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Labetalol versus Hydralazine in the Management of Severe Pre-Eclampsia at Tertiary Hospitals in a Low-Resource Setting: A Randomised Controlled Trial

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Open Journal of Obstetrics and Gynecology 2023年第6期13卷 1058-1067页

作者： uzoma otutoaja Adeyemo Olabisi Timothy Emmanuel Olumide Adewara Olufunmilayo Victoria Adebara Augustine Adebayo Adeniyi Babatunde Sunday Awoyinka Raymond Akujuobi Okere Idowu Oluseyi Adebara Adewumi Bakare Mojisola Olumide Ayankunle Department of Obstetrics and Gynaecology Ado-Ekiti/Federal Teaching Hospital Afe Babalola University Ido-Ekiti Nigeria Department of Paediatrics Ado-Ekiti/Federal Teaching Hospital Afe Babalola University Ido-Ekiti Nigeria

Objective: Intravenous labetalol and hydralazine are both considered first-line medications for the management of acute-onset, severe hypertension in pregnant and postpartum women. The study compared the efficacy and safety profile of intravenous labetalol and hydralazine in the control hypertension in severe pre-eclampsia. Materials and Methods: One hundred patients who presented with severe pre-eclampsia were randomized into two study groups. The fifty patients in each arm of the study received either intravenous labetalol or intravenous hydralazine for the control of blood pressure. Results: The mean age of the labetalol subjects was 28.6 ± 5.47 years while that of their hydralazine counterparts was 29.12 ± 5.77 years. The majority of respondents in both groups were primigravidae (76% vs. 78%) (P = 0.813). The number of doses of drug needed to significantly lower the mean systolic blood pressure was slightly lower in the labetalol group (2 doses) compared to the hydralazine group (5 doses) (t = 0.803Y, P = 0.977). The incidence of headaches which were the commonest complaints was comparable in both groups 8% and 10% of respondents respectively (P > 0.05). Conclusion: Although both intravenous labetalol and hydralazine are useful in patients with severe pre-eclampsia, the response to labetalol was better with comparable side effects.

关键词： Blood Pressure Hydralazine Labetalol Low-Resource Setting Severe Pre-Eclampsia Side Effects

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