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How Agent Orange impacts prostate cancer risk,pathology,and treatment outcomes

Current Urology 2024年第2期18卷 79-86页

作者： Awais Paracha Zohair siddiqui Ali Abid Ekamjit Deol Fatima Waheed Zachary Hamilton Saint Louis University School of Medicine Saint LouisMOUSA Saint Louis University Saint LouisMOUSA New York Institute of Technology College of Osteopathic Medicine OldWestburyNYUSA Department of Surgery Division of UrologySaint Louis University School of MedicineSaint LouisMOUSA

Between 2.6 and 3.8 million veterans served in Vietnam while the US military dispersed Agent Orange(AO),although the exact number of exposed individuals is *** Orange,an herbicide,is a known risk factor for various cancers,including sarcoma and leukemia,but less is known about its link with prostate cancer(PC).Prostate cancer is the most commonly diagnosed malignancy in men and the fifth most common cause of cancer-related death in men *** 2023,approximately 288,300 patients will be given a diagnosis of PC,and an estimated 34,700 fatalities will occur in the United ***,whether the pathologic characteristics of PC among those exposed to AO differ from those in the general population remains *** review synthesizes the literature regarding the impact of AO exposure on PC incidence and disease course.A comprehensive PubMed literature search of articles published beginning in 1950 was performed using the primary search terms“Agent Orange,”“TCDD,”and“tetrachlorodibenzodioxin”and the secondary search terms“prostate cancer”or“prostate neoplasm.”The search was limited to studies that focused on human participants and were published in *** authors thoroughly reviewed the retrieved articles for relevancy to the study aims:discussion of PC diagnosis,prognosis,or management among patients exposed to *** 108 studies identified in our search,13 were included in this systematic *** within studies concerning AO exposure with relation to PC incidence,age at diagnosis or treatment initiation,and PC severity seemed to be mixed and generally ***,the literature seems to indicate that there are no significant differences in survivorship between exposed and unexposed veterans who are given a diagnosis of *** these heterogeneous outcomes,the evidence does not encourage a significantly different approach to the diagnosis and management of PC for veterans exposed to *** shouldmake case-by-case decision

关键词： Agent Orange 2,3,7,8-Tetrachlorodibenzo-p-dioxin Prostate cancer Veterans

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Aldosterone synthase inhibitor“Baxdrostat”for resistant hypertension:A clinical approach or futuristic idea?

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Chronic Diseases and Translational Medicine 2024年第2期10卷 146-148页

作者： Muhammad Osama siddiqui Ayaan Ahmed Qureshi Arooba siddiqui Noor ul ain Liaquat National Hospital and Medical College KarachiSindhPakistan Karachi Medical and Dental College KarachiSindhPakistan

The American College of Cardiology/American Heart Association defines resistant hypertension(RH)as a clinical blood pressure(BP)reading of>130/80 mmHg in patients taking three antihypertensive drugs,including a renin–angiotensin system inhibitor,a calcium channel blocker(CCB),and a diuretic at well-tolerated doses.1,2 It is reported from multiple population-based surveys that in the United States,there is an approximately 12%–15%prevalence of RH among adults diagnosed with hypertension.2 A prospective study demonstrates that 20%of people diagnosed with RH had primary hyperaldosteronism.3,4 In addition to the classic three antihypertensive drugs,spironolactone and mineralocorticoid are also administered for ***,with respect to the safety profile of spironolactone,it has been reported to have several side effects such as low testosterone production,menstrual irregularities,and excessively raised serum potassium levels,leaving the drug unfit for the longitudinal therapeutic purpose of treating RH.

关键词： hypertension drugs hypertensive

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Shear wave velocity prediction:A review of recent progress and future opportunities

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Energy Geoscience 2024年第4期5卷 36-54页

作者： John Oluwadamilola Olutoki Jian-guo Zhao Numair Ahmed siddiqui Mohamed Elsaadany AKM Eahsanul Haque Oluwaseun Daniel Akinyemi Amany H.Said Zhaoyang Zhao State Key Laboratory of Petroleum Resources and Prospecting CNPC Key Laboratory of Geophysical ExplorationCollege of GeophysicsChina University of PetroleumBeijingChina Center of Excellence in Subsurface Seismic Imaging and Hydrocarbon Prediction Department of GeoscienceFaculty of Geoscience&Petroleum EngineeringUniversiti Teknologi PETRONAS(UTP)Malaysia Geology Department Faculty of ScienceAssiut UniversityAssiut71516Egypt

Shear logs,also known as shear velocity logs,are used for various types of seismic analysis,such as determining the relationship between amplitude variation with offset(AVO)and interpreting multiple types of seismic *** log is an important tool for analyzing the properties of rocks and interpreting seismic data to identify potential areas of oil and gas ***,these logs are often not collected due to cost constraints or poor borehole conditions possibly leading to poor data quality,though there are various approaches in practice for estimating shear wave *** this study,a detailed review of the recent advances in the various techniques used to measure shear wave(S-wave)velocity is carried *** techniques include direct and indirect measurement,determination of empirical relationships between S-wave velocity and other parameters,machine learning,and rock physics ***,this study creates a collection of employed techniques,enhancing the existing knowledge of this significant topic and offering a progressive approach for practical implementation in the field.

关键词： Shear wave(S-wave)velocity Direct and indirect measurement Empirical relationship Artificial intelligence(AI) Machine learning Rock physics model

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Toxicological and Life-Cycle Perspectives on Waste-Derived Nanoparticles

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Journal of Materials Science and Chemical Engineering 2024年第8期12卷 43-68页

作者： Irshad Ahmad Md Fahimul Hassan Weqar Ahmad siddiqui Department of Applied Science & Humanities Faculty of Engineering & Technology Jamia Millia Islamia University New Delhi India Department of Chemistry C.M. Science College Lalit Narayan Mithila University Darbhanga India

Many nanoparticles have been created over the last few decades using a variety of techniques and used to develop environmental technology, including water treatment, the detection of persistent contaminants, and soil and water remediation. The studies of alternative inputs for nanoparticle production as well as the use of green synthesis techniques are driven by the field of materials science and engineering’s growing interest in increasing the sustainability of the processes involved in their production. In this paper, we begin by providing an overview of the fundamental principles of producing nanoparticles from different sources, such as plastic, electronic, metal, and industrial waste. We elaborate on key facts of waste identification as a workable input for the treatment and recovery of metal and carbon-based nanoparticles. We next go over several controlling factors that play a role in creating nanoparticles, pointing out probable conclusions as we go. Then, we show some instances of waste-derived nanoparticles used in a proof-of-concept experiment of technology for applications in water quality and safety. Before scaling up production and implementing waste-derived nanoparticles, there are several present problems from the toxicological and life-cycle perspectives that must be taken into account.

关键词： Industrial Waste Plastic Trash Metal Waste Carbon Nanoparticles Nanoparticle-Enabled Technologies Electronic-Waste

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Leptomeningeal metastases in prostate cancer:A review of the current literature

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Current Urology 2024年第3期18卷 159-166页

作者： Umar Durrani Kasem Rifai Maha Arshad Awais Paracha Ekamjit Deol Maria Paracha Fatima Waheed Zohair siddiqui Ali Abid Esed Mustafic Wilson Rodriguez Zachary Hamilton Saint Louis University School of Medicine Saint LouisMOUSA University of Missouri School of Medicine ColumbiaMOUSA University of Virginia CharlottesvilleVAUSA New York Institute of Technology College of Osteopathic Medicine Old WestburyNYUSA Saint Louis University Saint LouisMOUSA Department of Neurology Saint Louis University School of MedicineSaint LouisMOUSA Division of Urology Department of SurgerySaint Louis University School of MedicineSaint LouisMOUSA

Leptomeningeal metastasis/leptomeningeal carcinomatosis(LMC;terms used interchangeably)is an inflammatory complication of primary tumors that involves the spread of the disease to the meninges(specifically the arachnoid and pia maters)and spinal *** the United States,approximately 110,000 new cases are diagnosed each year,and the prognosis is usually *** of LMC include cognitive impairment,cranial nerve dysfunction,ischemic stroke,and *** survival times of untreated and treated LMC are approximately 4–6 weeks and 2–4 months,*** carcinomatoses are usually metastatic cancers that spread to the central nervous *** lung and breast cancers have a clearly defined relationship with LMC,it remains unclear whether prostate cancer(PC)is also directly associated with *** determine whether such association exists,we conducted a PubMed review of the literature on patients with PC with coexisting *** search yielded 23 case reports of patients with preexisting PC who developed *** addition,2 retrospective cohort studies were *** findings were identified in the revised cases and *** first 3 findings were related to the progression of the disease:patients presenting with neurological disease symptoms were in remission from PC for 7 years on average,LMCs tended to occur after other cancer diagnoses,and the disease had already rapidly progressed by the time the symptoms were *** diagnosis,the major finding was that most LMCs were detected by magnetic resonance imaging(which does not detect early dissemination),and it was suggested that single-photon emission computed tomography or positron emission tomography imaging could be used for earlier ***,in terms of treatment,the main finding was that treatment was palliative rather than curative and that prognosis remained poor despite *** the basis of these results,we recommend for individuals with risk facto

关键词： Leptomeningeal carcinomatosis Prostate cancer Prostate cancer metastasis

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SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2702-2715页

作者： Hye Jin Shin Wooseong Lee Keun Bon Ku Gun Young Yoon Hyun-Woo Moon Chonsaeng Kim Mi-Hwa Kim Yoon-Sun Yi Sangmi Jun Bum-Tae Kim Jong-Won Oh Aleem siddiqui Seong-Jun Kim Department of Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Gyeongnam Biohealth Research Center Gyeongnam Branch InstituteKorea Institute of ToxicologyJinju 52834Republic of Korea Center for Research Equipment Korea Basic Science InstituteCheongjuChungcheongbuk-do 28119Republic of Korea Department of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Division of Infectious Diseases School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Present address:Department of Microbiology Chungnam National University School of MedicineDaejeon 35015Republic of Korea

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a‘highly transmissible respiratory pathogen,leading to severe multiorgan ***,knowledge regarding SARS-CoV-2-induced cellular alterations is *** this study,we report that SARSCoV-2 aberrantly elevates mitochondrial bioenergetics and activates the EGFR-mediated cell survival signal cascade during the early stage of viral ***-CoV-2 causes an increase in mitochondrial transmembrane potential via the SARS-CoV-2 RNAnucleocapsid cluster,thereby abnormally promoting mitochondrial elongation and the OXPHOS process,followed by enhancing ATP ***,SARS-CoV-2 activates the EGFR signal cascade and subsequently induces mitochondrial EGFR trafficking,contributing to abnormal OXPHOS process and viral *** EGFR inhibitors remarkably reduce SARS-CoV-2 propagation,among which vandetanib exhibits the highest antiviral *** of SARS-CoV-2-infected cells with vandetanib decreases SARS-CoV-2-induced EGFR trafficking to the mitochondria and restores SARS-CoV-2-induced aberrant elevation in OXPHOS process and ATP generation,thereby resulting in the reduction of SARS-CoV-2 ***,oral administration of vandetanib to SARS-CoV-2-infected hACE2 transgenic mice reduces SARS-CoV-2 propagation in lung tissue and mitigates SARS-CoV-2-induced lung *** also exhibits potent antiviral activity against various SARS-CoV-2 variants of concern,including alpha,beta,delta and omicron,in in vitro cell culture *** together,our findings provide novel insight into SARS-CoV-2-induced alterations in mitochondrial dynamics and EGFR trafficking during the early stage of viral infection and their roles in robust SARS-CoV-2 propagation,suggesting that EGFR is an attractive host target for combating COVID-19.

关键词： alterations aberrant thereby

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Congophilic fibrils in the glomeruli with polyclonal immunoglobulin gamma staining-another cause for diagnostic overlap:A case report

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World Journal of Clinical Cases 2024年第17期12卷 3200-3205页

作者： Maria Bernadette Che-Ying Chow Lucas Bushrow Irmeen siddiqui April Chiu Mirza Hamirani Anjali A Satoskar Department of Pathology The Ohio State University Medical CenterColumbusOH 43210United States Department of Pathology North District HospitalSheung ShuiHong KongChina Department of Laboratory Medicine and Pathology Mayo ClinicRochesterMN 55905United States Department of Internal Medicine S.Joseph's HospitalParkersburgWV 26101United States

BACKGROUND Glomerulopathy with fibrillary deposits is not uncommon in routine nephropathology practice,with amyloidosis and fibrillary glomerulonephritis being the two most frequently encountered *** amyloid heavy and light chain(AHL)is relatively uncommon and its biopsy diagnosis is usually limited to cases that show strong equivalent staining for a single immunoglobulin(Ig)heavy chain and a single light chain,further supported by mass spectrometry(MS)and serum studies for monoclonal *** polyclonal light chain staining can pose a *** SUMMARY Herein we present a challenging case of renal AHL with polyclonal and polytypic Ig gamma(IgG)staining pattern by *** patient is a 62-yearold Caucasian male who presented to an outside institution with a serum creatinine of up to 8.1 mg/dL and nephrotic range *** the finding of a polyclonal and polytypic staining pattern on immunofluorescence,ultrastructural study of the renal biopsy demonstrated the presence of fibrils with a mean diameter of 10 *** red was positive while DNAJB9 was *** suggested a diagnosis of amyloid AHL type with IgG and lambda,but kappa light chains were also present supporting the immunofluorescence staining *** immunofixation studies demonstrated IgG lambda monoclonal *** patient was started on *** chronic renal injury however was quite advanced and he ended up needing dialysis shortly *** Tissue diagnosis of AHL amyloid can be *** confirmation using other available diagnostic techniques is recommended in such cases.

关键词： Heavy and light chain amyloid Fibrillary glomerulonephritis DNAJB9 Serum immunofixation Protein electrophoresis Mass spectrometry Congo red Case report

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Impact of phytoconstituents on oral health practices:a post COVID-19 observation

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Food Science and Human Wellness 2024年第5期13卷 2386-2400页

作者： Harsh Kumar Reena Singh Daljeet Singh Dhanjal Chirag Chopra Natália Cruz-Martins Gheyath K.Nasrallah Amin F.Majdalawieh Sivakumar Manickam Shahida Anusha siddiqui Dinesh Kumar Indu Sharma Varun Sharma School of Bioengineering&Food Technology Shoolini University of Biotechnology and Management SciencesSolan 173229India School of Bioengineering and Biosciences Lovely Professional UniversityPunjab 144402India Faculty of Medicine University of PortoPorto 4200-319Portugal Institute for Research and Innovation in Health(i3S) University of PortoPorto 4200-135Portugal Institute of Research and Advanced Training in Health Sciences and Technologies(CESPU) RuaCentral de GandraGandra 4585-116Portugal TOXRUN-Toxicology Research Unit University Institute of Health SciencesCESPUCRLGandra 4585-116Portugal Biomedical Research Center Qatar UniversityDoha 2713Qatar Department of Biomedical Science College of Health SciencesQatar UniversityDoha 2713Qatar Department of Biology Chemistryand Environmental SciencesCollege of Arts and SciencesAmerican University of SharjahSharjah 26666United Arab Emirates Petroleum and Chemical Engineering Faculty of EngineeringUniversiti Teknologi BruneiBandar Seri Begawan BE1410Brunei Campus Straubing for Biotechnology and Sustainability Technical University of MunichStraubing 94315Germany Genetic Heritage Group New York UniversityAbu Dhabi 129188United Arab Emirates Bioinformatics Division NMC Genetics India Pvt.Ltd.Gurugram 122001India

Appropriate oral hygiene significantly reduces the possibility of oral ***,dental caries and periodontal diseases are major oral health issues causing chronic diseases due to poor oral ***,herbal compounds have gained interest in maintaining oral *** of burdock root(Arctium),noni fruit(Morinda citrifolia),and neem leaf(Azadirachta indica)are now used as intracanal medicaments in endodontics and *** amboinicus species and other plants produces essential oil likeβ-caryophyllene,p-cymene,andγ-terpinene can exhibit antibacterial activity;highlighting phytoconstituents plays a vital role in oral *** COVID-19 pandemic highlighted the importance of hygiene and sanitization,to curb *** cavity is among the gateways for virus entry into *** is a potential reservoir of SARS-CoV-2,and there is an increased risk of infection if there is any fissure in the *** enables entry of virus into the vascular system through gingival or periodontal pocket,possibly reaching lung periphery then to lung vessels by interacting with endothelial surface receptors triggering pulmonary vasoconstriction and lung damage due to endothelial *** review aims to draw attention to the possible route of SARS-CoV-2 infection via the oral cavity and the importance of oral hygiene against COVID-19.

关键词： COVID-19 SARS-CoV-2 Oral Hygiene Microbiota Phytochemicals

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Ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry-characterized extract of Aerides odorata Lour alleviates paracetamol-induced hepatotoxicity in animal model evidenced by biochemical,molecular,and computational studies

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Animal Models and Experimental Medicine 2024年第4期7卷 497-522页

作者： A.M.Abu Ahmed Md.Atiar Rahman Farjana Sharmen A.S.M.Ali Reza Md.Shahidul Islam Md.Mamunur Rashid Md.Khalid Juhani Rafi Tanvir Ahmed siddiqui Md.Muzahid Ahmed Ezaj Srabonti Saha Md.Nazim Uddin Walla Alelwani Department of Genetic Engineering and Biotechnology University of ChittagongChittagongBangladesh Department of Biochemistry and Molecular Biology University of ChittagongChittagongBangladesh Department of Pharmacy International Islami University ChittagongChittagongBangladesh Institute of Food Science and Technology Bangladesh Council of Scientific and Industrial ResearchDhakaBangladesh Department of Biochemistry College of ScienceUniversity of JeddahJeddahSaudi Arabia

Background:Many kinds of orchids have significant health benefits although ade-quate research on their biological functions is yet to be carried *** study inves-tigated the paracetamol-induced liver damage-protecting effect of epiphytic Aerides odorata methanol extract(AODE).Methods:The protective effects of AODE were studied by analyzing its effect on liver function parameters,messenger RNA(mRNA)expression,and tissue histopatho-logical *** results were confirmed by ligand-receptor interaction of molecular docking and multitarget interaction of network pharmacological ***:AODE significantly(p<0.05)minimized the dose-dependent increase in acid phosphatase,aspartate aminotransferase,alanine aminotransferase,alkaline phos-phatase,γ-glutamyl transferase,lactate dehydrogenase,and total bilirubin compared to the reference drug *** level decreased,and the antioxidant genes catalase(CAT),superoxide dismutase(SOD),β-actin,paraoxonase-1(PON1),and phosphofructokinase-1(PFK-1)were upregulated in AODE-treated paracetamol-intoxicated rats.A total of 376 compounds comprising phenols and flavonoids were identified using ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry(UPLC-qTOF-MS).The online toxicity assessment using SwissADME and admetSAR exhibited drug-like,nontoxic,and potential pharmaco-logical ***,in silico analysis showed that isoacteoside,one of the identified compounds,exhibited the best docking score(−11.42)with the liver pro-tein human pituitary adenylate cyclase-1(Protein Data Bank ID:3N94).Furthermore,network pharmacology analysis identified the top 10 hub genes,namely AKT1(protein kinase B),CTNNB1(catenin beta-1),SRC(proto-oncogene c-Src),TNF(tumor necrosis factor),EGFR(epidermal growth factor receptor),HSP90AA1(heat shock protein 90α),MAPK3(mitogen-activated protein kinase 3),STAT3(signal transducer and activator of transcription 3),CASP3(caspase protein),

关键词： Aerides odorata animal model mRNA expression PCM-induced hepatotoxicity UPLC-qTOF-MS

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A review of recent advancements in finite element formulation for sandwich plates

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Chinese Journal of Aeronautics 2019年第4期32卷 785-798页

作者： Shehzaib IRFAN Faisal siddiqui Aerospace Engineering Department College of Aeronautical Engineering National University of Sciences and TechnologyRisalpur

Use of composite structures is exponentially growing in different fields due to their higher strength-to-weight ratio. This application trend requires that accurate theoretical explanations and their finite element models be developed for analyzing sandwich plates before finalizing the designs. This paper reviews the recent research trends of finite element formulations developed for analyzing sandwich plates. This paper reviews the finite element models developed after the year 2000. Initially, the finite element formulations based on first order shear deformation theory, higher order shear deformation theories, mixed solid-shell elements, zig-zag theories and global–local theories are presented. Then, some finite element formulations developed to analyze a very new class of structures called piezoelectric structures are presented. At the end, some formulations to analyze a very critical phenomenon called buckling are presented.

关键词： Buckling Finite element FSDT HSDT Laminated composites Piezoelectric Sandwich plates Zig-zag theory

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