检索结果-南通市图书馆

Frontiers of Agricultural Science and Engineering 2019年第4期6卷 357-365页

作者： uwe LUDEWIG Lixing YUAN Gunter NEUMANN Crop Science Institute Nutritional Crop Physiology(340h)University of HohenheimFruwirthstr.20D-70593 StuttgartGermany National Academy of Agriculture Green Development Key Laboratory of Plant-Soil Interactions(Ministry of Education)College of Resources and Environmental SciencesChina Agricultural UniversityBeijing 100193China

Phosphorus(P)is essential for life and for efficient crop production,but global P use with limited recycling is inefficient in several sectors,including ***,plant physiologists,agronomists,farmers and end users employ different measures for P use efficiency(PUE),which often masks their values at different *** term P use effectiveness,which also considers energetic and sustainability measures in addition to P balances,is also a valuable *** physiological and genetic factors for plant P uptake and utilization have been identified,but there has been limited success in genetically improving PUE of modern crop *** maize,studies on root architectural and morphological traits appear *** processes assist in mobilizing and capturing sparingly soluble phosphate from rock *** of phosphate-solubilizing microorganisms with ammonium-based nitrogen fertilizer,as well as strategies of fertilizer placement near the roots of target crops,can moderately enhance *** desired concentration of P in the products differs,depending on the final use of the crop products as feed,food or for energy conversion,which should be considered during crop production.

关键词： acquisition efficiency plant growth promoting rhizobacteria phosphate use efficiency utilization efficiency

Stress-activated kinases as therapeutic targets in pancreatic cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第30期27卷 4963-4984页

作者： Benno Traub Aileen Roth Marko Kornmann uwe Knippschild Joachim Bischof Department of General and Visceral Surgery Ulm University HospitalUlm 89081Germany

Pancreatic cancer is a dismal disease with high incidence and poor survival *** the aim to improve overall survival of pancreatic cancer patients,new therapeutic approaches are urgently *** kinases are key regulatory players in basically all stages of development,maintaining physiologic functions but also being involved in pathogenic processes.c-Jun N-terminal kinases(JNK)and p38 kinases,representatives of the mitogen-activated protein kinases,as well as the casein kinase 1(CK1)family of protein kinases are important mediators of adequate response to cellular stress following inflammatory and metabolic stressors,DNA damage,and *** their physiologic roles,they are responsible for the regulation of cell cycle progression,cell proliferation and differentiation,and *** of the underlying pathways consequently has been identified in various cancer types,including pancreatic *** targeting of those pathways has been the field of interest for several *** success in earlier studies was limited due to lacking specificity and off-target effects,more recent improvements in small molecule inhibitor design against stress-activated protein kinases and their use in combination therapies have shown promising in vitro ***,targeting of JNK,p38,and CK1 protein kinase family members may actually be of particular interest in the field of precision medicine in patients with highly deregulated kinase pathways related to these ***,further studies are warranted,especially involving in vivo investigation and clinical trials,in order to advance inhibition of stress-activated kinases to the field of translational medicine.

关键词： Pancreatic cancer Stress-activated protein kinases Mitogen-activated protein kinases c-Jun N-terminal kinases Casein kinase 1 Small molecule inhibitor

Effects of yttria content on the CMAS infiltration resistance of yttria stabilized thermal barrier coatings system

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2020年第8期36卷 74-83页

作者： Juan JGomez Chavez Ravisankar Naraparaju Peter Mechnich Klemens Kelm uwe Schulz C.V.Ramana University of Texas at El Paso Department of Mechanical EngineeringEl PasoTX79968USA German Aerospace Center(DLR) Institute of Materials ResearchCologne51170Germany

The effects of YO(1.5)doping in yttria-zirconia based thermal barrier coatings(TBCs)against CMAS interaction/infiltration are *** TBCs with an YO(1.5)content ranging from 43–67 mol.%(balance Zr O2)were produced by electron beam physical vapor deposition(EB-PVD)*** results reveal a trend of higher apatite formation probability with the higher free YO(1.5)available in the yttriazirconia ***,the infiltration resistance and amount of consumed coating appears to be strongly dependent on the YO(1.5)content in the *** thinnest reaction layer and lowest infiltration was found for the highest produced 67 YO(1.5)*** XRD experiments with volcanic ash/YO(1.5)powder mixtures with higher yttria contents than in the coatings(80 YO(1.5)and pure YO(1.5))also showed higher apatite formation with respect to increasing yttria *** threshold composition to promote apatite-based reaction products was found to be around 50 YO(1.5)in zirconia which was proved in the coatings and XRD powder *** YO(1.5)-ZrO2-Fe O-TiO2 bearing zirconolite-type phase was formed as a reaction product for all the coating compositions which implicates that TiO2 in the melt acts as a trigger for zirconolite *** phase could be detrimental for CMAS/volcanic ash infiltration resistance since it can be formed alongside with apatite which controls or limits the amount of Y^(3+)available for glass *** Fe rich garnet phase containing all the possible elements exhibited a slower nucleation compared to apatite and its growth was enhanced with slow cooling *** implications of phase stability and heat treatment effects on the reaction products are discussed for tests performed at 1250°C.

关键词： CMAS Volcanic ash Infiltration Electron beam physical vapor deposition Thermal barrier coating

Targeted STAT1 therapy for LZTR1-driven peripheral nerve sheath tumor

在线全文

学校读者我要写书评

暂无评论

Cancer Communications 2023年第12期43卷 1386-1390页

作者： Tonci Ivanisevic Mikhail Steklov Benoit Lechat Christopher Cawthorne Willy Gsell Greetje Vande Velde Christophe Deroose Koen Van Laere uwe Himmelreich Raj N Sewduth Anna A Sablina VIB-KU Leuven Center for Cancer Biology VIB Leuven Belgium Nuclear Medicine and Molecular Imaging Department of Imaging and Pathology KU Leuven Leuven Belgium Biomedical MRI Department of Imaging and Pathology KU Leuven Leuven Belgium

Dear Editor,Schwannomas are peripheral nervous system tumors that cause chronic pain,numbness,and potentially lifethreatening organ *** is a conventional treatment for schwannoma ***,those who undergo surgery may experience neurological ***,the management of schwannomas can be problematic due to their unpredictable ***,there is a pressing need for nonsurgical treatments to manage both tumor growth and pain control.

关键词： STAT1 Surgery treatment

Quantum Transport across Amorphous-Crystalline Interfaces in Tunnel Oxide Passivated Contact Solar Cells: Direct versus Defect-Assisted Tunneling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letters 2021年第3期38卷 75-80页

作者：李峰端伟元 Manuel Pomaska Malte Köhler 丁凯宁普勇 Urs Aeberhard uwe Rau College of Science Nanjing University of Posts and TelecommunicationsNanjing 210023China IEK-5 Photovoltaik Forschungszentrum Jülich52425 JülichGermany

Tunnel oxide passivated contact solar cells have evolved into one of the most promising silicon solar cell concepts of the past decade,achieving a record efficiency of 25%.We study the transport mechanisms of realistic tunnel oxide structures,as encountered in tunnel oxide passivating contact(TOPCon) solar *** transport is affected by various factors,including oxide layer thickness,hydrogen passivation,and oxygen *** the thickness of the tunnel oxide layer increases,a faster decline of conductivity is obtained computationally than that observed *** tunneling seems not to explain the transport characteristics of tunnel oxide ***,it can be shown that recombination of multiple oxygen defects in a-SiOx can generate atomic silicon nanowires in the tunnel ***,new and energetically favorable transmission channels are generated,which dramatically increase the total current,and could provide an explanation for our experimental *** work proves that hydrogenated silicon oxide(SiOx:H) facilitates high-quality passivation,and features good electrical conductivity,making it a promising hydrogenation material for TOPCon solar *** carefully selecting the experimental conditions for tuning the SiOx:H layer,we anticipate the simultaneous achievement of high open-circuit voltage and low contact resistance.

关键词： tuning Tunnel conductivity

Evolution of endoscopic extraperitoneal radical prostatectomy （EERPE）： technique and outcome

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2012年第2期14卷 278-284页

作者： Jens-uwe Stolzenburg Odysseas Andrikopoulos Panagiotis Kallidonis Iason Kyriazis Minh Do Evangelos Liatsikos Department of Urology University of LeipzigLeipzig D-04103Germany Department of Urology University of PatrasRioPatras 26500Greece

Endoscopic extraperitoneal radical prostatectomy （EERPE） is a well-established and standardized technique for treating patients with localized prostate cancer. Nevertheless, the procedure is continuously being refined with the expansion of anatomical knowledge. The development of a nerve-sparing approach and improvements in currently used equipment are expected to yield better results in cosmesis and convalescence without sacrificing the procedure＇s established benefits in terms of potency, continence and oncological management. In this study, the technique and its evolution are presented in detail, along with an analysis of its clinical efficacy. We also consult the literature to compare EERPE to transperitoneal laparoscopic radical prostatectomy, and we also discuss new technical advancements regarding the use of robotic assistance during EERPE.

关键词： extraperitoneal laparoscopy prostate cancer radical prostatectomy robotic assistance

Techno-economic evaluation of a biogas-based oxidative coupling of methane process for ethylene production

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2018年第4期12卷 598-618页

作者： Alberto T.Penteado Mijin Kim Hamid R.Godini Erik Esche Jens-uwe Repke Process Dynamics and Operations Group Technische Universitat BerlinD-10623 BerlinGermany

This contribution is a preliminary techno-economic assessment of a biogas-based oxidative coupling of methane (OCM) process. Biogas is frequently utilized as a renewable energy source within small scale combined heat and power plants or as a natural gas substitute. The activation of methane also enables its utilization as a feedstock to produce chemicals. In this sense, the OCM process allows for the direct conversion of methane into ethylene, which is a major building block for the chemical and polymer industries. Biogas resulting from the anaerobic digestion of vinasse, a liquid effluent from bioethanol industry, is treated for contaminant removal and its methane content is converted into ethylene, which is then purified as the main product. The biogas cleaning process is assessed based on literature data, while an experimentally validated simulation model is used to assess the OCM process. A techno-economic evaluation is then performed through a Monte Carlo simulation, wherein uncertain parameters take random values between reasonable bounds. The net present value results positive in 74% of the cases, indicating that the project is profitable under a wide range of scenarios. Some performance improvement opportunities have been identified and highlighted to guide future studies in the topic.

关键词： biogas conversion ethylene production oxidative coupling of methane feasibility study

Green infrastructure： a planning concept for the urban transformation of former coal-mining cities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Coal Science & Technology 2018年第1期5卷 78-91页

作者： Peter Wirth Jiang Chang Ralf-uwe Syrbe Wolfgang Wende Tinghao Hu Leibniz Institute of Ecological Urban and Regional Development (IOER) Weberplatz 1 01217 DresdenGermany China University of Mining and Technology (CUMT) Daxue Road 1 Xuzhou 221116 China

Green infrastructure is a concept aimed at realizing a strategically planned network of valuable natural and semi-natural areas, designed and managed to deliver a wide range of ecosystem services and to protect biodiversity in rural and urban settings. In the general post-mining context of China and Germany, this paper suggests and outlines an approach that combines green infrastructure with specific concepts of post-mining landscapes. While Germany has a long tradition of post-mining restoration, concepts of green infrastructure are still poorly developed. China, on the other hand, has taken its first steps in the restoration of coal regions, and could profit from the new concepts while drawing on Germany’s experience. The potentials of relevant strategies are investigated here through two case studies from Germany and China. Although there are significant differences in the post-mining development strategies of these two countries, it is clear that the green infrastructure concept can contribute significantly to a growth in ecosystem services. Four advantages of the green infrastructure concept are seen: First, it enables a systematic and highly objective assessment of mining impacts on the ecosystem. Second, the concept assists in the implementation of urban sustainability goals. Third, it is rooted in the local characteristics of landscapes. And finally, the green infrastructure concept seems to be highly compatible with tools of landscape and regional planning.

关键词： Post-mining development Ecosystem services Urban planning Green space China Germany

Expression of toxin-related human mono-ADP-ribosyltransferase 3 in human testes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2006年第A3期8卷 281-287页

作者： Maik Friedrich Andreas Grahnert uwe Paasch Andrea Tannapfel Friedrich Koch-Nolte Sunna Hauschildt Institute of Biology Ⅱ Department of ImmunobiologyUniversity of Leipzig D-04103 Leipzig Germany Division of Andrology Department of DermatologyUniversity of Leipzig D-04103 Leipzig Germany Institute of Pathology University of Leipzig D-04103 Leipzig Germany Institute of lmmunology University Hospital D-20246 Hamburg Germany

Aim： To investigate wether the corresponding protein of mono-ADP-ribosyltransferase 3 （ART3） mRNA is expressed in human testes and, if so, whether the expression is cell type-specific. Methods： ART3 mRNA was determined in human testes and sperm by reverse transcription-polymerase chain reaction （RT-PCR）. The glycosylphosphatidylinositol linkage of ART3 was shown by treating ART3-transfected HEK-293-T cells with phospholipase C. Fluorescent activated cell sorter （FACS）-analyses were used to detect ART3 on mature spermatozoa and immunohistological studies to detect the protein in testes. Results： ART3 protein was shown to be present in testes. It was found on spermatocytes only. It was absent from spermatogonia, spermatids and spermatozoa. The absence of ART3 from spermatozoa was confirmed by FACS-analysis. ART3 protein was detected neither within a seminoma nor on Leydig cells. Conclusion： Here we show for the first time that ART3 protein is expressed in testes in particular on spermatocytes, indicating that ART3 exerts a specific function only required at a particular stage of spermatogenesis.

关键词： mono-ADP-ribosyltransferase 3 testes human spermatocyte spermatogenesis

Migration of Paramagnetic Ions in Glass Melts Under Influence of a Magnetic Field

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research(International) 2012年第S2期19卷 1068-1071页

作者： SCHADEWALD uwe HALBEDEL Bernd Dep.of Inorganic-Nonmetallic Materials Ilmenau University of Technology

Magnetic forces are widely used to influence the properties of *** main focus of recent investigations concerning oxide melts mainly was on the use of Lorentz forces either to mix glass melts to avoid an improved inhomogeneity or to measure the flow of these *** the last years also the use of magnetic gradient forces has become an object of research mainly in *** the basis of preliminary investigations the influence of these forces on paramagnetic ions such as Fe;in oxide melts is investigated to examine the potential of magnetic gradient forces as a tool to create defined gradient materials.

关键词： magnetic gradient force glass crystallization paramagnetic ions