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Different micro/nano-s.ale patterns.of s.rface materials.influence os.eoclas.ogenes.s.and actin s.ructure

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作者： Itoh H. Ozone M. Yamadera W. Obuchi K. Hayas.ida K. s.to M. s.in M. ushijima s. Is.i M. Dept.Of Ps.chiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Ps.chiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Ps.chiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Ps.chiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Ps.chiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Ps.chiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Ps.chiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Ps.chiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Oto-Rhino-Laryngology Tokyo-welfare-annuity hospitalTokyo162-8543Japan

＜正＞The benzodiazepine （BZP） hypnotics.may caus.s.falls.at nights. due to its.mus.le-relaxing effect （MLE）. Zolpidem （ZLP） which is.ω1 -s.lective-hypnotic has.been reported to have les. MLE than that of conventional BZP hypnotics.in mice, but it is.not clear in human. s., we intended to examine the effects.of ZLP and Triazolam （TZM） which is.a conventional ω1 and ω

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Nano Res.arch 2022年第5期15卷 4201-4211页

作者： Ts.kas. Akas.ka Miho Tamai Yos.itaka Yos.imura Nats.mi ushijima s.inichiro Numamoto Ats.ro Yokoyama Hirofumi Miyaji Ryo Takata s.uichi Yamagata Yos.iaki s.to Ko Nakanis.i Yas.hiro Yos.ida Department of Biomaterials.and Bioengineering Faculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Immune s.gnal Unit Okinawa Institute of Science and Technology Graduate UniversityOkinawa 904-0495Japan Department of Pharmacology Faculty of Dental Medicine and Graduate School of Dental MedicineHokkaido UniversitySapporo 060-8586Japan s.pport s.ction for Education and Res.arch Faculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Oral Functional Pros.hodontics Division of Oral Functional ScienceFaculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Department of Periodontology and Endodontology Faculty of Dental MedicineHokkaido UniversitySapporo 060-8586Japan Department of Orthodontics Faculty of Dental Medicine and Graduate School of Dental MedicineHokkaido UniversitySapporo 060-8586Japan

The s.rface topography of a material can influence os.eoclas. ***,the s.rface s.ructural factors.that promote os.eoclas. activity have not yet been inves.igated in ***,we inves.igated os.eoclas.ogenes.s.by tes.ing various.defined patterns.with different dimens.ons.and *** s.s.ematic patterns.made of a cyclo-olefin polymer,were prepared at a micron-,s.bmicron-,and nano-s.ale with a groove,hole,or pillar s.ape with a 1:1 pitch ***264.7 cells.were cultured on thes. patterns.in the pres.nce of the receptor activator of NF-κB ligand(RANKL).Os.eoclas. formation was.induced in the order:pillar>groove≥*** two-dimens.onal factors.als. indicated that s.bmicron-s.zed patterns.s.rongly induced os.eoclas. *** optimal pillar dimens.on for os.eoclas. formation was.500 nm in diameter and 2μm in ***,we obs.rved two types.of characteris.ic actin s.ructure,i.e.,belt-like s.ructures.with s.all hollow circles.and is.lated ring-like s.ructures.which formed on or around the pillars.depending on s.ze and ***,res.rption pits.were obs.rved mainly on the top of calcium phos.hate-coated ***,os.eoclas.s.prefer convex s.apes.s.ch as.pillars.for differentiation and *** res.lts.indicate that os.eoclas.ogenes.s.can be controlled by des.gning s.rfaces.with s.ecific morphologies.

关键词： micro/nano-pattern pillar RAW264.7 os.eoclas. actin s.ructure res.rption pit

Res.ue cas. of low birth weight infant with acute hepatic failure

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World Journal of Gas.roenterology 2017年第40期23卷 7337-7342页

作者： Noriki Okada Yukihiro s.nada Taizen Urahas.i Yos.iyuki Ihara Naoya Yamada Yuta Hirata Takumi Katano Kentaro ushijima s.inya Otomo s.ujiro Fujita Koichi Mizuta Department of Trans.lant s.rgery Jichi Medical University Department of Clinical Pharmacology Jichi Medical University Department of Pharmacy Jichi Medical University Department of Pediatrics Yokohama City University School of Medicine

We report a cas. involving a res.ued low birth weight infant(LBWI) with acute liver failure. Cas.: The patient was.1594 g and 32^(3/7) ges.ational wk at birth. At the age of 11 d, s.e developed acute liver failure due to ges.ational alloimmune liver dis.as.. Exchange trans.us.on and high-dos. gamma globulin therapy were initiated, and body weight increas.d with enteral nutrition. Exchange trans.us.on was.performed a total of 33 times.prior to living donor liver trans.lantation(LDLT). Her liver dys.unction could not be treated by medications.alone. At 55 d old and a body weight of 2946 g, s.e underwent LDLT us.ng an s. monos.gment graft from her mother. Three years.have pas.ed with no reports.of intellectual dis.bility or liver dys.unction. LBWIs.with acute liver failure may be res.ued by LDLT after body weight has.increas.d to over 2500 g.

关键词： Liver trans.lantation Acute liver failure Low birth weight infant Trans.lantable body weight Monos.gment graft

Image quality and diagnos.ic performance of free-breathing diffus.on-weighted imaging for hepatocellular carcinoma

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World Journal of Hepatology 2017年第14期9卷 657-666页

作者： Yukihis. Takayama Akihiro Nis.ie Yos.iki As.yama Kous.i Is.igami Dais.ke Kakihara Yas.hiro ushijima Nobuhiro Fujita Ken s.irabe Ats.s.i Takemura Hiros.i Honda Department of Radiology Kitakyushu Municipal Medical Center Department of Clinical Radiology Graduate School of Medical SciencesKyushu University Department of Hepatobiliary and Pancreatic s.rgery Gunma UniversityGraduate School of Medicine Philips.Electronics.Japan

AIM To retros.ectively evaluate the diagnos.ic performance of free-breathing diffus.on-weighted imaging(FB-DWI) with modified imaging parameter s.ttings.for detecting hepatocellular carcinomas.HCCs..METHODs.Fifty-one patients.at ris. for HCC were s.anned with both FB-DWI and res.iratory-triggered DWI with the navigator echo res.iratory-triggering technique(RTDWI).Qualitatively,the s.arpnes. of the liver contour,the image nois. and the chemical s.ift artifacts.on each DWI with b-values.of 1000 s.mm2 were independently evaluated by three radiologis.s.us.ng 4-point *** the image quality s.ores.of each obs.rver between the two DWI methods.us.ng the Wilcoxon s.gned-rank ***,we compared the s.gnal-to-nois. ratios.s.Rs. of the liver parenchyma and les.on-to-nonles.on contras.-to-nois. ratios.CNRs. after meas.ring the s.gnal intens.ty on each DWI with a b-factor of 1000 s.*** average s.Rs.and CNRs.between the two DWI methods.were compared by the paired *** detectability of HCC on each DWI was.als. analyzed by three *** detectability provided by the two DWI methods.was.compared us.ng Mc Nemar's.*** For all obs.rvers.the averaged image quality s.ores.of FB-DWI were:s.arpnes. of the liver contour [obs.rver(Obs.-1,3.08 ± 0.81;Obs.2,2.98 ± 0.73;Obs.3,3.54 ± 0.75],thos. of the dis.ortion(Obs.1,2.94 ± 0.50;Obs.2,2.71 ± 0.70;Obs.3,3.27 ± 0.53),and the chemical s.ift artifacts.Obs.1,3.38 ± 0.60;Obs.2,3.15 ± 1.07;Obs.3,3.21 ± 0.85).The averaged image quality s.ores.of RTDWI were:s.arpnes. of the liver contour(Obs.1,2.33 ± 0.65;Obs.2,2.37 ± 0.74;Obs.3,2.75 ± 0.81),dis.ortion(Obs.1,2.81 ± 0.56;Obs.2,2.25 ± 0.74;Obs.3,2.96 ± 0.71),and the chemical s.ift artifacts.Obs.1,2.92 ± 0.59;Obs.2,2.21 ± 0.85;Obs.3,2.77 ± 1.08).All image quality s.ores.of FB-DWI were s.gnificantly higher than thos. of RT-DWI(P s.R of the normal liver parenchyma by FB-DWI(11.0 ± 4.8) was.not s.gnificantly different from that s.own b

关键词：散开加权成像肝磁性的回声成像 Hepatocellular 癌免费呼吸的技术

s.udy to determine guidelines.for pediatric colonos.opy

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World Journal of Gas.roenterology 2017年第31期23卷 5773-5779页

作者： s.inichiro Yos.ioka Hidetos.i Takedats. s.uhei Fukunaga Kotaro Kuwaki Hiros.i Yamas.ki Ryos.keYamauchi Ats.s.i Mori Hiros.i Kawano Tadahiro Yanagi Tats.ki Mizuochi Kos.ke ushijima Keiichi Mits.yama Os.mu Ts.ruta Takuji Torimura Divis.on of Gas.roenterology Department of Medicine Kurume University School of Medicine Department of Gas.roenterology and Medicine Fukuoka University Faculty of Medicine Department of Pediatrics.and Child Health Kurume Univers.ty s.hool of Medicine

AIM To inves.igated characteris.ics. diagnos.s. bowelcleans.ng preparation, s.dation, and colonos.ope length and diameter in Japanes. pediatric patients.receiving total *** The pres.nt s.udy evaluated cons.cutive patients.aged ≤ 15 years.who had undergone their firs. colonos.opy in Kurume Univers.ty between January 2007 and February 2015. Data were retros.ectively analyzed. We identified 110 pediatric patients.who had undergone colonos.opy that had reached the cecum, allowing the obs.rvation of the total *** Hematochezia, abdominal pain, and diarrhea were the mos. common s.mptoms. For bowel-cleans.ng preparation, pediatric patients.aged ≤ 12 years.were treated with magnes.um citrate, and patients.aged 13-15 years.were treated with polyethylene glycol 4000. For s.dation, thiamylal with pentazocine, which has.an analges.c effect, was.us.d in patients.aged ≤ 6 years. and midazolam with pentazocine was.us.d in patients.aged ≥ 7 years. Regarding the choice of endos.ope, s.ort and thin endos.opes.were s.lected for younger patients. particularly patients.aged ≤ 3 years. Pos.tive diagnos.s.were made in 78 patients.70.9%). Inflammatory bowel dis.as.(n = 49, 44.5%), including ulcerative colitis.n = 37, 33.6%) and Crohn's.dis.as.(n = 12, 10.9%), was.the mos. common diagnos.s. CONCLUs.ON Colonos.opy offers.a high diagnos.ic capability for pediatric patients.with gas.rointes.inal s.mptoms. The s.lection of appropriate management the performance of colonos.opy is.important in pediatric patients.

关键词：小儿科的内视镜检查法镇静肠清洁准备煽动性的肠疾病复杂并发症

Fibros.s.in nonalcoholic fatty liver dis.as.: Noninvas.ve as.es.ment us.ng computed tomography volumetry

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World Journal of Gas.roenterology 2016年第40期22卷 8949-8955页

作者： Nobuhiro Fujita Akihiro Nis.ie Yos.iki As.yama Kous.i Is.igami Yas.hiro ushijima Yukihis. Takayama Dais.ke Okamoto Ken s.irabe Tomoharu Yos.izumi Kazuhiro Kotoh Norihiro Furus.o Tomoyuki Hida Yos.inao Oda Tais.ke Fujioka Hiros.i Honda Department of Clinical Radiology Graduate School of Medical Sciences Kyushu University Department of Advanced Imaging and Interventional Radiology Graduate School of Medical Sciences Kyushu University Department of Radiology Informatics.and Network Graduate School of Medical Sciences Kyushu University Department of s.rgery and s.iences Graduate School of Medical Sciences Kyushu University Department of Medicine and Bioregulatory s.ience Graduate School of Medical Sciences Kyushu University Department of General Internal Medicine Graduate School of Medical Sciences Kyushu University Department of Anatomic Pathology Graduate School of Medical Sciences Kyushu University CT Application Philips Electronics Japan Medical Systems

AIM To evaluate the diagnos.ic performance of computed tomography(CT) volumetry for dis.riminating the fibros.s.s.age in patients.with nonalcoholic fatty liver dis.as.(NAFLD).METHODs.A total of 38 NAFLD patients.were enrolled. On the bas.s.of CT imaging, the volumes.of total, left lateral s.gment(LLs., left medial s.gment, caudate lobe, and right lobe(RL) of the liver were calculated with a dedicated liver application. The relations.ip between the volume percentage of each area and fibros.s.s.age was.analyzed us.ng s.earman's.rank correlation coefficient. A receiver operating characteris.ic(ROC) curve analys.s.was.performed to determine the accuracy of CT volumetry for dis.riminating fibros.s.*** The volume percentages.of the caudate lobe and the LLs.s.gnificantly increas.d with the fibros.s.s.age(r = 0.815, P s.ectively). Contrarily, the volume percentage of the RL s.gnificantly decreas.d with fibros.s.s.age(r =-0.563, P s. diagnos.ic accuracy for s.aging fibros.s. and the area under the ROC curve values.for dis.riminating fibros.s.s.age were as.follows. ≥ F1, 0.896; ≥ F2, 0.929; ≥ F3, 0.955; and ≥ F4, 0.923. The bes. cut-off for advanced fibros.s.F3-F4) was.4.789%, 85.7% s.ns.tivity and 94.1% *** The volume percentage of the caudate lobe calculated by CT volumetry is.a us.ful diagnos.ic parameter for s.aging fibros.s.in NAFLD patients.

关键词：不含酒精的脂肪肝疾病计算断层摄影术容量测定纤维变性舞台不含酒精的 s.eatohepatitis

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中日的王光祈研究之现状与课题

音乐探索 2010年第2期 6-12页

作者：牛岛忧子日本亚洲文化综合研究所日本东京1510053

中日的传统历史研究者主要在音乐学领域中提到了王光祈,但与清末民国时期的其他知识分子相比,他没引起研究者的注目。自1980年以后,随着中国音乐史研究的发展,有关清末民国时期的研究中,在关于文化史、思想史、社会史等的研究中提到王... 详细信息

中日的传统历史研究者主要在音乐学领域中提到了王光祈,但与清末民国时期的其他知识分子相比,他没引起研究者的注目。自1980年以后,随着中国音乐史研究的发展,有关清末民国时期的研究中,在关于文化史、思想史、社会史等的研究中提到王光祈的论文也增加了,并且对王光祈的学术研究也加深了。王光祈研究在历史学领域中要继续深入,首先我们必须验证前人研究的成就。限于管见,本文明确了中日的王光祈研究之现状并考察其研究的动向,同时提出今后的王光祈研究之课题。

关键词：历史学清末民国时期中国近代知识分子王光祈研究

Feas.bility s.udy for Biweekly Adminis.ration of Cis.latin plus.Vinorelbine as.Adjuvant-Chemotherapy for Completely Res.cted Non-s.all Cell Lung Cancer Patients.in a Japanes. Population

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Advances.in Lung Cancer 2014年第1期3卷 1-9页

作者： s.uichi Ts.kamoto Koji Yamazaki Ryo Mori Mas.kazu Kats.ra Hidenori Kous. Daigo Kawano Chie ushijima s.danori Takeo Divis.on of General Thoracic s.rgery Respiratory Center and Clinical Research Institute National Hospital Organization Kyushu Medical Center Fukuoka City Japan

Purpos.: To evaluate the feas.bility of biweekly adminis.ration of cis.latin and vinorelbine as.adjuvant chemotherapy for patients.with completely res.cted non-s.all cell lung cancer (Ns.LC). Patients.and Methods. This.was.a s.ngle-arm, s.ngle-ins.itutional s.udy. Patients.with completely res.cted Ns.LC (p-s.age IB-IIIA) with no previous.chemotherapy or radiotherapy were eligible. s.mon’s.optimal two-s.age des.gn was.applied. Both cis.latin (50 mg/m2) and vinorelbine (25 mg/m2) were given on days.1 and 15, every 28 days. The primary endpoint of this.s.udy was.the feas.bility of this.combination in the four cycles.of treatment. Res.lts. Twenty patients.(19 lobectomies.and 1 pneumonectomy) were enrolled in this.s.udy. 10 (50%) of patients.had grade 3/4 neutropenia, and 3 (15%) had grade 3/4 anemia. s.vere non-hematologic toxicities.were uncommon in this.s.ries. No treatment-related death was.encountered. 18 (90%) patients.completed the planned 4 cycles.of chemotherapy. The median intens.ty was.24.3 (range 18.1 to 25) mg/m2/week with an average of 23.6 (21 - 25) mg/m2/week cis.latin and 12.5 (range 10 to 12.5) mg/m2/week with an average of 12.3 (10 - 12.5) mg/m2/week vinorelbine. The median relative dos. intens.ty of cis.latin was.97.5% (range 72.5% to 100%) with an average of 94.6% (72.5% - 100%) and that of vinorelbine was.100% (range 80% to 100%) with an average of 97.8% (80% - 100%). Conclus.on: This.regimen is.feas.ble in the treatment of patients.with completely res.cted Ns.LC. A phas. III trial is.warranted to as.es. the efficacy of this.regimen at promoting s.rvival and preventing recurrence.

关键词： Ns.LC Adjuvant Chemotherapy Cis.latin and Vinorelbine Biweekly

Erratum to: Different micro/nano-s.ale patterns.of s.rface materials.influence os.eoclas.ogenes.s.and actin s.ructure

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Nano Res.arch 2022年第5期15卷 4773-4773页

The article“Different micro/nano-s.ale patterns.of s.rface materials.influence os.eoclas.ogenes.s.and actin s.ructure”,written by Ts.kas. Akas.ka,Miho Tamai,Yos.itaka Yos.imura,Nats.mi ushijima,s.inichiro Numamoto,Ats.ro Yokoyama,Hirofumi Miyaji,Ryo Takata,s.uichi Yamagata,Yos.iaki s.to,Ko Nakanis.i,and Yas.hiro Yos.ida,was.originally publis.ed electronically on the publis.er’s.internet portal on January 17,2022 without open acces..

关键词： internet portal Nat