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ISRM-Sponsored International Symposium on Rock Mechanics:"Rock Characterisation,Modelling and Engineering Design Methods"(SINOROCK2009)

作者： utku ahmet ozden Tamer TOPAL MTA 06520AnkaraTurkey Department of Geological Engineering

ISBN: (纸本)9789628014170

Black sea coast line is a hazardous region in Turkey especially in winter due to the dominant wave ***,rubble mound breakwaters used as ship shelters are vital structures especially for the *** of the breakwater requires good quality durable armourstones(natural rock).Due to the nature of the rubble mound breakwaters,the armourstones with various sizes and types are used in the construction of these *** deterioration of these armourstones with time may result in the failure of the breakwater. In this study,various field and laboratory tests suggested in CIRIA/CUR(1991) and RERS(1998) of five armourstones(mainly limestone,andesite and sandstone) are performed. The test results are compared with their site performances in breakwaters and used to evaluate the suitability of the test *** the studied stones,the sandstone displays very poor *** others are found to be relatively good. Based on the data obtained,it is observed that some of the physico-mechanical parameters of the armourstones are good at predicting the long-term field performance of the *** paper will discuss the parameters to be used in the durability assessments of the armourstones.

关键词： Armourstones

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Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis

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World Journal of Gastroenterology 2007年第23期13卷 3237-3244页

作者： Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin Comert Gunay Alcigir Nuket Mas Cemal Akay Mithat Bozdayi Cihan Yurdaydin Hakan Bozkaya ozden Uzunalimoglu ahmet Turan Isik Harun M Said Department of Internal Medicine Gulhane School of Medicine Ankara 06018 Turkey Department of Pathology Veterinarian Faculty Ankara University Ankara Turkey Department of Pathology Gulhane School of Medicine Ankara 06018 Turkey Department of Anatomy Baskent University Ankara Turkey Institute for Hepatology Ankara University Ankara Turkey Department of Radiation Oncology Medical Faculty University of Würzburg Wiürzburg Germany 不详

AIM: To investigate the antif ibrotic effects of peginterferon- alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological f ibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine ***: Peginterferon-alpha 2b exerts anti- f ibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antif ibrotic strategy.

关键词： Liver fibrosis Liver cirrhosis Pegylated interferons Taurine Oxidative stress Hepatic stelate cells Apoptosis Malondialdehyde Glutathione peroxidase Superoxide dismutase

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