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Discovery and design of cyclic peptides as dengue virus inhibitors through structure-based molecular docking

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Asian Pacific Journal of Tropical Medicine 2014年第7期7卷 513-516页

作者： Sobia Idrees usman ali Ashfaq Department of Bioinformatics and Biotechnology Government College University

Objective:To find potential peptide inhibitors against the NS2B/NS3 protease of DENV which in turn,can inhibit the viral replication inside host ***:Cyclic peptides were designed having combination of positively charged amino acids using ChemSketch software and were converted to 3D *** NS3 protein structure was retrieved from Protein Data Bank(PDB)using PDB Id:*** NS3 and cylic peptides were docked using MOE software after structural ***:Through molecular docking it was revealed that most of the peptides bound deeply in the binding pocket of DENV NS2B/NS3 protease an had interactions with catalytic *** 2 successfully blocked the catalytic triad of NS2B/NS3 *** 1,,4 and 6 also had potential interactions with active residues of the NS2B/NS3 protease while all other peptides were in close contact with the active sites of NS2B/NS3 protease thus,these peptides can serve as a potential drug candidate to stop viral ***:*** can be concluded from the study that these peptides could serve as important inhibitors to inhibit the viral replication and need further in-vitro investigations to confirm their efficacy.

关键词： Dengue virus Peptides Molecular docking Inhibitors

Emerging Roles of Sphingolipid Signaling in Plant Response to Biotic and Abiotic Stresses

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Molecular Plant 2018年第11期11卷 1328-1343页

作者： usman ali Hehuan Li Xuemin Wang Liang Guo National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China Department of Biology University of MissouriSt.LouisMO 63121USA Donald Danforth Plant Science Center St.LouisMO 63132USA

Plant sphingolipids are not only structural components of the plasma membrane and other endomembrane systems but also act as signaling molecules during biotic and abiotic ***,the roles of sphingolipids in plant signal transduction in response to environmental cues are yet to be investigated in detail. In this review,we discuss the signaling roles of sphingolipid metabolites with a focus on plant *** also mention some microbial sphingolipids that initiate signals during their interaction with plants, because of the limited literatures on their plant *** equilibrium of nonphosphorylated and phosphorylated sphingolipid species determine the destiny of plant cells,whereas molecular connections among the enzymes responsible for this equilibrium in a coordinated signaling network are poorly understood.A mechanistic link between the phytohormone-sphingolipid interplay has also not yet been fully understood and many key participants involved in this complex interaction operating under stress conditions await to be *** research is needed to fill these gaps and to better understand the signal pathways of plant sphingolipids and their interplay with other signals in response to environmental stresses.

关键词： sphingolipids long-chain bases sphingolipid signaling biotic stress abiotic stress

Scenario of dengue infection & its control in Pakistan: An up-date and way forward

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Asian Pacific Journal of Tropical Medicine 2018年第1期11卷 15-23页

作者： Muhammad Zubair Yousaf Adeena Siddique usman ali Ashfaq Muhammad ali Department of Biological Sciences Forman Christian College(A Chartered University) Department of Bioinformatics and Biotechnology Government College University Faisalabad Department of Biotechnology Quad-e Azam University Islamabad

Dengue fever is one of the major health problems in tropical and subtropical areas throughout the world. The causative agent of dengue fever is the dengue virus which is an enveloped single stranded RNA virus belongs to the family Flaviviridae and has five distinct serotypes(DENV-1,DENV-2, DENV-3, DENV-4 and DENV-5). Dengue virus is transmitted to human via bite of Aedes aegypti and Aedes albopictus mosquitoes. The clinical symptoms of dengue fever ranging from mild to severe form as dengue hemorrhagic fever and dengue shock syndrome. Pakistan is dengue endemic since 1994 but from 2006, Pakistan faced the worst condition regarding dengue in which thousands of people affected by the disease and hundreds of people lost their lives. DENV-2, DENV-3 and DENV-1 are the prevalent serotypes in Pakistan. Common diagnostic techniques are being used in Pakistan such as enzyme-linked immunosorbent assay,polymerase chain reaction and rapid diagnostic tests, while differential diagnosis, limitations of diagnostic methods and poor health care system are the real challenges in dengue *** climatic conditions, unplanned urbanization, travelling etc., are major factors responsible for dengue epidemics in Pakistan. This presentation provides update about dengue circumstances in Pakistan and also describes the way how to improve dengue situation in Pakistan.

关键词： Dengue infection Diagnosis Treatment Prevention Pakistan

Novel Double-Damped Tuned AC Filters in HVDC Systems

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Computers, Materials & Continua 2023年第4期75卷 1467-1482页

作者： Rana Shaheer Mehmood Asif Hussain usman ali Muhammad Tariq Mahmood Department of Electrical Engineering University of Management and TechnologyLahore54782Pakistan Department of Electrical and Computer Engineering Sungkyunkwan University2066Seobu-roJangan-guSuwon-si16419Gyeonggi-doKorea School of Computer Science and Engineering Korea University of Technology and Education1600ChungjeolnoByeogchunmyunCheonan31253Korea

This paper presents a performance analysis of novel doubledampedtuned alternating current (AC) filters in high voltage direct current(HVDC) systems. The proposed double-damped tuned AC filters offer theadvantages of improved performance of HVDC systems in terms of betterpower quality, high power factor, and lower total harmonic distortion (THD).The system under analysis consists of an 878 km long HVDC transmissionline connecting converter stations at Matiari and Lahore, two major cities inPakistan. The main focus of this research is to design a novel AC filter usingthe equivalent impedance method of two single-tuned and double-dampedtuned AC filters. Additionally, the impact of the damping resistor on the ACchannel is examined. TheTHDof theHVDCsystem with and without currentAC filters was also compared in this research and a double-damped tuned ACfilter was proposed. The results of the simulation represent that the proposeddouble-damped tuned AC filter is far smaller in size, offers better powerquality, and has a much lower THD compared to the AC filters currently inplace in the converter station. The simulation analysis was carried out utilizingpower systems computer-aided design (PSCAD) software.

关键词： Double-damped tuned AC filters harmonics high voltage DC systems long distance transmission power quality total harmonic distortion

MagneFi: Multiuser, Multi-Building and Multi-Floor Geomagnetic Field Dataset for Indoor Positioning

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Computers, Materials & Continua 2022年第10期73卷 1747-1768页

作者： Imran Ashraf Muhammad usman ali Soojung Hur Gunzung Kim Yongwan Park Department of Information and Communication Engineering Yeungnam UniversityGyeongsan-si38541Korea Department of Computer Science University of GujratGujrat50700Pakistan

Indoor positioning and localization have emerged as a potential research area during the last few years owing to the wide proliferation of smartphones and the inception of location-attached services for the consumer *** to the importance of precise location information,several positioning technologies are adopted such as Wi-Fi,ultrawideband,infrared,radio frequency identification,Bluetooth beacons,pedestrian dead reckoning,and magnetic field,*** Wi-Fi and magnetic field-based positioning are more attractive concerning the deployment of Wi-Fi access points and ubiquity of magnetic field data,the latter is preferred as it does not require any additional infrastructure as other approaches *** the advantages of magnetic field positioning,comparing the performance of positioning and localization algorithms is very difficult due to the lack of good public datasets that cover various aspects of the magnetic field *** datasets do not provide the data to analyze the impact of device heterogeneity,user heights,and time-specific magnetic field ***,multi-floor and multibuilding data are available for the evaluation of state-of-the-art *** overcome the above-mentioned issues,this study presents multi-user,multidevice,multi-building magnetic field data which is collected over a longer *** dataset contains the data from five different smartphones including Samsung Galaxy S8,S9,A8,LG G6,and LG G7 for three geographically separated *** users including one female and two males collected the data for various path geometry and data collection ***,the data contains the magnetic field samples collected on stairs to test multifloor *** the magnetic field data,the data from inertial measurement unit sensors like the accelerometer,motion sensors,and barometer is provided as well.

关键词： Magnetic field dataset magnetic-field based positioning smartphone sensors benchmark analysis indoor positioning and localization

Enhancing through-plane thermal conductivity of fluoropolymer composite by developing in situ nano-urethane linkage at graphene–graphene interface

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Nano Research 2020年第10期13卷 2741-2748页

作者： Muhammad Maqbool Haichang Guo Akbar Bashir ali usman Adeel YAbid Guansong He Yanjuan Ren Zeeshan ali Shulin Bai Department of Materials Science and Engineering Key Laboratory of High Eenergy Density Physics Simulation(HEDPS)Center of Applied Physics and Technology(CAPT)/Laboratory of Turbulence and Complex System(LTCS)Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCollege of EngineeringPeking UniversityBejing 100871China Institute of Chemical Materials Chinese Academy of Engineering Physics(CA EP)Mianyang 621900China School of Chemical and Materials Engineering(SCME) National University of Sciences and Technology(NUST)Islamabad 4000Pakistan

Attributed to the intense development and complexity in electronic devices,energy dissipation is becoming more essential *** carbonaceous materials particularly graphene(Gr)-based thermal interface materials(TIMs)are exceptional in heat ***,because of the anisotropic behavior of Gr in composites,the TIMs having outstanding through-plane thermal conductivity(┴TC)are needed to fulfill the upcoming innovation in numerous *** order to achieve this,herein,nano-urethane linkage-based modified Gr and carbon fibers architecture termed as nanourethane linkage(NUL)-Gr/carbon fibers(CFs)is ***,toluene diisocyanate is utilized to develop a novel but simple NUL to shape a new interface between graphene ***,the prepared composite of NUL-Gr/CFs with polyvinylidene fluoride matrix shows outstanding performance in heat *** to the unique structure of NUL-Gr/CFs,an unprecedented value of┴TC(~7.96 W·m^–1·K^–1)is achieved at a low filler fraction of 13.8 wt.%which translates into an improvement of^3,980%of pristine *** achieved outcomes elucidate the significance of the covalent interaction between graphene sheets as well as strong bonding among graphene and matrix in the composites and manifest the potential of proposed NUL-Gr/CFs architecture for practical applications.

关键词： graphene thermal interface materials polymer composites

Metric Identification of Vertices in Polygonal Cacti

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Computer Modeling in Engineering & Sciences 2023年第7期136卷 883-899页

作者： Xiujun Zhang Muhammad Salman Anam Rani Rashna Tanveer usman ali Zehui Shao School of Computer Science Chengdu UniversityChengduChina Department of Mathematics The Islamia University of BahawalpurBahawalpurPakistan Centre for Advanced Studies in Pure and Applied Mathematics Bahauddin Zakariya UniversityMultanPakistan Institute for Intelligent Information Processing South China Business College of Guangdong University of Foreign StudiesGuangzhouChina

The distance between two vertices u and v in a connected graph G is the number of edges lying in a shortest path(geodesic)between them.A vertex x of G performs the metric identification for a pair(u,v)of vertices in G if and only if the equality between the distances of u and v with x implies that u=v(That is,the distance between u and x is different from the distance between v and x).The minimum number of vertices performing the metric identification for every pair of vertices in G defines themetric dimension of *** this paper,we performthemetric identification of vertices in two types of polygonal cacti:chain polygonal cactus and star polygonal cactus.

关键词： Metric metric identification metric generator metric dimension cactus graph

Enabling Reachability Across Multiple Domains Without Controller Synchronization in SDN

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Computers, Materials & Continua 2021年第10期69卷 945-965页

作者： Nauman Khan Rosli Bin Salleh Ihsan ali Zahid Khan Noman Mazhar Roobaea Alroobaea Fahad Almansour usman ali Department of Computer System and Technology Faculty of Computer Science and Information TechnologyUniversity of MalayaMalaysia Department of Computer Science and IT University of MalakandPakistan Robotics and Internet-of-Things Lab Prince Sultan UniversityRiyadhSaudi Arabia Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia Department of Computer Science College of Sciences and Arts RassQassim UniversityBuraydah51452Saudi Arabia

Software-defined networking(SDN)makes network agile and flexible due to its programmable *** extensive network has multiple domains in SDN for the scalability and performance of the ***,the inter-domain link is also crucial for the stability of the entire network on the data plane *** than one inter-domain connection enhances the scalability of the data plane ***,it faces a reachability problem with the principal root,which causes forwarding loops and packet drops in the network,thereby degrading network *** proposed solution is a multiple controller architecture;however,this approach increases the complexity and affects network ***,in this study,we propose a framework that avoids forwarding loops and packet drops without the synchronization of multiple-domain controllers in the network using an avoid loop with test packet ***,we collect the link status for improved routing and load balancing for the upcoming flow across inter-domain links to prevent congestion and increase throughput in real *** proposed methodology can significantly reduce the controller workload against multiple controller architecture,minimize flow setup latency,and improve throughput.

关键词： Multiple domain packet drop forwarding loop load balancing SDN multiple controller

On the Constant Metric Dimension of Generalized Petersen Graphs P(n,4)

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Acta Mathematica Sinica,English Series 2014年第7期30卷 1145-1160页

作者： Saba NAZ Muhammad SALMAN usman ali Imran JAVAID Syed Ahtsham-ul-Haq BOKHARY Center for Advanced Studies in Pure and Applied Mathematics Bahauddin Zakariya University

In this paper, we consider the family of generalized Petersen graphs P（n,4）. We prove that the metric dimension of P（n, 4） is 3 when n = 0 （mod 4）, and is 4 when n = 4k ＋ 3 （k is even）.For n = 1,2 （mod 4） and n = 4k ＋ 3 （k is odd）, we prove that the metric dimension of P（n,4） is bounded above by 4. This shows that each graph of the family of generalized Petersen graphs P（n, 4） has constant metric dimension.

关键词： Metric dimension constant metric dimension generalized Petersen graphs