检索结果-南通市图书馆

Biosynthesis of gold nanoparticles using aqueous extract of Ricinus cummunis leaves to augment catalytic degradation of organic dyes and study of its antifungal and antibacterial activities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第4期87卷 87-98页

作者： Mrinalini parmar Mallika Sanyal Department of Chemistry Gujarat UniversityAhmedabadGujarat 380009India St.Xaviers College NavrangpuraAhmedabadGujarat 380009India

In this study,biosynthesis of gold nanoparticles(Au NPs)using aqueous extract of fresh leaves of Ricinus cummunis plant is reported without the use of any synthetic chemical in the reaction *** prepared NPs are mostly spherical in shape with some particles having triangular or hexagonal *** average size of the particles as calculated using TEM data is 18 *** biosynthesised Au NPs were studied for their application in remediation of Congo Red,Methylene Blue,Reactive Red 120 and Rhodamine B dyes present in industrial *** degradation of dyes was confirmed spectropho-tometrically using UV-Vis *** Red 120 and Congo red dyes were most effec-tively reduced with 88%*** Au NPs were further studied for their potential as an effective antifungal agent against fungal strains namely Candida albicans and Aspergillus fumigatus and antibac-terial properties against Bacillus subtilis(Gram+ve)and Pseudomonas aeruginosa(Gram-ve)bacterial *** MIC values being 7.8 and 15.6(μg/mL)for Bacillus subtilis and Pseudomonas aeruginosa respectively.

关键词： Gold nanoparticles Photocatalysts Dye degradation Antifungal studies Antibacterial studies

Genetic and epigenetic dependencies in colorectal cancer development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gastroenterology Report 2022年第1期10卷 115-131页

作者： Sehej parmar Hariharan Easwaran Cancer Genetics and Epigenetics OncologySidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMDUSA

Recent studies have mapped key genetic changes in colorectal cancer(CRC)that impact important pathways contributing to the multistep models for CRC initiation and *** parallel with genetic changes,normal and cancer tissues harbor epigenetic alterations impacting regulation of critical genes that have been shown to play profound roles in the tumor ***,these molecular changes are only loosely associated with heterogenous transcriptional programs,reflecting the heterogeneity in the various CRC molecular subtypes and the paths to CRC *** from mapping molecular alterations in early CRC lesions and use of experimental models suggest that the intricate dependencies of various genetic and epigenetic hits shape the early development of CRC via different pathways and its manifestation into various CRC *** highlight the dependency of epigenetic and genetic changes in driving CRC development and discuss factors affecting epigenetic alterations over time and,by extension,risk for cancer.

关键词： colorectal cancer epigenetics aging classification subtyping DNA methylation consensus molecular subtypes

Study on demand and characteristics of parking system in urban areas:A review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traffic and Transportation Engineering(English Edition) 2020年第1期7卷 111-124页

作者： Janak parmar Pritikana Das Sanjaykumar M.Dave Department of Civil Engineering Faculty of Technology and EngineeringThe Maharaja Sayajirao University of BarodaVadodara 390001India Transportation Planning and Environment Division CSIR-Central Road Research InstituteNew Delhi 110025India

The increasing rate of private car usage in the urban areas as a result of fast-growing economy,derelict policies and subsidies are the main causes making car parking one of the main concerns for transport and traffic management all over the *** coordination between parking policies and traffic management revealed how parking is becoming a barrier to the through-traffic ***,it is responsible for the inefficient use of available resources,even the decisions are made on an ad-hoc basis while making ***,it is necessary to understand the parking choice behaviour and actual demand of parking *** the last three decades,ample studies have been done to evaluate parking characteristics,to estimate the demand for parking and on driver’s behaviour while choosing the parking *** paper integrates all these aspects and presents the state-of-the-art review of models and studies on the parking *** related to and due to the parking,various parking characteristics and their applications,parking choice behaviour of drivers,development of demand models considering various factors and review of parking policies as an integral part of the urban transport system are discussed in *** underdeveloped,authors found the literatures suggest that greater attention should be given to metrics like ease of access,walk time,parking charges,parking guidance and information system,management,etc.,at all stages of planning and policy *** together,mentioned studies demonstrate useful information concerning the entire parking *** also provides useful information to the planners and policy makers for planning,designing and evaluating parking system.

关键词： Transportation engineering Parking demand and capacity Parking characteristics Parking choice behaviour Policy guideline Planning and management

Self nano-emulsifying drug delivery system for Embelin:Design,characterization and in-vitro studies

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2015年第5期10卷 396-404页

作者： Komal parmar Jayvadan Patel Navin Sheth Department of Pharmaceutical Sciences Saurashtra UniversityRajkotGujarat 360005India Nootan Pharmacy College VisnagarGujarat 384315India

CThe objective of the present study was to prepare solid self-nanoemulsifying drug delivery system(S-SNEDDS)containing Capryol-90 as oil phase for the delivery of Embelin,a poorly water soluble herbal active ***-Behnken experimental design was employed to optimise the formulation variables,X1(amount of oil;Capryol 90),X2(amount of surfactant;Acrysol EL 135)and X3(amount of co-surfactant;PEG 400).Systems were appraised for visual characteristics for self emulsifying time,globule size and drug *** liquid formulations were formulated into free flowing granules(S-SNEDDS)by adsorption on the porous materials like Aerosil 200 and Neusilin and thereby compressed into *** vitro dissolution studies of SNEDDS revealed increased in the dissolution rate of the ***-IR data revealed no physicochemical interaction between drug and *** state characterization of S-SNEDDS by DSC and Powder XRD confirmed reduction in drug crystallinity which further supports the results of dissolution *** analysis exhibited spherical ***,the accelerated stability studies for 6 months revealed that S-SNEDDS of Embelin are found to be stable without any significant change in physicochemical ***,the present studies demonstrated dissolution enhancement potential of porous carrier based S-SNEDDS for poorly water soluble herbal active ingredient,Embelin.

关键词： Embelin SNEDDS Dissolution enhancement Box-Behnken design Characterization

Multidimensional evaluation of salt tolerance in groundnut genotypes through biochemical responses

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oil Crop Science 2024年第2期9卷 102-110页

作者： Rushita D.parmar Vaishali G.Varsani Vijay parmar Suhas Vyas Dushyant Dudhagara Department of Life Sciences Bhakta Kavi Narsinh Mehta UniversityJunagadhGujaratIndia

The manuscript explores the complex interplay between groundnut genotypes,salt tolerance and hormonal influence,shedding light on the dynamic responses of three specific groundnut genotypes,KDG-128,TG-37 A and GG-20,to salt treatments and gibberellic acid(GA3).The study encompasses germination,plant growth,total protein content and oil content as key *** comprehensive analysis,it identifies TG-37 A and KDG-128 as salt-tolerant genotypes,and GG-20 as salt-susceptible genotypes,which highlighting the potential for targeted breeding efforts to develop more resilient groundnut ***,the quantification of protein and oil content under different treatments provides vital data for optimizing nutritional profiles in groundnut *** Component Analysis(PCA) underscores the significance of the first principal component(PC1)in explaining the majority of variance,capturing primary trends and differences in plant *** of Variance(ANOVA) and hierarchical analysis confirm the presence of statistically significant differences in protein and oil content among the ***'s correlation coefficient matrix analysis reveals strong positive correlations between plant length and protein content,plant length and oil content,and a moderately positive correlation between protein content and oil *** findings provide valuable insights into groundnut physiology,salt tolerance,and nutritional composition,with implications for future research in sustainable agriculture and crop improvement.

关键词： Groundnut Salt tolerance Genotypes Salt-hormone interaction Protein and oil content Statistical analysis

G-protein coupled receptors and synaptic plasticity in sleep deprivation

在线全文

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2021年第11期11卷 954-980页

作者： Shweta parmar Ramakrishna Tadavarty Bhagavatula R Sastry Department of Anesthesiology Pharmacology and TherapeuticsThe University of British ColumbiaVancouver V6T 1Z3British ColumbiaCanada

Insufficient sleep has been correlated to many physiological and psychoneurological *** the years,our understanding of the state of sleep has transcended from an inactive period of rest to a more active state involving important cellular and molecular *** addition,during sleep,electrophysiological changes also occur in pathways in specific regions of the mammalian central nervous system(CNS).Activity mediated synaptic plasticity in the CNS can lead to long-term and sometimes permanent strengthening and/or weakening synaptic strength affecting neuronal network *** consolidation and learning that take place during sleep cycles,can be affected by changes in synaptic plasticity during sleep disturbances.G-protein coupled receptors(GPCRs),with their versatile structural and functional attributes,can regulate synaptic plasticity in CNS and hence,may be potentially affected in sleep deprived *** this review,we aim to discuss important functional changes that can take place in the CNS during sleep and sleep deprivation and how changes in GPCRs can lead to potential problems with therapeutics with pharmacological interventions.

关键词： G-protein coupled receptors Metabotropic glutamate receptors Gammaamino butyric acid-B receptor Synaptic plasticity Sleep deprivation Memory consolidation

Underpinning the molecular programming attributing heat stress associated thermotoleranee in tea (Camellia sinensis (L.) O. Kuntze)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Horticulture Research 2021年第1期8卷 1333-1351页

作者： Romit Seth Tony Kipkoech Maritim Rajni parmar Ram Kumar Sharma Biotechnology Department CSIR-I nstitute of Himalayan Bioresource Technology(CSIR-IHBT)PalampurHimachal Pradesh 176061India Academy of Scientific and Innovative Research(AcSIR) CSIR-HRDC CampusGhaziabadUttar Pradesh 201002India Teabreeding and genetic improvement division KALRO-Tea Research InstituteBox 82020200 KerichoKenya

The most daunting issue of global climate change is the deleterious impact of extreme temperatures on tea productivity and quality,which has resulted in a quest among researchers and *** current study aims to unravel molecular programming underpinning thermotolerance by characterizing heat tolerance and sensitivity response in 20 tea *** signi fi cantly higher negative in fl uence of heat stress was recorded in a sensitive cultivar with reduced water retention(47%),chlorophyll content(33.79%),oxidation potential(32.48%),and increase in membrane damage(76.4%).Transcriptional pro fi ling of most tolerant and sensitive cultivars identi fi ed 78 differentially expressed unigenes with chaperon domains,including low and high molecular weight heat shock protein(HSP)and heat shock transcription factors(HSFs)involved in heat shock response(HSR).Further,predicted transcriptional interactome network revealed their key role in thermotolerance via well-co-ordinated transcriptional regulation of aquaporins,starch metabolism,chlorophyll biosynthesis,calcium,and ethylene mediated plant signaling *** study identi fi ed the key role of HSPs(CsHSP90)in regulating HSR in tea,wherein,structure-based molecular docking revealed the inhibitory role of geldanamycin(GDA)on CsHSP90 by blocking ATP binding site at N-terminal domain of predicted ***,GDA mediated leaf disc inhibitor assay further af fi rmed enhanced HSR with higher expression of CsHSP17.6,CsHSP70,HSP101,and CsHSFA2 genes in *** the current study,efforts were made to extrapolate a deeper understanding of chaperons mediated regulation of HSR attributing thermotolerance in tea.

关键词： metabolism programming stress

Differential advantages of musical backgrounds on binaural integration and interaction skills in instrumentalists,vocalists,and non-musicians

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Otology 2023年第4期18卷 185-192页

作者： Kavassery Venkateswaran Nisha Adya parmar Chandana Shivaiah Prashanth Prabhu Department of Audiology All India Institute of Speech and Hearing(AIISH)Naimisham CampusManasagangothriMysore570006India

Background:Musical perception requires a host of *** musicians place greater emphasis on motor coordination,whereas vocal musicians rehearse vocal *** study explored the differential advantages of musical background on binaural integration and interaction in musicians(instrumentalists,vocalists)and compared them with age-matched ***:Eight six participants aged 20e40 y with normal hearing sensitivity were subjected to binaural tests using a standard group comparison research *** participants were segregated into three groups e Group 1 included instrumentalists(n?26,mean age:17.73±2.83 y),while Group 2 and Group 3 consisted of vocalists(n?30,mean age:19.30±2.47 y)and non-musicians(n?30,mean age:18.20±3.02 y)*** binaural processes namely integration(Dichotic syllable test,DST;and virtual acoustic space identification-VASI)and interaction(Interaural difference thresholds for time and level:ITD&ILD),were administered on all the ***:Statistical analyses showed the main effect of *** pair-wise test revealed that the musicians(instrumentalists and vocalists)outperformed(p0.05).Conclusion:Musical background-induced differential advantages can be reasonably noted in the binaural skills of instrumentalists and vocalists(compared to non-musicians).

关键词： Musicians Instrumentalist Vocalist Musical training Binaural processing Localization VASI Binaural integration Binaural interaction

Quantitation of tadalafil in human plasma using a sensitive and rapid LC-MS/MS method for a bioequivalence study

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2018年第4期8卷 271-276页

作者： Abhaysingh Bhadoriya Bhavesh Dasandi Dharmesh parmar Priyanka A. Shah Pranav S. Shrivastav Bioanalytical Department Synchron Research Services Pvt. Ltd. Department of Chemistry School of Sciences Gujarat University

A highly sensitive liquid chromatography-tandem mass spectrometry（LC-MS/MS） method was developed for the determination of tadalafil（TAD） in human plasma. TAD and its deuterated internal standard（IS）, tadalafil-d3, were extracted from 200 mL plasma using Phenomenex Strata-X-C 33 m extraction cartridges. Chromatographic analysis was carried out on Synergi Hydro-RP C18（100 mm × 4.6 mm, 4 mm）column with a mobile phase consisting of methanol and 10 m M ammonium formate, p H 4.0（90：10, v/v）,delivered at a flow rate of 0.9 m L/min. Quantitation of the protonated analyte was done on a triple quadrupole mass spectrometer using multiple reaction monitoring via electrospray ionization. The precursor to product ions transitions monitored for TAD and TAD-d3 were m/z 390.3-268.2 and m/z393.1-271.2, respectively. The calibration curve was linear over the concentration range of 0.50–500 ng/m L with correlation coefficient, r2 Z 0.9994. Acceptable intra-batch and inter-batch precision（r3.7%） and accuracy（97.8% to 104.1%） were obtained at five concentration levels. The recovery of TAD from spiked plasma was highly precise and quantitative（98.95% to 100.61%）. Further, the effect of endogenous matrix components was minimal. TAD was found to be stable under different storage conditions in human plasma and also in whole blood samples. The validated method was successfully used to determine TAD plasma concentration in a bioequivalence study with 20 mg TAD tablets in 24 healthy volunteers. Method performance was evaluated by reanalyzing 115 study samples.

关键词： Tadalafil Tadalafil-d3 LC-MS/MS Sensitive Bioequivalence study Human plasma