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Adipokines and ghrelin in gastric cancer cachexia

World Journal of Gastroenterology 2008年第23期14卷 3633-3641页

作者： Mustafa Kerem Zafer Ferahkose utku tonguc yilmaz Hatice Pasaoglu Ebru Ofluoglu Abdulkadir Bedirli Bulent Salman Tevfik Tolga Sahin Murat Akin Department of General Surgery Medical FacultyGazi UniversityBesevler 06510AnkaraTurkey Department of Biochemistry Medical FacultyGazi UniversityBesevler 06510AnkaraTurkey

AIM:To investigate the roles of the adipocytokines,ghrelin and leptin in gastric cancer cachexia. METHODS:Resistin,ghrelin,leptin,adiponectin,insulin and insulin-like growth factor(IGF-Ⅰ),were measured in 30 healthy subjects,and 60 gastric cancer patients of which 30 suffered from cancer-induced cachexia and 30 served as a control group. The relationships between hormones,body mass index(BMI) loss ratio,age,gender,and Glasgow Prognostic Score(GPS) were investigated. RESULTS:Cachexia patients had higher tumor stage and GPS when compared with non-cachexia patients(P < 0.05). Ghrelin,resistin,leptin,adiponectin and IGF-Ⅰ,showed a significant correlation with BMI loss ratio and GPS(P < 0.05). A strong correlation was seen between GPS and BMI loss(R = -0.570,P < 0.0001). Multivariate analysis indicated that BMI loss was significantly independent as a predictor of ghrelin,resistin,leptin and IGF-Ⅰ(P < 0.05). Existence of an important significant relationship between resistin and insulin resistance was also noted. CONCLUSION:These results showed that serum ghrelin,leptin,adiponectin,and IGF-Ⅰ play important roles in cachexia-related gastric cancers. No relationshipwas found between resistin and cancer cachexia. Also,because of the correlation between these parameters and GPS,these parameters might be used as a predictor factor.

关键词： Gastric cancer Cachexia Resistin Ghrelin Leptin Adiponectin Insuline

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A Non-Singleton Type-3 Fuzzy Modeling: Optimized by Square-Root Cubature Kalman Filter

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Intelligent Automation & Soft Computing 2023年第7期37卷 17-32页

作者： Aoqi Xu Khalid A.Alattas Nasreen Kausar Ardashir Mohammadzadeh Ebru Ozbilge tonguc Cagin School of Economics Fujian Normal UniversityFuzhou350007China Department of Computer Science and Artificial Intelligence College of Computer Science and EngineeringUniversity of JeddahJeddah23890Saudi Arabia Department of Mathematics Faculty of Arts and ScienceYildiz Technical UniversityEsenler34220IstanbulTurkey Multidisciplinary Center for Infrastructure Engineering Shenyang University of TechnologyShenyang110870China American University of the Middle East Department of Mathematics&Statistics54200EgailaKuwait

In many problems,to analyze the process/metabolism behavior,a mod-el of the system is identiﬁ*** main gap is the weakness of current methods *** *** primary objective of this study is to present a more robust method against *** paper proposes a new deep learning scheme for modeling and identiﬁcation *** suggested approach is based on non-singleton type-3 fuzzy logic systems(NT3-FLSs)that can support measurement errors and high-level *** the rule optimization,the antecedent parameters and the level of secondary memberships are also adjusted by the suggested square root cubature Kalmanﬁlter(SCKF).In the learn-ing algorithm,the presented NT3-FLSs are deeply learned,and their nonlinear structure is *** designed scheme is applied for modeling carbon cap-ture and sequestration problem using real-world data *** various ana-lyses and comparisons,the better efﬁciency of the proposed fuzzy modeling scheme is veriﬁ*** main advantages of the suggested approach include better resistance against uncertainties,deep learning,and good convergence.

关键词： Modeling computational intelligence fuzzy logic systems modeling identiﬁcation deep learning type-3 fuzzy systems optimization

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What Caused the Inconsistency between Rb-Sr and^(40)Ar-^(39)Ar Ages of Authigenic Illites?

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Journal of Earth Science 2022年第5期33卷 1145-1151页

作者： Entao Liu I.tonguc Uysal Jian-Xin Zhao Zi'ao Zhang Xudong Lin Hubei Key Laboratory of Marine Geological Resources China University of GeosciencesWuhan 430074China Radiogenic Isotope Facility School of Earth and Environmental SciencesThe University of QueenslandBrisbaneQld4072Australia Department of Geological Engineering Istanbul University-CerrahpaşaIstanbul34098Turkey

Radiogenic isotope dating of illitic clays has been widely used to reconstruct thermal and fluid flow events in siliciclastic sedimentary basins,the information of which is critical to investigate mechanisms of hydrocarbon *** study carried out Rb-Sr and^(40)Ar-^(39)Ar dating of authigenic illitic clay samples separated from the Palaeogene sandstone in the northern South China *** Rb-Sr data further confirm the previously reported three periods of fluid flow events(at 34.5±0.9,31.2±0.6,and 23.6±0.8 Ma,respectively)in the northern South China Sea,which are related to regional episodic ***,^(40)Ar-^(39)Ar ages of illite obtained in this study are significantly younger than the corresponding Rb-Sr *** significantly younger^(40)Ar-^(39)Ar ages were probably due to ^(40)Ar loss caused by later dry heating events on the Hainan Island that have not affected the Rb-Sr isotopic *** inconsistency between Rb-Sr and^(40)Ar-^(39)Ar data should be attributed to different isotopic behaviors of K-Ar and Rb-Sr isotopic systematics in *** results indicate that Rb-Sr isotopic dating method may be a preferential approach for clay dating in geological settings where exist younger dry heating events.

关键词： authigenic illite isotope dating Rb−Sr isochron ^(40)Ar-^(39)Ar dating inconsistency geochemistry

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Management of Epileptic Patients in Dentistry

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Surgical Science 2012年第1期3卷 47-52页

作者： Yaltirik Mehmet Ozer Senem tonguc Sulun Kocaelli Humeyra Department of Oral Surgery Faculty of DentistryIstanbul UniversityIstanbulTurkey Department of Prosthodontics Faculty of DentistryIstanbul UniversityIstanbulTurkey

Epilepsy has direct negative effects on sufferers’ general dental condition and oral health, both of which are further affected by inadequate oral hygiene;poor oral hygiene itself is often also caused by epilepsy-related poor health. Consequently, tooth loss, caries and periodontal disease occur increasingly often in epilepsy sufferers and they need more dental treatment. However, in fact the epileptic patients can receive fewer and simpler treatment modalities. The aim of this study was to review and synthesize recent studies on dental treatment in epilepsy patients and to mention potential triggers for seizures in dental practice.

关键词： Epilepsy Dental Seizure Prosthodontic Treatment

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Investigation of photon energy absorption properties for some biomolecules

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Nuclear Science and Techniques 2019年第7期30卷 1-9页

作者： Mohammed Sultan Al-Buriahi Halil Arslan Baris T. tonguc Department of Physics Sakarya University Sakarya Turkey Electrical and Electronics Engineering Sakarya University of Applied Sciences Sakarya Turkey

The mass energy absorption coefficient (len=q), effective atomic number (ZPEAeff ), and electron density (NPEAeff ) of some biomolecules with potential application in radiation dosimetry were calculated for their photon energy absorption (PEA) in the energy region of 1–20 MeV. It was noticed that the values of len=q, ZPEAeff , and NPEAeff vary with the energy and composition of the biomolecules. The results for ZPEAeff were compared with effective atomic numbers (ZPIeff ) owing to the photon interaction (PI). Significant differences were noted between ZPEAeff and ZPIeff in the energy region of 10–150 keV for all of the biomolecules involved. A maximum difference of 45.36% was observed at 50 keV for creatinine hydrochloride. Moreover, the studied attenuation parameters were found to be sharply affected at the K-absorption edge of relatively high-Z elements present in the biomolecules.

关键词： Photon energy absorption Effective atomic number Electron density Biomolecule

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