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番石榴果对贮藏期间存放姿势的生理和品质反应

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国外农学（果树） 1992年第2期 41-43页

作者： S.siddiqui 莫治雄

在绿熟阶段采收番石榴(Psidium guajava L.)的冬季果实,并在室温条件下贮藏,存放姿势分为三种,(1)正放,果梗端垂直向上;(2)倒放,果梗端垂直向下;(3)平放,果梗端横向。在贮藏过程中,正放果实的生理失重、后熟果百分率、乙稀和二氧化碳释... 详细信息

在绿熟阶段采收番石榴(Psidium guajava L.)的冬季果实,并在室温条件下贮藏,存放姿势分为三种,(1)正放,果梗端垂直向上;(2)倒放,果梗端垂直向下;(3)平放,果梗端横向。在贮藏过程中,正放果实的生理失重、后熟果百分率、乙稀和二氧化碳释放率最小,可溶性固形物和抗坏血酸浓度最大,感官分级和其它特性表明,番石榴果的包装应该取自然姿势(正放),以便较长时期保持良好的品质。

关键词：番石榴果实贮藏生理品质

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新型N-(2-芳基氨基苯基)-2,3-二苯基喹喔啉-6-磺胺类药物作为潜在抗疟疾、抗真菌和抗细菌药物的合理药物设计、合成和生物学评价

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Digital Chinese Medicine 2021年第4期4卷 290-304页

作者： Ahmed Hassen Shntaif Sharuk Khan Ganesh Tapadiya Anand Chettupalli Shweta Saboo Mohd Sayeed Shaikh Falak siddiqui Ramkoteswra Rao Amara College of Science for Women Babylon UniversityHillaBabil 00964Iraq MUPs College of Pharmacy(B Pharm) WashimMaharashtra 444506India Shreeyash Institute of Pharmaceutical Education and Research AurangabadMaharashtra 431010India Department of Pharmaceutical Sciences Center for NanomedicineAnurag UniversityHyderabad 501301India Government College of Pharmacy KaradMaharashtra 415124India Department of Pharmacy Shri Jagdishprasad Jhabarmal Tibrewala UniversityVidya NagariRajasthan 333001India

目的磺胺、磺胺嘧啶和氨苯砜是第一批通过破坏叶酸生物合成过程来治疗疟疾的磺胺类药物,叶酸生物合成过程是寄生虫存活的关键。因此,我们旨在通过合理的药物设计方法合成新型N-(2-芳基氨基苯基)-2,3-二苯基喹喔啉-6-磺酰胺衍生物。方法... 详细信息

目的磺胺、磺胺嘧啶和氨苯砜是第一批通过破坏叶酸生物合成过程来治疗疟疾的磺胺类药物,叶酸生物合成过程是寄生虫存活的关键。因此,我们旨在通过合理的药物设计方法合成新型N-(2-芳基氨基苯基)-2,3-二苯基喹喔啉-6-磺酰胺衍生物。方法按常规方法合成所有化合物,并用光谱分析(1H核磁共振和质谱)对产物进行表征。使用薄层色谱法(TLC)监测反应进程。分析了所有衍生物在疟原虫半胱氨酸蛋白酶falcipain-2变构位点的有效结合模式。采用肉汤稀释法测定抗菌和抗真菌活性。结果S6(N-(2-噻唑-4-基)-乙酰基-氨基苯基)-2,3-二苯基喹喔啉-6-磺酰胺与S9(N-(1H-苯并[d]咪唑-2-基)氨基苯基)-2,3-二苯基喹喔啉-6-磺酰胺形成5个氢键;S8(N-(2-1H-咪唑-2-基)氨基苯基)-2,3-二苯基喹喔啉-6-磺酰胺和S10(N-(1-苯并[d]咪唑-5-基)氨基苯基)-2,3-二苯基喹喔啉-6-磺酰胺与酶的变构位点形成四个氢键。考虑到与目标酶的对接分数和氢键的形成,新的衍生物被加工用于湿实验室合成。所有新合成的衍生物都具有体外抗疟疾、抗真菌和抗菌活性。与标准品相比,所有衍生物对恶性疟原虫株表现出足够的敏感性。此外,化合物S9和S10显示出最有效的双重抗微生物和抗疟疾活性。它们在分子对接研究中也显示出强大的分子相互作用。结论基于以上结果,我们认为N-(2-芳基氨基苯基)-2,3-二苯基喹喔啉-6-磺酰胺衍生物具有作为抗疟药、抗真菌药和抗菌剂的优异生物潜力。

关键词：磺胺类抗疟药抗真菌抗细菌疟原虫半胱氨酸蛋白酶falcipain-2 2,3-二苯基喹喔啉恶性疟原虫

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Does music reduce anxiety and discomfort during flexible sigmoidoscopy?A systematic review and meta-analysis

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World Journal of Gastrointestinal Endoscopy 2017年第5期9卷 228-237页

作者： Arun P Shanmuganandan Muhammad R Sameem siddiqui Nicholas Farkas Kiran Sran Rhys Thomas Said Mohamed Robert I Swift Al Mutaz Abulafi Department of Colorectal Surgery Croydon University Hospital Department of Surgery Royal Free Hospital

AIM To investigate the role of music in reducing anxiety and discomfort during flexible sigmoidoscopy. METHODS A systematic review of all comparative studies up to November 2016, without language restriction that were identified from MEDLINE and the Cochrane Controlled Trials Register(1960-2016), and EMBASE(1991-2016). Further searches were performed using the bibliographies of articles and abstracts from major conferences such as the ESCP, NCRI, ASGBI and ASCRS. Me SH and text word terms used included "sigmoidoscopy", "music" and "endoscopy" and "anxiety". All comparative studies reporting on the effect of music on anxiety or pain during flexible sigmoidoscopy, in adults, were included. Outcome data was extracted by 2 authors independently using outcome measures defined a priori. Quality assessment was *** A total of 4 articles published between 1994 and 2010, fulfilled the selection criteria. Data were extracted and analysed using OpenM etaA nalyst. Patients who listened to music during their flexible sigmoidoscopy had less anxiety compared to control groups [Random effects; SMD: 0.851(0.467, 1.235), S.E = 0.196, P < 0.001]. There was no statistically significant heterogeneity(Q = 0.085, df = 1, P = 0.77, I2 = 0). Patients who listened to music during their flexible sigmoidoscopy had less pain compared to those who did not, but this difference did not reach statistical significance [Randomeffects; SMD: 0.345(-0.014, 0.705), S.E = 0.183, P = 0.06]. Patients who listened to music during their flexible sigmoidoscopy felt it was a useful intervention, compared to those who did not(P < 0.001). There was no statistically significant heterogeneity(P = 0.528, I2 = 0). CONCLUSION Music appeared to benefit patients undergoing flexible sigmoidoscopies in relation to anxiety and was deemed a helpful intervention. Pain may also be reduced however further investigation is required to ascertain this.

关键词：音乐灵活 sigmoidoscopy 焦虑不快屏蔽

Petrological and Geochemical Studies of Lepidolite (LCT Type) and Non-Lepidolite Pegmatite’s from Chakrasila, Dhubri District, Assam, North East India

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Open Journal of Geology 2021年第3期11卷 81-104页

作者： Rajkumar R. Meshram Bhupender Singh Mukesh Kumar Mishra H. Hrushikesh Alam siddiqui Devaseesh Shukla Rafique Akhtar Tushar M. Meshram Regional Petrology Division Geological Survey of India CR Nagpur India Geological Survey of India State Unit: P& H NR Chandigarh India Geological Survey of India Western Region Jaipur India Geological Survey of India State Unit: Assam NER Guwahati India Geological Survey of India Central Region Bhopal India

Lepidolite pegmatite occurs as intrusive within biotite gneiss and amphibolite of Assam Meghalaya Gneissic Complex (AMGC) or Precambrian Gneissic Complex in the Dhubri district, Assam. AMGC is the north western extension of the Proterozoic rocks of Meghalaya Plateau or Shillong plateau. In the field it occurs as small to large veins and scattered boulders. Lepidolite pegmatite is later intruded by non lepidolite pegmatite. Pegmatites are medium to coarse grained with quartz and K-feldspar. It also contains lepidolite, which occurs in the form of flakes and clusters varying from pink to purple in colour. Petrography of lepidolite pegmatite reveals lepidolite as major constituents with quartz, K-feldspar and muscovite as minor constituents. XRD analysis reveals lepidolite (muscovite) is major mineral phase with kaliophilite in minor amount. Geochemically, they are calc-alkaline to high calc-alkaline and per-aluminous in nature. On the basis of Alumina Saturation Index (ASI), these pegmatites resemble Lithium-Cesium-Tantalum (LCT) family and compositional affinity with S-type granites of orogenic environments. Trace element compositions (Rb, Sr, Ba) indicate crystal fractionations, variable degrees of fractionation, highly evolved nature of pegmatite’s and strongly differentiated granites protoliths as source. The different tectonic discrimination diagrams indicate S-type and I-type melt for pegmatite derivations. Therefore, both the studied pegmatites could be an evolved variety of granitic rocks that originated from the same magma. The REE is relatively low to moderate.

关键词： Lepidolite LCT XRD Per-Aluminous Fractionations AMGC and Shillong Plateau

Modeling&Evaluating the Performance of Convolutional Neural Networks for Classifying Steel Surface Defects

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Journal on Artificial Intelligence 2022年第4期4卷 245-259页

作者： Nadeem Jabbar Chaudhry M.Bilal Khan M.Javaid Iqbal siddiqui Muhammad Yasir Department of Computer Science Superior UniversityLahorePakistan Department of Computer Science University of Central PunjabLahorePakistan Department of Mechanical System Engineering Tongmyong UniversityBusanKorea

Recently,outstanding identification rates in image classification tasks were achieved by convolutional neural networks(CNNs).to use such skills,selective CNNs trained on a dataset of well-known images of metal surface defects captured with an RGB *** must be detected early to take timely corrective action due to production *** image classification up till now,a model-based method has been utilized,which indicated the predicted reflection characteristics of surface defects in comparison to flaw-free *** problem of detecting steel surface defects has grown in importance as a result of the vast range of steel applications in end-product sectors such as automobiles,households,construction,*** processes for detections are time-consuming,labor-intensive,and *** strategies have been used to automate manual processes,but CNN models have proven to be the most effective rather than image processing andmachine learning *** using differentCNNmodels with fine-tuning,easily compare their performance and select the best-performing model for the same kinds of ***,it is important that using different CNN models either from fine tuning can be computationally expensive and ***,our study helps the upcoming researchers to choose the CNN without considering the issues of model complexity,performance,and computational *** this article,the performance of various CNN models like Visual Geometry Group,VGG16,VGG19,ResNet152,ResNet152V2,Xception,InceptionV3,InceptionResNetV2,NASNetLarge,MobileNetV2,and DenseNet201 with transfer learning techniques are *** models were chosen based on their popularity and impact in the field of computer vision research,as well as their performance on benchmark *** to the outcomes,DenseNet201 outperformed the other CNN models and had the greatest detection rate on the NEU dataset,falling in at 98.37 percent.

关键词： Convolutional neural network transfer learning defect detection

Transhepatic venous approach to permanent pacemaker placement in a patient with limited central venous access

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World Journal of Clinical Cases 2015年第9期3卷 835-837页

作者： Adeel M siddiqui Gregory S Harris Assad Movahed Karl S Chiang Mihail G Chelu Rajasekhar Nekkanti Department of Internal Medicine East Carolina School of Medicine Department of Cardiovascular Sciences East Carolina Brody School of Medicine Vascular Interventional Radiology Vidant Medical Center

The end-stage renal disease population poses a challenge for obtaining venous access required for life-saving invasive cardiac procedures. In this case report, we describe an adult patient with end-stage renal disease in whom the hepatic vein was the only available access to implant a single-lead permanent cardiac pacemaker. A 63-year-old male with endstage renal disease on maintenance hemodialysis and permanent atrial fibrillation/atrial flutter presented with symptomatic bradycardia. Imaging studies revealed all traditional central venous access sites to be occluded/non-accessible. With the assistance of vascular interventional radiology, a trans-hepatic venous catheter was placed. This was then used to place a right ventricular pacing lead with close attention to numerous technical aspects. The procedure was completed successfully with placement of a single-lead permanent cardiac pacemaker.

关键词： Trans-hepatic venous access Permanent cardiac pacemaker End-stage renal disease

喹啉或喹啉/吡啶混合取代阳离子型卟啉化合物的制备和端粒酶抑制活性研究(英文)

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中国药科大学学报 2001年第3期32卷 172-179页

作者：陆涛 Adamsiddiqui LaurenceH Hurley College of Pharmacy and Arizona Cancer Center

目的 :寻找具有阳离子型卟啉结构的强效端粒酶抑制剂。方法 :通过芳香醛和吡咯的缩合反应制得 4 乙酰氨基苯基或 4 乙酰氨基苯基 / 4 吡啶基卟啉 ,经水解得相应氨基物 ,然后采用Skraup喹啉合成法制备 6 喹啉 / 4 吡啶取代卟啉碱基 ,最... 详细信息

目的 :寻找具有阳离子型卟啉结构的强效端粒酶抑制剂。方法 :通过芳香醛和吡咯的缩合反应制得 4 乙酰氨基苯基或 4 乙酰氨基苯基 / 4 吡啶基卟啉 ,经水解得相应氨基物 ,然后采用Skraup喹啉合成法制备 6 喹啉 / 4 吡啶取代卟啉碱基 ,最后经甲基化、离子交换得阳离子型卟啉化合物。同法制得 6 喹啉 / 3喹啉取代卟啉碱基。测试所合成化合物的端粒酶抑制活性。结果

关键词：端粒酶端粒酶抑制剂 G-四链体卟啉抗癌药

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代表性特殊岩心分析样品在选择标准上的一些改进

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国外油气地质信息 2007年第3期 56-62页

作者： S．siddiqui 谢小箐（译）赵洪才（校）

通过特殊岩心分析（SCAL）测试得到的数据对油藏工程模型具有重要的影响。本文阐述了为SCAL测试选择代表性样品时所需要的一些标准和测试。推荐的这项技术可以保证选取到代表储层内合适的流体封隔箱或者地层岩相的高质量岩心栓。肉眼观... 详细信息

通过特殊岩心分析（SCAL）测试得到的数据对油藏工程模型具有重要的影响。本文阐述了为SCAL测试选择代表性样品时所需要的一些标准和测试。推荐的这项技术可以保证选取到代表储层内合适的流体封隔箱或者地层岩相的高质量岩心栓。肉眼观察、有时还有计算机层析成象术是用于SCAL研究中评价和选择岩心栓的两种主要手段。虽然可以对卤水渗透率进行测量，但没有一种可以直接测量SCAL岩心栓的孔隙度（φ）而不影响其润湿性的方法。其它的选择手段包括使用“姐妹岩心栓”上传统的岩心分析数据（k和φ）作为SCAL样品性质的通用指标。开发出了一种非常适合于保存样品或原状样品的选择技术来识别具有类似孔隙度／渗透率关系的储层层段。它综合应用了电缆测井、伽马扫描、定量CT和原状卤水渗透率数据。该技术利用这些数据来计算合适的深移储层性质指数（RQI）和流动层指标（FZI）数据。然后再用这些数据从每个储层封隔箱中选取具有代表性的岩心栓样品。作为一个实例，采用该选择指标从中东的上侏罗统碳酸盐岩储层申选取了大约400块SCA工。岩心栓。本文阐述了选择性岩心栓的具体步骤以及将这些岩心栓组合起来用于有意义的SCAL测试的选择标准。

关键词：岩心栓 SCAL测试 CT扫描润湿性渗透率切片

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宫颈癌治疗：SIGN指南概要

英国医学杂志中文版 2008年第2期11卷 113-115页

作者： R M James M E Cruickshank N siddiqui Scottish IntercollegiateGuidelines Network( SIGN ) 28 ThistleStreet EdinburgEH2 IEN Department ofObstetrics andGynaecology Aberdeen MaternityHospital AB25 7ZD Department ofGynaecologyOncology GlasgowRoyal InfirmaryG40SF

为什么阅读本概要？在英国尽管有一个组织严谨的宫颈癌前病变筛查程序，每年仍有2800例的宫颈癌新发病例和1000例的死亡病例^1。很多患者仍然会因宫颈癌相关症状就诊于全科医生。接种和免疫联合委员会宣布明年引进人乳头瘤病毒疫苗用于1... 详细信息

为什么阅读本概要？在英国尽管有一个组织严谨的宫颈癌前病变筛查程序，每年仍有2800例的宫颈癌新发病例和1000例的死亡病例^1。很多患者仍然会因宫颈癌相关症状就诊于全科医生。接种和免疫联合委员会宣布明年引进人乳头瘤病毒疫苗用于12～13岁少女接种。但可以预见，其对宫颈癌发生率的影响需要40～60年的时间才能看出。

关键词：宫颈癌前病变人乳头瘤病毒疫苗治疗联合委员会死亡病例新发病例全科医生