hypertension-induced rats with particular emphasis on nitric oxide and trace metals

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World Journal of Gastroenterology 2005年第23期11卷 3570-3573页

作者： Titiz Izzet Krand Osman Unal Ethem Yavuz Nihat Kusaslan Ramazan Dogan Mustafa uzun hafize Kiziler Ali Riza Aydemir Birsen Genc Habibe Aydin Seval Simsek Gonul Department of Surgery Department of Biochemistry Department of Biophysics Department of Physiology

AIM: To investigate the oxidative-stress-related changes in rats with portal hypertension with particular emphasis on nitric oxide (NO) and trace metals. METHODS: Cirrhosis was induced by partial portal vein ligation (PVL) in Wistar rats. The lipid peroxidation marker (malondialdehyde, MDA), antioxidant defense enzymes including superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and agents known to have antioxidant features including nitric oxide (NO), zinc (Zn), copper (Cu) were determined both in serum and in liver tissue at 4 wk after surgery in PVL and sham-operated rats. Portal pressure of all experimental animals was measured. MDA was detected by thiobarbituric acid reactivity *** activity was determined by inhibition of nitroblue tetrazolium reduction with xanthine/xanthine oxidase used asa superoxide generator. CAT activity was determined by the breakdown of hydrogen peroxide. GSH concentrations were measured by using metaphosphoric acid for protein precipitation and 5'-5'-dithio-bis-2-nitrobenzoic acid for color development. NO was detected by the Griess method after reduction of nitrate to nitrite with nitrate reductase, and the concentrations of Zn and Cu were measured by a Shimadzu 680 AA atomic absorption spectrometer. Histopathological confirmation was done under light microscope. Statistical analyses were done by Student's t-test, and significance of the difference was tested by the unpaired Mann-Whitney test. P＜0.05 was considered statistically ***: Histopathological studies confirmed PVL induced cirrhotic changes. There was a statistically significant difference in portal pressure between PVL and control groups (P＜0.001). The results showed significant increases in the levels of MDA and NO in both tissue and serum (P＜0.05 and P＜0.001, respectively in tissue; P＜0.001 for each in serum), and Zn only in tissue (P＜0.001)in rats with PVL compared with sham-operated rats. Besides, PVL rats exhibited reduced plasma and tis

关键词：肝门静脉高压氧化损伤小鼠动物实验一氧化氮

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Recent developments of lactic acid bacteria and their metabolites on foodborne pathogens and spoilage bacteria:Facts and gaps

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Food Bioscience 2022年第3期47卷 1312-1329页

作者： hafize Fidan Tuba Esatbeyoglu Vida Simat Monica Trif Giulia Tabanelli Tina Kostka Chiara Montanari Salam A.Ibrahim FatihÖzogul Department of Tourism and Culinary Management University of Food Technologies4002PlovdivBulgaria Institute of Food Science and Human Nutrition Gottfried Wilhelm Leibniz University HannoverAm Kleinen Felde 3030167HannoverGermany University Department of Marine Studies University of SplitRuđera Boškovića 3721000SplitCroatia Centre for Innovative Process Engineering (CENTIV) GmbH 28857SykeGermany Department of Agricultural and Food Sciences University of Bologna40127BolognaItaly Food Microbiology and Biotechnology Laboratory North Carolina Agricultural and Technical State UniversityGreensboroNC27411USA Department of Seafood Processing Technology Faculty of FisheriesCukurova University01330AdanaTurkey

Lactic acid bacteria(LAB)are common microorganisms found in various ecosystems including in plants,fermented foods,and the human *** the biodiversity of lactic acid microflora and characterization of LAB is a new approach to form a variety of starter communities to create innovative nutritional food *** has been growing interest in LAB isolated from non-dairy environments as these bacteria exhibit significant metabolic diversity and have unique taste-forming *** may be prevented,or treated by LAB but the treatment of disease conditions with LAB is highly dependent on the host's microbiome and diet and varies in both effectiveness and side effects from individual to *** perspectives on the study of LAB may be related to the expansion of our knowledge in the fields of genetics and genetic *** application of genetic science may help to improve existing strains and develop new strains with characteristics designed for specific ***,the preservative effects of LAB and their metabolites,as well as their interaction on the growth of food borne pathogens and food spoilage microorganisms were *** addition,the competitive models for microbial growth between LAB and other microorganisms as well as the role of LAB in the elimination of toxic compounds in food products were ***,the review provided an overview of the risks and benefits of using LAB in the food industry.

关键词： Lactic acid bacteria Starter culture Fermented products Food-borne pathogens Microbial interaction

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A Generalization on Sλ^L（I）- Asymptotically Statistical Equivalent Sequences

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Journal of Mathematics and System Science 2014年第10期4卷 683-688页

作者： hafize Gumus Ekrem Savas Necmettin Erbakan University Istanbul Commerce University

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