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Silicon and silicon nitride photonic circuits for spectroscopic sensing on-a-chip [Invited]

Photonics Research 2015年第5期3卷 47-59页

作者： Ananth Z.Subramanian Eva Ryckeboer Ashim Dhakal Frédéric Peyskens Aditya Malik Bart Kuyken Haolan Zhao Shibnath Pathak Alfonso Ruocco Andreas De Groote Pieter Wuytens Daan Martens Francois Leo Weiqiang Xie utsav deepak dave Muhammad Muneeb Pol Van Dorpe Joris Van Campenhout Wim Bogaerts Peter Bienstman Nicolas Le Thomas Dries Van Thourhout Zeger Hens Gunther Roelkens Roel Baets Photonics Research Group INTEC Department Ghent University-imec Centre for Nano and Biophotonics Ghent University University of California Department of Molecular Biotechnology Ghent University imec Kapeldreef 75 Physics and Chemistry of Nanostructures Ghent University

There is a rapidly growing demand to use silicon and silicon nitride（Si3N4） integrated photonics for sensing applications, ranging from refractive index to spectroscopic sensing. By making use of advanced CMOS technology,complex miniaturized circuits can be easily realized on a large scale and at a low cost covering visible to mid-IR wavelengths. In this paper we present our recent work on the development of silicon and Si3N4-based photonic integrated circuits for various spectroscopic sensing applications. We report our findings on waveguide-based absorption, and Raman and surface enhanced Raman spectroscopy. Finally we report on-chip spectrometers and on-chip broadband light sources covering very near-IR to mid-IR wavelengths to realize fully integrated spectroscopic systems on a chip.

关键词： Invited SOI mode

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Coronary heart disease:Significance of liver X receptor α genomics

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World Journal of Cardiology 2010年第6期2卷 140-149页

作者： Vivek Priy dave deepak Kaul Department of Experimental Medicine and Biotechnology Post Graduate Institute of Medical Education and Research

Crosstalk between lipid peroxidation and inflammation is known to be a pathognomonic feature for the development of coronary heart disease(CHD).In this regard ligand activated liver X receptor(LXR)-α has emerged as a key molecular switch by its inherent ability to modulate an array of genes involved in these two fundamental cellular *** addition,LXR-α has also been found to play a role in hepatic lipogenesis and innate *** several lines of evidence in experimental model systems have established the atheroprotective nature of LXR-α,human subjects have been reported to possess a paradoxical situation in which increased blood cellular LXR-α gene expression is always accompanied by increased coronary *** apparent paradox was resolved recently by the finding that CHD patients possess a deregulated LXR-α transcriptome due to impaired ligand-receptor *** blood cellular mutated LXR-α gene ex- pression correlated specifically with the extent of coro- nary occlusion and hence need is felt to devise new synthetic ligands that could restore the function of this mutated LXR-αprotein in order to modulate genes involved in reverse cholesterol transport and suppression of the inflammatory response leading to the effective treatment of CHD.

关键词： Coronary heart disease Liver X receptor Lipid metabolism Inflammation

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Heart and Brain:A neutro-genomic link

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World Journal of Biological Chemistry 2013年第2期4卷 16-17页

作者： Vivek Priy dave deepak Kaul Boditech Med Inc Central LabR and D Center Department of Experimental Medicine and Biotechnology Post Graduate Institute of Medical Education and Research

The philosophy of heart and brain are very ancient in our literature where the things good for the heart are not suggested good for the brain and *** medicine is characterized by a high degree of specialization and the heart-brain connection that could be targeted to treat these complex cardiovascular/brain *** idea that adverse diet/genome interactions can cause disease is not *** the recent era the science of nutritional genomics have increased our understanding of diet-health-gene interactions and have provided a number of benefits for individuals,groups and *** dietary chemicals are regularly ingested and participate indirectly and directly in regulating gene expression,it follows that a subset of genes regulated by diet must be involved in disease initiation,progression,and *** this regards Liver X Receptor(LXR)-a,a key transcription factors,associated with the several chronic pathological situation including coronary heart disease and neurodegenerative diseases have recently been found to be regulated by the dietary *** crucial findings at molecular biology unit,Post Graduate Institute of Medical Education and Research(PGIMER),Chandigarh,INDIA have not only forced us to explore nutritional genomics as a holistic systems approach to understand the relationship between diet and health,but also to look into the disease preventing and health promoting foods that match our lifestyles,cultures and *** all,we are what we eat.

关键词： Heart Brain Nutrition Gene interaction Liver X Receptor

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