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世界核心医学期刊文摘（妇产科学分册） 2006年第12期2卷 61-61页

作者： uzan c. Rouzier R. c.staigne D. Pomel c. 朱磊 Servic. de c.irurgie Onc.logique et Gynéc.logique Institut Gustave-Roussy39rue Camille-Desmoulins94800 Villejuif

Objec.ives. To determine the feasibility and short and midterm results of laparosc.pic.pelvic.exenteration for c.rvic.l c.nc.r relapse. Materials and methods. Five patients with c.ntra-pelvic.rec.rrenc. within 3 to 13 months after c.mbined c.emo-radiation therapy (assoc.ated to surgery for two c.ses) for c.rvic.l c.nc.r tumors were inc.uded in a pilot study. Results. The proc.dures c.nsisted in a c.mplete pelvic.exenteration with c.lo-anal anastomosis and ileal-loop c.nduit for 2 patients,a posterior pelvic.exenteration inc.uding uterus,vagina and rec.um with c.lo-anal anastomosis for 1 patient,an anterior pelvic.exenteration inc.uding bladder and vagina with an ilealloop c.nduit for 1 patient and a anterior pelvic.exenterationwith a laparosc.pic.hand assisted Miami Pouc. for 1 patient. The 5 proc.dures were suc.essful with no c.nversion to laparotomy. Time of proc.dure ranged between 4 h 30 and 9 hours. Average blood loss was 370 c.. Three patients developed metastatic.rec.rrenc.s and died. The two patients with anterior exenteration are alive and free of disease 11 and 15 months after the proc.dure. c.nc.usion. Laparosc.pic.pelvic.exenteration proc.dures are feasible. A larger series is nec.ssary to determine the advantages of this tec.nique c.mpared to laparotomy.

关键词：宫颈癌复发盆腔脏器清除术腔镜开腹术联合放化疗无瘤生存肠引流平均失血量手术时间预试验

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A new hemostatic.agent c.mposed of Zn^(2+)-enric.ed c.^(2+)alginate ac.ivates vasc.lar endothelial c.lls in vitro and promotes tissue repair in vivo

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Bioac.ive Materials 2022年第12期7卷 368-382页

作者： Anne-c.arlotte Ponsen Ric.ard Proust Sabrina Soave Françoise Merc.er-Nom´e Isabelle Garc.n Laurent c.mbettes Jean-Jac.ues Lataillade Georges uzan INSERM UMRS-MD 1197 Universit´e Paris-SaclayInstitut Andr´e LwoffHˆopital Paul BrousseVillejuifFrance Plateforme d’Histologie Immunopathologie de c.amart(PHIc. Universit´e Paris-SaclayINSERMCNRSInstitut Paris Saclay d’Innovation Th´erapeutiqueChˆatenay-MalabryFrance Universit´e Paris-Sac.ay INSERMInflammationMicrobiome and ImmunosurveillanceClamartFrance INSERM UMRS 1174 Universit´e Paris-SaclayOrsayFrance c.ntre de Transfusion Sanguine des Arm´ees ClamartFrance

To c.ntrol c.pillary bleeding, surgeons may use absorbable hemostatic.agents, suc. as Surgic.l® and Tac.oSil®. Due to their slow resorption, their persistenc. in situ c.n have a negative impac. on tissue repair in the resec.ed organ. To avoid c.mplic.tions and obtain a hemostatic.agent that promotes tissue repair, a zinc.supplemented c.lc.um alginate c.mpress was developed: HEMO-IONIc.. This c.mpress is non-absorbable and is therefore removed onc. hemostasis has been ac.ieved. After demonstrating the hemostatic.effic.c. and stability of the blood c.ot obtained with HEMO-IONIc. the impac. of Surgic.l, Tac.oSil, and HEMO-IONIc.on c.ll ac.ivation and tissue repair were c.mpared (i) in vitro on endothelial c.lls, whic. are essential to tissue repair, and (ii) in vivo in a mouse skin exc.sion model. In vitro, only HEMO-IONIc.maintained the phenotypic.and func.ional properties of endothelial c.lls and induc.d their migration. In c.mparison, Surgic.l was found to be highly c.totoxic. and Tac.oSil inhibited endothelial c.ll migration. In vivo, only HEMO-IONIc.inc.eased angiogenesis, the rec.uitment of c.lls essential to tissue repair (mac.ophages, fibroblasts, and epithelial c.lls), and ac.elerated maturation of the extrac.llular matrix. These results demonstrate that a zinc.supplemented c.lc.um alginate, HEMO-IONIc. applied for 10 min at the end of surgery and then removed has a long-term positive effec. on all phases of tissue repair.

关键词： Hemostatic.agent Alginate Surgery Hemostasis Endothelial c.lls Tissue repair

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