检索结果-南通市图书馆

COVID-19 therapeutics:Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2023年第4期10卷 1402-1428页

作者： Sunny kumar Malini Basu Pratyasha Ghosh uttam Pal Mrinal k.Ghosh Cancer Biology and Inflammatory Disorder Division Council of Scientific and Industrial Research-Indian Institute of Chemical Biology(CSIR-IICB)TRUE CampusCN-6SectoreVSalt LakeKolkata-700091&4Raja S.C.Mullick RoadJadavpurKolkata 700032India Department of Microbiology Dhruba Chand Halder CollegeDakshin BarasatWest Bengal 743372India Department of Economics Bethune CollegeUniversity of CalcuttaKolkata 700006India

Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)causes the compli-cated disease *** are continuously facing huge problems in the treatment of patients,as COVID-19-specific drugs are not available,hence the principle of drug repurpos-ing serves as a one-and-only ***,the repurposing of many drugs is underway;few of them are already approved by the regulatory bodies for their clinical use and most of them are in different phases of clinical *** in this review,our main aim is to discuss in detail the up-to-date information on the target-based pharmacological classification of repurposed drugs,the potential mechanism of actions,and the current clinical trial status of various drugs which are under repurposing since early *** last,we briefly proposed the probable phar-macological and therapeutic drug targets that may be preferred as a futuristic drug discovery approach in the development of effective medicines.

关键词： Clinical trials COVID-19 Drug discovery Pharmacology Repurposing of drugs SARS-CoV-2

Thermal inertia at the MSL and InSight mission sites on Mars

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Earth and Planetary Physics 2022年第1期6卷 18-27页

作者： D.Singh S.uttam Centre of Studies in Resources Engineering Indian Institute of Technology BombayMumbaiIndia Physical Research Laboratory AhmedabadIndia

For planetary surface materials,thermal inertia is the critical property that governs the surface’s daily thermal response and controls diurnal and seasonal surface temperature *** we use the ground measurements made by the MSL Curiosity rover and the InSight lander to determine the thermal inertia of two sites on *** study compares the variation of thermal inertia during and after the Large Dust Storm(LDS)of Martian Year(MY)*** determine surface thermal inertia,we derive a simple approximation(using energy balance),which utilizes surface albedo,surface energy flux,and diurnal change in the surface *** average thermal inertia in MY34 is about 39.2%,3.7%,and 3.4%higher than MY35 average thermal inertia for the MSL,InSight(FOV1),and InSight(FOV2),***,the thermal inertia at the InSight(FOV1)is consistently lower by about 20 J·m^(-2)·s^(-1/2)·k^(-1) than the InSight(FOV2)site for all scenarios,indicating variation in the region’s surface *** best-fit surface albedo in MY34(determined using the kRC model)are about 0.08,0.05,and 0.03 higher than MY35 surface albedo for the MSL,InSight(FOV1),and InSight(FOV2),*** increase in both surface albedo and thermal inertia during the LDS indicates that the underlying surface is both more thermally resistant and more reflective than the overlying loose dust.

关键词： Mars Mars surface thermal inertia dust storm Mars climate

Ultra-small amorphous MoS2 decorated reduced graphene oxide for supercapacitor application

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2020年第5期40卷 196-203页

作者： Poulami Hota Milon Miah Saptasree Bose Diptiman Dinda uttam k.Ghorai Yan-kuin Su Shyamal k.Saha Department of Materials Science Indian Association for the Cultivation of ScienceJadavpurKolkata700032India Department of Materials Science and Engineering Seoul National UniversitySeoul151-744Republic of Korea Department of Industrial Chemistry and Applied Chemistry Ramakrishna Mission Vidyamandira and Swami Vivekananda Research CenterBelur MathHowrah711202India Green Energy Technology Research Center Kun Shan UniversityTainanTaiwanChina

Amorphous materials have recently gained much attention as electrode materials in supercapacitor application due to the presence of larger amount active sites which can efficiently increase the storage capacity of the *** engineering is an elegant approach to fully utilize the advantages of the amorphous ***,large surface area and high conductivity of reduced graphene oxide(RGO)can efficiently increase the storage capacity of the *** this idea,in the present work,we have successfully synthesized amorphous MoS2 of two different sizes on reduced graphene oxide and thoroughly investigated the supercapacitor behavior of the *** specific capacitance of the composite structures has been found to be largely increased with decreasing size of the amorphous nano *** specific capacitance of amorphous MoS2-RGO composite containing nearly 50 nm of MoS2 found to be 270 F/g whereas when the particle size is reduced to 5–7 nm,value of specific capacitance increases to 460 F/*** large increase in specific capacitance with the tuning of the size of amorphous nano particle has been explained by the presence of a large number of active sulfur edges of ultra-small MoS2 nano structure along with the better charge transport which can effectively increase the storage capacity of the overall *** retention in the capacitance of the material has been found to be 90%after 5000 cycles.

关键词： Supercapacitor Ultrasmall amorphous MoS2 nanoparticles Sulfur edge sites Reduced graphene oxide(RGO) Specific capacitance

First-principles study on the mechanical and thermodynamic properties of MoNbTaTiW

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2020年第10期27卷 1398-1404页

作者： uttam Bhandari Congyan Zhang Shengmin Guo Shizhong Yang Department of Computer Science Southern University and Agricultural&Mechanical CollegeBaton RougeLouisiana 70813USA Department of Mechanical and Industrial Engineering Louisiana State UniversityBaton RougeLouisiana 70803USA

Refractory high-entropy alloys(RHEAs)are emerging as new materials for high temperature structural applications because of their stable mechanical and thermal properties at temperatures higher than 2273 *** this study,the mechanical properties of MoNbTaTiW RHEA are examined by applying calculations based on first-principles density functional theory(DFT)and using a large unit cell with 100 randomized *** phase calculation of MoNbTaTiW with CALPHAD method shows the existence of a stable body-centered cubic structure at a high temperature and a hexagonal closely packed phase at a low *** predicted phase,shear modulus,Young’s modulus,Poisson’s ratio,and hardness values are consistent with available experimental *** linear thermal expansion coefficient,vibrational entropy,and vibrational heat capacity of MoNbTaTiW RHEA are investigated in accordance with Debye-Grüneisen *** results may provide a basis for future research related to the application of RHEAs.

关键词： high-entropy alloy MoNbTaTiW mechanical properties thermodynamic properties density functional theory

Selection of appropriate analytical tools to determine the potency and bioactivity of antibiotics and antibiotic resistance

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2016年第4期6卷 207-213页

作者： Nishant A.Dafale uttam P.Semwal Rupak k.Rajput G.N.Singh Microbiology Division Indian Pharmacopoeia Commission

Antibiotics are the chemotherapeutic agents that kill or inhibit the pathogenic *** of microorganism to antibiotics is a growing problem around the world due to indiscriminate and irrational use of *** order to overcome the resistance problem and to safely use antibiotics,the correct measurement of potency and bioactivity of antibiotics is *** assay and high performance liquid chromatography（HPLC） method are used to quantify the potency of *** method is commonly used for the quantification of potency of antibiotics,but unable to determine the bioactivity;whereas microbiological assay estimates both potency and bioactivity of ***,bioassay is used to estimate the effective dose against antibiotic resistant ***,microbiological assay addresses the several parameters such as minimal inhibitory concentration（MIC）,minimum bactericidal concentration（MBC）,mutation prevention concentration（MPC） and critical concentration（Ccr） which are used to describe the potency in a more informative *** assay is a simple,sensitive,precise and cost effective method which gives reproducible results similar to ***,the HPLC cannot be a complete substitute for microbiological assay and both methods have their own significance to obtain more realistic and precise results.

关键词： Potency Antibiotics Antibiotic resistance Microbiological assay Bioactivity HPLC

Formulation optimization and characterization of transdermal film of curcumin by response surface methodology

在线全文

学校读者我要写书评

暂无评论

Chinese Herbal Medicines 2021年第2期13卷 274-285页

作者： Priyanka kriplani kumar Guarve uttam Singh Baghel Guru Gobind Singh College of Pharmacy Yamuna Nagar135001India I.k.Gujral Punjab Technical University Jalandhar 144603India Department of Pharmacy University of KotaKota 324005India

Objective:India is referred as goldmine of herbal drugs but still lack of optimization of herbal drugs,which has kept us on the back *** rationale of the study is to prepare optimized transdermal drug delivery system of curcumin employing response surface methodology to study the collective effect of independent variables like concentration of ethyl cellulose,hydroxyl propyl methyl cellulose and dibutyl phthalate which significantly influenced characteristics like percentage elongation and in vitro drug ***:Twenty formulations containing varying concentrations of polymers and permeation enhancer were prepared using solvent casting ***:The study revealed that the effect of dibutyl phthalate(DBP) concentration was the highest on percentage elongation(P kin showed that the cumulative drug release from the optimized patch showed flux of(30.68±18) μg/cm~2/***:It can be concluded that in future if proper optimization of herbal formulations is carried out,they can become the first choice for patients as compare to synthetic drugs.

关键词： Curcumin herbal drugs osteoarthritis formulation optimization transdermal film

Development and validation of microbial bioassay for quantification of Levofloxacin in pharmaceutical preparations

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2015年第1期5卷 18-26页

作者： Nishant A.Dafale uttam P.Semwal Piyush k.Agarwal Pradeep Sharma G.N.Singh Microbiology Division Indian Pharmacopoeia Commission

The aim of this study was to develop and validate a simple,sensitive,precise and cost-effective onelevel agar diffusion（5＋1） bioassay for estimation of potency and bioactivity of Levofioxacin in pharmaceutical preparation which has not yet been reported in any *** 16 microbial *** pumilus ATCC-14884 was selected as the most significant strain against *** was optimized by investigating several factors such as buffer pH,inoculums concentration and reference standard *** of Levofioxacin in commercial sample Levoflox tablet was done by FTIR *** potency recovery value for Levofioxacin in Levoflox tablet was estimated as 100.90%.A validated bioassay method showed linearity（r^2 = 0.988）,precision（Interday RSD=1.05%,between analyst RSD=1.02%） and accuracy（101.23%,RSD=0.72%）.Bioassay was correlated with HPLC using same sample and estimated potencies were 100.90% and 99.37%.*** show that bioassay is a suitable method for estimation of potency and bioactivity of Levofioxacin pharmaceutical preparations.

关键词： Levofloxacin Antibiotic resistance Microbiological bioassay HPLC Pharmacopoeia

Sphk1 Expression and Survival Outcomes in Squamous Cell Carcinoma of the Oral Cavity

在线全文

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2013年第3期4卷 704-708页

作者： Brianna N. Harris Rizwan Masood uttam k. Sinha Department of Otolaryngology and Pathology Keck School of Medicine University of Southern California Los Angeles USA

Sphingosine kinase 1 (Sphk1) is an important mediator of apoptosis and the proliferation of cancer cells. It is upregulated in cells showing increasing radioresistance. Here we present the correlation between Sphk1 expression and survival outcomes in patients with carcinoma of the oral cavity. A retrospective chart review was performed between January 2009 and August 2010 at the University of Southern California. Patients diagnosed with an advanced-stage primary tumor restricted to the oral cavity and a minimum follow-up of two years were included. Patients who did not receive post-operative radiation therapy were excluded. Eighteen patients met the inclusion criteria with 10 (55.6%) patients demonstrating high expression of Sphk1 and 8 (44.4%) patients demonstrating a low-to-moderate expression of Sphk1. Tumor recurrence occurred in 9 patients (50.0%): 5 patients (27.8%) in the Sphk1high cohort at a mean time to progression of 2.5 mo and 4 patients (22.2%) in the Sphk1low cohort at a mean time to progression of 11.0 mo (p = 0.023). Death occurred in 8 patients (66.7%) in the Sphk1high cohort and 3 patients (16.7%) in the Sphk1low cohort (p = 0.036). Higher expression of Sphk1 correlates with greater radioresistance and poorer survival outcomes in patients with HNSCC of the oral cavity.

关键词： Sphingosine kinase 1 Squamous Cell Carcinoma Radiation Sphingolipids Oral Cavity

印度北方河流中主要鲤科鱼类卡拉鲃的年龄和生长(英文)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

动物学报 2008年第1期54卷 136-143页

作者： Prashant k.DEEPAk uttam k.SARkAR Raje S.NEGI Samir k PAUL National Bureau of Fish Genetic Resources Canal Ring RoadPO-Dilkusha Lucknow-226002

为了获得印度北部赣达(Ganga)盆地河流中野生卡特拉鲃种群的年龄结构和重要生长参数,对该鱼的年龄和生长进行了研究。鳞片取自商业捕捞和实验室饲养的样品。根据研究分析,该鱼最大年龄可达8龄;巴吉拉蒂河(Bhagirathi R.)的种群平均体长... 详细信息

为了获得印度北部赣达(Ganga)盆地河流中野生卡特拉鲃种群的年龄结构和重要生长参数,对该鱼的年龄和生长进行了研究。鳞片取自商业捕捞和实验室饲养的样品。根据研究分析,该鱼最大年龄可达8龄;巴吉拉蒂河(Bhagirathi R.)的种群平均体长为521·51 mm,退算体长为288·9 -1132·3 mm;旁遮普邦(Punjab)Satluj河种群平均体长为641·6 mm,退算体长为335·4 -1096·08 mm。2龄时,种群线性生长率(Cl)和体重增加率(Cw)表现出迅速下降的趋势。其它生长参数值(Clt)也呈现快速下降。退算体长差异(ANOVA)分析显示,生活在赣达盆地不同流域中的种群, 1+-4+龄组的长度差异较明显(P<0·05) ,高龄组(5+-8+)差异不显著。根据本项研究结果,提出了对印度北部赣达盆地相关河流中生活的野生卡特拉鲃种群资源持续利用的对策。

关键词：野生卡特拉鲃年龄和生长保护和持续利赣达盆地印度